Article Per Year (5 Year)
p-Index From 2021 - 2026
0.61
P-Index
This Author published in this journals
All Journal Jurnal Tumbuhan Obat Indonesia Pharmaciana: Jurnal Kefarmasian Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Journal of Pharmascience
Ririn Lispita Wulandari
Universitas Wahid Hasyim Semarang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Engineering Medicine & Pharmacology Public Health Social Sciences

Published : 17 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 17 Documents
Search

 1   2 
TOKSISITAS AKUT INFUSA KULIT ARI KACANG TANAH (Arachis hypogea L.) PADA MENCIT BALB/ C Risha Fillah Fithria; Ririn Lispita Wulandari; Devi Nisa Hidayati; Lilis Rejeki
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (352.109 KB) | DOI: 10.31942/jiffk.v15i2.2568

Abstract

ABSTRACTPeanut shell (PS) infusion has been shown to be antithrombocytopenia, but there has been no research on safety standards. This study aims to identify the symptoms of toxic effects, the potency of toxicity and histopathology of liver male Balb/C mice after a single dose of PS infusion. This research uses randomized matched posttest only control group design. Twenty five mice were divided into 5 orally dosage groups, ie, PS infusion with a dose of 0,026; 0.052; 0.104; 0.208 g/20gBW; and negative control of CMC Na 0.5%. The observation period is for 14 days. The results showed that single dose of PS infusion had a pseudo LD50 value ie > 0.208g/20gBW which was practically non toxic. Symptoms to watch out for the BW infusion were passive behavior, bradycnea, hair color change, hair loss, and weight loss at doses of 3 and 4. It is unclear whether liver damage ie inflammation, necrosis, and albuminous degeneration caused by PS infusion or other causes.keywords: acute toxicity, infusion, peanut shell
PENGARUH KOMBINASI EKSTRAK ETANOL DAUN SIRSAK (Annona Muricata L.) DAN SIMVASTATIN TERHADAP KADAR KOLESTEROL TOTAL DAN LOW DENSITY LIPOPROTEIN (LDL) TIKUS YANG DIINDUKSI PAKAN TINGGI LEMAK Ririn Lispita Wulandari; Sri Susilowati; Murnik Asih
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No.2 Desember 2015
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (272.236 KB) | DOI: 10.31942/jiffk.v12i2.1409

Abstract

ABSTRACT Soursop leaves can be used as a drug hypercholesterolemia. Simvastatin is one of the drugs that can be used to lower total cholesterol and LDL. This study aims to determine the effectiveness of combination therapy EEDS and simvastatin in inhibiting elevated levels of total cholesterol and LDL induced rats a high-fat feed when compared with simvastatin alone or single EEDS. This study is experimental with post-test only control group design. Using the test animals were 30 male rats Wistar strain were divided into 6 groups. Test animals fed a high-fat twice daily for 14 days except for the normal control group, the test preparation administration once a day for 5 days. Measurement of total cholesterol using  the reagent kit CHOD-PAP and LDL measurement method  Direct Enzymatic Colorimetric Test with a spectrophotometer UV-Visibel. Data were statistically analyzed by One Way Anova followed by Tukey test. The results showed that administration of EEDS can inhibit LDL levels induced rats a high-fat feed. eeds combination and simvastatin can inhibit the increase in total and LDL cholesterol levels did not differ significan (p> 0.05), which means it has the same ability in lowering total cholesterol and LDL induced rats a high-fat feed simvastatin compared with administration of single and single EEDS. Keywords: Hypercholesterolemia, Soursop Leaf Extract Ethanol, Total Cholesterol, LDL.
AKTIVITAS MUKOLITIK FRAKSI METANOL DARI EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocotum Ruiz and Pav.) PADA MUKOSA USUS SAPI DAN KANDUNGAN KIMIANYA Ririn Lispita Wulandari; Yulias Ninik Windriyati; Aqnes Budiarti
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.10 No.1 Juni 2013
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (316.836 KB) | DOI: 10.31942/jiffk.v10i1.872

Abstract

 ABSTRACT Red betel leaves (Piper crocotum  Key words: red betel leaves, mucolitic, cow’s mucous Ruiz and Pav.) can cure many kinds of diseases, including cough. The aim of this research is to determine mucolitic activity of methanol fraction from ethanol extract of red betel leaves on cow’s intestine mucous in vitro and to identify its active compound group.  Ethanol extract of red betel leaves was made by maceration method using ethanol 70%. Methanol fraction was made from ethanol extract by partitioned gradually using petroleum eter, ethyl acetate, and methanol. The obtained methanol fraction was made serial concentration started from 0.1%, 0.3%, 0.5%, 0.7%, 0.9% in 80% cow’s mucous. The mucolitic activity was tested using Viscometer Rion, and 0.1% acethylcystein as positive control. Identification the active compound using thin layer chromatography. The viscosity cow’s mucous analyzed statistically. Normality test using Shapiro Wilk, non parametric statistic test using Kruskal Wallis, and then continued using Mann Whitney Test with degree of trust of 95%.The result shows that methanol fraction has mucolitic activity whether at concentration 0.3% is equivalent to 0.1% acethylcystein. Methanol fraction contains saponin, flavonoid, and polyphenol.
Acute Toxicity of Petai Cina (Leucaena leucocephala (Lam.) de Wit) Leaf Extract to the Hepar of Balb/c Mice Wulandari, Ririn Lispita
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.49645

Abstract

Daun petai cina memiliki banyak efek farmakologi namun belum diketahui profil keamanannya sebagai obat tradisional. Penelitian ini bertujuan untuk menguji efek toksik akut ekstrak daun petai cina (EEDPC) terhadap hepar mencit Balb/C dan menentukan nilai LD50. Pemeriksaan yang dilakukan meliputi gejala toksik, jumlah  hewan mati, berat badan, makroskopis hepar, dan kadar SGPT SGOT. Penelitian ini merupakan penelitian eksperimental. Ekstrak daun petai cina diperoleh dengan cara maserasi. Uji toksisitas akut dilakukan menggunakan metode fixed dose melalui uji pendahuluan dan utama. Berdasarkan uji pendahuluan ditetapkan dosis 2000 mg/kg BB sebagai dosis awal uji utama. Hewan uji dibagi menjadi 2 kelompok, masing-masing diberi CMC Na 1% (kontrol) dan EEDPC 2000 mg/kg BB. Gejala toksik dan kematian diamati selama 14 hari untuk menentukan kisaran nilai LD50. Pada hari ke-15 dilakukan pemeriksaan makroskopis dan SGPT SGOT hepar. Gejala toksik dan makroskopis hepar dianalisis deskriptif, sedangkan berat badan dan kadar SGOT SGPT dianalisis statistik. Hasil penelitian menunjukkan bahwa EEDPC memiliki kisaran nilai LD50>2000 mg/kg BB dan menurunkan berat badan tidak signifikan. Kondisi hepar secara makroskopis dan rata-rata kadar SGPT SGOT tergolong normal, meskipun kadar SGPT berbeda signifikan dengan kontrol, dan kadar SGOT berbeda tidak signifikan dengan kontrol.
Aktivitas Antioksidan dan Penetapan Kadar Flavonoid Total Ekstrak Etil Asetat Daun Kersen (Muntingia calabura) Anita Dwi Puspitasari; Ririn Lispita Wulandari
Journal of Pharmascience Vol. 4 No. 2 (2017): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v4i2.5770

Abstract

Daun kersen (Muntingia calabura ) secara empiris di masyarakat digunakan untuk mengobati berbagai macam penyakit. Salah satu potensi yang dimiliki dari daun kersen adalah sebagai antioksidan. Senyawa aktif yang dimiliki oleh daun kersen yang memiliki aktivitas antioksidan diantaranya adalah fenolik, flavonoid, dan alkaloid. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dan penetapan kadar flavonoid total ekstrak etil asetat daun kersen (Muntingia calabura). Pembuatan ekstrak etil asetat daun kersen menggunakan metode maserasi dengan pelarut etil asetat. Analisis aktivitas antioksidan menggunakan metode DPPH (1,1-difenil-2-pikrilhidrazil) dengan pembanding vitamin C. Penetapan kadar flavonoid total menggunakan metode spektrofotometri Ultra Ungu-Sinar Tampak dengan pembanding Quersetin. Hasil penapisan fitokimia menunjukkan adanya kandungan senyawa alkaloid, saponin, fenolik, flavonoid, dan tannin. Hasil pengujian aktivitas antioksidan ekstrak etil asetat daun kersen dengan nilai IC50 sebesar 53,25 µg/mL dengan penbanding vitamin C (IC50 25,74 µg/mL ). Hasil penetapan kadar flavonoid total sebesar 93,21 mgEQ/g Ekstrak. Kata kunci: antioksidan, flavonoid total, muntingia calabura
Sand Granules Ekstrak Etanol Daun Kirinyuh (Eupatorium inulifolium Kunth.) sebagai Larvasida Alami Pemberantas Demam Berdarah Dengue Puji Hartati; Yance Anas; Ririn Lispita Wulandari
Journal of Pharmascience Vol. 7 No. 1 (2020): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i1.8067

Abstract

ABSTRAK             Penelitian sebelumnya telah mengungkap efek larvasida ekstrak etanol daun kirinyuh (Eupatorium inulifolium Kunth.) terhadap larva nyamuk Aedes aegypti. Ekstrak ini selanjutnya dapat dikembangkan dalam bentuk sediaan sand granules sehingga mudah digunakan sebagai larvasida alami. Penelitian ini bertujuan untuk mendapatkan formula sand granules ekstrak etanol daun Eupatorium inulifolium Kunth (EEDE) yang memenuhi standar karakteristik fisik granul dan menguji efek larvasidanya pada larva nyamuk Aedes aegypti. Sand granules EEDE dibuat dengan metode  granulasi basah dengan variasi konsentrasi kollidon (1%-5%), explotab (1%-3%) dan sacharum lactis (78,44%-84,44%). Karakteristik fisik berbagai formula Sand granules EEDE yang diuji adalah kecepatan alir dan sudut diam. Uji efek larvasida dilakukan pada 25 ekor larva instar III nyamuk Aedes aegypti selama 24 jam dengan replikasi sebanyak 5 kali. Hasil penelitian menunjukkan bahwa semua formula Sand granules EEDE (F1-F5) memenuhi standar karakteristik fisik dengan kecepatan alir (16,69-19,35) g/detik dan sudut diam granul 32,94°-35,76°. F1-F5 juga memiliki efek larvasida terhadap larva nyamuk Aedes aegypti dengan persentase kematian larva dalam 24 jam sebesar (33,0-39,2) %. Akan tetapi, efek larvasida tersebut lebih kecil dibandingkan dengan EEDE 670 ppm (49,6%) dan Temefos® 0,01 ppm (100,0%). Hasil penelitian ini juga menyimpulkan bahwa proses pembuatan sand granules akan menyebabkan penurunan efek larvasida EEDE. Kata Kunci: Daun kirinyuh, efek larvasida, karakteristik fisik, sand granules  ABSTRACT Previous studies reported Eupatorium inulifolium Kunth. leaves ethanol extract (ELEE) have a larvicidal effect on Aedes aegypti larvae. This extract can be developed into sand granules formulation, making it easy to use as a natural larvicidal. This study means to obtain the ELEE sand granules formula that meets the granule's physical characteristics standard, and asses it's a larvicidal effect on Aedes aegypti larvae. Sand granules of ELEE produced with the wet granulation method. The differences between formulas are variations of Kollidon (1%-5%), Explotab (1%-3%), and Saccharum Lactis (78.44%-84.44%) concentration. The physical characteristics of the various KLEE sand granules formulas observed are flow rate and angle of repose. The assay of the ELEE larvicidal effect was carried out on twenty-five Aedes aegypti Instar III larvae for 24 hours with five replications. The results showed that all ELEE sand granules formulas (F1-F5) met the physical characteristics standard, with a flow rate (16.69-19.35) g/sec and an angle of repose 32.94 °-35.76°. F-F5 also had larvicidal effects on Aedes aegypti larvae, with larval mortality within 24 hours (33.0-39.2) %. However, their larvicidal effect is slight compared to ELEE 670 ppm (49.6%) and Temefos® 0.01 ppm (100.0%). This study also concludes that the process of sand granules preparation will diminish the larvicidal effects of ELEE. Keywords: Kirinyuh leaves, larvacidal effect, physical characteristics, sand granules
Piper betle Leaf Extract Spray Gel for Diabetic Wound Causes by Bacterial Infections Wulandari, Ririn Lispita; Aljufri, Achmad Quraisy; Chafiffa, Safira; Andani, Geges Arstri
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 3
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.63060

Abstract

Antibiotic resistance in the treatment of diabetic wound infections is common. Piper betle leaf extract has antibacterial, anti-inflammatory, and antioxidant activities. This study aims to formulate a spray gel from Piper betle leaf extract and test its effect on diabetic wounds infected with Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. The gel was made with 10% (F1), 15% (F2), and 20% (F3) extracts. The organoleptic physical characteristics, pH, homogeneity, viscosity, spray pattern, adhesive spreadability, drying time, and physical stability were tested. All rats were given alloxan 170 mg/kgBW, fasting glucose levels were measured, and then grouped into control, MRSA-exposed, and P. aeruginosa-exposed groups. The negative and positive controls were also included in the test. A 2 cm wound with a depth of 0.3 cm was given bacteria, except for the normal control. The length of the wound was measured, and the wound reduction was calculated as a percentage of wound closure and statistically analyzed. All the formulas met the physical criteria, significantly closing MRSA wounds by 100%. F2 and F3 significantly closed P. aeruginosa wounds by 89.88% and 93.13%, respectively. Collectively, the Piper betle leaf extract spray gel had an effect that could relieve diabetic wound infections.
Co-Authors Achmad Quraisy Aljufri Andani, Geges Arstri Anita Dwi Puspitasari Aqnes Budiarti Chafiffa, Safira Devi Nisa Hidayati Dwara Andriani Astuti Eli Mahmud Elya Zulfa Lilis Rejeki Maulida Shofiatun Maulita Cut Nuria Mufrod Mufrod Murnik Asih Nilam Eka Putri Nurahmah Hidayati Pia Annisa Puji Hartati risha fillah fithria Sri Susilowati Sucyati Amelya Yance Anas Yulias Ninik Windriati