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All Journal Media Kesehatan Masyarakat Indonesia AL KAUNIYAH Jurnal Kesehatan Andalas Damianus Journal of Medicine Bioeksperimen: Jurnal Penelitian Biologi Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Ilmu Kesehatan Masyarakat (The Public Health Science Journal) Jurnal Riset Biologi dan Aplikasinya Riset Informasi Kesehatan Jurnal Ilmu Kesehatan Masyarakat (The Public Health Science Journal) Journal of Medicine and Health
Komang Ardi Wahyuningsih
Departemen Histologi, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Katolik Indonesia Atma Jaya, Jakarta.
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Perbandingan obesitas general dan obesitas sentral terhadap risiko hipertensi pada usia dewasa di wilayah Kecamatan Cisauk Kabupaten Tangerang Komang Ardi Wahyuningsih; Ardini Raksanagara; Yuni Susanti; Nita Arisanti; Siska Wiramihardja; Elsa Pudji Setiawati
Bahasa Indonesia Vol 21 No 3 (2022): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v21i3.3927

Abstract

Pendahuluan: Hipertensi dan obesitas menjadi masalah kesehatan utama hampir diseluruh dunia saat ini. Kejadian hipertensi maupun obesitas meningkat dalam beberapa tahun terakhir. Obesitas telah diketahui sebagai faktor risiko utama terjadinya hipertensi. Penelitian ini bertujuan untuk membandingkan risiko obesitas general dengan menggunakan parameter indeks massa tubuh (IMT) dengan obesitas sentral yang menggunakan parameter rasio lingkar pinggang tinggi badan terhadap kejadian hipertensi pada subjek dewasa usia 26-45 tahun di Wilayah Kecamatan Cisauk Kabupaten Tangerang. Metode: Penelitian ini adalah penelitian potong lintang, pada subjek dewasa usia 26-45 tahun dengan obesitas general (IMT ≥ 25 kg/m2) dan obesitas sentral (rasio lingkar pinggang tinggi badan >0,5). Masing-   masing kelompok obesitas sebanyak 88 orang, diperoleh dengan menggunakan tehnik non probability sampling dengan metode consecutive sampling. Berat badan, tinggi badan, lingkar pinggang, dan tekanan darah diukur pada masing-masing responden. Indeks massa tubuh dan rasio lingkar pinggang tinggi badan dihitung. Analisis yang dipergunakan analisi univariat, bivariat dengan independent t-test, kemudian dilanjutkan dengan analisis multivariate regresi logistik.  Hasil: Responden berusia dewasa awal (26-35 tahun) yang mengalami hipertensi sebanyak 26 orang (14,8%) sedangkan yang berusia dewasa akhir (36-45 tahun) sebanyak 63 orang (35,8%). Responden laki-laki yang mengalami hipertensi sebanyak 24 orang (13,6%) dan perempuan sebanyak 120 (36,9%). Responden dengan riwayat keluarga hipertensi dan saat ini mengalami hipertensi didapatkan sebanyak 52 orang (29,5%) dan tanpa riwayat keluarga hipertensi sebanyak 37 orang (21,0%). Responden dengan riwayat keluarga hipertensi dan saat ini mengalami hipertensi adalah 52 (29,5%) dan 37 (21,0%) tanpa riwayat keluarga hipertensi. Responden dengan riwayat keluarga hipertensi memiliki risiko hipertensi 2,7 kali (OR (CI 95%) =2,670 (1,450 – 4,919)) jika dibandingkan dengan responden yang tidak memiliki riwayat hipertensi dalam keluarga.  Responden dengan obesitas general secara signifikan meningkatkan risiko hipertensi 0.5 kali (OR (CI95%) = 0,457 (0,250 – 0,835), p=0,016) jika dibandingkan dengan responden tanpa obesitas general. Sedangkan responden dengan obesitas sentral memiliki risiko 0.5 kali (OR (CI 95%) = 0,489 (0,420 – 0,569), p=0,243). Simpulan: Hasil penelitian ini menunjukkan bahwa antara obesitas general obesitas sentral memiliki risiko yang sama terhadap hipertensi.  
The association between vitamin D intake and sleep quality index within the 17-35 year age group Veronika Maria Sidharta; Patricia Anggraeni; Komang Ardi Wahyuningsih; Mariani Mariani
Riset Informasi Kesehatan Vol 12 No 1 (2023): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v12i1.738

Abstract

Background : Vitamin D deficiency is a common health problem in the world, even in tropical countries such as Indonesia. The Lack of vitamin D intake from food or supplements can increase the risk of having vitamin D deficiency. The association between vitamin D and sleep quality has been proven by the discovery of vitamin D receptors in the brain and brainstem, which are the sleep centers of the body. Vitamin D also takes part in the process of light transduction and melatonin production, that affects circadian rhythm and sleep quality. Poor sleep quality often causes health problems which will affect the quality of life, work productivity, and increases the risk of death. The purpose of this study is to determine the association between vitamin D intake and sleep quality index within the 17-35 year age group.Method : This study is an observational analytic study using a cross-sectional approach. Data was collected using consecutive sampling methods. Vitamin D intake was measured by the Vitamin D Estimation Only - Food Frequency Questionnaire (VIDEO-FFQ) and sleep quality index was measured by the Pittsburgh Sleep Quality Index (PSQI). Data analysis is proceeded using the chi-square method.Results : The total of respondents were 119. 68,1% of the respondents had inadequate vitamin D intake and 80.4% of the respondents had poor sleep quality index. The analysis shows that there was no significant association between vitamin D intake and sleep quality index (p value = 0.325). Conclusion : Most of the respondents had inadequate vitamin intake and poor sleep quality index. There was no significant association between vitamin D intake and sleep quality index within the 17-35 year age group. Key words: Vitamin D intake, food and supplement, sleep quality index, 17-35 year age group
Comparison Between Platelet-Rich Plasma Single- and Double-Spin Centrifugation to Treat Androgenetic Alopecia: A Systematic Review Stella Skolastika Suwana; Komang Ardi Wahyuningsih; Laurentius Aswin Pramono
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v7i10.13319

Abstract

There are no established guidelines for the management of androgenetic alopecia (AGA). A new therapy with promising results is Platelet-Rich Plasma (PRP). PRP has a variety of preparation methods, such as single spin and double spin centrifugation and still there is no consensus on the method of preparation. There is controversy of which preparation method is better. We searched PubMed, EBSCO, Clinical Key, ProQuest, Cochrane Library, Science Direct, Clinical Trial, Open Access, Wolters Kluwer, Google Scholar, GARUDA, and AtmaLib until Oct 2020 for human studies using PRP for AGA treatment. We assessed 3375 papers; 6 studies met the inclusion criteria and evaluated 128 AGA patients, 112 male and 16 female, 18-63 years old. Participants varied from type II-VI based on the Hamilton-Norwood classification system and degree 2 based on the Ludwig classification system. Four studies used the single-spin centrifugation PRP preparation method and two studies used the double-spin PRP preparation method. The studies stated the increases in growth factor levels. All studies showed PRP significantly affected hair growth in AGA patients. PRP has been shown to increase hair growth parameters in form of hair density (P <0.0001). PRP has been shown to increase hair density and hair count. Growth factors in PRP induce cell proliferation and tissue angiogenesis. The results of single-spin centrifugation preparation method provide a greater increase in hair density. But, data reports from the study did not allow comparisons to determine the best PRP preparation method for AGA treatment. Therefore further study is needed.
Hubungan Asupan Vitamin D dan Keluhan Muskuloskeletal pada Kelompok Usia 17-35 Tahun Florent Hasthiono; Komang Ardi Wahyuningsih; Veronika Maria Sidharta; Nawanto Agung Prastowo
Jurnal Ilmu Kesehatan Masyarakat Vol 12 No 02 (2023): Jurnal Ilmu Kesehatan Masyarakat
Publisher : UIMA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33221/jikm.v12i02.1676

Abstract

Defisiensi vitamin D masih menjadi masalah kesehatan global sampai saat ini, tidak terkecuali negara tropis yang memiliki lebih banyak paparan sinar matahari. Studi di negara-negara Eropa, Amerika dan Asia menunjukkan tingkat defisiensi vitamin D berkisar antara 45-90%. Indonesia termasuk negara dengan tingkat defisiensi vitamin D yang tinggi, tetapi laporan mengenai status vitamin D dan upaya pencegahannya belum banyak dilakukan. Keluhan pada muskuloskeletal akan menimbulkan gangguan atau sensasi ketidaknyamanan, memengaruhi performa dalam bekerja dan mengurangi produktivitas terutama pada kelompok usia dewasa. Penelitian ini bertujuan untuk mengetahui hubungan antara asupan vitamin D dan keluhan muskuloskeletal pada kelompok usia 17-35 tahun pada mahasuswa Fakultas Kedokteran dan Ilmu Kesehatan (FKIK) Unika Atma Jaya dan kerabatnya pada rentang usia tersebut. Desain penelitian observasional analitik dengan pendekatan potong lintang. Pengambilan data dilakukan dengan metode consecutive sampling pada tahun 2021 di Indonesia. Asupan vitamin D diukur dengan Vitamin D Estimation Only - Food Frequency Questionnaire dan keluhan muskuloskeletal diukur dengan kuesioner Nordic Body Map. Data dianalisis dengan menggunakan uji Chi-square. Subjek penelitian sebanyak 108 responden. Hasil penelitian menunjukkan terdapat 67,6% responden dengan asupan vitamin D yang tidak adekuat dan 80,6% yang memiliki keluhan muskuloskeletal. Tidak terdapat hubungan yang signifikan antara asupan vitamin D dengan keluhan muskuloskeletal pada kelompok usia 17-35 tahun (P-value= 0,379).
Perbandingan Perubahan Luas Luka dan Angiogenesis pada Jaringan Luka Bakar Derajat IIB Tikus Sprague Dawley yang Diberikan Platelet Rich Fibrin dan Advanced Platelet Rich Fibrin Kurnia, Shantika Aqilla; Wahyuningsih, Komang Ardi
Jurnal Kesehatan Andalas Vol. 10 No. 1 (2021): Online March 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i1.1464

Abstract

Burns increase tissue damage by free radicals, thus hindering the healing process. Platelet Rich Fibrin (PRF) and Advanced Platelet Rich Fibrin (A-PRF) are autologous fibrin matrices that contain growth factors and have been proven to increase tissue formation and regeneration. Objectives: To determined the effect of applying PRF and A-PRF on deep second-degree burns. Methods: This study was experimental research on twenty male Sprague Dawley rats were randomly divided into four groups. Group A and B as control groups received NaCl 0,9% and silver sulfadiazine ointment, respectively. Group C was given PRF and group D was given A-PRF. Burns are photographed and the area was calculated using the ImageJ application. After 14 days of therapy, the burn areas were excised and made into histological slides. Microscopic study of angiogenesis was observed using a microscope at 400x magnification. Results: Changes in wound surface area in PRF and A-PRF groups were 3,106 cm and 2,333 cm. The number of angiogenesis in PRF and A-PRF groups were 3.88 and 5.88. The data was analyzed using One-Way Anova and the results showed that there were no significant differences between the changes in the wound area and angiogenesis of PRF and A-PRF groups. Conclusion: This study showed that there are no significant differences in changes in wound surface area and angiogenesis of burn injury after topical application of PRF and A-PRF.Keywords:  angiogenesis, burn injury, changes in wound surface area, A-PRF, PRF
Perbandingan Perubahan Luas Luka dan Angiogenesis pada Luka Bakar Derajat IIB Tikus Sprague Dawley yang Diberikan Advanced Platelet-rich Fibrin dan Advanced Platelet-rich Fibrin Plus Stella, Ellia; Wahyuningsih, Komang Ardi
Jurnal Kesehatan Andalas Vol. 10 No. 2 (2021): Online July 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i2.1616

Abstract

Platelet-rich fibrin (PRF) has a lot of benefits in the process of healing. The new generation of PRF, namely advanced PRF plus (A-PRF+), has a different fibrin structure and more growth factors compared to Advanced PRF (A-PRF), the generation before A-PRF+. Objectives:To compared the effects of A-PRF and A-PRF+ on the IIB degree burn. Methods: This experimental study used 20 male Sprague Dawley rats. All rats were given IIB degree burn and divided into four groups. Group 1 was treated with saline, Group 2 was treated with silver sulfadiazine 1%, Group 3 was treated with A-PRF, and Group 4 was treated with A-PRF+. Wound size reduction will be calculated every two days and measured with ImageJ and the wound would be made into a histological slide on day 14 to calculate angiogenesis. Results: Changes in the wound surface area for the group that was given A-PRF dan A-PRF+ are 2,333cm and 4,827cm. The wound surface area’s data were analyzed using Kruskal-Wallis and the results are statistically not significant (p>0,05). The number of angiogenesis for the group that was give A-PRF and A-PRF+ as followed are 5,88 and 4,867. The angiogenesis data were analyzed using one-way ANOVA and the results are statistically not significant (p>0,05). Conclusion: There is no difference between the effect of A-PRF and A-PRF+ towards changes in wound surface area and angiogenesis in IIB degrees burn wounds.Keywords:  A-PRF, A-PRF+, burn wound, angiogenesis, wound surface area
Perbandingan Kemampuan Migrasi Adipose-Derive Stem Cells Asal Manusia pada Berbagai Medium Pertumbuhan Rosadi, Imam; Karina, Karina; Rosliana, Iis; Widyastuti, Tias; Wahyuningsih, Komang A; Sobariah, Siti; Afini, Irsyah
Bioeksperimen: Jurnal Penelitian Biologi Vol 6, No 1: March 2020
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v6i1.10432

Abstract

Mesenchymal Stem Cell (MSC) Secretome and Vitamin C Combination Additively Enhance Epidermal Keratinocyte Proliferation and Morphology: Evidence from Intrinsic and Extrinsic Rat Skin Aging Models Olivia Belinda; Veronika M Sidharta; Komang A Wahyuningsih; Reynelda J Sagala; Christania Christania; Vallery B Setiawan; Nadia A Sjoekri; Renata Angelia; Laurie Marcella
Journal of Medicine and Health Vol 8 No 1 (2026)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v8i1.13091

Abstract

Skin aging, driven by intrinsic and extrinsic factors, impairs keratinocyte proliferation and morphology. Mesenchymal stem cell (MSC) secretome and vitamin C possess regenerative and anti-aging properties that may counteract these changes. This study aimed to evaluate the additive effects of MSC secretome and vitamin C on keratinocyte proliferation and morphology in intrinsic and extrinsic rat skin aging models. Thirty-two male Sprague-Dawley rats were randomly divided into eight groups: intrinsic aging control (IAC; D-galactose-induced), extrinsic aging control (EAC; UVB-induced), MSC secretome-treated (IS and ES; 0.2 mL MSC secretome), vitamin C-treated (IC and EC; 0.2 mL vitamin C at 75 μg/mL), and combination-treated (ISC and ESC; 0.1 mL of each treatment). Treatments were administered intradermally once weekly for four weeks. Histological analysis assessed keratinocyte count and size in the stratum granulosum and stratum basale. Combination treatment (ISC, ESC) produced the most pronounced and statistically significant increases in keratinocyte counts and reductions in cell size across both strata (p < 0.01 to ≤ 0.001), whereas individual treatments showed variable effects, with most failing to reach statistical significance. These findings suggest that combined MSC secretome and vitamin C treatment produces the most pronounced histological effects in keratinocyte counts and size, likely reflecting complementary actions, and supports its potential as a cell-free anti-aging therapy.
Co-Authors Afini, Irsyah Anggraini Barlian Ardini Raksanagara Christania Christania Elsa Pudji Setiawati Florent Hasthiono Iis Rosliana Iis Rosliana Iis Rosliana Iis Rosliana Imam Rosadi In Sil Huh Irsyah Afini Irsyah Afini Irsyah Afini Irsyah Afini Karina Karina Karina Karina Karina Karina Kurnia, Shantika Aqilla Laurentius Aswin Pramono Laurie Marcella Mariani Mariani Nadia A Sjoekri Nawanto Agung Prastowo Nita Arisanti Olivia Belinda Patricia Anggraeni Renata Angelia Reynelda J Sagala Rosliana, Iis Rosliana, Iis Shantika Aqilla Kurnia Siska Wiramihardja Siti Sobariah Siti Sobariah Siti Sobariah Siti Sobariah Sobariah, Siti Stella Skolastika Suwana Stella, Ellia Suci Prasetyo Tias Widyastuti Tias Widyastuti Tias Widyastuti Vallery B Setiawan Veronika Maria Sidharta Widyastuti, Tias Yuni Susanti Yunisa Astiarani