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Journal : Bali International Scientific Forum

Pengaruh Variasi Dosis Dekstrometorfan Terhadap Kadar Serum Glutamic Pyruvic Transaminase dan Gamma Glutamyl Transferase Pada Tikus Wistar Iswari, Ni Wayan Gita; Putra, I Gusti Putu Agus Ferry Sutrisna; Widayanti, Ni Putu
Bali International Scientific Forum Vol. 1 No. 1 (2020): Bali International Scientific Forum
Publisher : Bali International University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34063/bisf.v1i1.127

Abstract

Background: Dextromethorphan is an antitussive drug commonly found in cough medicine, besides that dextromethorphan has the function as an expectorant or cough suppressant. Dextromethorphan is widely misused by the community, especially adolescents. Objective: to determine the effect of variations in dextromethorphan doses on SGPT and GGT levels in wistar rats. Method: using an experimental research design using the pretest-posttest control group design method. The analysis technique uses SPSS One Way Annova analysis. Results: Giving doses of dextromethorphan can increase levels of SGPT and GGT, namely in group P1 of 5.68% and 14.06%, P2 of 16.67% and 26.82%, and P3 of 20.95% and 36.54 %. Conclusion: There are effects of variations in dextromethorphan doses on increasing levels of SGPT and GGT in Wistar rats. Suggestion: It is necessary to conduct examination parameters and need to do research with more varied and longer doses.
Pengaruh Ekstrak Batang Dan Daun Pakis Sayur (Diplazium Esculentum) Terhadap Kadar Hemoglobin, Hematokrit dan Jumlah Eritrosit Pada Tikus Putih Jantan yang Disuntikkan Natrium Nitrit (NaNO2) Sashmita, Geby; Putra, I Gusti Putu Agus Ferry Sutrisna; Widayanti, Ni Putu
Bali International Scientific Forum Vol. 1 No. 1 (2020): Bali International Scientific Forum
Publisher : Bali International University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34063/bisf.v1i1.128

Abstract

Background: Anemia is a decrease in hemoglobin level, hematocrit value and the number of erythrocytes in the body due to a lack of iron intake in the body. One plant that is rich in iron is vegetable ferns (diplazium esculentum). This research was conducted at the Animal Unit Laboratory of the Faculty of Medicine, Udayana University. Objective: To determine the effect of vegetable ferns and stem extracts on hemoglobin levels, hematocrit values and the number of erythrocytes. Method: This study uses true experimental design. Results: The results of this study prove that stem fern extract and vegetable ferns can increase hemoglobin levels, hematocrit values and the number of erythrocytes in experimental male rats with a dose of 0.18 grams, 0.36 grams and 0.72 grams. Conclusion: There was a significant effect on male white mice with anemia treatment after being given stem and vegetable fern leaf extract, where the administration of vegetable fern extracts and ferns with a dose of 0.72 grams resulted in an increase in hemoglobin levels of 52.07%, a hematocrit value of 32, 91% and the number of erythrocytes is 29.41%.
Pengaruh Pemberian Variasi Dosis Rifampisin Terhadap Kadar Gamma Glutamyl Transferase dan Alkaline Phosphatase Pada Tikus Putih Galur Wistar Jeharu, Sofiana Agustin; Putra, I Gusti Putu Agus Ferry Sutrisna; Widayanti, Ni Putu
Bali International Scientific Forum Vol. 1 No. 1 (2020): Bali International Scientific Forum
Publisher : Bali International University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34063/bisf.v1i1.129

Abstract

Background: Tuberculosis is a contagious infectious disease caused by the bacterium Mycobacterium tuberculosis. Rifampicin is a first-line drug for the treatment of tuberculosis. Rifampicin has a bactericidal effect and the sterilizing effect is effective against intracellular and extracellular tuberculosis bacteria. In addition, one of the side effects of using rifampicin is hepatotoxicity. Objective: to determine the effect of rifampicin drug dosage on GGT and ALP levels in wistar rats. Methods: using an experimental study design with the pretest and posttest control group design method with the use of test animals 24 wistar rats divided into 4 groups. The technique of analyzing data using SPSS One Way Annova was followed by a Post-Hoc Test. Results: The results of the study showed an average increase in GGT levels in treatment groups 1, 2 and 3 was 29.5%, 40.9% and 55.4% and the mean increase in ALP levels in treatment groups 1, 2 and 3 was 27.5 %, 46.7% and 53.5%. The One Way ANOVA test results obtained p = 0.00 (p <0.05) followed by the Post Hoc test obtained α> 0.05. Conclusions: there was a significant effect on the levels of GGT and ALP after the administration of dose variations of the rifampicin drug in wistar strain white rats.
Hubungan Kadar Timbal Dengan Kejadian Hipertensi Pada Pekerja Mekanik Dealer Motor Di Desa Dalung, Kecamatan Kuta Utara, Badung Tahun 2022 Pramesti, Ayu Christin; Widayanti, Ni Putu
Bali International Scientific Forum Vol. 6 No. 1 (2025): Bali International Scientific Forum
Publisher : Bali International University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34063/bisf.v6i1.491

Abstract

Latar Belakang: Paparan timbal (Pb) menyebabkan oxidative stress meningkat, sehingga mengakibatkan inflamasi dan mengganggu kerja nitric oxide (NO) yang berfungsi untuk memperlebar arteri dan mengatur tekanan darah, pada akhirnya memicu proses terjadinya hipertensi. Tujuan: Tujuan pada penelitian ini untuk mengetahui faktor demografi dan hubungan kadar timbal dengan kejadian hipertensi pada pekerja mekanik Dealer Motor di Desa Dalung Kecamatan Kuta Utara Kabupaten Badung. Metode: Metode yang digunakan penelitian ini adalah metode desrktif observasional dengan desain cross sectional study. Hasil: Faktor demografi responden pada kelompok umur kadar timbal tertinggi sebanyak 50% terdapat pada usia 20-35 tahun dengan tensi darah diastolik tertinggi sebanyak 25%, responden yang memiliki kebiasaan konsumsi alkohol memiliki kadar timbal dan tensi darah diastolik tertinggi sebanyak 8,3%, dan responden yang memiliki kebiasaan merokok sebanyak 41,6 %. Kesimpulan: tidak terdapat hubungan yang signifikan antara kadar timbal dengan kejadian hipertensi pada pekerja mekanik dealer motor di Desa Dalung Kecamatan Kuta, Utara Kabupaten Badung.