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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Abdi Insani Journal of Pharmaceutical and Sciences. AMMA : Jurnal Pengabdian Masyarakat
Syafika Alaydrus
STIFA Pelita Mas Palu
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health

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SWAMEDIKASI PENGGUNAAN OBAT ALERGI SEBAGAI UPAYA MENINGKATKAN PENGETAHUAN MASYARAKAT DI DESA SEJAHTERA KECAMATAN PALOLO: SWAMEDIKASI PENGGUNAAN OBAT ALERGI SEBAGAI UPAYA MENINGKATKAN PENGETAHUAN MASYARAKAT DI DESA SEJAHTERA KECAMATAN PALOLO indah kurnia utami; Ratna Ika Yususf; niluh puspita dewi; Syafika Alaydrus
AMMA : Jurnal Pengabdian Masyarakat Vol. 1 No. 06 (2022): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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Abstract

Self-medication or what is known as self-medication is one of the actions that are often taken by the community to treat skin disorders. Based on a systematic review, it is known that the prevalence of self-medication in skin diseases ranges from 6-44%. Research in Togo, Africa found that 91.1% of people with skin disorders who seek treatment at health services have self-medicated before going to health services, while research conducted in Jakarta showed 44.64% of people were self-medicating for skin diseases with modern or traditional medicines. Allergies are reactions of the human immune system to certain objects, which should not cause reactions in other people's bodies. The reaction can appear in the form of a runny nose, itchy skin rash, or even shortness of breath. The drugs used by the public in self-medication of skin diseases are oral and topical drugs, including preparations containing corticosteroids, antibiotics and antifungals, a combination of salicylic acid and benzoic acid. Self-medication behavior can be influenced by knowledge, sociodemographic characteristics, family and advertising. Based on research, knowledge is the most significant factor influencing self-medication behavior.
Prostate Anticancer Activity Testing α Mangostin Invitro Study on Sel DU 145 Using WST 8 Method Rai Chika Dewi; Syafika Alaydrus; Tien Wahyuhandayani
Jurnal Penelitian Pendidikan IPA Vol 10 No 8 (2024): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i8.8517

Abstract

Prostate cancer is a cancer that has a high risk of death. Prostate cancer, specifically prostate adenocarcinoma, arises from the cells in the prostate gland or its peripheral zone. Chemotherapy, radiation therapy, and surgery are the main treatments for prostate cancer today. Empirical evidence shows that α-mangostin is used as a cancer therapy. At every stage of carcinogenesis, including cell division, proliferation, apoptosis, inflammation, and metastasis, α-mangostin can inhibit it. This study aims to evaluate the activity of α-mangostin against the DU145 prostate cancer cell line, and compare the %survival rate between cisplatin and α-mangostin. The method used is cytotoxicity testing in vitro with the WST-8 method. The research results showed that α-mangostin had an IC50 value of 16.89 ppm, in the active category, IC50 of cisplatin was 4.69 in the active category. Then statistical analysis was carried out using GraphPad Prism versi9.0.0 The results obtained were no significant differences between %survival rate cisplatin and α-mangostin at a concentration of 12.5 ppm. The conclusion of this study is The IC50 values of α-Mangostin and cisplatin against DU 145 cells were 16.89 ppm and 4.65 ppm, respectively. At a concentration of 12.5 ppm, there was no significant difference in their effects.
Anti-Cancer Activity Of The Combination Of Marine Mineral Consentrates And α Mangostin On Prostate Cancer Line DU 145 And HEK 293 By WST-8 Method Giska Putri Agustina; Syafika Alaydrus; Niluh Puspita Dewi
Jurnal Penelitian Pendidikan IPA Vol 10 No 8 (2024): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i8.8518

Abstract

Marine mineral concentrates have good activity against normal cells, but are less effective against cancer cells. This research was carried out by combining concentrations of sea minerals with natural ingredients that have anti-cancer potential, one of which is α-mangostin. This study aims to determine the IC50 of the combination of α-mangostin, marine mineral concentrate, the combination of α-mangostin & marine mineral concentrate when compared cisplatin and evaluate the activity of α-mangostin, KML and the combination of α-mangostin and KML compared with ciplatin against the DU 145 cancer cell line and HEK 293. The method used is cytotoxicity testing using the WST-8 method. The results of the test materials were α-Mangostin 16.89 ppm, the combination of α-Mangostin-KML with a concentration of 12.5 ppm, namely 1,732 ppm, the combination of α-Mangostin-KML with a concentration of 25 ppm, namely 4,930 ppm, the combination of α-Mangostin-KML with concentration of 50 ppm 5,194 ppm, and cisplatin 4,649 ppm. The results of data analysis show significant differences for all samples. Conclusion α-Mangostin helps KML increase the cytotoxic effect on DU 145 cancer cells and sea mineral concentrate helps reduce the cytotoxic effect of α-Mangostin on normal HEK-293 cells.
Determination of specific and non-specific standardization parameters for ethanol extract of purple leaves (Graptophyllum pictum (L) Griff ) Rivani Tampang; Syafika Alaydrus; Niluh Puspita Dewi; Joni Tandi
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8812

Abstract

this study aims to determine the standardization of specific parameters (organoleptic and chemical content) and non-specific parameters (ash content, water content, drying loss, heavy metal contamination, Yeast Mold Number (AKK), microbial contamination / Total Plate Count (ALT)). The results showed that the specific parameters of the organoleptic properties of 96% ethanol extract of purple leaves (Grapthophyllum pictum (L) Griff) were black, shaped like a paste, a distinctive purple leaf odor and a bitter taste. The results of phytochemical screening of 96% purple leaf ethanol extract contained alkaloids, flavonoids, and tannins. However, the saponin test was negative for saponins. Non-specific parameters of 96% ethanol extract of cherry leaves were water content of 5.96%, total ash content of 16.86%, drying loss of 17.26%, heavy metals As and Cd were not detected, the presence of metals in Pb was 0.12 mg / kg, microbial contamination (Alt) and yeast mold numbers (Akk) were not found colonies. Based on these results, it can be concluded that the standardization test of specific and non-specific parameters, the ethanol extract of purple leaves has met the quality standards of simple drugs.
Effect of Purple Leaf (Graptophyllum pictum (L.) Griff) Emulsion on the Histological Parameters of Streptozotocin-Induced Diabetic Rats Niluh Puspita Dewi; Komang Dewik; Syafika Alaydrus; Athia Kurnia Kasim; Nani Astria Polontalo; Wayan Wirawan; Dian Andini; Irma Irma; Imelda Synthia Fatu
Jurnal Penelitian Pendidikan IPA Vol 12 No 1 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i1.14172

Abstract

Damage to vital organs such as the liver, kidneys, and pancreas is a common complication of diabetes mellitus, characterized by chronic hyperglycemia due to pancreatic cell dysfunction. Graptophyllum pictum (purple leaf) is a potential herbal therapy containing bioactive compounds with antioxidant and organ-protective effects. This study aimed to evaluate the effect of purple leaf emulsion on blood glucose levels and the histopathological features of diabetic rats induced by streptozotocin. Rats were divided into six groups: normal control, negative control, positive control (glibenclamide), and three doses of purple leaf emulsion (100, 200, and 300 mg/kg BW). After 28 days of treatment, the emulsion significantly reduced blood glucose levels and improved the histological structures of the liver, kidneys, and pancreas. The 200 mg/kg BW dose was most effective for pancreatic protection, while 300 mg/kg BW provided optimal hepatoprotective and renoprotective effects. These findings highlight the potential of purple leaf as a natural antidiabetic and organ-protective agent.
EDUKASI PEMANFAATAN SEDUHAN DAUN TEH HIJAU SEBAGAI ANTIKARIES DI DESA BOSA KEC. TAWAELI, SULAWESI TENGAH Sririzqi Muthmainnah A. R; Syafika Alaydrus; Mariyani Mariyani; Faikah Dyah Utami; Sandra Sri Dewi Djumiran; Annisa Fitria Tamuntuan
Jurnal Abdi Insani Vol 13 No 1 (2026): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v13i1.2775

Abstract

Bosa Village is categorized as a 3T priority area (Frontier, Outermost, and Disadvantaged), resulting in a lack of dental health facilities and limited public knowledge regarding the dangers of dental caries, as well as a lack of understanding of utilizing plants for disease prevention. Shredded green tea leaves (Camellia sinensis) are a widely available commercial product that can be utilized for dental caries prevention due to their antibacterial properties. Therefore, the objective of this community service is to educate the public on dental caries prevention, specifically through the formulation of mouthwash from steeped green tea leaves to enhance knowledge of dental health maintenance using accessible products. The method employed was the lecture method, complemented by the distribution of brochures. This was followed by a recall of the material through a Q&A session. The results showed a significant improvement in the participants' competence between the pre-test and post-test. Although participants initially lacked understanding in several aspects, there was a substantial increase in comprehension following the post-test. This improvement was evident after the community of Bosa, Hamlet II, received education on utilizing green tea leaves as a mouthwash for dental caries prevention. Consequently, the community has begun to understand the prevention and maintenance of oral health, including the use of shredded green tea leaves as an anti-caries mouthwash.
Pengaruh Ekstrak Bunga Kecombrang (Etlingera elatior (Jack)) Terhadap Gambaran Histopatologi Lambung Pada Tikus Putih Jantan (Rattus norvegicus) Yang Diindukasi Streptozotocin Matra Novalia Palipadang; Syafika Alaydrus; Joni Tandi; Utami Islamiati; Ficanata Adhiguna Toding; Vianda Managanta
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1293

Abstract

Background: Hyperglycemia induced by streptozotocin (STZ) increases oxidative stress and inflammatory responses that may lead to gastric mucosal damage. Kecombrang flower (Etlingera elatior (Jack)) contains flavonoids and other secondary metabolites with antioxidant, anti-inflammatory, and antihyperglycemic properties that are potentially gastroprotective. Objective: This study aimed to evaluate the effect of ethanol extract of kecombrang flower on the histopathological profile of the stomach in male white rats (Rattus norvegicus) induced by streptozotocin and to determine the most effective dose. Methods: This experimental in vivo study employed a posttest-only control group design. Twenty-five male rats were divided into five groups (n=5): normal control, negative control (STZ-induced), positive control (STZ + glibenclamide), extract 50 mg/kg body weight (BW), and extract 100 mg/kg BW. Streptozotocin was administered intraperitoneally at 40 mg/kg BW. Gastric tissues were examined histopathologically using hematoxylin-eosin staining and assessed based on degeneration, necrosis, and inflammation scoring. Data were analyzed using Kruskal–Wallis followed by Mann–Whitney test with Bonferroni correction (p<0.05). Results: Phytochemical screening confirmed the presence of alkaloids, flavonoids, saponins, and tannins in the extract. Statistical analysis showed significant differences among groups in degeneration (p=0.013) and inflammation (p=0.047), but not in necrosis (p=1.000). The 100 mg/kg BW dose demonstrated the most prominent protective effect, with lower degeneration and inflammation scores and an average gastric damage score of 1, comparable to the positive control group. Conclusion: Ethanol extract of kecombrang flower at a dose of 100 mg/kg BW effectively reduced gastric histopathological damage in streptozotocin-induced male rats, indicating its potential gastroprotective activity through antioxidant and anti-inflammatory mechanisms.
Co-Authors Annisa Fitria Tamuntuan Athia Kurnia Kasim Dian Andini Faikah Dyah Utami Ficanata Adhiguna Toding Giska Putri Agustina Imelda Synthia Fatu Indah Kurnia Utami Irma Irma Joni Tandi, Joni Komang Dewik Mariyani Mariyani Matra Novalia Palipadang Nani Astria Polontalo Niluh Puspita Dewi Rai Chika Dewi Ratna Ika Yususf Rivani Tampang Sandra Sri Dewi Djumiran Sririzqi Muthmainnah A. R Tien Wahyuhandayani Utami Islamiati Vianda Managanta Wayan Wirawan