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All Journal Jurnal Farmasi Udayana Jurnal Kedokteran Brawijaya Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Klinik Indonesia Majalah Obat Tradisional JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JURNAL PENGABDI Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Jurnal Ilmu Kefarmasian Indonesia Cendekia Journal of Pharmacy Journal SAGO Gizi dan Kesehatan Rengganis Jurnal Pengabdian Masyarakat Jurnal Locus Penelitian dan Pengabdian Makara Journal of Science
Phebe Hendra, Phebe
Faculty of Pharmacy, Universitas Sanata Dharma
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Health Professions Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

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The Effect of Adherence to Antihypertensive Therapy and Cardiovascular Risk Among Hypertensive Patients in Purworejo Regency Arwinda, Prili; Virginia, Dita Maria; Hendra, Phebe
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007334

Abstract

Uncontrolled hypertension will increase mortality and morbidity rates. The adherence is an important factor in controlling blood pressure. Uncontrolled blood pressure will affect cardiovascular risk. Therefore, hypertensive patients must comply with taking medication to control blood pressure and cardiovascular risk. This study was an analytical observational study with a cross-sectional design. A total of 85 respondents who met the inclusion criteria were measured for adherence using the MPR (Medication Possession Ratio) method and the MARS-5 (Medication Adherence Report Scale-5) questionnaire.  A patient who had blood pressure 140/90 mmHg was categorized as controlled hypertension. The cardiovascular risk was measured using the ACC/AHA criteria method. Data were analyzed using chi-square tests and odds ratio (OR) with 95% confidence interval (CI) and p0.05 considered significant. This study showed that there was a significant association between adherence to antihypertensive therapy to controlled blood pressure, either according to MPR (OR=18.262; 95%CI=5.259-63.412; p=0.000) and MARS-5 (OR=31.607; 95%CI=8.170-122.277; p=0.000). A significant association was found between antihypertensive adherence and cardiovascular risk, either according to MPR (OR=3.733; 95%CI=1.269-10.983; p=0.020) and MARS-5 (OR=9.000; 95%CI=2.702-29.983; p=0.000). Therefore, this study concludes a significant relationship between antihypertensive adherence to controlled blood pressure and cardiovascular risk in Purworejo Regency.
The Relationship of Medication Adherence to Controlled HbA1c and ASCVD Risk in Type II Diabetes Mellitus Patients in Minggir Primary Health Care Dewita, Aquina Nino Rama Dhanti; Hendra, Phebe; Virginia, Dita Maria
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007464

Abstract

Type II diabetes mellitus (DM) therapy can be evaluated from the controlled HbA1c. Another aspect that needs to be controlled in patients with DM is lipid levels. Lipid levels should be controlled in a patient with type II DM to prevent atherosclerotic cardiovascular disease (ASCVD). The study was conducted to determine the relationship between medication adherence with controlled HbA1c and ASCVD risk in patients with type II DM. The study was an analytical observational study with a cross-sectional research design used to examine the relationship between medication adherence with controlled HbA1c and ASCVD risk. Our respondents were patients following a chronic disease management program at Minggir Primary Health Care. The level of medication adherence was measured using the Medication Adherence Report questionnaires. The ASCVD risk was measured using the American College of Cardiology/American Heart Association tools. The chi-squared test was applied to determine the relationship between medication adherence with HbA1c values and ASCVD risk in patients with type II DM. Most patients with type II DM had high medication adherence (60%), controlled HbA1c values (56.4%), and high ASCVD risk (70.9%). There was no significant relationship between medication adherence in type II DM patients with controlled HbA1c values and ASCVD risk.
Analisis Faktor Perilaku Swamedikasi Gout Arthritis : Kajian Persepsi Masyarakat di Kabupaten Ende Hane, Angelina Rosari; Hendra, Phebe
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 9 (2025): : JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i9.4775

Abstract

Swamedikasi merupakan upaya masyarakat dalam menangani penyakit ringan secara mandiri dengan menggunakan obat bebas yang aman tanpa resep dokter. Faktor yang memengaruhi perilaku ini antara lain tingginya biaya pengobatan, kurangnya pengetahuan kesehatan, keterjangkauan obat, keterbatasan fasilitas medis, serta pengaruh lingkungan. Penelitian ini bertujuan menganalisis faktor yang berkontribusi terhadap perilaku swamedikasi gout arthritis dengan menggunakan tinjauan Theory of Planned Behaviour (TPB). Metode penelitian yang digunakan adalah observasional analitik dengan pendekatan cross sectional. Responden adalah masyarakat Kabupaten Ende yang melakukan swamedikasi gout arthritis. Variabel bebas terdiri dari konstruk TPB yaitu attitude (sikap), subjective norms (norma subjektif), dan perceived behaviour control, sedangkan variabel terikatnya adalah intention (niat). Instrumen penelitian berupa kuesioner yang disusun berdasarkan konstruk TPB dan diisi langsung oleh responden. Hasil penelitian terhadap 105 responden menunjukkan bahwa piroxicam (66,7%) merupakan obat yang paling banyak dibeli dibandingkan allopurinol dan natrium diklofenak. Sebagian besar responden melakukan pembelian obat 2–3 kali dalam sebulan (45,7%). Analisis hubungan menunjukkan adanya pengaruh signifikan antara subjective norms dengan intention (p=0,030; p<0,05). Faktor yang paling berkontribusi terhadap perilaku swamedikasi adalah subjective norms, diikuti oleh perceived behaviour control.
Pemberdayaan Kesehatan Masyarakat Dusun Kemantren II Semawung Melalui Edukasi Pengelolaan Obat Hendra, Phebe; Riswanto, Florentinus Dika Octa; Setyani, Wahyuning; Julianus, Jeffry; Rajagukguk, ⁠Greysianita; Santi , Nyoman Pradnya Yoni Meytri; Bramantyo , Dominicus Adyatma; Siallagan , Angela Meirella; Putri , Elsha Tiany
Rengganis Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2025): November 2025
Publisher : Pendidikan Matematika, FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/rengganis.v5i2.608

Abstract

The misuse of drugs is a major health issue in Indonesia, largely due to a lack of understanding about proper drug management. Knowledge of correct medication use is essential to prevent administration errors. Key issues in Dusun Kemantren II, Semawung Village include a limited understanding of medication usage and inadequate drug storage systems. Engaging the community with information on effective drug management is essential to address this. This community service initiative aims to improve drug management knowledge in Dusun Kemantren II, Semawung Village, Purworejo District. The activity was carried out on May 4, 2025, with 23 participants. Evaluation results showed increased participants' knowledge after the education, based on average pre-test and post-test scores. This program successfully improved public knowledge and awareness regarding the importance of proper drug management. It provided practical means, such as medicine boxes, to support the implementation of this knowledge at the household level.
HUBUNGAN KONTROL HBA1C TERHADAP PROFIL LIPID PADA PASIEN DIABETES MELITUS TIPE 2 DI PUSKESMAS SALAH SATU KECAMATAN, YOGYAKARTA Pramono, Zita Dhirani; Virginia, Dita Maria; Hendra, Phebe
Cendekia Journal of Pharmacy Vol 8, No 3 (2024): Cendekia Journal of Pharmacy
Publisher : Institut Teknologi Kesehatan Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v8i3.298

Abstract

Diabetes melitus merupakan suatu penyakit kronis yang memiliki tingkat prevalensi tinggi di Indonesia. HbA1c menjadi prediktor pada kontrol glikemik pada pasien diabetes melitus. Nilai HbA1c yang tinggi menyebabkan kondisi peningkatan profil lipid baik trigliserida, LDL (Lipoprotein Kepadatan Rendah) , total kolesterol maupun penurunan kadar HDL (lipoprotein kepadatan tinggi). Penelitian ini bertujuan untuk mengetahui adanya hubungan kadar HbA1c terhadap profil lipid pada pasien diabetes melitus di Puskesmas salah satu kecamatan di Sleman, Yogyakarta. Penelitian ini dilakukan secara cross sectional, dengan subjek penelitian sebanyak 36 pasien yang telah memenuhi kriteria inklusi dan eksklusi.  Analisis statistika dilakukan secara univariat dan uji korelasi pearson antar variabel. Penelitian ini menunjukkan 26 pasien (72,2%) berjenis kelamin perempuan yang mengalami diabetes dan hipertensi pada kelompok peserta prolanis. Selain itu, 22 pasien memiliki umur berkisar antara 60-75 tahun, juga diketahui rata-rata pasien memiliki nilai sistolik yang didominasi sebesar 140-159 mmHg (33,3%) dan diastolik sebesar 85 mmHg (44,4%). Adanya 28 pasien (77,8%) memiliki nilai LDL ?100 mg/dL, 20 pasien (55,6%) memiliki nilai  HDL 50 mg/dL, 20 pasien (55,6%) memiliki nilai kolesterol total ?200 mg/dL, dan trigliserida. Kontrol glikemik yang ditunjukkan dengan kadar HbA1c pada subjek penelitian belum terkontrol dengan kadar ?7% sebanyak 23 orang (63,9%).  Hasil uji korelasi antar variabel diketahui bahwa terdapat korelasi kadar HbA1c terhadap profil lipid trigliserida, dengan nilai korelasi sebesar 0,480 (p0,05), dan tidak adanya korelasi antara kadar HbA1c terhadap profil lipid lainnya seperti LDL -0,057 (p0,05); HDL -0,290 (p0,05); Kolesterol Total   0,007 (p0,05). Sehingga dapat disimpulkan bahwa terhadap hubungan kontrol HbA1c terhadap profil trigliserida pada pasien diabetes melitus tipe 2. 
Evaluasi implementasi program rujuk balik (PRB) di Puskesmas Kota Semarang Karti, Indah Mayang; Priyatni, Nunung; Hendra, Phebe
Jurnal SAGO Gizi dan Kesehatan Vol 6, No 3 (2025): Nopember
Publisher : Poltekkes Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/gikes.v6i3.2968

Abstract

Background: The Referral Back Program (PRB) is a strategy of the Indonesian Health Insurance Agency (BPJS Kesehatan) to transfer the management of chronic disease patients from hospitals to community health centers in order to reduce referral burdens, improve efficiency, and maintain continuity of therapy. Its implementation still faces limitations in resources, suboptimal coordination, and low patient compliance, thus requiring a comprehensive evaluation to assess the program's effectiveness.Objective: This study aims to evaluate the implementation of the Referral Back Program (PRB) by reviewing the input, process, and output aspects of PRB implementation in community health centers in Semarang City in 2024.Method: This study is a descriptive qualitative study conducted in 10 pilot project community health centers in Semarang City in 2024. Data were collected through observation, in-depth interviews, and document studies. Respondents consisted of health center heads, health workers, PRB administrative staff, and PRB patients. Data analysis was performed using triangulation of sources, methods, and documents.Results: The implementation of PRB at the Semarang City Health Center in 2024 was not optimal. In terms of input, there was a shortage of health workers, uneven distribution of medicines, and manual administration. In terms of service implementation, guidelines were followed, but coordination between FPKTP and FPKTL was inconsistent and patient education was not structured. In terms of output, patient compliance was still low, program effectiveness was not optimal, and patient satisfaction was influenced by the availability of medicines and the smooth running of services.Conclusion: PRB at the Semarang City Health Center has not been effective due to limited resources, weak coordination, and low patient compliance. This condition shows a gap between policy and practice, so it is necessary to strengthen human resources, improve administration, increase coordination, and educate patients to support the success of PRB.
The The Impact of Antidiabetic Dose Appropriateness Based on Renal Function on Therapeutic Outcomes among Geriatric at Bali, Indonesia Sugiastana, Bagus N.; Hendra, Phebe; Virginia, Dita Maria
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.330-341

Abstract

Background: Diabetes mellitus is a significant global health issue, especially in the older population. Appropriate drug dosing is crucial in geriatric patients because renal function generally declines with age. A decline in renal function is directly associated with the adverse effects of antidiabetic drugs, particularly hypoglycemia, rather than their therapeutic efficacy. Objective: The objective of the present study was to assess the effect of antidiabetic dose appropriateness according to renal function on therapeutic outcomes among geriatric patients at three hospitals in Bali Province. Methods: The research was designed as an observational analytic study with a cross-sectional design. The study involved patients with diabetes aged ≥ 60 years, with or without renal function impairment. Medical records from January to December 2024 were also reviewed for this study. The suitability of antidiabetic drug dosing was evaluated using the estimated glomerular filtration rate (eGFR) calculated using the Cockcroft–Gault equation. The prescribed doses were compared with the dosage guidelines based on the renal function. A Chi-square analysis was performed to assess the relationship between the appropriateness of the antidiabetic dose and the therapeutic outcomes. Moreover, multivariate analysis was performed using logistic regression after adjusting for other factors. Results: Among the included patients, 27.6% were diagnosed with CKD and 28.4% had renal function classified as stage G2. A total of 51.5% of patients received appropriately adjusted antidiabetic doses. Dose appropriateness was significantly associated with primary clinical outcomes (p<0.05) but not with secondary clinical outcomes. Conclusion: In conclusion, appropriate dose adjustment is essential for enhancing diabetes treatment strategies for geriatric patients with diverse stages of kidney dysfunction.
Co-Authors Andrestia Dias, Velia Aris Widayati Ariyanti, Ni Kadek Nining Arwinda, Prili Bramantyo , Dominicus Adyatma Celine Dinanda, Laurenza Christianus Heru Setiawan Conrad Rambung, Charles Co’o, Maria Dolorosa Dewi Puspitasari Tirtaningtyas Gunawan Puteri, Maria Dewita, Aquina Nino Rama Dhanti Dita Maria Virginia Fenty Fenty, Fenty Filiana Santoso Florence Ignatia, Florence Ignatia Florentinus Dika Octa Riswanto Gidion Krisnadi, Gidion Gollumawo, Serly Sofia D. Gunawan Puteri, Maria Dewi Puspitasari Tirtaningtyas Hane, Angelina Rosari Ike Kumalasari, Ike Jeffry Julianus Karti, Indah Mayang Lisa Kurnia Sari, Lisa Kurnia Ni Luh Putu Dian Perwita, Ni Luh Putu Dian Nina Artanti Pinaryanto, Kartono Pramono, Zita Dhirani Pratiwi, Vera Dwi Priyatni, Nunung Putri , Elsha Tiany Rajagukguk, ⁠Greysianita Rita Suhadi Santi , Nyoman Pradnya Yoni Meytri Sari, Theresia Maria Fioretty Ine Siallagan , Angela Meirella Sugiastana, Bagus N. Tjiptadi, Felicia Melissa Wahyuning Setyani Yuditha Anggarhani Quraisyin, Yuditha Anggarhani Zalinar Udin