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Taro (Colosia esculenta) Leaves Extract Inhibits Streptococcus mutans ATCC 31987 Ayu Nala El Muna Haerussana; Angreni Ayuhastuti; Siti Fira Yuniar; Hana Alifah Bustami; Widyastiwi Widyastiwi
Borneo Journal of Pharmacy Vol. 5 No. 3 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i3.3156

Dental caries was the most common disease in both adults and children. Streptococcus mutans is the main bacteria causing plaque formation and was the initiator of dental caries. Antibacterials derived from plants can be used to prevent plaque formation. Taro (Colosia esculenta) has been used in traditional medicine. Antibacterial compounds have been discovered in C. esculenta leaves. This study aimed to determine the ability of C. esculenta leaf ethanol extract to inhibit the growth of S. mutans ATCC 31987. Simplicia preparation, extract preparation, and phytochemical screening was carried out. Then, the antibacterial activity test was performed using the disc diffusion method to determine the zone of inhibition at various concentrations of 10, 20, 30, 40, 50, 60, and 70%. Colosia esculenta leaf ethanol extract contains alkaloids, flavonoids, triterpenoids, saponins, and produces an inhibition zone at each concentration variation. Very strong antibacterial activity was produced at a concentration of 70% at 21.11±0.46 mm, which was higher than the positive control.

POTENSI AKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK DAUN SIRIH HIJAU, SIRIH MERAH DAN SIRIH HITAM TERHADAP BAKTERI Propionibacterium acne Irvan Herdiana; Ayu Nala El Muna Haerussana; Nizella Syahla; Neneng Melawati; Siti Nurfitri Diniyati
Jurnal Bahana Kesehatan Masyarakat (Bahana of Journal Public Health) Vol 7 No 2 (2023): Jurnal Bahana Kesehatan Masyarakat (Bahana of Journal Public Health)
Publisher : Poltekkes Kemenkes Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35910/jbkm.v7i2.680

Background: Acne or acne vulgaris an inflammatory disorder derived from the follicle pilosebasea. The trigger bacteria is Propionibacterium acne., which often appears in adolescence. This condition is a very common skin disorder present with inflammatory and non-inflammatory lesions especially in the face, but it can happen in other parts of the body like the upper arm and the back. Purified ethanol extracts of betel green betel leaf concentration 20mg / ml has very strong antibacterial activity against Propiobacterium acne. Another study on the red betel leaf proved to have a Propionibacterium acne activity of concentration 10 %, 15 %, 20 % and 25 %. The next betel variety is that the black betel leaf has its benefits as the Propionibacterium acne antibacterium concentration 5 %, and strong activity zones at 10 % concentrations. Method: This research is experimental. Samples from this study are betel leaf green, Red betel and black betel. Samples of a fresh, domesticated plant, And then dried up in the wind. Next, there's an extraction of three-by-four-hour masseration methods with an hour-to-hour solvent change for each variety of betel leaf. The extraction results are applied to the solvent until it becomes a thick extract. Phytochemical screening is done to ensure any group of compounds extracted .Antibacterial testing using diffusion disk methods with concentration 5 %, 10 % and 15 % for each extract and extract combination with comparison (1: 1 ). Result: Screening results show an extract of ethanol 96 % green betel leaves (Piper betle L) and red betel (Piper crocatum ) positive alkaloid secondary metabolic compound, terpenoid, steroids, tannin, and flavonoids. Extract black betel leaf (Piper betle L. Var nigra ) positive is an alkaloid positive, terpenoid, steroids, tannin, saponin and flavonoid compound. Antibacterium Propionibacterium acne test results show the average positive control zone disk antibiotics clindamisin 8.67 mm strong categories, while for extracting concentration 15 % betel green is 8.69 mm strong category, Red betel 2.71 mm weak category, black betel 1.8 mm weak category, 577 mm medium red-green betel combination, 477 mm black-green betel. medium category and red-black betel of 1.89 weak categories. Normality test with result p>0,05 and the non parametric test of krkskall-wallis results asym sip values are 0,0000 (p<0,05) there is a significant difference between two group samples. Conclusion: The largest average value of the clear zone occurs on a concentration of 15 % green betel extract with 8.69 mm.

Averrhoa bilimbi (Belimbing Wuluh) Leaves Extract Evaluation as Anti-Cariogenic Mouthwash Oktavia Dwi Nugraheni; Ayu Nala El Muna Haerussana
Jurnal Riset Kesehatan Vol 13, No 1 (2024): MEI 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jrk.v13i1.10750

The practice of using mouthwash has become increasingly common as people have become more aware of the importance of oral hygiene in preventing dental issues. In order to mitigate any potential risks associated with alcohol-based mouthwashes, researchers are exploring natural sources of anti-cariogenic compounds. This study aimed to assess the effectivity of Averrhoa bilimbi leaf extract as an ingredient in mouthwash formulations, as the use of Averrhoa bilimbi leaves is still limited. The evaluation of the mouthwash included a thorough examination of its antibacterial activity, viscosity, density, pH, and organoleptic qualities. The results indicated that formula with 30 grams extract (F3) was the most effective, exhibiting more robust antibacterial properties, appropriate viscosity and density, and a pH level similar to that of a solution. F3 resulted in an effectiveness of 41.67%, 1.36 cPs for viscosity, 1.0785 mg/l for density, pH of 5.25+0.006, organoleptically liquid, mint odor, and blackish brown clear color. Based on these findings, it appears that Averrhoa bilimbi leaf extract could be a promising ingredient in mouthwash formulations.

Antibacterial Activity of Salam (Syzygium polyanthum) Leaves 70% Ethanolic Extract on Staphylococcus aureus and Staphylococcus epidermidis Ayu Nala El Muna Haerussana; Wulan Putri Dwiastuti; Cindi Arwan Sukowati
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 4 (2021): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i4.352

Indonesia has a high diversity of potential medicinal plants, which are the second-largest number of indigenous medicinal plants in the world. Syzygium polyanthum, known as Indonesian Bay Leaf or Salam, easily found, widely used in Indonesia as a spice in cooking and traditional medicine. Salam contains secondary metabolites such as flavonoids, alkaloids, tannins, essential oils, sesquiterpenes, triterpenes, phenols, steroids, and saponins. Staphylococcus aureus and Staphylococcus epidermidis are the main bacteria that cause commensal infection and the most common nosocomial infections. This study aims to know the antibacterial activity of the Salam ethanolic extract against Staphylococcus aureusand Staphylococcus epidermidis bacteria. Salam leaves were extracted by 70% ethanol in the maceration method. Antibacterial activity was conducted by the disk diffusion method. The extract exhibits moderate activity (10.51±0.3 mm) at 75% of concentration and low activity (3.69±0.4 mm) at 100% of concentration against Staphylococcus aureus and Staphylococcus epidermidis respectively. The test showed that salam leaves extract had antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis.

Penetapan Kadar Fenol Total dengan Spektrofotometer UV-Vis dan Uji Sitotoksisitas Ekstrak Air Daun Lidah Mertua (Sansevieria masoniana C.) Terhadap Sel Kanker Paru A-549 Lilis Febriyanti; Ayu Nala El Muna Haerussana
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 2 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.30080

Cancer is the second most common cause of mortality globally, following cardiovascular disease, according to the World Health Organization (WHO). Leading the list of fatal cancers annually are lung, breast, stomach, liver, and colorectal cancers. Hence, the discovery and development of effective agents to treat various types of cancer is urgently needed. Mother-in-law tongue (Sansevieria masoniana Chahin) leaves contain flavonoids and saponins. However, information regarding the total phenolic content of the aqueous extract of the S. masoniana Chahin leaves is currently unavailable. Hence, this research aims to determine the total phenol content using a UV-Vis spectrophotometer and assess the invitro anticancer activity of the water extract of S. masoniana Chahin through the MTT Assay. From the results of measuring the total phenolic content, the water extract of the leaves contained a phenol content of 3.3061 mgGAE/g. Meanwhile, the results of the cytotoxicity assay on lung cancer cells A-549 showed that the IC50 value of the aqueous extract of S. masoniana Chahin leaves was above 100 ppm, indicating that the extract has less potential as an anti-lung cancer agent.

Antihyperlipidemic activity of Marchantia paleacea herb and Zingiber officinale var. Rubrum rhizome ethanol extracts in Triton X-100-induced mice Purkon, Dicki Bakhtiar; Ningsih, Padmasari Diah Ayu Kumala; Pambudi, Fatimah Ayu Putri; Widyastiwi, Widyastiwi; Roseno, M.H.; Haerussana, Ayu Nala El Muna; Fadhlillah, Faizah Min; Trinovani, Elvi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1458

Non-communicable diseases cause 71% of deaths in the world, one of which is caused by dyslipidemia. Dyslipidemia has been established as a cause of various non-communicable diseases such as obesity and heart disease. This study aims to determine the antihyperlipidemic activity of the ethanol extract of the liverworts of Marchantia paleacea (EEMP) and the rhizome of Zingiber officinale var. rubrum (EEZOR) on male mice induced by Triton X-100. Grouping the number of test animals per group based on the Federer formula. Triton X-100 is used as an inducer of hyperlipidemic given intraperitoneally at a dose of 140 mg/kg body weight. Total cholesterol levels were measured by the colorimetric enzymatic method (CHOD-PAP) using a UV-Vis clinic photometer. Results from ethanol extract of the herb liverwort Marchantia paleacea (EEMP) and red ginger rhizomes Zingiber officinale var. Rubrum (EEZOR) can respectively reduce total hypercholesterol levels in male mice induced by Triton X-100 whose data were analyzed using the One-Way Anova test. The results of optimal dose of EEMP 200 mg/kg bw had the highest percentage of antihyperlipidemic activity and effectiveness (%) and also had a significant reduction in total cholesterol levels compared to the negative control group (p<0.05). While the results for the optimal dose of EEZOR 1000 mg/kg bw with the highest percentage of activity and effectiveness (%) and having a significant decrease compared to the negative control group (p <0.05). In conclusion, these findings suggest that both extracts have potential as natural antihyperlipidemic agents that can be further explored in the management of hyperlipidemic (dyslipidemic) and related non-communicable diseases.

Gas Chromatography Mass Spectroscopy (GCMS) Qualitative Analysis for Morphine, Heroin and Codeine used in Doping Haerussana, Ayu Nala El Muna; Mimin Kusmiyati; Irvan Herdiana
Indonesian Journal of Science and Education Vol. 7 No. 1 (2023): Indonesian Journal of Science and Education
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/ijose.v7i1.207

Three types of doping drugs, morphine, heroin, and codeine were analyzed qualitatively in urine using GCMS: HP5MS column containing a nonpolar substance, phenylmethyl siloxane, with a temperature range of 90-250ºC and a rate of increase of 10ºC/minute. Diethyl ether was used to extract morphine, codeine, and heroin. The extractions were performed at pH 8, the organic phase was evaporated, followed by derivatization. Morphine and its derivatives were treated with a solution of N-methyl-N-trimethylsilyl-trifluoroacetamide and N-methyl-bis-trifluoroacetamide. The results of the gas chromatographic analysis showed that the retention times of morphine, heroin, and codeine the retention times were 8.01, 7.32, 6.21 minutes, while those of their derivatives were 8.10, 8.10, 7.95 minutes respectively. The identification of each drug using mass spectrometry revealed that their mass spectra were identical to the standard. The mass spectra of the derivatives: morphine-TMS and codeine-TMS showed a resemblance index of 93% respectively compound to the standard, with a detection limit of 2 ug/ml.

Inhibitory Test of Bay Leaf (Eugenia polyantha) Extract Against Pseudomonas aeruginosa and Escherichia coli Haerussana, Ayu Nala El Muna; Dwiastuti, Wulan Putri; Sukowati, Cindi Arwan; Widyastiwi, Widyastiwi
Journal of Applied Science, Engineering, Technology, and Education Vol. 4 No. 2 (2022)
Publisher : PT Mattawang Mediatama Solution

Bay leaf has traditionally been used by Indonesians as a cooking spice and for disease treatment. Bay leaves contain secondary metabolites that are known to have antibacterial properties. The secondary metabolites produced are influenced by several factors, including the growth area and the extraction solvent. The main causative bacteria in nosocomial infections are Pseudomonas aeruginosa and Escherichia coli. This study aimed to evaluate the antibacterial activity of bay leaf extract against the two gram-negative bacteria. The maceration method and 70% ethanol were used to extract bay leaves. The antibacterial activity was evaluated using the disc diffusion method. The extract exhibits the widest zone of inhibition (11.91±0,84 mm) at 100% of concentration against Pseudomonas aeruginosa. The extract showed antibacterial activity against Pseudomonas aeruginosa but not against Escherichia coli.

Penetapan Kadar Fenol Total dengan Spektrofotometer UV-Vis dan Uji Sitotoksisitas Ekstrak Air Daun Lidah Mertua (Sansevieria masoniana C.) Terhadap Sel Kanker Paru A-549 Febriyanti, Lilis; Haerussana, Ayu Nala El Muna
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.30080

Cancer is the second most common cause of mortality globally, following cardiovascular disease, according to the World Health Organization (WHO). Leading the list of fatal cancers annually are lung, breast, stomach, liver, and colorectal cancers. Hence, the discovery and development of effective agents to treat various types of cancer is urgently needed. Mother-in-law tongue (Sansevieria masoniana Chahin) leaves contain flavonoids and saponins. However, information regarding the total phenolic content of the aqueous extract of the S. masoniana Chahin leaves is currently unavailable. Hence, this research aims to determine the total phenol content using a UV-Vis spectrophotometer and assess the invitro anticancer activity of the water extract of S. masoniana Chahin through the MTT Assay. From the results of measuring the total phenolic content, the water extract of the leaves contained a phenol content of 3.3061 mgGAE/g. Meanwhile, the results of the cytotoxicity assay on lung cancer cells A-549 showed that the IC50 value of the aqueous extract of S. masoniana Chahin leaves was above 100 ppm, indicating that the extract has less potential as an anti-lung cancer agent.

Averrhoa bilimbi (Belimbing Wuluh) Leaves Extract Evaluation as Anti-Cariogenic Mouthwash Nugraheni, Oktavia Dwi; Haerussana, Ayu Nala El Muna
Jurnal Riset Kesehatan Vol 13 No 1 (2024): MEI 2024
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jrk.v13i1.10750

The practice of using mouthwash has become increasingly common as people have become more aware of the importance of oral hygiene in preventing dental issues. In order to mitigate any potential risks associated with alcohol-based mouthwashes, researchers are exploring natural sources of anti-cariogenic compounds. This study aimed to assess the effectivity of Averrhoa bilimbi leaf extract as an ingredient in mouthwash formulations, as the use of Averrhoa bilimbi leaves is still limited. The evaluation of the mouthwash included a thorough examination of its antibacterial activity, viscosity, density, pH, and organoleptic qualities. The results indicated that formula with 30 grams extract (F3) was the most effective, exhibiting more robust antibacterial properties, appropriate viscosity and density, and a pH level similar to that of a solution. F3 resulted in an effectiveness of 41.67%, 1.36 cPs for viscosity, 1.0785 mg/l for density, pH of 5.25+0.006, organoleptically liquid, mint odor, and blackish brown clear color. Based on these findings, it appears that Averrhoa bilimbi leaf extract could be a promising ingredient in mouthwash formulations.

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