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Irza Wahid
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Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Hubungan Kadar Laktat Dehidrogenase dengan Stadium Limfoma Maligna Non Hodgkin di Rumah Sakit Dr. M. Djamil Padang periode Desember 2009 sampai Maret 2013 Dian Rahma Kasir; Irza Wahid; Hafni Bachtiar
Jurnal Kesehatan Andalas Vol 3, No 2 (2014)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v3i2.46

Abstract

AbstrakAwal abad ke-2l masyarakat Indonesia mengalami transisi epidemiologi penyakit. Perubahan pola penyakit ini dapat dilihat dari peningkatan insiden penyakit kanker sebagai penyebab kematian di Indonesia dalam 10 tahun terakhir, yaitu dari urutan ke-12 menjadi urutan ke-6. Di Indonesia, limfoma non Hodgkin (LNH) menduduki urutan keenam keganansan yang sering terjadi. Berdasarkan penelitian yang dilakukan oleh Olivia Putri Perdana di bagian patologi anatomi Fakultas Kedokteran Universitas Andalas didapatkan data bahwa pada januari 1997-desember 2001 terdapat 70 (81,39%) penderita limfoma maligna non Hodgkin dari keseluruhan penderita limfoma maligna. Penelitian ini bertujuan untuk mengetahui hubungan kadar laktat dehidrogenase (LDH) dengan stadium pada penderita limfoma maligna non Hodgkin. Penelitian ini adalah penelitian analitik dengan pendekatan cross sectional dengan menggunakan data yang bersumber dari rekam medik pasien. Populasi dari penelitian ini adalah data rekam medik seluruh penderita limfoma maligna non hodgkin yang berobat ke RSUP Dr. M. Djamil Padang yaitu 317 data rekam medik, tetapi yang memenuhi syarat untuk menjadi sampel hanya 40 data. Analisis statistik yang digunakan adalah uji T. Hasil uji statistik menunjukkan adanya hubungan kadar laktat dehidrogenase dengan stadium pada penderita limfoma non Hodgkin (P = 0,001). Diketahui nilai laktat dehidrogenase pada stadium III-IV lebih tinggi daripada nilai laktat dehidrogenase pada stadium I-II.Kata kunci: Laktat dehidrogenase, Limfoma maligna non Hodgkin, Stadium AbstractEarly 21th century, Indonesian society in transition epidemiology of the disease. Changing patterns of disease can be seen from the increased incidence of cancer as a cause of death in Indonesia in the last 10 years, ie from 12th to 6th order. In Indonesia, non-Hodgkin's lymphoma (NHL) ranks sixt frequent in all of cancer. Based on research conducted by Olivia Putri Perdana in anatomic pathology at the Faculty of Medicine, University of Andalas that the data obtained during the January 1997 - December 2001 there were 70 (81.39%) patients with non -Hodgkin's malignant lymphoma of the overall malignant lymphoma patients.This study aims to determine the relationship of levels of lactate dehydrogenase (LDH) with stage of non -Hodgkin's malignant lymphoma patients.This research is a cross sectional analytic approach using data derived from patient medical records. The population is the entire medical record malignant non Hodgkin lymphoma patients who went to DR. M. Djamil Padang hospital, they are 317 medical records, but are eligible to be sampled only 40 data. Statistical analysis used is the T test.Statistical test results show that there is relationship between lactate dehydrogenase levels with stage in non -Hodgkin's lymphoma patients (P = 0.001). Known value of lactate dehydrogenase in stage III - IV is higher than the value of lactate dehidrodenase in stage I - II.Keywords: Lactate dehydrogenase, malignant non-Hodgkin's lymphoma, Stage
TERAPI TRANSFUSI DARAH LEUKODEPLETED PADA PASIEN THALASSEMIA Bobby Rojas; Irza Wahid
HUMAN CARE JOURNAL Vol 5, No 2 (2020): Human Care Journal Special Edition
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v5i2.756

Abstract

Thalassemia merupakan gangguan sintesis hemoglobin (Hb), khususnya rantai globin, yang diturunkan.  Data Pusat Thalassemia, Departemen Ilmu Kesehatan Anak, FKUI-RSCM, sampai dengan bulan Mei 2014 terdapat 1.723 pasien dengan rentang usia terbanyak antara 11-14 tahun.1,  Pengobatan penyakit thalassemia sampai saat ini belum sampai pada tingkat penyembuhan. Di seluruh dunia tata laksana thalassemia bersifat simptomatik berupa transfusi darah seumur hidup. Dahulu target Hb pra transfusi darah 6gr% dan pasca transfusi 8-10gr%, namun sekarang target Hb pra transfusi adalah 9-10gr% dan pasca transfusi adalah 12gr% pada wanita dan 13gr% pada pria.3,4 Transfusi darah merupakan tindakan transplantasi organ yang sederhana, tetapi mengandung banyak risiko, seperti reaksi transfusi dan tertularnya penyakit akibat tercemarnya darah donor oleh virus seperti hepatitis B, C, Human Immunodeficiency Virus (HIV), dan human t-cell leukemia virus (HTLV). Baru pada akhir tahun 2011 pasien thalassemia di RS tertentu bisa mendapatkan packed red cells (PRC) rendah leukosit dengan menggunakan skrining nucleic acid test (NAT), namun tidak rutin tersedia. Selain risiko tertular penyakit infeksi, pasien yang mendapatkan transfusi berulang juga dapat mengalami reaksi transfusi mulai dari ringan seperti menggigil, urtikaria, sampai berat seperti syok anafilaksis. Penggunaan bedside filter saat pemberian transfusi darah non leukodeplesi pada saat transfusi belum rutin dilakukan, karena akan menambah biaya.
Miliary Tuberculosis in Immunocompromised Patient Induced by Imatinib and Steroid Fermada, Randa; Fauzar, Fauzar; Kurniati, Roza; Wahid, Irza
Andalas Journal of Health Vol. 10 No. 3 (2021): Online November 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i3.1821

Abstract

Miliary tuberculosis occurs due to the hematogenous spread of Mycobacterium Tuberculosis from the primary complex.  The use of steroid and cytotoxic drugs increases the incidence of miliary tuberculosis.  Typical manifestations of miliary tuberculosis is snowstorm appearance seen on chest x-ray and evidence of tuberculosis microorganism from the microbiological examination.  It has been reported a 33 years old male patient was admitted to the hospital due to breathlessness, chronic coughing, fever, anorexia, weight loss and night sweating with a "damp shadow sign".  Due to chronic myelogenous leukemia and autoimmune hemolytic anemia, the patient is known under imatinib and steroid therapy.  There was no specific sign found from the physical examination.  Chest x-ray showed snowstorm appearance.  The patient underwent GeneXpert MTB/RIF, with the result low MTB detected.  The patient was treated with a 2(HRZE)/4(HR) tuberculosis drugs regimen.  Imatinib and steroid therapy was discontinued.  2-4 weeks of steroid usage with a daily dose equivalent to prednisone 15 mg increases the risk of activating a latent tuberculosis infection.  Imatinib affects the response of T cells to Mycobacterium, thereby triggering tuberculosis reactivation.  In this case, the diagnosis has been made from typical manifestations of tuberculosis, snowstorm appearance from the chest x-ray, and low MTB detected from GeneXpert MTB/RIF.  It has been recommended to detect latent tuberculosis infection before using steroid and cytotoxic drugs.Keywords:  imatinib, miliary tuberculosis,  steroid
Co-Authors Bobby Rojas Dian Rahma Kasir Fauzar, Fauzar Fermada, Randa Hafni Bachtiar Roza Kurniati