Garuda - Garba Rujukan Digital

p-Index From 2020 - 2025

3.978

P-Index

This Author published in this journals

All Journal Indonesian Journal of Cancer Chemoprevention Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) INDONESIAN JOURNAL OF PHARMACY Jurnal Ilmu Kebidanan (Journal of Midwivery Science) Jurnal Ternak International Journal of Economics, Business and Accounting Research (IJEBAR) Jurnal Peternakan Lokal JUMORA: Jurnal Moderasi Olahraga Media Farmasi Indonesia Dirkantara Indonesia Jurnal BisTek Pertanian : Agribisnis dan Teknologi Hasil Pertanian Dinamika Rekasatwa: Jurnal Ilmiah (e-Journal)

Sri Susilowati

Wahid Hasyim University, Semarang

Author-ID : 3097087

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

Published : 46 Documents Claim Missing Document

Claim Missing Document

Articles

1 2 3 4 5

Chemopreventive effect of ethanolic extract of Gynura procumbens (Lour), Merr on the carcinogenesis of Rat breast cancer development Meiyanto, Edy; Susilowati, Sri; Tasminatun, Sri; Murwanti, Retno; ., Sugiyanto
INDONESIAN JOURNAL OF PHARMACY Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Gynura procumbens (Lour) Merr., empirically, used to prevent cancer development and has been proven to be able to suppress lung cancer development. The aim of this research is to examine the potential of ethanolic extract of G. procumbens to suppress DMBA-induced breast cancer development. Sprague Dawly Rats were used in this research and were grouped as indicated treatment. Ethanolic extract of G. procumbens was administered into 3 levels of doses, namely 250, 500, and 750 mg/kgBW. Tumor development was examined by palpation every week and terminated at week 16th after the end of DMBA treatment. The result showed that extract treatment at the dose of 250, 500, and 750 mg/kgBW reduced tumor incidence by 60%, 30 %, and 20 % respectively. The doses of 500 and 750 mg/kgBW exhibited strong suppression of tumor multiplicity, where as the dose of 250 performed less potential suppression. In conclusion, ethanolic extract of G. procumbens performs chemopreventive effect to suppress breast cancer development at the dose of 250 mg/kgBW.Key words : chemopreventive, Gynura procumbens (Lour) Merr, breast cancer.

Suppression of DMBA-induced carcinogenesis of breast cancer in post initition stage by ethanolic extract of Gynura procumbens (Lour), Merr leaves Edy Meiyanto; Sri Tasminatun; Sri Susilowati; Retno Murwanti; Sugiyanto .
Indonesian Journal of Pharmacy Vol 18 No 4, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Gynura procumbens (Lour) Merr., has been shown to suppress lung cancer development in mice and breast cancer development in rat when the extract was given at initiation stage. The aim of this research is to examine the potential of ethanolic extract of G. procumbens to suppress DMBAinduced breast cancer development at early development (post initiation I) and late development (post initiation II). Sprague Dawley Rats were used in this research and were grouped as indicated treatment. Ethanolic extract of G. procumbens was administered into 2 levels of doses, namely 250, 750 mg/kgBW. Tumor development was examined by palpation every week and terminated at week 16th after the end of DMBA treatment. The result showed that extract treatment at the dose of 250, and 750 mg/kgBW at the post initiation I could not reduce tumor incidence but suppressed of tumor multiplicity. However, the treatment at the post initiation II, the extract could not reduce neither incidence nor multiplicity. In conclusion, ethanolic extract of G. procumbens performs potential effect to suppress breast cancer development at the dose of 250 mg/kgBW when administered at the early stage of carcinogenesis.Key words : Carcinogenesis inhibition, G. procumbens, breast cancer, post initiation

IDENTIFIKASI KANDUNGAN SENYAWA KIMIA EKSTRAK ETANOL HERBA ALFALFA (Medicago sativa, L) Sri Susilowati; Maulita Cut Nuria; Agnes Budiarti
Media Farmasi Indonesia Vol. 9 No. 2 (2014): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (300.119 KB)

ABSTRAK Alfalfa merupakan tumbuhan yang berasal dari Iran (Medicago sativa, L), namun dapat tumbuh di daerah tropis seperti Indonesia. Herba alfalfa secara umum dimanfaatkan sebagai pakan ternak, karena kandungan gizinya yang tinggi antara lain : protein, lemak dan serat kasar. Selain itu, alfalfa juga berfungsi sebagai tanaman berkhasiat obat untuk menyembuhkan berbagai penyakit. Tempat tumbuh dapat mempengaruhi kandungan senyawa kimia aktif dari suatu tanaman. Penelitian ini bertujuan untuk melakukan identifikasi secara kualitatif dan kuantitatif dari kandungan senyawa kimia herba alfalfa dalam bentuk sediaan ekstrak etanol. Sediaan ekstrak dibuat dengan metode perkolasi dengan pelarut etanol 96%. Identifikasi secara kualitatif dilakukan dengan pereaksi kimia yang dilanjutkan dengan Kromatografi Lapis Tipis terhadap senyawa yang diduga ada di dalam ekstrak yaitu flavonoid dan alkaloid serta kumarin. Identifikasi kuantitatif untuk senyawa flavonoid dilakukan secara spektrofotometri dengan panjang gelombang 505 nm, sedangkan alkaloid dilakukan dengan TLC densitometry dengan panjang gelombang 309 nm, dan kumarin secara TLC densitometry dengan panjang gelombang 304 nm. Hasil penelitian diperoleh ekstrak etanol herba alfalfa dengan rendemen sebesar 13,04%, dan memiliki kandungan flavonoid dengan kadar total 8,13%, alkaloid dengan kadar 48,86 ppm dan kumarin dengan kadar 229,83 ppm.

IDENTIFIKASI DRUG RELATED PROBLEMS (DRPs) YANG POTENSIAL MEMPENGARUHI EFEKTIVITAS TERAPI PADA PASIEN DIABETES MELLITUS TIPE II RAWAT INAP DI RSUD TUGUREJO SEMARANG PERIODE 2007-2008 Sri Susilowati; wiwit pamuji rahayu
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 7 NO. 2 DESEMBER 2010
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT The management of Type II Diabetes Mellitus with prolonged drug therapy might affect the life qualities of patients and lead to Drug Related Problems (DRPs). Several types of DRPs frequently occur and they result in sub-optimum treatment, increased side effects and expensive costs. Objective of this study was to know about the uses of anti-diabetic drugs, prevalence of DRPs, the numbers of DRPs cases and the factors causing DRPs having the potentials to affect the therapeutic effectiveness for Type-II Diabetes Mellitus treated at Semarang Tugurejo Hospitals during the period of 2007-2008. The possible factors that might lead to DRPs were inaccuracy in the drug selection and sub-therapeutic. Non experimental, retrospective and non analytical observational study design was done. The population for this study consisted of 43 Type-II Diabetes Mellitus patients hospitalized in Tugurejo Hospital, Semarang. Sample collected by retrospectively from Hospital’s medical records of the 2007-2008 period in the whole population. The results showed there were 23,3% of the patient experienced DRPs which had the potentials to affect the therapeutic effectiveness for Type-II Diabetes Mellitus. Eleven cases of inaccuracies in selecting the drugs affected the effectiveness of the therapies. These cases of inaccuracies consisted of 5 cases of ineffective drugs, 4 cases of effective but expensive drugs, 2 cases of unnecessary combinations of drugs and one case of sub-therapeutic dosages. Key words : Drug Related Problems (DRPs), diabetes mellitus

UJI AKTIVITAS REPELLENT FRAKSI KLOROFORM EKSTRAK ETANOL DAUN MIMBA (Azadirachta indica A.Juss) TERHADAP NYAMUK Aedes aegypti sri susilowati; Fransiska Vita Kurniawati
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.1 JUNI 2014
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Dengue haemorragic fever is a disease caused by dengue virus by mediator Aedes aegypti. The effort of overcoming this disease could be done by preventing the mosquito from bitting using repellent. One of natural repellents is neem (Azadiracta indica A.Juss). This study aimed to determine the repellent activity of chloroform fraction of ethanolic extract neem leaf against Aedes aegypti mosquito. Extraction neem leaf done using ethanol 96% by maceration methode and followed fractionation with chloroform. This study was conducted in 5 groups, positive control (DEET 13%), negative control (liquid paraffin) and three series concentrations of chloroform fraction of ethanol extract neem leaf; they were 5%, 10% and 20%. Repellent activity was carried out by counting number of mosquitoes alighted. The amount of repellent activity was obtained from the protection value which was then analyzed using two-ways Anova. The EC90 value gained from probit analysis at significance of 95%. Identification of chemical compound of chloroform fraction of ethanolic extract neem leaf was done using thin layer chromatography (TLC). The results showed that chloroform fraction of ethanolic extract neem leaf had repellent activity against Aedes aegypti mosquito. The average protection value for 6 hours in positive control group and chloroform fraction of ethanolic extract neem leaf at 5%, 10% and 20% concentration were 92,43%, 66,76%, 76,90% and 88,35%. The 6-hours treatment had caused decrease in protection value in all of treatment groups. The effective concentration of chloroform fraction ethanolic extract neem leaf to repel 90% population of Aedes aegypti mosquito for 6 hours treatment was 26,1%. The chemical compund of chloroform fraction of ethanolic extract neem leaf was terpenoid. Keyword: repellent, chloroform fraction of ethanolic extract neem leaf, Aedes aegypti

UJI SITOTOKSISITAS FRAKSI n-HEKSANA EKSTRAK ETANOL HERBA ALFALFA (Medicago Sativa L.) PADA SEL T47D DAN SEL HeLa SERTA IDENTIFIKASI KANDUNGAN SENYAWA KIMIANYA sri susilowati; anggun claresa; ibrahim arifin
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.9 No.2 Desember 2012
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTBreast and cervical cancers were the high prevalency, both in the world and Indonesia. This study aimed to determine the cytotoxic activities and its potentcy of n-hexane fraction of ethanol extract alfalfa herb (Medicago sativa L.) in T47D cells and HeLa cells, also identificated its chemical compounds.Extraction was done using ethanol by soxhletation method and then followed fractionation with n-hexane. Cytotoxic assay to get the value of IC50 was carried out by using MTT assay with a series of concentration of fraction 62,5; 125; 250; 500; 1000 μg/ ml. The cytotoxic activities was determined with viability cells from absorbance ELISA reader. Identification of chemical compounds of n-hexane fraction of ethanol extract alfalfa herb was done using chemical reactan and paper chromatography and then was evaluated qualitatively.The results showed that the n-hexane fraction of ethanol extract of alfalfa herb had cytotoxic activities in T47D cells and HeLa cells. The IC50 values were 523,9 μg/ml in T47D cells and 503,5 μg/ml in HeLa cells. The chemical compounds of n-hexane fraction of ethanol extract of alfalfa herb were coumarin and flavonoid.Key words : cytotoxic assay, n-hexane fraction of ethanol extract of herb alfalfa, Medicago sativa L., T47D cells, HeLa cells, flavonoid, coumarin

UJI SITOTOKSISITAS FRAKSI ETIL ASETAT EKSTRAK ETANOL HERBA ALFALFA (Medicago sativa L.) TERHADAP SEL KANKER PAYUDARA T47D DAN SEL KANKER LEHER RAHIM (SEL HeLa) SERTA UJI KANDUNGAN SENYAWA KIMIANYA Devi Nisa Hidayati; Ibrahim Arifin; Sri Susilowati Susilowati
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peranan dan Kontribusi Herbal dalam Terapi Penyakit Degeneratif"
Publisher : Universitas Wahid Hasyim Semarang

Kanker payudara dan kanker leher rahim merupakan jenis penyakit ganas di Indonesia maupun dunia. Penelitian ini bertujuan untuk mengetahui potensi sitotoksik fraksi etil asetat dari ekstrak etanol herba alfalfa terhadap sel kanker payudara (sel T47D) dan sel kanker leher rahim (sel HeLa) serta mengetahui kandungan kimianya. Proses ekstraksi herba alfalfa dilakukan dengan metode sokletasi menggunakan pelarut etanol kemudian dilanjutkan fraksinasi secara bertingkat menggunakan n-heksan, kloroform, dietil eter dan etil asetat. Uji sitotoksisitas menggunakan metode MTT dengan seri konsentrasi fraksi uji 1000; 500; 250; 125; 62,5 µg/ml terhadap kultur sel T47D dan sel HeLa. Data berupa absorbansi sel hidup digunakan untuk menghitung persentase kehidupan sel T47D dan sel HeLa kemudian ditetapkan IC50 dengan analisis probit menggunakan SPSS 16 for Windows. Uji kandungan kimia dilakukan dengan pereaksi kimia kemudian dilanjutkan dengan kromatografi lapis tipis (KLT). Hasil penelitian menunjukkan bahwa fraksi etil asetat ekstrak etanol herba alfalfa memiliki efek sitotoksik terhadap sel T47D namun tidak memiliki efek sitotoksik pada sel HeLa. Potensi sitotoksik fraksi etil asetat ekstrak etanol herba alfalfa terhadap sel T47D yang dinyatakan dalam nilai IC50 sebesar 1893,4 µg/ml. Fraksi etil asetat dari ekstrak etanol herba alfalfa mengandung flavonoid. Kata kunci: Uji sitotoksisitas, fraksi etil asetat ekstrak etanol herba alfalfa (Medicago sativa L.), sel T47D, sel HeLa, flavonoid

EFEK ANTIINFLAMASI EKSTRAK ETANOLIK HERBA ALFALFA (Medicago sativa L.) PADA TIKUS JANTAN YANG DIINDUKSI KARAGENIN BESERTA IDENTIFIKASI KANDUNGAN SENYAWA AKTIFNYA sri susilowati; yuniarti rosyidah
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 1 JUNI 2008
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTAlfalfa plant (Medicago sativa L.) contains of flavonoids compound, it has already known. One of the effects of flavonoids is anti-inflammatory effect of alfalfa herb (M. sativa L.). The purpose of this research to know about anti-inflammatory effect of alfalfa herb ethanolic extract on carragenan induced male rats and also to know the content of its active compound. Thirty male wistar rats were randomly divided into 5 group of 6. Group I, negative control, were treathed CMC-Na 0,5 %, group II, positive control, were treathed natrium diclofenac 6,3 mg/ kg BB. Group III, IV and V were treathed ethanolic extract of alfalfa herb orally dose 45 mg/ kg BW, 90 mg/ kg BW and 180 mg/ kg BW. Anti-inflammatory effect were measured of edema feet were done every 30 minutes for 6 hours using plestismometer. After edema feet data vs time got, then we can get AUC0-360 value and percentase anti-inflammatory effect. Statistic analytical used one way ANOVA (p<0,05) and continued with Tukey test then. Identification of active compound of alfalfa herb ethanolic extract was used Thiny Layer Chromatography (TLC). The result of the research shown that ethanolic extract of alfalfa herb by dosage 45 mg/ kg BW, 90 mg/ kg BW and 180 mg/ kg BW could reduce edema in carrageenan induced rats, significantly. The percentase of anti-inflammatory effect on dosage of 45 mg/ kg BW is 58,99 %, on 90 mg/ kg BW is 72,64 % and on 180 mg/ kg BW is 64,23 %. TLC result shown that active compound the ethanolic extract of alfalfa herbs was flavonoids. We could be concluded that ethanolic extract of alfalfa herb have anti-inflammatory effect. Key word : ethanolic extract of alfalfa herb (Medicago sativa L.), flavonoids, anti-inflammatory.

EFEK SITOTOKSIK FRAKSI ETIL ASETAT EKSTRAK ETANOL UMBI BIT (Beta vulgaris L.var rubra L.) TERHADAP SEL T47D DAN UJI KANDUNGAN KIMIANYA Sri Susilowati; Iga Dewinta Putri; Aqnes Budiarti
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI & FARMASI KLINIK VOL. 13 NO. 1 JUNI 2016
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Breast cancer is the prime cause of women death in various parts of the world. Many research to get breast cancer drug has been widely applied. The aims of this study were to determine the cytotoxic effect of ethyl acetate fraction of ethanolic extract of the beet root (Beta vulgaris L. var. rubra L.) on T47D cell line which was the breast cancer cell and test their chemical compound. The extract was made by macerare method, and than it was fractionated by using ethyl acetate. Cytotoxicity test using MTT assay method with concentration 500; 250; 125; 62,5; 31,25 µg/ml. Observation was done to get the viability cell absorbance by using ELISA reader. Analytical data carried out toward percentage viability T47D cell line to determine a value IC50. The chemical compound tests done through a process of preliminary test with a chemical reagent and thin layer chromatografi. The chemical compound were qualitative analysis. The result showed that ethyl acetate fraction of ethanolic extract beet roots had cytotoxic effect against T47D cell line with IC50 253,86 µg/ml. The chemical compound of the ethyl acetate fraction of ethanolic extract of beet root were flavonoids. Keywords: Ethyl acetate fraction of ethanolic extract of beet roots, Beta vulgaris L. var. rubra L., Cell line T47D, Flavonoids

UJI SITOTOKSISITAS EKSTRAK METANOL UMBI BIT (Beta vulgaris L. var. rubra L.) TERHADAP CELL LINE T47D Elya Zulfa; sri susilowati; aqnes budiarti
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No. 1 Juni 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTTherapy failure of breast cancer as a consequence of cell resistention has encouraged the effort to develop a cancer medicine including herbal medicine. Based on some research, it can be concluded that there is antioxydant and anticancer activity from beetroot involved with betasianin and betasantin substance that belong to flavonoid compound. The purpose of this research was to find the effect cytotoxic of methanolic extract of beetroot (Beta vulgaris L. var. rubra L.) on cell line T47D which was a breast cancer cell.This research was conducted on several experiment step namely plant determination, cell preparation, cell harvest, methanolic extraction, and cytotoxic test. The extraction of beetroot is conducted by maceration method using methanol 70 %. Cytotoxic test on cell line T47D is conducted by MTT assay using five concentration ceries were 500, 250, 125, 62,5 and 31,25 ug/ml. Data analysis uses probit analysis.Research result shows that methanolic extract of beetroot there was no cytotoxic activity on cell line T47D. It shows that five consentration series methanolic extraction of beetroot have % cell viability more than 100%.Keyword: Beetroot, Beta vulgaris L. var. rubra L, Cell line T47D, Cytotoxic, Flavonoid.

Co-Authors Abdhi Firdhana, Sulthon Afif Khoirul Hidayat, Afif Khoirul Ahsanul Ikhwanda, Dian Mirza Al Kibar, Alam Fayid Alfarisi, Ahmad Daris Andika Novanto Putra Wijaya anggun claresa Aqnes Budiarti Arnoldus Alvin Aryati Rambu Nalu Aziz, Zainul Budiman, Widi Catharina Suharti Daniel Happy Putra Deas, M Rizky Ibnu Dedi Suryanto Devi Nisa Hidayati Dewi Masyitoh Dian Oktrianis Buulolo Didik Julianto Dinasari, Irawati Disa Ardelia Ilyas Dyah Lestari Yulianti Edy Meiyanto Edy Meiyanto Ekawanto, Iwan Elya Zulfa Ester Ayu Yuwidasari Falahuddin Alfahmi, Syafiq Farida, Ilya Firmansyah Firmansyah Fransiska Vita Kurniawati Hafidi, Moh. Haq, Aqamal Hastina, Sri Hidayat, Tony Rachmad Hilmi, Anas Ibrahim Arifin Iga Dewinta Putri Inggit Kentjonowaty Irawati Dinasari Jinarti Kukuk Yudiono Margaretha Putri Sariningrum Masyithoh, Dewi Maulida, Putri Maulita Cut Nuria Munajah, Ahmad Anang Murnik Asih Neni Susilaningsih Nisa'us Sholikah Nurrahman, Abidi Zaky Nurul Humaidah Oktavia Rahayu Puspitarini Olivia De Jesus Martins Pinaraswati, Sandra Oktaviana Retnaningtyas, irawati Dinasari Retno Murwanti Ririn Lispita Wulandari Salsabila, Maulida Santoso, Rahmawan Saputra, David Eka saroja saroja Serfansius Laia Setiawan, Bagus Wahyu Sri Tasminatun Suartini, Desk Ayu Sucyati Amelya Sugiyanto . Sugiyanto . Sumartono Sumartono Suprihati - Umi Kalsum USMAN ALI Veril B, Presiden Veronika Merianti Wahyu Saputra, Fany Wibawa, Surya Jaya Winarni Winarni Wisyaputra, Khalif Aikal wiwit pamuji rahayu Yambedoan, Thadius Yohana Eurensiani Kurnia Yudiono, Kukuk Yuni Fitriana yuniarti rosyidah

Title

Found 46 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 46 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 46 Documents
Search