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All Journal WMJ (Warmadewa Medical Journal) Journal of Agromedicine and Medical Sciences UNEJ e-Proceeding Pharmascience Indonesian Journal of Cardiology Indonesian Journal of Medicine Jurnal Ilmiah Kesehatan Journal of Health Sciences GANESHA MEDICINA Jurnal Kesehatan Kusuma Husada Indonesian Journal of Cancer International Journal of Health and Information System (IJHIS)
Pipiet Wulandari
Fakultas Kedokteran Universitas Jember
Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Nursing Public Health

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THE EFFECT OF CONSUMPTION OF YOUNG COCONUT (COCOS NUCIFERA L) ON CHOLESTEROL LEVELS IN HEALTHY PEOPLE Aris Prasetyo; Alif Kufari; Septa Surya Wahyudi; Jauhar Firdaus; Adelia Handoko; Kristianingrum Dian Sofiana; Pipiet Wulandari
UNEJ e-Proceeding 2022: E-Prosiding Kolokium Hasil Penelitian dan Pengabdian kepada Masyarakat
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

High blood cholesterol levels are risk factors that cause an increase in Low Density Lipoprotein (LDL) that it can form clots and plaque in the vascular which will result in the formation of atherosclerosis. Galactomannan is a natural ingredient that can reduce blood cholesterol levels by inhibiting its absorption and forming hydrogen bonds with cholesterol. In Indonesia, a potential source of galactomannan is coconut (Cocos Nucifera L). This study aims to determine the effect of consumption of young coconuts on cholesterol levels in healthy people. This research is an experimental clinical trial study with a pretest-posttest design. The sample of this study was twenty healthy people aged 18-25 years consisting of 10 men and 10 women. The treatment is in the form of consumption of coconut with 250 gram coconut meat and 150 mL coconut water with administration once a day for 14 days. The beginning and the end of the treatment blood cholesterol level were examined. after the treatment of coconut, consumption obtained a decrease in blood cholesterol levels by 17 participants and 3 participants with an increase in blood cholesterol levels. it can be concluded that there is a significant influence on the consumption of young coconuts to reduce blood cholesterol levels in healthy people. Keywords: cholesterol, coconut, galactomanan
Aktivitas Renoprotektif Daun Kelor (Moringa oleifera Lamk) pada Tikus Model Diabetes Mellitus Tipe 2 Miranda Dewi; Suryono Suryono; Pipiet Wulandari
Jurnal Pharmascience Vol 9, No 2 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i2.13188

Abstract

Indonesia negara dengan kekayaan alam yang dapat dimanfaatkan sebagai bahan pangan, papan dan kesehatan. Daun kelor merupakan bagian dari sumber kekayaan alam Indonesia. Daun kelor memiliki senyawa aktif flavonoid yang memiliki khasiat antioksidan sehingga dapat membantu menurunkan stress oksidatif pada multiorgan akibat hiperglikemia, misalnya pada ginjal. Tujuan penelitian ini untuk mengetahui pengaruh pemberian ekstrak daun kelor (Moringa oleifera Lamk.) terhadap kadar serum kreatinin tikus Wistar jantan yang diinduksi streptozotosin. Penelitian ini merupakan penelitian true experimental design dengan rancangan post test only control group design. Penelitian ini menggunakan 28 ekor tikus Wistar jantan (Rattus novergicus) sebagai populasi dengan berat 200-300 gram yang dibagi menjadi 7 kelompok melalui metode simple random sampling. Pemberian dosis ekstrak daun kelor dibagi menjadi 5 kelompok yaitu dengan dosis 62,5 kgBB, 125, 250, 500, dan 1000 mg/kgBB. Analisis data yang digunakan adalah uji korelasi Spearman. Pada penelitian ini menunjukkan p< 0,001 yang dapat disimpulkan bahwa adanya korelasi yang signifikan antara dosis ekstrak daun kelor dan kadar serum kreatinin. Kata Kunci: Daun Kelor, Streptozotosin, Hiperglikemik Indonesia is a country with natural resources that can be used as food, basic necessities and health. Moringa leaves are part of Indonesia's natural resources. Moringa leaves have flavonoid active compounds that have antioxidant properties so that they can help reduce oxidative stress in multiple organs due to hyperglycemia, for example in the kidneys. The purpose of this study was to determine the effect of giving moringa leaf extract (Moringa oleifera Lamk) on serum creatinine levels of male Wistar rats induced by streptozotocin. This research is a true experimental design with a post test only control group design. This study used 28 male Wistar rats (Rattus novergicus) as a population weighing 200-300 grams which were divided into 7 groups through simple random sampling method. The doses of moringa leaf extract were divided into 5 groupsdoses of 62.5, 125, 250, 500 and 1000 mg/kgBW. Analysis of the data used was the Spearman correlation test (p < 0.001) which could be concluded that the correlation between the dose of moringa leaf extract and serum creatinine levels had a significant effect.
POTENSI KECERDASAN BUATAN DALAM PENINGKATAN AKURASI PEMBACAAN HASIL MAMOGRAFI: TINJAUAN SISTEMATIS DAN META-ANALISIS MUNAWIR, AL; Sekar Arum Srigati; Pipiet Wulandari
Ganesha Medicina Vol. 3 No. 1 (2023)
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/gm.v3i1.55575

Abstract

ABSTRAK Kanker payudara merupakan suatu penyakit keganasan oleh karena proliferasi tak terkontrol dari sel-sel di payudara. Jumlah morbiditas dan mortalitas yang cukup tinggi menjadikan upaya skrining dan deteksi dini kanker payudara penting untuk dilakukan. Mamografi merupakan modalitas utama skrining kanker payudara yang diinterpretasikan oleh ahli radiologi berdasarkan persepsi visual. Namun, peningkatan permintaan skrining selaras dengan peningkatan beban kerja yang dapat mempengaruhi efektivitas dan menyebabkan kesalahan interpretasi hasil mamografi. Perkembangan teknologi, salah satunya kecerdasan buatan (AI) dengan algoritma deep learning diklaim memiliki kinerja yang lebih baik daripada kinerja rata-rata ahli radiologi. Tujuan penelitian ini adalah untuk mengkaji potensi AI dalam meningkatkan akurasi pembacaan hasil mamografi. Penelitian ini merupakan tinjauan sistematis dan meta-analisis menggunakan artikel dengan desain penelitian retrospektif dari lima basis data sesuai panduan Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Risiko bias dikaji menggunakan Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). Total terdapat 12 artikel terinklusi yang dianalisis berdasarkan penggunaan tunggal AI, ahli radiologi, dan kombinasi ahli radiologi-AI. Hasil meta-analisis penggunaan tunggal AI menunjukkan hasil yang lebih tinggi dibandingkan lainnya pada sensitivitas (88% (95% CI 82%-92%)), spesifisitas (89% (95% CI 81%-93%)), dan AUC (0,94 (95% CI 0,92-0,96)). Penelitian ini menunjukkan adanya potensi yang menjanjikan dari kecerdasan buatan (AI) untuk meningkatkan akurasi pembacaan hasil mamografi. Kata Kunci: AI, deep learning, kanker payudara, mamografi ABSTRACT Breast cancer is a malignancy caused by the uncontrollable proliferation of breast cells. The high morbidity and mortality make an essential excuse for screening and early detection of breast cancer. Mammography is the main modality in the examination of breast cancer screening which is interpreted by radiologists based on visual perception. The increase in screening demand leads to workload which affects the effectiveness and misinterpretation of mammography results. These years, technological development such as artificial intelligence (AI) in its deep learning algorithm claimed to have better performance than the average performance of radiologists. Hence, this study aimed to investigate the potency of AI to enhance the accuracy of a mammography reading. This systematic review and meta-analysis conducted retrospective articles from five electronic databases based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The risk of biases was assessed from each study using Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). Twelve articles were included and analyzed for the AI stand-alone, radiologists stand-alone, and combination of radiologists with AI. The current study showed the higher results of AI stand-alone compared to others in its sensitivity (88% (95% CI 82%-92%)), specificity (89% (95% CI 81%-93%)), and area under the curves (0,94 (95% CI 0,92-0,96)). In conclusion, this systematic review and meta-analysis provide valuable evidence about AI's promising potency to enhance mammography reading accuracy. Keywords: AI, breast cancer, deep learning, mammography
ANALISIS FAKTOR RISIKO KEJADIAN ATRIAL FIBRILASI PADA PASIEN MITRAL STENOSIS DI RSD Dr. SOEBANDI JEMBER Hairrudin, Hairrudin; Triastiana Kurbaini, Feby; Wulandari, Pipiet
Jurnal Kesehatan Kusuma Husada Vol. 15 No. 2, Juli 2024
Publisher : Universitas Kusuma Husada Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34035/jk.v15i2.1308

Abstract

Mitral stenosis merupakan kelainan katup jantung dengan prevalensi yang masih tinggi di negara-negara berkembang seperti Indonesia. Penyakit ini menjadi penyebab tersering morbiditas dan mortalitas dini pada generasi muda di seluruh dunia. Salah satu komplikasi dari mitral stenosis adalah atrial fibrilasi yang dapat disebabkan oleh beberapa faktor risiko seperti, usia lanjut, dilatasi atrium sinistra, rendahnya nilai Left Ventricular Ejection Fraction (LVEF) dan Tricupsid Annular Plane Systolic Excursion (TAPSE), serta presentasi trombus. Penelitian ini bertujuan untuk menilai faktor risiko kejadian atrial fibrilasi pada pasien mitral stenosis. Penelitian ini menggunakan jenis analitik deskriptif dengan desain penelitian cross sectional. Sampel penelitian adalah seluruh pasien rawat jalan yang terdiagnosis mitral stenosis di Poli Jantung RSD dr. Soebandi Jember pada periode antara Januari 2022 - Januari 2024. Data variabel dianalisis menggunakan analisis univariat, bivariat (chi-square), dan multivariat (regresi logistik berganda). Jumlah sampel penelitian sebanyak 70 pasien, pasien mitral stenosis didominasi oleh wanita dan pasien berusia >40 tahun. Sebanyak 81% pasien mitral stenosis mengalami atrial fibrilasi. Dari enam variabel yang diteliti didapatkan bahwa derajat mitral stenosis (P = 0,005 ; OR = 12,744) dan usia >40 tahun (P = 0,012 ; OR = 15,835) memiliki hubungan yang signifikan terhadap kejadian atrial fibrilasi berdasarkan hasil uji bivariat dan multivariat. Dapat disimpulkan bahwa faktor risiko terkait kejadian atrial fibrilasi pada pasien mitral stenosis di RSD dr. Soebandi Jember adalah derajat mitral stenosis dan usia lanjut. Mitral stenosis is a heart valve disorder with a high prevalence in developing countries such as Indonesia. This disease is the most common cause of morbidity and premature mortality in young people throughout the world. One of the complications of mitral stenosis is atrial fibrillation, which can be caused by several risk factors such as advanced age, left atrial enlargement, low Left Ventricular Ejection Fraction (LVEF), and Tricupsid Annular Plane Systolic Excursion (TAPSE), as well as thrombus presentation. This study aims to assess the risk factors for atrial fibrillation in mitral stenosis patients. This research uses descriptive analytics with a cross-sectional research design. The research sample was all outpatients diagnosed with mitral stenosis at the Cardiac Polyclinic, RSD Dr. Soebandi Jember in the period between January 2022 - January 2024. Variable data was analyzed using univariate, bivariate (chi-square), and multivariate analysis (multiple logistic regression). The total research sample was 70 patients, with mitral stenosis patients being dominated by women and patients aged >40 years. As many as 81% of mitral stenosis patients experience atrial fibrillation. Of the six variables studied, it was found that the degree of mitral stenosis (P = 0.005; OR = 12.744) and age >40 years (P = 0.012; OR = 15.835) had a significant relationship with the incidence of atrial fibrillation based on the results of bivariate and multivariate tests. It can be concluded that the risk factors related to the incidence of atrial fibrillation in mitral stenosis patients at RSD Dr. Soebandi Jember is the degree of mitral stenosis and advanced age.
The Correlation Between Organophosphate Pesticide Exposure and Incidence of Prostate Cancer: A Systematic Review Octavia, Aulia Mega Nur; Wisudanti, Desie Dwi; Wulandari, Pipiet
Indonesian Journal of Cancer Vol 18, No 4 (2024): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i4.1112

Abstract

Background: Organophosphate is a type of pesticide that is widely used. However, organophosphates are a group of highly toxic chemicals. The World Health Organization (WHO) estimates that nearly 3 million individuals experience organophosphate poisoning annually. One of the cancers that can develop due to exposure to organophosphate pesticides is prostate cancer. Prostate cancer is the second most prevalent cancer among men. In Indonesia, new cases of prostate cancer reached 13.563, or 7.4% of all new cancer cases in men. This study aims to determine the correlation between organophosphate exposure and the incidence of prostate cancer.Methods: This study is a research with a systematic review design. The data in this study is secondary data obtained from research articles using SPICE criteria. Pubmed, Science Direct, Springer, and Google Scholar are the databases used. The used articles were articles published between 2012 and 2022. Critical assessment was carried out using the NewcastleOttawa Quality Assessment Scale (NOS) questionnaire.Results: A total of 2.149 articles were obtained, with a range of research years from 2012 to 2022. Then a duplication selection process was carried out, free and fulltext selection. This article used the NewcastleOttawa Quality Assessment Scale questionnaire to select eligibility, so 5 articles were obtained. Among all the articles that underwent critical evaluation, it was reported that a relationship exists between organophosphate exposure and the incidence of prostate cancer among farmers. Conclusions: The evidence of this reviewed study suggests a possible association between the incidence of prostate cancer and exposure to organophosphate pesticides.
Cardiac Tamponade in a Chronic Renal Failure Patient with Suspicion of Dialysis Pericarditis: A Case Report Wulandari, Pipiet; Suryono, Suryono; Prasetyo, Aris; Firdaus, Jauhar; Sofiana, Kristianingrum Dian; Indreswari, Laksmi; Handoko, Adelia; Setia, Bagus
International Journal of Health and Information System Vol. 2 No. 1 (2024): May
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/ijhis.v2i1.39

Abstract

Pericardial effusion is a condition characterized by fluid accumulation in the pericardial cavity. This fluid accumulation can cause disturbances in cardiac contractility, affecting hemodynamic stability. Fluid accumulation is caused by several factors, ranging from the amount of fluid, the speed of fluid accumulation, and the ability of the pericardium to accommodate fluid. One of the causes of pericardial effusion is pericarditis. Pericarditis can be caused by infection and non-infection, such as in patients with chronic renal failure with an incidence of 2-21%, which can lead to cardiac tamponade. In this study, a 46-year-old male patient who came to the emergency room of Dr. Soebandi Hospital, Jember with complaints of shortness of breath in the last 2 months. The patient also complained of heartburn. The patient had a history of chronic renal failure and routinely performed hemodialysis. On examination of vital signs, thoracic photographs, and echocardiography, a picture of cardiac tamponade was found. Cardiac tamponade can occur in patients with chronic renal failure. This is due to the condition of uremia which causes pericarditis. Inflammation of the pericardium causes blood that is intravascular to enter the pericardial cavity, causing fluid accumulation there. If not treated immediately, it can lead to cardiac tamponade which endangers the patient's life.
The Relationship Between Hypertension and Mortality in COVID-19 Patients at Soedirman M. S. Wonogiri Hospital Anisa, Devisda Shafiy; Wisudanti, Desie Dwi; Wulandari, Pipiet
WMJ (Warmadewa Medical Journal) 80-87
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.10.2.12434.80-87

Abstract

According to data from the Ministry of Health of the Republic of Indonesia, there were 6,103,533 confirmed positive cases of COVID-19, with 156,776 deaths. One factor contributing to the high mortality rate of COVID-19 is the presence of comorbidities. Hypertension and diabetes mellitus are the most common comorbidities found in COVID-19 patients. In cases of hypertension, the SARS-CoV-2 virus can interfere with blood pressure regulation, resulting in sustained increases in blood pressure in infected patients. If this condition is not managed, organ damage may occur and worsen the patient’s clinical status. This study aims to evaluate the effect of comorbid hypertension on the mortality of COVID-19 patients at dr. Soediran M. S. Wonogiri Hospital. This research employed an analytical observational method with a cross-sectional design. Medical record data from 94 COVID-19 patients, consisting of 47 patients with hypertension and 47 patients without hypertension, were analyzed using the Chi-square test. The highest age distribution among COVID-19 patients was in the 51–60-year age group (21.3%). The results showed a significant association between comorbid hypertension and mortality in COVID-19 patients (p = 0.001), with an RR value of 1.27. COVID-19 patients with comorbid hypertension were 1.27 times more likely to die than those without hypertension. This study provides a better understanding of health risks in COVID-19 patients with comorbid hypertension and may assist in developing more effective health policies.
Co-Authors . Suryono Adelia Handoko Adistha Eka Noveyani Al Munawir Ali Santosa Alif Kufari Alyssandra Afqorina Agung Ancah Caesarina Novi Marchianti Angga Mardro Raharjo Anisa, Devisda Shafiy Aris Prasetyo Athiyah Fi Ramadani Atina Robbiatul Azizah Bhisma Murti Cholis Abrori, Cholis Desie Dwi Wisudanti Dina Ayu Savitri Dwi Ariyanti Emda Zein Cik Fitria Hairrudin Hairrudin Handoko, Adelia Inke Kusumastuti Jarwoto Roestanajie Jauhar Firdaus Karisma Adya Pertiwi Khadijah Nur Al Firdausi Kristianingrum Dian Sofiana Kristianingrum Dian Sofiana Laksmi Indreswari M. Ihwan Narwanto Miranda Dewi Naesilla Naesilla Nindya Shinta Rumastika Octavia, Aulia Mega Nur Prasetyo, Aris Purwaningtyas, Niniek Sekar Arum Srigati septa surya wahyudi, septa surya Setia, Bagus Sofiana, Kristianingrum Dian Sugiyanta Sugiyanta Suryono Suryono Suryono Suryono Syadza Salsabila Triastiana Kurbaini, Feby Wasyanto, Trisulo Yonas Hadisybroto Yuli Hermansyah