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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmascience Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Jurnal Ilmiah Cendekia Eksakta Jurnal Vokasi Jurnal Ilmiah Medicamento Abdi Masya Jurnal Farmasi Sains dan Praktis

Prihantini, Malinda

Universitas Wahid Hasyim

Author-ID : 1252073

Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Formulasi Tablet Paracetamol dengan Bahan Pengikat Pati Umbi Gembili (Dioscorea esculenta L) Elya Zulfa; Malinda Prihantini
Jurnal Pharmascience Vol 6, No 2 (2019): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v6i2.7351

ABSTRAK Pati umbi gembili (PUG) memiliki kandungan utama amilopektin sebesar 75,7%. Amilopektin bersifat lekat dan dapat membentuk gel bila disuspensikan dengan air, sehingga dapat dimanfaatkan sebagai bahan pengikat. Tujuan penelitian ini adalah mengetahui sifat fisik tablet paracetamol dengan penambahan PUG sebagai bahan pengikat. Proses pembuatan pati dari umbi gembili dilakukan dengan cara basah. Tablet Parasetamol dibuat dengan metode granulasi basah dengan variasi kadar mucilago PUG FI 5%, FII 10%, FIII 15%. Tablet yang dibuat, diuji sifat fisik (keseragaman bobot, kekerasan, kerapuhan dan waktu hancur) dan dianalisis secara deskriptif. Hasil uji sifat fisik tablet menunjukkan bahwa seluruh formula yang dibuat memenuhi syarat yang ditetapkan dalam kompendial. Kata Kunci : Parasetamol, pati umbi gembili, bahan pengikat, granulasi basah ABSTRACT Gembili tuber (PUG) starch has a major component of amylopectin of 75.7%. Amylopectin is sticky and can form a gel when suspended with water, so that it can be used as a tablet binding agent in the form of PUG mucilago. The purpose of this study was to determine the physical characteristics in paracetamol tablets of adding PUG mucilago (Dioscorea esculenta) as a binder. The process of making starch from gembili tuber is done by wet. Paracetamol tablets are made by wet granulation method with variations in levels of FI PUG mucilago 5%, FII 10%, FIII15%. Tablets were made, tested for physical properties (weight uniformity, hardness, friability and disintegration time) with descriptive analysis. The test results of the physical properties of tablets indicate that all formulas made meet the requirements set out in the literature Keywords: Paracetamol, gembili tuber starch, binder, wet granulation

Optimasi Nanoemulsi A/M/A Ekstrak Etanol Daun Binahong dan Konjugat AG-Kitosan Menggunakan Desain Box-Behnken Malinda Prihantini; Irda Fidrianny; Tri Suciati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Skin premature aging which is characterized by fine wrinkles can be overcome by stimulating collagen production and inhibiting its degradation, and also reducing corneocyte buildup. Madeira vein has been shown to induce collagen production and inhibit its degradation, while glycolic acid increase desquamation. The aim of this research was to optimize W/O/W multiple nanoemulsion formula of Madeira vein-leaves extract in W1 phase and glycolic acid in W2 phase. Glycolic acid was added after conjugated with chitosan to reduce its stinging effect on skin. The W/O/W multiple nanoemulsion was prepared through two emulsification steps: W1/O primary emulsion using high speed homogenizer, and the secondary emulsion using magnetic stirrer. W1/O was optimized including the selection of co surfactant and extract concentration, followed by secondary emulsion optimization using response surface methodology consisted of 2-level factorial and Box-Behnken design. The W1/O consisted of extract, polysorbate 80 as surfactant, PEG 400 as co surfactant and isopropyl myristate as oil phase. The 2-level factorial gave the three significant factors: W1/O sonication time, W1/O concentration, and secondary emulsification stirring time. Box-Behnken optimization for globule size below 400 nm was obtained by 6-10 minutes W1/O sonication time, 12-16% W1/O concentration, and 32-42 minutes stirring time of secondary emulsification.

EKSTRAK ETANOL DAUN SUJI (Pleomele angustifolia) TERENKAPSULASI NANOPARTIKEL KITOSAN DALAM SEDIAAN KRIM TABIR SURYA DENGAN VARIASI TWEEN 80-SETIL ALKOHOL Muhammad Ridho Putra Santosa; Malinda Prihantini
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 18, No 2 (2021): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Antioxidants in the ethanolic extract of suji leaves (Pleomele angustifolia) have the potential as a sunscreen. The use of chitosan in the nanoparticle system is able to protect the degradation of flavonoids due to the influence of temperature and light. Tween 80 and cetyl alcohol play a strategic role in the formation of cream preparations. The purpose of this study was to determine the characteristics of sunscreen cream with variations of Tween 80-cetyl alcohol containing the active ingredient of ethanol extract of suji leaves encapsulated in a nanoparticle system. Chitosan nanoparticles of suji leaf ethanol extract (KEEDS) were prepared using ultrasonic agitation. KEEDS nanoparticles were made into cream preparations with variations of Tween 80-cetyl alcohol (T80:SA) FI (3:3)%, FII (3:10)%, FIII (10:10)%. The formed cream was observed for organoleptic, homogeneity, type of cream, and measured the value of pH, spreadability, adhesion, viscosity, and sunscreen activity using a UV-Vis Spectrophotometer at a wavelength of 290–320 nm. Organoleptic data, homogeneity, pH and cream type were analyzed descriptively, while the spreadability, adhesion, viscosity and sunscreen activity were analyzed using ANOVA with 95% confidence limit. KEEDS nanoparticle cream visually looks homogeneous, with a brownish white color, soft texture, and the aroma of suji leaves. The pH value of the preparation is 4.74-4.88, the type of cream is O/W. The variation of the T80:SA combination resulted in significant differences in the values of dispersion, adhesion, viscosity and sunscreen activity between the three formulas (sig < 0.05).

PENGARUH WAKTU ULTRASONIKASI TERHADAP KARAKTERISTIK FISIKA NANOPARTIKEL KITOSAN EKSTRAK ETANOL DAUN SUJI (Pleomele angustifolia) DAN UJI STABILITAS FISIKA MENGGUNAKAN METODE CYCLING TEST Malinda Prihantini; Elya Zulfa; Listyana Dewi Prastiwi; Ikha Dyah Yulianti
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 16, No 02 (2019): Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 02 Desember 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT The nanoparticle system encapsulates and protects flavonoids of suji leaves from photolysis and oxidation instability. Chitosan is a biocompatible, biodegradable and non-toxic nanoparticles forming polymer. Ultrasonication is a materials mixing technique under high vibration energy. The ultrasonication time affects the particle size. The aim of this study was to determine the effect of the ultrasonication time on physical characteristics of chitosan nanoparticles of suji (Pleomele angustifolia) leaf ethanol extract and its physical stability after cycling test. Ethanol extract of suji leaves (EEDS) was obtained by maceration using 70% ethanol. Chitosan EEDS nanoparticles were made under ionic gelation method using an ultrasonication time of 3 minutes (FI), 6 minutes (FII), and 9 minutes (FIII). The physical characterization of nanoparticles includes particle size, polydispersity index, and zeta potential. Chitosan EEDS nanoparticles with the best physical characteristics (FIII) were tested for stability using cycling test method. The data obtained were analyzed using the Anova statistical method with a 95% confidence level. The size of EEDS chitosan nanoparticles (nm) was significantly different in all formulas, FI (374.47), FII (288.43), and FIII (233.37). The polydispersity index of FI (0.38) and FIII (0.65) were significantly different, while FII (0.41) was not significantly different. The zeta potential (mV) FI (51.70), FII (46.10), and FIII (48.60) were not significantly different in all formulas. The physical characteristics of Formula III after Cycling Test showed a particle size of 455.0 nm, a polydispersity index of 0.174, and a zeta potential of 20.1 mV. Keywords: ultrasonication, nanoparticles, chitosan, cycling test, suji leaf (Pleomele angustifolia)

Pengaruh Bentuk Sediaan terhadap Potensi Antioksidan Ekstrak Etanol Daun Sirsak (Annona muricata L.) dalam Sistem Nanopartikel Malinda Prihantini; Nopbrillian Fine Setya; Anisa Rizki Amelia; Tsabita Udkhiya Zulfa
Jurnal Ilmiah Medicamento Vol 8 No 2 (2022): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v8i2.3699

Flavonoids in soursop leaf ethanol extract have various pharmacological effects but are easily degraded due to the influence of pH, oxygen, and intense light exposure. Encapsulation using chitosan polymer in nanoparticles is able to overcome these limitations. The formulation of the nanoparticle system in lotion and cream preparations can increase the comfort of use by consumers. Therefore, this study was conducted to determine the effect of lotion and cream dosage forms on the antioxidant activity of soursop leaf ethanol extract nanoparticles. Soursop leaf extraction was done by soaking at room temperature for 3 days using 70% ethanol as solvent. The soursop leaf ethanol extract nanoparticle system was prepared with three graded Soursop leaf ethanol extract concentrations F1 100 mg, F2 200 mg, and F3 300 mg. The nanoparticle system is then formulated into lotion and cream preparations. Evaluation of antioxidant activity was carried out by reacting it with DPPH, and the IC50 value of lotion preparation was obtained and showed the result was (F1) 83,34±0,130; (F2) 74,69±0,131; and (F3) 64,26±0,129 ppm, while the IC50 value of cream was (F1) 84,32±0,133; (F2) 75,35±0,130; and (F3) 63,74±0,120 ppm. The antioxidant activity of soursop leaf ethanol extract nanoparticles in lotion and cream preparations is included in the category of strong antioxidants. Statistical analysis using an independent t-test of the antioxidant activity showed p>0.05, so it was concluded that the ability to scavenge free radicals from soursop leaf ethanol extract in the nanoparticle system was not affected by the dosage form.

PELATIHAN PEMBUATAN CAIRAN BUNGA TELANG SEBAGAI BAHAN SEMPROTAN ANTISERANGGA & ANTIBAKTERI ALAMI DAN RAMAH LINGKUNGAN DI KELURAHAN PLALANGAN KECAMATAN GUNUNGPATI KOTA SEMARANG Malinda Prihantini; M Fatchur Rochman; Danang Novianto Wibowo
ABDIMAS UNWAHAS Vol 8, No 1 (2023)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/abd.v8i1.8581

Kelurahan Plalangan merupakan salah satu kelurahan di Kecamatan Gunungpati Kota Semarang. Lokasinya yang berada di daerah Kota Semarang bagian selatan, membuat sebagian besar wilayahnya berupa perbukitan yang didominasi oleh hutan dan kebun. Dari seluruh luas wilyahnya, hanya separuhnya yang digunakan sebagai pemukiman dan perkebunan budidaya atau pertanian. Sisanya belum dimanfaatkan dan dibiarkan terbengkalai. Padahal banyak tanaman di area tersebut yang berpotensi dan berdaya guna, salah satunya adalah bunga telang yang berkhasiat sebagai antiserangga dan antibakteri. Selain potensi sumber daya alam, Kelurahan Plalangan juga memiliki potensi sumber daya manusia yang besar karena memiliki jumlah usia produktif yang besar. Namun, sayangnya separuh kelompok usia produktif belum atau tidak bekerja. Melalui kegiatan pengabdian dalam wujud pelatihan pembuatan air rebusan bunga telang sebagai antiserangga dan antibakteri, diharapkan mampu mengoptimalkan potensi sumber daya yang dimiliki oleh Kelurahan Plalangan sehingga mampu menghasilkan produk berdaya guna. Kata kunci: antibakteri, antiserangga, bakteri, bunga telang, serangga

Optimasi Konsentrasi Surfaktan Cremophor RH 40 dalam Nanoemulsi Kompleks Molekular Asam Glikolat-Kitosan Menggunakan Metode Multilevel Categoric-One Factor Prihantini, Malinda; Fayakun, Fabryla Lutfiani
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 20, No 2 (2023)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v20i2.9858

Asam glikolat (AG) digunakan untuk mengatasi photoaging, namun menyebabkan rasa menyengat pada kulit. Kompleks molekular asam glikolat-kitosan (AG-KS) dapat mengatasi masalah tersebut namun berpotensi memperbesar ukuran partikel sehingga dibentuk sediaan nanoemulsi dengan Cremophor RH 40 sebagai surfaktan. Nanoemulsi diharapkan meningkatkan bioavailabilitas bahan aktif dengan meningkatkan luas permukaan dan Cremophor RH 40 mendukung peningkatkan permeabilitas membran dengan menurunkan tegangan antarmuka. Konsentrasi Cremophor RH 40 optimum diperlukan untuk mencapai kondisi tersebut. Tujuan penelitian ini untuk memperoleh formula optimum nanoemulsi kompleks molekular AG-KS dengan variasi konsentrasi Cremophor RH 40 menggunakan metode desain faktorial. Kompleks AG-KS (1:1) disonikasi selama 10 menit. Nanoemulsi dibuat dengan variasi Cremophor RH 40 10%, 20%, 30%. Sediaan diuji organoleptik, homogenitas, tipe emulsi, pH, viskositas, daya sebar, daya lekat, ukuran partikel, indeks polidispersitas (PI), dan potensial zeta. Data dianalisis menggunakan multilevel categoric-one factor. Sediaan berwarna putih, tekstur lembut, homogen, tidak beraroma, dengan tipe emulsi minyak dalam air. pH rata-rata sediaan 3,9 ±0,00 memenuhi persyaratan BPOM, viskositas dan daya lekat meningkat dengan meningkatnya variabel bebas, sedangkan daya sebar menurun. Hasil ukuran partikel dari ketiga formula di bawah 400 nm. Indeks polidispersitas menunjukkan monodisperse (<0,6) dengan potensial zeta <30 mV. Hasil formula optimum menggunakan desain faktorial didapatkan F2 dengan nilai desirability 0,608. Cremophor RH 40 konsentrasi 20% optimal digunakan pada nanoemulsi kompleks molekuler AG-KS.

APPLICATION OF LAKES SYSTEM IN PREPARATION OF HAIR DYES POMADE CREAM OF FREEZE-DRIED RED DRAGON (Hylocereus polyrhizus) FRUIT PEEL JUICE AND ACUTE DERMAL IRRITATION Prihantini, Malinda; Ikhsan, Muhammad; Karim, Hasan Abdul; Rianis, Sindi Fadillah; Sobari, Sobari; Rheza, Faykar
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.8889

Dyes used in market products are mostly synthetic, which can irritate the skin and in the long term increase the risk of skin cancer. The peel of dragon fruit contains the red-violet pigment Betacyanin, which is potential as hair dyes but extremely sensitive to light and oxygen. The lakes system is the option to overcome the problem and increase the stability of pigments. The objective of this study was to learn about the use of the lakes system in the preparation of hair dyes pomade cream of freeze-dried red dragon fruit peel juice and its irritation aspect on skin. The lakes system was made with a 50% red dragon fruit peel juice, mixed with 5% alucol, then dried with 45% aerosil. Pomade cream was prepared by mixing oil phase and water phase at a temperature of ±60 °C with continuous mixing in 600 rpm for 10 minutes. Formula III is the bases without freeze-dried red dragon fruit peel juice. The non-lakes system of freeze-dried red dragon fruit peel juice was added to the bases for the FII, while the lakes system was added for the FI. Hair dyes pomade cream of red dragon fruit peel juice prepared in the lakes system has superior properties to the formula prepared without the lakes system. It demonstrated better homogeneity and softer texture, in addition acceptable skin pH range. The lakes system is suitable for the preparation of natural hair dye cream and does not irritate the skin.

Formulasi dan Evaluasi emulgel Celecoxib dengan Tween 80 dan Lesitin untuk Penghantaran Obat Transdermal Wibowo, Danang Novianto; Prihantini, Malinda; Aini, Rakhmatul; Yudianti, Husna S.
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.48498

Celecoxib merupakan senyawa yang termasuk kategori BCS (Biopharmaceutics Classification System) kelas II yang memiliki kelarutan rendah dengan permeabilitas tinggi dan berdampak pada penurunan bioavailabilitas. Tujuan penelitian ini adalah untuk mengetahui pengaruh variasi konsentasi surfaktan lesitin terhadap karakteristik fisik sediaan emulgel celecoxib dan untuk mengetahui permeasi secara in vitro sediaan emulgel celecoxib dengan variasi konsentrasi lesitin sebagai surfaktan.Sediaan emulgel celecoxib dibuat dalam enam formula dengan masing-masing variasi konsentrasi surfaktan lesitin pada formula 1 (3%), formula 2 (5%), dan formula 3 (7%) dan variasi konsentrasi surfaktan tween 80 pada formula 4 (5%), formula 5 (10%), dan formula 6 (15%). Sediaan emulgel dievaluasi karakteristik fisiknya meliputi organoleptis, homogenitas, penentuan tipe emulsi, pH, viskositas, daya lekat, daya sebar, dan dilakukan uji permeasi in vitro menggunakan metode sel difusi Franz. Data hasil uji organoleptis, homogenitas, dan penentuan tipe emulsi dianalisis secara deskriptif. Sedangkan untuk pH, viskositas, daya sebar, dan daya lekat dari setiap formula dianalisis menggunakan regresi linier, untuk data hasil uji permeasi in vitro dianalisis secara statistik menggunakan uji ANOVA.Hasil penelitian menunjukkan bahwa semakin tinggi konsentrasi surfaktan lesitin maka semakin tinggi pula nilai pH, viskositas, dan daya lekat emulgel. Peningkatan konsentrasi lesitin sebagai surfaktan meningkatkan jumlah celecoxib terpenetrasi per satuan luas area difusi dan laju penetrasi celecoxib.Kata kunci: Celecoxib, emulgel, surfaktan, lesitin.

Multilevel Categoric-One Factor Optimization Of Cremophor Rh 40 As Surfactant in Cream With Calabash (Crescentia cujete Linn) Leaves Ethanolic Extract Winanti Adi Riyanti; Dewi Wulandari Auliasari; Kharisma Raudlatul Firdaus; Malinda Prihantini
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.10796

Indonesia's location on the equator is exposed to a high UV index, which triggers various health problems due to ultraviolet radiation, including melanoma. Melanoma is the 5th deadliest cancer that develops from the malignant transformation of melanin in oxidative stress conditions. Therefore, antioxidants are needed. Calabash is a natural exogenous antioxidant with an IC₅₀ value of 80.21 µg/mL (strong activity). Optimal formulations of cream containing calabash are determined by the concentration of ingredients and the selection of comprehensive analytical methods. This research aims to optimize cream preparations of calabash leaves ethanol extract with varying concentrations of Cremophor RH 40 as a surfactant using the multilevel categoric-one factor method. The cream was made with Cremophor RH 40 concentrations of 5%, 10%, and 15%. The cream was made by mixing the water phase (Nipagin, Glycerine, and Aquadest) and the oil phase (Cremophor RH 40, BHT, IPM, Cetostearyl alcohol, and Nipasol) after both phases reached a temperature of 60ºC in mixer speed no 1 for 15 minutes then followed by adding calabash leaves ethanolic extract until a homogeneous cream was formed. The parameters observed were organoleptic, homogeneity, the type of cream, pH, viscosity, dispersibility, and adhesion. The viscosity, dispersibility, and adhesion were chosen as the parameters for the formula optimization. The cream of calabash ethanolic extract was shown as green, homogeneous semi-solid with a soft texture and distinctive aroma, and was an oil-in-water (O/W) type cream. The average pH of 5.6 was suitable for facial skin. The viscosity value increased with increasing surfactant concentration while dispersibility decreased. The results of formula optimization obtained the optimum formula was FIII with a concentration of Cremophor RH 40 of 15% and a desirability value of 0,896.

Co-Authors Aini, Rakhmatul Anisa Rizki Amelia Auliasari, Dewi Wulandari Ayu Shabrina Bukhori, M. Fariz Annas Dewi Wulandari Auliasari Elya Zulfa Elya Zulfa Fatinah Shahab Fayakun, Fabryla Lutfiani Fresiva, Urva Heroweti, Junvidya Ikha Dyah Yulianti Irda Fidrianny Karim, Hasan Abdul Kharisma Raudlatul Firdaus Listyana Dewi Prastiwi M Fatchur Rochman Mahardika, Muhammad Farel Mahmud, Nurlela Mindiono, Imam Arif Muhammad Ikhsan Muhammad Ridho Putra Santosa Muhammad Ridho Putra Santosa Najibah, Muna Ulya Nopbrillian Fine Setya Nur Azizah Nur Kholis Pradasari, Frisya Rheza, Faykar Rianis, Sindi Fadillah Rinna Dwi Lestari risha fillah fithria Riyanti, Winanti Adi Rochman, M Fatchur Rosya, Shilva Putri Setiawan, Pratama Yuda Setiyawan, Luky Setya, Nopbrillian Fine Sholehah, I Ana Sobari Sobari Tri Suciati Tsabita Udkhiya Zulfa Wafa, Nurul Wibowo, Danang Novianto Winanti Adi Riyanti Yudianti, Husna S. Yulias Ninik Windriati

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