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All Journal Prosiding Seminar Biologi Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Kebidanan Mutiara Mahakam Open Access Health Scientific Journal Jurnal Sains dan Kesehatan
Yadi Yasir
Fakultas Kedokteran Universitas Mulawarman Samarinda Kalimantan Timur
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Open Access Health Scientific Journal

 1 
Potential of Propolis for Diabetic Wound Healing: A Literature Review Sukmana, Mayusef; Rasyid, Muhammad; Paramita, Swandari; Yasir, Yadi; Wahyuningsih, Sri
Open Access Health Scientific Journal Vol. 6 No. 2 (2025): August 2025
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v6i2.96

Abstract

Background: Diabetes mellitus, a chronic metabolic disorder often leads to impaired wound healing, a serious complication resulting in diabetic ulcers, infections and even amputations. Conventional treatments for diabetic wounds can be costly and have side effects. Propolis, a natural resinous substance collected by honeybees from various plants, has long been recognized for including antibacterial, anti-inflammatory, antioxidant, and immunomodulatory properties. This literature review aims to summarize and analysed the scientific evidence regarding the potential of propolis in accelerating wound healing in diabetic conditions.Methods: Google Scholar, PubMed, Science Direct, EBSCO, Watase UAKE and Proquest using relevant keywords including "propolis," "wound," "diabetic ulcer,". The selected articles included original research studies only that discussed the potential of propolis in diabetic wound healing. Inclusion criteria were articles published in English and specifically addressing the effects of propolis on wound healing in diabetic patients, randomised clinical trial sampling technique and the article published in 2015-2025.Results: The article search process found in Google Scholar are 184 articles, PubMed are 10 articles, Science Direct are 185 articles, EBSCO are one article, and Watase UAKE is one article and ProQuest are 721 articles. There were 2 articles that met the inclusion criteria. The article discussed the potential and relationship of propolis with Erythema and Exudates, White Blood Cell (WBC) Count and ESR, Ulcer Discharge, Surrounding Erythema, Wound healing, connective tissue formation, oxidative stress markers, inflammatory markers, HbA1c level.Conclusion: Propolis, as a natural product, offers a potential alternative or complementary treatment to conventional therapies. affects wound healing through a complex process erythema and exudates, White Blood Cell (WBC) Count and ESR, ulcer discharge, surrounding erythema, wound healing, connective tissue formation, oxidative stress markers, inflammatory markers, HbA1c level. This is a new strategy for managing diabetic foot ulcers.
Phytochemical Composition, and Antioxidant Activity of Stingless Bee (Heterotrigona Itama) Propolis for Wound Healing Potentials Sukmana, Mayusef; Paramita, Swandari; Yasir, Yadi; Wahyuningsih, Sri; Mandang, Idris; Ramdan, Iwan Muhammad; Sawitri, Endang; Tarigan, Daniel
Open Access Health Scientific Journal Vol. 7 No. 1 (2026): February 2026
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v7i1.203

Abstract

Background: Propolis from stingless bees Heterotrigona itama(H.itama) is a promising natural product with diverse biomedical applications. However, its bioactivity and antioxidant for wound healing remain poorly understood. This study aimed to evaluate phytochemical profile, and antioxidant activity of H. itama propolis collected from land forest in Kalimantan, Indonesia.Methods: Qualitative phytochemical screening was performed to identify secondary metabolites, and antioxidant capacity was assessed using the DPPH radical scavenging assay with ascorbic acid as a reference standard. The result of the phytochemical content and antioxidant activity will be compared with the literature study on wound healing.Results: Phytochemical tests showed the presence of flavonoids, saponins, tannins, phenolics, triterpenoids, terpenoids, and DPPH assay revealed  antioxidant activity with an IC₅₀ value of 159.91 ppm compared to 2.71 ppm for ascorbic acid.Conclusion: H. itama propolis biologically active, demonstrating  antioxidant potential linked to its phenolic and flavonoid content. These findings support that phytochemical content and antioxidant activity are  potentials for wound healing.
Co-Authors Abda Abda Daniel Tarigan Endang Sawitri Evi Fitriany Ibnu Sina Idris Mandang, Idris Marihot Pasaribu Meiliati Aminyoto Muhammad Khairul Nuryanto Muhammad Rasyid, Muhammad Nataniel Tandirogang Nurwijayanti Rahmat Bakhtiar Ramdan, Iwan Muhammad Ronny Isnuwardana Rudi Saputra Sholihatuz Zahro, Abidah Sinaga, Tumpak Swandari Paramita Yuniati Yuniati