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All Journal Medfarm: Jurnal Farmasi dan Kesehatan Journal of Fundamental and Applied Pharmaceutical Science Proceedings of the International Conference on Nursing and Health Sciences JURNAL JAMU KUSUMA Proceeding of International Conference Health, Science And Technology (ICOHETECH) Detector: Jurnal Inovasi Riset Ilmu Kesehatan Jurnal Medika Nusantara Parapemikir Jurnal Ilmiah Farmasi Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Kusumaningtyas Siwi Artini
Universitas Duta Bangsa Surakarta
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Journal : Journal of Fundamental and Applied Pharmaceutical Science

 1 
Total Flavonoid Content of Lemongrass Leaf (Cymbogoncitratus (DC.) Stapf) Extract and Antioxidant Activity with Frap Ahda Maulida Ulufan Nurinnafi'a; Kusumaningtyas Siwi Artini; Desy Ayu Irma Permatasari
Journal of Fundamental and Applied Pharmaceutical Science Vol 3, No 1 (2022): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v3i1.15556

Abstract

Lemongrass (Cymbogoncitratus (DC.) Stapf) leaves contain alkaloids, saponins, tannins, anthraquinones, steroids, phenols and flavonoids. Flavonoids act as antioxidants as they can reduce free radicals. This study aims to determine the total flavonoid content, antioxidant activity, and IC50 value of lemongrass leaf extract (Cymbogoncitratus (DC.) Stapf). Extracts were made by maceration using 96% ethanol as solvent. Testing of total flavonoid content with the AlCl3 method using UV-Vis spectrophotometry was carried out three times. The antioxidant activity test used the FRAP (ferric reducing antioxidant power) method on extracts containing 100, 200, 300, 400, and 500 ppm. The test results showed that the leaf extract of citronella (Cymbogoncitratus (DC.) Stapf) had a total flavonoid content of 22,60 mg QE/g extract. Furthermore, there was antioxidant activity in the leaf extract of lemongrass (Cymbogoncitratus (DC.) Stapf indicated by the formation of a blue color purplish when reacted with FRAP solution, and IC50 extract value was 71,59 ppm and included in the category of strong antioxidants.
Antibacterial Activity of Abrus precatorius L. Leaves Against Streptococcus mutans ATCC 25175 Bacteria Nadia Aisy Andika; Kusumaningtyas Siwi Artini; Tatiana Siska Wardani
Journal of Fundamental and Applied Pharmaceutical Science Vol 3, No 2 (2023): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v3i2.16206

Abstract

One of the herbal plants that have medicinal properties is Abrus precatorius L or commonly known as Saga in Indonesia. Empirically, the boiled water of saga leaves is widely used as an ingredient in cough medicine, cancer sores and swollen tonsils. The chemical constituents of antibacterial activity in the saga leaves are glycosides (abrusoside AD and abrusgenin), flavonoids and saponins (glycerin). This study aims to determine the antibacterial activity of extracts and fractions from saga leaves and the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the most active fraction of saga leaves on the growth of Streptococcus mutans ATCC 25175. Saga leaf powder was macerated using 96% ethanol, then fractionated using n-hexane, ethyl acetate, water as solvent, 96% ethanol extract, and n-hexane fraction. The antibacterial activity test using the diffusion method showed that the extract, n-hexane fraction, ethyl acetate fraction, and water fraction of saga leaves had antibacterial activity against Streptococcus mutans. The most active fraction was the ethyl acetate fraction, with a concentration of 50% with an average inhibition zone diameter of 12.2 mm. The ethyl acetate fraction from saga leaves had the most active antibacterial activity compared to ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction, as seen from the average diameter of the inhibition zone obtained. The test results of the dilution method of the ethyl acetate fraction of saga leaves showed a Minimum Inhibitory Concentration of 12.5% and a Minimum Killing Concentration of 25%.
Co-Authors Ahda Maulida Ulufan Nurinnafi'a Annissha Azzahra Wurnasari Bangkit Riska Permata Bangkit Riska Permata Desy Ayu Irma Permatasari Ferry Effendi Galuh Puspita Sari Galuh Puspitasari Ilham La Tansa Ilham Latansa Listyani, Tiara Ajeng Muhammad Andira Ibnu Shina Nadia Aisy Andika Noka Riyani Nur Hidayah Rifda Husna Arifah Tatiana Siska Wardani Tatiana Siska Wardani Triya Choirin Nisa Veranita, Weri Wardani, Tatiana Siska