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All Journal KOVALEN: Jurnal Riset Kimia Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal FARMAKU (Farmasi Muhammadiyah Kuningan) ad-Dawaa : Journal of Pharmaceutical Sciences Mattawang: Jurnal Pengabdian Masyarakat JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Pengabdian Kefarmasian Duta Abdimas: Jurnal Pengabdian Masyarakat Gema Kesehatan Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian
Ayu Wulandari
STIFA Pelita Mas Palu
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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MACROSCOPIC AND MICROSCOPIC GASTROPROTECTIVE ACTIVITY OF MUCOADHESIVE GRANULE FORMULATIONS OF CLOVE LEAF ETHANOL EXTRACT Dhitania Ivana Harliwong; Ayu Wulandari; Niluh Puspita Dewi; Sririzqi Muthmainnah; Joni Tandi; Putu Intan
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8949

Abstract

Gastric ulcers can be triggered by excessive HCl secretion, and the regenerative capacity of mucosal cells can be weakened by high alcohol levels and anti-inflammatory drugs, including NSAIDs. Gastrin functions to stimulate the secretion of gastric juice, particularly HCl and pepsinogen This study aims to evaluate the macroscopic and microscopic gastroprotective activity of clove leaf ethanol extract mucoadhesive granule formulations. The study used 25 rats divided into five groups: normal control, negative control, positive control, clove leaf ethanol extract group, and mucoadhesive granule formulation of clove leaf ethanol extract group. All groups except the normal control were administered acetylsalicylic acid. Treatments were conducted over 9 days, with surgical examination and observations performed macroscopically and microscopically on day 10. Macroscopic assessments revealed ulcer damage improvement in the positive control, extract, and mucoadhesive granule groups, all scored at 1. Microscopic assessments also indicated a significant difference between the negative control and the positive control, extract, and mucoadhesive granule groups, showing better gastric repair, scored at 0.5. Therefore, it can be concluded that the administration of the mucoadhesive granule formulation of clove leaf ethanol extract exhibits gastroprotective activity comparable to that of the clove leaf ethanol extract.
Co-Authors Agung Budiawan, Erick Dhitania Ivana Harliwong Ernawati Ernawati Febry Grasela Aula Gloria, Yovanka Lista Handayani, Kiki Rizki Indah Kurnia Utami Joni Tandi, Joni Monica Sandra Monica Sandra Makatang Muthmainah Tuldjanah Niluh Puspita Dewi Niluh Puspita Dewi Palumpun, Tri Olan Putu Intan Recky Patala Rezky Yanuarty Rezky Yanuarty Sarwadana, I Made Sririzqi Muthmainnah Suci Rahmayanti Syafika Alaydrus Wayan Wirawan Wayan Wirawan