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All Journal Jurnal Gizi Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences NUTRIRE DIAITA Indonesian Journal of Human Nutrition Majalah Kesehatan FKUB Amerta Nutrition JURNAL Al-AZHAR INDONESIA SERI SAINS DAN TEKNOLOGI
Laksmi Karunia Tanuwijaya
Jurusan Gizi Fakultas Kedokteran Universitas Brawijaya Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Electrical & Electronics Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health Other

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The Correlation between Serum Concentration of Vitamin D with Vitamin D Receptor Expression and Disease Activity in Indonesian Patients with Systemic Lupus Erythematosus: Preliminary Study Handono, Kusworini; Tanuwijaya, Laksmi Karunia; Fitri, Loeki Enggar; Kalim, Handono
Journal of Tropical Life Science Vol 4, No 2 (2014)
Publisher : Journal of Tropical Life Science

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Abstract

The vitamin D role on the immune response of systemic lupus erythematosus (SLE) patient is mediated by vitamin D receptor (VDR). Low level of vitamin D correlated with disease activity in SLE patients, and circulating levels of activated vitamin D (1,25(OH)2D) contribute to VDR protein levels and its function. The objective of this study was to determine the correlation between vitamin D status with expression of VDR in peripheral blood mononuclear cell (PBMC) and the disease activity in SLE patients. The Research Subjects were 15 SLE patients (ACR 1997 criteria) from the Rheumato-Immunology Division, dr. Saiful Anwar Hospital, Malang and 5 healthy controls. Serum vitamin D (25(OH)D3) level was assessed using ELISA method. VDR expression in PBMC was assessed using immunocytochemistry technique. The disease activity was measured by Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score. This study showed no difference on VDR expression in PBMC between patient and healthy control group, but patient with vitamin D deficiency had lower VDR expression in PBMC than the other group. No difference on SLEDAI score between the group. Vitamin D status correlated positively with VDR expression in PBMC (p < 0,035, r = 0,473). However vitamin D status did not correlate with disease activity scores (p = 0,686).
Co-Authors Afifah Yasyfa Dhiyanti Amalia Ruhana, Amalia Amanda Putri Gita, Amanda Putri Andina Devi Arvita, Andina Devi Anggun Rindang Cempaka Anisa Handayani Anugerah, Paramita Nur Dina Elok Wulandari Dini, Cleonara Yanuar Eva Putri Arfiani Handono Kalim Ismi Indah Ummi, Ismi Indah Kusworini Handono Loeki Enggar Fitri Nur Amaliah Ahmad Nurdiana Nurdiana Rahma Micho Widyanto Sanarto Santoso Sembiring, Lydia Gresari Tiara Dian Novitasari Titis Sari Kusuma Widya, Novita Yosfi Rahmi Yudi Arimba Wani Yudi Arimba Wani, Yudi Arimba