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All Journal Microbiology Indonesia Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) INDONESIAN JOURNAL OF PHARMACY PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Inovasi Teknik Kimia Mediagro Media Farmasi Indonesia
Maulita Cut Nuria
Universitas Wahid Hasyim
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Engineering Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Other

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EFEK ANTI JAMUR TRICHOPHYTON MENTAGROPHYTES LOSION EKSTRAK ETANOL BUAH MENGKUDU MENTAH (MORINDA CITRIFOLIA L.) SECARA IN VIVO Ririn Lispita Wulandari; Nurahmah Hidayati; Maulita Cut Nuria
Prosiding SNST Fakultas Teknik Vol 1, No 1 (2019): PROSIDING SEMINAR NASIONAL SAINS DAN TEKNOLOGI 10 2019
Publisher : Prosiding SNST Fakultas Teknik

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (215.026 KB)

Abstract

Losion ekstrak etanol buah mengkudu mentah (EEBMM) dengan emulgator PGA 20% pada konsentrasi ekstrak 12 mg/mL terbukti mempunyai aktivitas anti jamur terhadap Trichophyton mentagrophytes secara in vitro (persentase inhibisi 100%). Penelitian ini bertujuan untuk menguji efek anti jamur losion EEBMM secarain vivo pada kelinci yang diinfeksi Trichophyton mentagrophytes. Penelitian ini menggunakan Posttest Only Control Group Design. Ekstrak buah mengkudu mentah diperoleh dengan cara perkolasi dan losion dibuat dengan emulgator PGA 20% yang mengandung tiga konsentrasi EEBMM berbeda yaitu 12, 18, 27 mg/mL. Efek anti jamurlosion dengan konsentrasi EEBMM 12 mg/mL (P1), 18 mg/mL (P2) dan 27 mg/mL (P3), losion tanpa eksrak (K-) dan krim ketokonazol 2 % (K+) diuji secara in vivo terhadap kelinci yang diinfeksi jamur Trichophyton mentagrophytes dan diobati selama 16 hari. Parameter yang diukur berupa data skor luka infeksi, lalu dianalisa statistik menggunakan Uji Kruskal Wallis dan Mann Whitney. Hasil penelitian menunjukkan bahwa losion EEBMM memiliki efek anti jamur pada kelinci yang diinfeksi Trichophyton mentagrophytes secara in vivo dibandingkan dengan kontrol negatif mulai hari ke-9 untukkonsentrasi 18 mg/mL dan 27 mg/mLsertahari ke-11 untuk konsentrasi 12 mg/mL.Kata kunci:Losion ekstrak etanol buah mengkudu mentah, PGA, Trichophyton mentagrophytes, in vivo. 
Isolation and identification of kaempferol from jangkang (Homalocladium platycladum (F. Muell) Bailey) leaves and its antibacterial activity Maulita Cut Nuria; Wahyono .; Ratna Asmah Susidarti
Indonesian Journal of Pharmacy Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (312.188 KB) | DOI: 10.14499/indonesianjpharm0iss0pp1-8

Abstract

Isolation and  identification  of  kaempferol  from  jangkang  (Homalocladium platycladum (F.  Muell)  Bailey)  leaves  and  its  activity  against  B.  subtilis ATCC 9466 dan S. typhi ATCC 1408 has been done. The dried ground leaves (300.04 gram)  were  macerated  with  petroleum  ether,  chloroform  and  methanol respectively.  The  methanol  extract  was  the  most  active  extract  against  both bacteria.  Further  separations  of  this  extract  using preparative  thin  layer chromatography  yielded  flavonoid  glycoside.  Its  aglicon  was  identified  as kaempferol  based  on  its  spectroscopic  data  (MS,  IR, and  UV-Vis)  and  UV spectrum  (densitometry).  This  compound  shows  iradical  zone  of  6.62  mm (Bacillus  subtilis)  and  6.27  mm  (Salmonella  typhi)  at  concentration  of  200 µg/disk.Key words : kaempferol, jangkang, glycoside, aglicon
Aktivitas Antibakteri Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) Dari Beberapa Metode Ekstraksi Siska Maila Sari; Asri Melati Dewi; Erika Indah Safitri; Maulita Cut Nuria
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 01 Juli 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i1.8681

Abstract

Penyakit infeksi dapat disebabkan oleh bakteri Staphylococcus aureus dan Escherichia coli. Pertumbuhan kedua bakteri tersebut dapat dihambat dengan bahan alam, salah satunya herba krokot (Portulaca oleracea L). Tumbuhan ini mengandung senyawa saponin, flavonoid, tanin, glikosida dan steroid. Senyawa-senyawa tersebut memiliki karakteristik berbeda terhadap metode ekstraksi, baik cara panas maupun dingin. Penelitian ini bertujuan untuk mengetahui perbedaan aktivitas antibakteri ekstrak etanol herba krokot dari berbagai metode ekstraksi terhadap pertumbuhan bakteri S. aureus dan E. coli. Ekstraksi herba krokot dilakukan dengan empat variasi metode yaitu cara dingin (maserasi dan perkolasi) dan cara panas (soklet dan refluks) menggunakan pelarut etanol 96%. Penentuan aktivitas antibakteri ekstrak menggunakan metode difusi agar. Ekstrak etanol herba krokot diuji pada empat seri konsentrasi yakni 20, 25, 30 dan 35%. Kloramfenikol digunakan sebagai kontrol positif, sedangkan kontrol negatifnya adalah DMSO. Hasil uji aktivitas antibakteri berupa Diameter Daerah Hambat (DDH) yang dianalisis secara statistik Two Way Anova pada taraf kepercayaan 95 %. Ekstrak etanol herba krokot yang dihasilkan dari berbagai metode ekstraksi memiliki aktivitas antibakteri terhadap S. aureus dan E. coli, namun variasi metode ekstraksi tidak berbeda secara signifikan (p>0,05) terhadap aktivitas antibakterinya.
PERBANDINGAN KADAR FLAVONOID DAN FENOLIK TOTAL EKSTRAK METANOL DAUN BELUNTAS (Pluchea indica L.) PADA BERBAGAI METODE EKSTRAKSI Ikke Safitri; Maulita Cut Nuria; Anita Dwi Puspitasari
Jurnal Inovasi Teknik Kimia Vol 3, No 1 (2018)
Publisher : Fakultas Teknik Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/inteka.v3i1.2123

Abstract

Beluntas (Pluchea indica L.) merupakan tumbuhan yang mengandung sterol, flavonoid, tanin, dan fenol hidrokuinon. Flavonoid dan fenolik dapat diekstraksi dengan metode perkolasi, maserasi, soxhlet, dan refluks. Penelitian ini bertujuan untuk membandingkan kadar flavonoid dan fenolik total ekstrak metanol daun beluntas (EMDB) pada berbagai metode ekstraksi. Penentuan kadar flavonoid dan fenolik total dilakukan secara spektrofotometri. Pereaksi AlCl3 dan Folin-ciocalteu digunakan pada metode spektrofotometri tersebut dengan senyawa pembanding kuersetin dan asam galat. Seri konsentrasi kuersetin adalah 5, 10, 15, 20 dan 25 µg/mL pada λ=428,90 nm dengan operating time 30 menit. Persamaan kurva baku yang diperoleh adalah y= 0,02001x + 0,10906 (x= kadar flavonoid dalam µg/mL, y= absorbansi) dengan nilai r = 0,99848. Serial konsentrasi asam galat adalah 10, 20, 30, 40 dan            50 µg/mL pada λ= 757,80 nm dengan operating time 2 jam. Persamaan kurva bakunya adalah y= 0,01086 x + 0,12030 (x=kadar fenolik dalam µg/mL, y=absorbansi) dengan nilai r=0,99808. Kadar flavonoid dan fenolik total EMDB dari berbagai metode ekstraksi dianalisis statistik One-Way Anova kemudian dilanjutkan uji Bonferroni pada taraf kepercayaan 95%.Hasil penelitian menunjukkan kadar flavonoid total EMDB dengan metode perkolasi, maserasi, soxhlet dan refluks berturut-turut sebesar 66,75; 51, 80 ; 47,72 dan 38,39 mg/gram ekstrak. Adapun kadar fenolik total berturut-turut sebesar 116,95; 84,11; 67,53 dan 44,36 mg/gram ekstrak. Hasil statistika menunjukkan adanya perbedaan bermakna pada kadar flavonoid dan fenolik total EMDB diantara berbagai metode ekstraksi. Kata kunci: ekstraksi, fenolik, flavonoid
Antibacterial Activities From Jangkang (Homalocladium platycladum (F. Muell) Bailey) Leaves Maulita Cut Nuria
MEDIAGRO Vol 6, No 2 (2010)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (176.946 KB) | DOI: 10.31942/mediagro.v6i2.883

Abstract

Jangkang (Homalocladium platycladum (F. Muell) Bailey) is ashrub under the Polygonaceae family and grows throughout Indonesia. Thisplant has been traditionally used to relief pain, to cure skin infection and hasantiinflamatory activity. Phytochemical studies showed that this speciescontains saponin, flavonoid and tannin. The aim of this research is to findout antibacterial activities of several extract from jangkang leaves againstGram positive bacteria (Staphylococcus aureus dan Bacillus subtilis) andGram negative bacteria (Escherichia coli dan Salmonella typhi).The dried ground leaves (300.04 gram) were macerated withpetroleum ether, chloroform and methanol respectively. Petroleum ether,chloroform and methanol extracts were obtained after evaporation of thesolvents. The extracts tested for their antibacterial activities using agardiffusion method aided by paper disks in order to find out the inhibitory areadiameters.The result showed that petroleum ether extract did not inhibited thegrowth of bacteria but chloroform and metanol extracts show antibacterialactivity except at E. coli. Chloroform extract shows inhibition zone againstbacteria at concentration of 1000 μg/disk while methanol extract atconcentration of 500 μg/disk.Keywords : Jangkang (Homalocladium platycladum (F. Muell) Bailey)leaves, Antibacterial activity
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN JARAK PAGAR (Jatropha curcas L) TERHADAP BAKTERI Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Dan Salmonella typhi ATCC 1408 Maulita Cut Nuria; Arvin Faizatun; Sumantri .
MEDIAGRO Vol 5, No 2 (2009)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (298.727 KB) | DOI: 10.31942/mediagro.v5i2.559

Abstract

Jatropha curcas L is a plant species that can be used for curing, since it contains flavonoid, saponin, and tanin. Jatropha multifida L is proved to have antibacterial activities (Sisunandar, et.al., 2002). This research was intended to find out the antibacterial activities of ethanol extracts of Jatropha curcas L leaves on bacteria Staphylococus aureus, Escherichia coli, and Salmonella typhi, find out the effectiveness of those antibacterial  activities and identify the compound groups contained in the ethanol extracts, the result of antibacterial activity of ethanol extracts of Jatropha curcas L was analized by statistic. Employing a maceration method, Jatropha curcas L leaves were extracted using ethanol 70% for five days. Employing an agar-diffusion method aided by disk papers and in order to find out the inhibitory area diameters of the extracts, the extracts were then tested for their antibacterial activities. Qualitative analysis on the chemical contents of the extracts were conducted employing. TLC method aided by silica-gel stationary phases for saponin and tanin and cellulose phases for flavonoid. The motion phases used ethyl acetat-acidformiat-acid acetat-water for flavonoid, chloroform-methanol for saponin and buthanol-acid acetat-water for tanin. The result of the test on antibacterial activities were analyzed statistically using Kruskall Wallis and Mann & Whitney tests. The analysis showed that ethanol extracts of the Jatropha curcas L leaves inhibited the growth of Staphylococcus aureus but not the growth of Eschericia coli and Salmonella typhi. The testing concentrations of 20%, 40%, 60%, 80%, and 100% b/v produed inhibitory area diameters averaging 8.25, 9.25, 11.00, 13.25, and 19.00 mm respectively. The positive control of Ampicillin produced an average inhibitory area diameters of 40.00 mm while the solvent control did not produce any inhibitory area diameters. Statistical test showed that there were significant differences among  the different concentrations of the extracts.Thin Layer Chromatography tests produced yellow color showing the existence of flavonoid, bluish violet color showing the existence of saponin, and grayish green color showing the existence of tanin. Keyword : ethanol extracts of Jatropha curcas L leaves, inhibitory area diameters, Staphylococcus aureus, Escherichia coli, and Salmonella typhi
Antibacterial Activities of Ethyl Acetate Fraction of Methanol Extract From Sosor Bebek Leaves (Kalanchoe pinnata Pers.) Maulita Cut Nuria; Enny Puji Astuti; Sumantri Sumantri
MEDIAGRO Vol 6, No 2 (2010)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (201.518 KB) | DOI: 10.31942/mediagro.v6i2.888

Abstract

Kalanchoe pinnata Pers. is one of the famous herbal in Indonesiathat has been used traditionally to treat diarrhea and dysentery. Akinsulire etal., (2007) proved the antibacterial effects of metanolic extract fromKalanchoe pinnata Pers. leaves, and its sensitive to Gram positive andnegative bacteria. Aims of this research are to find out antibacterialactivities of ethyl acetate fraction of methanolic extract from Kalanchoepinnata Pers. leaves to Gram positive bacteria (Staphylococcus aureus,Bacillus subtilis) and Gram negative bacteria (Pseudomonas aeruginosa,Escherichia coli, Salmonella typhi), to determine Minimum InhibitoryConcentration (MIC) of the fraction, and to find out the active chemicalsubstance of the fraction.Methanolic extract of Kalanchoe pinnata Pers. leaves was made byusing maceration method, then the extract was partitioned gradually byusing hexane, chloroform, diethyl ether and ethyl acetate. Ethyl acetatefraction was examinated in vitro according to turbidimetry methods.Concentrations of the fraction were 256, 192, 160, 128, 96, 64, 32 and 16mg/ml. The active chemical substance of the fraction was identified by ThinLayer Chromatography (TLC) method.The result of this research shows the antibacterial activities of ethylacetate fraction of methanolic extract from Kalanchoe pinnata Pers. leavesboth to Gram positive bacteria and Gram negative bacteria. MIC value ofthe fraction to Gram positive bacteria (Staphylococcus aureus, Bacillussubtilis) is 192 mg/ml, and Gram negative bacteria which are Escherichiacoli ATCC 25922 and Pseudomonas aeruginosa is 192 mg/ml, but the MICvalue to Salmonella typhi is 128 mg/ml. TLC identification show that thefraction contains flavonoid.Keywords : Ethyl acetate fraction of methanolic extract from Kalanchoepinnata Pers. leaves, Antibacterial activity, MinimumInhibitory Concentration (MIC), Flavonoid
UJI KANDUNGAN BAKTERI Escherichia coli PADA AIR MINUM ISI ULANG DARI DEPOT AIR MINUM ISI ULANG DI KABUPATEN REMBANG Testing of Escherichia Coli Bacteria Content in Drinking Water Refill from Drinking Water Refill Depot in Rembang Sub-district Maulita Cut Nuria; Abdur Rosyid; Sumantri Sumantri
MEDIAGRO Vol 5, No 1 (2009)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (913.66 KB) | DOI: 10.31942/mediagro.v5i1.893

Abstract

Water refill is water that has through purification processes both Ultraviolet and ionization, by many stages of filtration to obtain clean water, in order to provide human needs.  This research performed by Athena,  et.al., (2003) to shows that Total Coli and Escherichia coli  in high-enough amounts inside water refill from water refill depot (DAMIU) in Jakarta, Tangerang, and Bekasi. There are many efforts related with this water refill that causes DAMIU developed rapidly, so that required monitoring improvement because water  is the primary needs of human being. This research aims to identify Escherichia coli  bacteria content that exist in drinking water of water refill from DAMIU in Rembang Sub district. This research is survey type, equipped with  microbiology  test using MPN method (Most Probable Number). The populations are 25 DAMIU in Rembang sub-district. Data analysis performed descriptively. Test, conducted by water refill sampling, which produced by DAMIU in Rembang sub-district. The testing includes: approximation test using  Lactosa Broth  (LB) medium, confirmation test using Briliant Green Lactose Bile Broth  (BGLB) medium, complementary test using Mc. Conkey medium and Gram painting was performed to identify bacteria types using microscope by 100 times magnification, and Biochemistry test that is IMVIC (Indol,  Methyl-Red,  Voges Proskauer, and Citrat).  In water  refill which produced by DAMIU in Rembang Sub  district, there is 1 sample (4%) with MPN value of E. coli 13/100 ml and Coliform MPN 21/100 ml, does not fulfill the bacteriology requirements of drinking water quality, according to Health Minister Decree No.907/MENKES/SK/VII/2002 :  ³The existence of E.Coli bacteria 0/100 ml sample´, while 24 samples has fulfill the requirements, with MPN value of E.Coli and Coliform < 2, so that it safe and ready to consume. Keywords: Water refill Depot (DAMIU), Most Probable Number (MPN), Escherichia coli
IDENTIFIKASI KANDUNGAN SENYAWA KIMIA EKSTRAK ETANOL HERBA ALFALFA (Medicago sativa, L) Sri Susilowati; Maulita Cut Nuria; Agnes Budiarti
Media Farmasi Indonesia Vol. 9 No. 2 (2014): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (300.119 KB)

Abstract

ABSTRAK Alfalfa merupakan tumbuhan yang berasal dari Iran (Medicago sativa, L), namun dapat tumbuh di daerah tropis seperti Indonesia. Herba alfalfa secara umum dimanfaatkan sebagai pakan ternak, karena kandungan gizinya yang tinggi antara lain : protein, lemak dan serat kasar. Selain itu, alfalfa juga berfungsi sebagai tanaman berkhasiat obat untuk menyembuhkan berbagai penyakit. Tempat tumbuh dapat mempengaruhi kandungan senyawa kimia aktif dari suatu tanaman. Penelitian ini bertujuan untuk melakukan identifikasi secara kualitatif dan kuantitatif dari kandungan senyawa kimia herba alfalfa dalam bentuk sediaan ekstrak etanol. Sediaan ekstrak dibuat dengan metode perkolasi dengan pelarut etanol 96%. Identifikasi secara kualitatif dilakukan dengan pereaksi kimia yang dilanjutkan dengan Kromatografi Lapis Tipis terhadap senyawa yang diduga ada di dalam ekstrak yaitu flavonoid dan alkaloid serta kumarin. Identifikasi kuantitatif untuk senyawa flavonoid dilakukan secara spektrofotometri dengan panjang gelombang 505 nm, sedangkan alkaloid dilakukan dengan TLC densitometry dengan panjang gelombang 309 nm, dan kumarin secara TLC densitometry dengan panjang gelombang 304 nm. Hasil penelitian diperoleh ekstrak etanol herba alfalfa dengan rendemen sebesar 13,04%, dan memiliki kandungan flavonoid dengan kadar total 8,13%, alkaloid dengan kadar 48,86 ppm dan kumarin dengan kadar 229,83 ppm.
AKTIVITAS INHIBISI ASETILKOLINESTERASE EMPAT JENIS SAYURAN SECARA IN VITRO Maulita Cut Nuria; Elin Yulinah Sukandar; Asep Gana Suganda; Muhamad Insanu
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 1 Juni 2019
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (317.129 KB) | DOI: 10.31942/jiffk.v16i01.2928

Abstract

ABSTRACTAcetylcholine is a conducting compound of nerve excitatory (neurotransmitter), while acetylcholinesterase is an enzyme that can hydrolyze the acetylcholine into choline and acetic acid. This reaction is needed so that the nerves can return to take a rest after the activation process, but it can cause damage to the cells in the brain. The most common case is dementia characterized by memory loss. The prevalence of this disease is lower in China and some other Asian countries compared to the United States. It supposed because food consumption commonly by Asians contain vegetables. Extracts derived from vegetables potentially inhibit the activity of acetylcholinesterase (AChE) enzyme which related to chemical contents of the plant. This research aims to investigate the inhibitory activity of acetylcholinesterase enzyme from 4 types of vegetables namely soybean sprouts (bean sprout of Glycine max (L.) Merr.), green bean sprouts (bean sprout of Vigna radiata), carrot (Daucus carota L.), and winged beans (Psophocarpus tetragonolobus (L.) DC.) by in vitro with the Ellman method. Total phenolic and flavonoids contents from fourth types of extracts were also determined. The winged beans extract had the smallest total phenolic and flavonoid contents, but the inhibitory activity against AChE was the biggest. The results showed that IC50 extract of winged beans was 893.86 μg/ml, IC50 carrot extract higher than 1500 μg/ml while the other extracts had no activity. The winged beans extract potential to be further developed as an inhibitor AChE.Keywords : inhibitor of acetylcholinesterase, IC50, vegetables
Co-Authors Abdur Rosyid Agung Endro Nugroho Agung Endro Nugroho Aminuyati Amprih Martha, Amprih Anita Dwi Puspitasari Aqnes Budiarti aqnes tuning dyah a Arvin Faizatun Asep Gana Suganda Asri Melati Dewi AULIA EVERESTINA PUJAKA dedeh ratna dewi Elin Yulinah Sukandar Enny Puji Astuti Erika Indah Safitri Fahrina Rachmawati Ikke Safitri mohammad djatmiko Muhamad Insanu Niken Puspitasari Nurahmah Hidayati Puji Astuti Puji Astuti Ratna Asmah Susidarti Ririn Lispita Wulandari risha fillah fithria septaningsih septaningsih Siska Maila Sari Sri Susilowati Sulasmi Sulasmi Sumantri ) Sumantri . Sumantri Sumantri Sumantri Sumantri Sumantri Sumantri Syahar Banu Wahyono . Yance Anas yeni lutfiani Yunita Midkha Zumrotul Chabibah