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All Journal AKSIOMA: Jurnal Program Studi Pendidikan Matematika Majalah Patologi Indonesia Didaktika: Jurnal Pemikiran Pendidikan Repong Damar: Jurnal Pengabdian Kehutanan dan Lingkungan Agroista: Jurnal Agroteknologi Journal of Medicine and Health Media Pendidikan Matematika Jurnal Lingkar Mutu Pendidikan Journal of Emerging Techologies in Ethnomathematics
Sri Suryanti
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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Peran EGFR sebagai Prediktor Sensitivitas Radioterapi pada Adenokarsinoma Serviks Fennisia Wibisono; Sri Suryanti; Bethy S. Hernowo
Majalah Patologi Indonesia Vol. 25 No. 3, September 2016
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

Latar belakang Karsinoma serviks menduduki urutan pertama dari kejadian keganasan pada wanita dan merupakan masalah penting dalam onkologi ginekologi di Indonesia. Mayoritas pasien karsinoma serviks termasuk adenokarsinoma serviks datang pada stadium lanjut dan radioterapi merupakan salah satu modalitas terapinya. Keberhasilan radioterapi dinilai dari respons radioterapi yang dipengaruhi beberapa faktor prognostik, yaitu keadaan umum, stadium, histopatologi dari tumor, adanya gangguan fungsi organ, dan beberapa petanda molekular seperti epidermal growth factor receptor (EGFR). Saat ini sedang dikembangkan studi-studi mengenai EGFR berhubungan dengan sensitivitas radioterapi namun hasilnya masih kontroversi. Aktivasi sinyal EGFR dapat menginduksi terjadinya radioresistensi pada adenokarsinoma serviks. Tujuan dari studi penelitian ini adalah untuk menganalisis korelasi antara ekspresi EGFR, dan sensitivitas radioterapi adenokarsinoma serviks. Metode Penelitian ini merupakan studi retrospektif, cross sectional, dan analisis korelasional. Sampel penelitian sebanyak 32 blok parafin yang berasal dari pasien adenokarsinoma serviks yang telah mendapatkan radioterapi dan merupakan sampel yang tersimpan di Departemen Patologi Anatomik RSUP Dr. Hasan Sadikin Bandung, periode Januari 2007-Mei 2014. Pada sampel tersebut dilakukan pulasan imunohistokimia EGFR. Hasil Analisis statistik antara ekspresi EGFR dan sensitivitas radioterapi adenokarsinoma serviks menunjukkan adanya perbedaan bermakna (p=0,000). Kesimpulan Ekspresi EGFR dapat digunakan sebagai prediktor sensitivitas radioterapi karsinoma serviks. Kata kunci : adenokarsinoma serviks, EGFR, radioterapi.
Validitas Pemeriksaan Imunositokimia HMGA2 dalam Penegakan Diagnosis Nodul Jinak dan Ganas Tiroidpada Sediaan Biopsi Aspirasi Jarum Halus Yenni Wisudarma; Hasrayati Agustina; Sri Suryanti; Bethy S. Hernowo
Majalah Patologi Indonesia Volume 26 No. 1, Januari 2017
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Latar belakang Tindakan biopsi aspirasi jarum halus (BAJAH) merupakanpemeriksaan preoperatif baku yang sederhana dan relatif lebih murah dalam penegakan diagnosis karsinoma tiroid, tetapi diagnosis sitologi BAJAH tersebut tidak selalu mudah. Penelitian ini bertujuan untuk mengetahui validitas pemeriksaan imunositokimia HMGA2 dalam penegakan diagnosis sediaan BAJAH nodul tiroid jinak, ganas dan indeterminate. Metode Penelitian ini merupakan penelitian uji diagnostik yang dilakukan terhadap 62 kasus nodul tiroid yang terdiri dari 18 kasus karsinoma papiler,13 kasus nodul folikular jinak dan 31 kasus indeterminate (27 kasus follicular neoplasmdan 4 kasus suspicious for papillary carcinoma) yang didiagnosis tahun 2011-2014 dan telah dilakukan pemeriksaan histopatologi pasca operasi sebagai konfirmasi diagnosis. Pemeriksaan imunositokimia HMGA2 dilakukan terhadap semua kasus dengan metode cell transfer. Hasil Akurasi, sensitivitas, spesifisitas, nilai duga positif dan nilai duga negatif pemeriksaan imunositokimia HMGA2 dalam diagnosis nodul tiroid masing-masing adalah 85,5%, 79,4%, 92,8%, 93,1% dan 78,8%. Sedangkan untuk kasus indeterminate, akurasi, sensitivitas, spesifisitas, nilai duga positif dan nilai duga negatif pemeriksaan imunositokimia HMGA2 adalah 77,4%, 68,7%%, 86,7%, 84,6% dan 72,2%. Kesimpulan Pemeriksaan imunositokimia HMGA2 relatif spesifik dan sensitif dalam menegakkan diagnosis preoperatif nodul tiroid termasuk pada kasus indeterminate. Kata kunci : biopsi aspirasi jarum halus, HMGA2, indeterminate, nodultiroid.
Korelasi antara Imunoekspresi Retinoid Acid Receptor (RAR) Alfa dan Ki-67 dengan Stadium Klinis dan Diferensiasi Retino-blastoma Friska Mardianty; Sri Suryanti; Bethy S Hernowo
Majalah Patologi Indonesia Volume 26 No. 1, Januari 2017
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Latar belakang Retinoblastoma merupakan keganasan mata tersering pada anak usia dibawah 5 tahun dan 50-60% kasus retinoblastoma di negara berkembang berakhir dengan kematian. Terapi saat ini sangat tergantung dengan stadium klinis dan walaupun telah diberikan terapi yang sesuai, masih ditemukan kasus rekurensi atau metastasis. Vitamin A diketahui banyak berperan untuk mata, dan telah terbukti pula vitamin A berperan pada karsinogenesis di beberapa keganasan lainnya. RAR alfa adalah reseptor dari retinoid acid yang salah satu fungsinya adalah sebagai anti proliferasi, sedangkan Ki-67 adalah petanda untuk menilai indeks proliferasi dari suatu sel. Tujuan penelitian ini dapat menilai adakah hubungan RAR dan Ki-67, berdasarkan diferensiasi dan stadium klinis pada retinoblastoma. Metode Penelitian ini dilakukan secara retrospektif dengan desain analisis korelasi terhadap 40 kasus retinoblastoma yang memenuhi kriteria penelitian, periode januari 2010-november 2014 di Departemen Patologi Anatomik RS Hasan Sadikin, Bandung. Seluruhnya dilakukan pulasan imunohistokimia RAR alfa dan Ki-67 dikorelasikan dengan stadium klinis dan diferensiasi sel. Hasil penelitian dianalisis statistik dengan uji Coefficient Contingensy dan kriteria Guillford. Hasil Hasil penelitian ini seluruhnya memberikan imunoekspresi positif pada RAR alfa dan Ki-67. Didapatkan imunoekspresi Ki-67 berkorelasi positif terhadap diferensiasi (p=0,042 dan R=0,370), namun tidak terdapat korelasi bermakna dengan stadium klinis, sedangkan pada pemeriksaan RAR alfa tidak terdapat korelasi bermakna baik dengan stadium klinis maupun tipe diferensiasi sel. Kesimpulan Tipe yang tidak berdiferensiasi menunjukkan indeks proliferasi yang lebih tinggi dibandingkan tipe yang berdiferensiasi. Kata kunci : diferensiasi, Ki-67, RAR alfa, retinoblastoma, stadium.
Analisis Imunoekspresi Programmed Death Ligand 1 (PD-L1) dan Indeks Proliferasi Ki-67 pada Tumor Astrositik Difus Billy Parulian Lubis; Hasrayanti Agustina; Hermin Aminah Usman; Bethy Surjawathy Hernowo; Sri Suryanti; Ahmad Faried; Hendrikus Bolly
Majalah Patologi Indonesia Vol. 29 No. 2, Mei 2020
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i2.418

Abstract

BackgroundDiffuse astrocytic tumours (DAT) is a diffuse infiltrative astrocytoma tumor accompanied by molecular parameters in the form or absence ofIsocitrate Dehydrogenase (IDH) gene mutations. The DAT category without the examination of the IDH gene mutation is classified as NotOtherwise Specified (NOS). Ki-67 is a marker for DAT proliferation so that it can assess the degree of DAT. Diffuse astrocytic tumoursbehavior is influenced by proliferative ability and the presence of a tumor microenvironment. The tumor microenvironment PD-L1 factorinfluences DAT behavior and allows the development of target therapy in DAT cases. This study aimed to analyze the relationship betweenPD-L1 and Ki-67 imunoexpression in the histopathological degree of DAT.MethodsCross-sectional study of 30 paraffin blocks of DAT NOS cases from 2014-2018 in the Department of Anatomical Pathology RSUP dr. HasanSadikin, Bandung. The sample consisted of 15 cases of grade II, 7 cases of grade III and 8 cases of grade IV, carried outimmunohistochemical staining with GFAP, PD-L1 and Ki-67. Assessment of PD-L1 immunoexpression was carried out by the histoscoremethod. The Ki-67 assessment was assessed based on its distribution, which was <10% and ≥10%. PD-L1 and Ki-67 immunoexpressionwith histopathological degrees in DAT were statistically analyzed by Kolmogorof Smirnov test, however association betweenimmunoexpression of PD-L1 and Ki-67 were analyzed by chi-square test.ResultsThere was a significant relationship between PD-L1 immunoexpression and histopathological degree in DAT (p=0.005). There was asignificant relationship between Ki-67 immunoexpression and DAT histopathology degree and with PD-L1 (p=0.001 and p=0.010).ConclusionPD-L1 immunoexpression and proliferation rates affect the degree of DAT. Proliferation rate of DAT is influenced by PD-L1 so that in thisstudy, PD-L1 and Ki-67 can be used as a marker of prognosis predictors.
From Traditional Game to Mathematical Representation: An Ethnomodelling Study of Congklak Sri Suryanti; Clinton Chidiebere Anyanwu
Journal of Emerging Technologies in Ethnomathematics Vol. 2 No. 1 (2026): Journal of Emerging Technologies in Ethnomathematics
Publisher : Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/jetie.v2i1.52982

Abstract

This research examines congklak game as a local practice involving mathematics and represents mathematical aspects of the congklak using ethnomodeling approach. Using qualitative methods with an interpretive ethnographic design, data were gathered through observations of congklak players, documentation of congklak paraphernalia, and analysis of seed arrangement on the congklak board. The analysis followed emic, etic, and dialogic stages to translate local gameplay practices into formal mathematical representations. Results showed that congklak includes mathematical aspects such as enumeration, discrete distribution, one-to-one relationship, cycles, positionality, conservation of quantity, and transformations from one board position to another. Congklak mathematical structures were then represented mathematically in the form of cyclic discrete position systems, distribution function that leads to final board position, and transformations of game positions. Findings show that congklak cannot simply be described as a form of play or learning situation that takes place in a cultural context; it is also a local body of knowledge having mathematics in its operations. Ethnomodeling is further advanced as an analytical approach in lieu of descriptive ethnomathematics while acknowledging local culture as the basis of contextualized mathematics education.
TRANSITIONAL STRUCTURE OF MATHEMATICAL THINKING FROM STRUCTURAL INTUITIVE TO DEDUCTIVE WITH THE FREEMAN FRAMEWORK Abdul Aziz; Wayan Rumite; Sri Suryanti; Agung Setiawan
AKSIOMA: Jurnal Program Studi Pendidikan Matematika Vol. 15 No. 2 (2026)
Publisher : UNIVERSITAS MUHAMMADIYAH METRO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24127/ajpm.v15i2.16273

Abstract

Formal thinking requires analytical skills to evaluate whether a statement is true or false. However, researchers have found that some students complete the mathematical proof process using intuitive thinking. Students who studied mathematical proof in their early semesters often struggle to construct structural proofs intuitively. Therefore, this study aims to explore students' thought processes in conducting mathematical proofs, transitioning from intuitive reasoning to deductive reasoning, and achieving correct conclusions. The research employs a qualitative descriptive method, validated by experts in mathematical proof and reasoning, all of whom have at least ten years of teaching experience in the field. The subjects of this study were two students selected based on their thought processes, ranging from intuitive to deductive reasoning, with both providing correct and incorrect answers. Students who struggle with this transition tend to rely on institutional and evaluative assurances. In contrast, those who successfully navigate the transition are able to integrate evaluative, empirical, and a priori warrants into their reasoning. This research suggests that all parties involved in mathematical proof need to pay careful attention to each stage of the reasoning process to ensure accuracy.
Co-Authors Aaron T Sihombing Abdul Aziz Abdul Hadi Hassan AGUNG SETIAWAN Ahmad Faried Ainu Putri Rahmawati Antonius Janes Ridwan Anugrah Tegar Putra Farabibah Bethy S Hernowo Bethy S. Hernowo Bethy Surjawathy Hernowo Billy Parulian Lubis Chronika Maria Vombora Sitorus Clinton Chidiebere Anyanwu Didika Indradewa Fauzan Abdurrahman Fennisia Wibisono Fenny Ariyanni Friska Mardianty Hasrayanti Agustina Hasrayati Agustina Hendrikus Bolly Hermin Aminah Usman Irwani Zawawi Jaka Widada Nur Ana Asiana Rahayu Lailatul Maghfiroh Siwi Istiana Dinarti Sri Uchtiawati Titin Setyorini Wayan Rumite Yenni Wisudarma Yuslinawari Yuslinawari