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All Journal EKSAKTA: Journal of Sciences and Data Analysis Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Klinik Indonesia Jurnal Ilmiah Kedokteran Wijaya Kusuma Universa Medicina Smart Medical Journal JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Teknologi Kesehatan JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Biomedika
Ety Sari Handayani
Departement Of Anatomy, Medical Faculty, Universitas Islam Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Application of Cavalieri Method on Measurement of Brain Haemorrhage Volume of Stroke Patients Ety Sari Handayani
Jurnal Teknologi Kesehatan (Journal of Health Technology) Vol. 17 No. 2 (2021): 2
Publisher : POLTEKKES KEMENKES YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29238/jtk.v17i2.1002

Abstract

In stroke, CT Scan is a standard gold examination to distinguish infarction from bleeding. The stereology principle of the Cavalieri method has been used in several studies that calculate the volume of ischemia and the volume of bleeding in the radiological photos of stroke patients. The availability of stereology software in Indonesia is still limited. Measurement of the volume of ischemia of the brain is still using a manual way that is with a grid of points. The accuracy of this technique still needs to be proven. This study aims to find out the accuracy of cavalieri method in measuring the volume of brain hemorrhage in CT Scan photos of stroke patients. The study consisted of two groups. Group A is the volume of bleeding that comes from CT scan photos without the Cavalieri method. Group B is the volume of bleeding derived from CT scan photos with the Cavalieri method. The difference in bleeding volume was analyzed using t-test. The results of the study did not differ in measuring the volume of bleeding between the CT Scan method and the Cavalieri method (p > 0.05). This indicates that the result of measuring the volume of bleeding by Cavalieri method is the same as the measurement result using CT Scan.
PENGARUH EKSTRAK ETANOL Centella asiatica TERHADAP JUMLAH SEL NEURON DI KORTEKS PREFRONTALIS TIKUS YANG DIBERI PERLAKUAN STRES Ayu Kurnia Priyantiningrum; Kuswati -; Ety Sari Handayani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 6, No 4, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol6.Iss4.art5

Abstract

Latar Belakang Stres berdampak pada penurunan fungsional tubuh yang dapat menimbulkan suatu penyakit seperti ketidakmampuan kognitif yang serius, diketahui bahwa kemampuan kognitif diatur pada Korteks Prefrontalis di otak. Respon tubuh terhadap stress berupa kemampuan untuk bertahan hidup hingga apoptosis. Centella asiatica merupakan tanaman obat yang memiliki senyawa triterpen sebagai antioksidan yang mampu memproteksi sel untuk dapat terhindar dari apoptosis. Tujuan Penelitian Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak etanol pegagan (Centella asiatica) terhadap jumlah sel neuron di korteks prefrontalis tikus putih (Rattus norvegicus) yang diberi perlakuan stres Metode Penelitian Penelitian ini merupakan penelitian eksperimental dengan menggunakan rancangan post test-with control group. Subyek penelitian ini menggunakan 12 tikus dewasa (Rattus norvegicus) galur Wistar yang memenuhi kriteria inklusi dan eksklusi. Subyek terbagi sama rata menjadi kelompok kontrol dan perlakuan. Kedua kelompok dilakukan stres restrain selama 21 hari. Tiga puluh menit sebelum stress, kelompok kontrol diberikan Pulvis Gum Arabica 3%. Kelompok perlakuan diberikan ekstrak etanol pegagan 300 mg/kgBB/hari. Perbedaan jumlah sel neuron rerata pada seluruh lapang pandang setiap kelompok dianalisis dengan uji T-test independent. Hasil Hasil penelitian ini menunjukkan bahwa jumlah sel neuron rerata di Korteks Prefrontalis setelah pemberian ekstrak etanol pegagan (Centella asiatica) lebih banyak dibandingkan kelompok kontrol (p-value 0,004; CI 95%). Kesimpulan Pemberian ekstrak etanol pegagan (Centella asiatica) signifikan meningkatkan jumlah sel neuron di Korteks Preftontalis tikus (Rattus norvegicus) yang diberi perlakuan stres, dibanding tikus kontrol yang tidak diberikan pegagan Kata Kunci: Stres Restrain, Centella asiatica, Korteks Prefrontalis, Rattus norvegicus
PENGARUH PEMBERIAN PROPOLIS TERHADAP EKSPRESI BDNF DI HIPPOCAMPUS TIKUS YANG DIINDUKSI STRES Kuswati Kuswati; Zainuri Sabta Nugraha; Ety Sari Handayani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art8

Abstract

Background: Brain-derived neurotrophic factor (BDNF) is a neurotrophin secreted by dendrite, which plays a role in differentiation, maturation, neuroplasticity, learning, and memory, which the expression decreases under stress conditions. Propolis contains chrysin which has antioxidant and neuroprotectant effects.Objective: This study aimed to examine the effect of propolis on BDNF expression in the hippocampus of stress-induced rats.Methods: Experimental study using posttest only control group design. The subjects were 25 male Spraque-Dawley rats (Rattus norvegicus), four months old, weighing 200-300 grams. Rats were randomly divided into five groups: group N, did not receive any treatment; group K, received stress treatment; groups P1, P2, and P3, received stress treatment and followed by administered propolis at doses of 100, 150, and 200 mg/kg/day. Social isolation stress was carried out by putting one rat in one cage. Oral propolis administration used oral gavage. In the end, the rats were terminated and brain tissue was collected. Immunohistochemical staining using anti-BDNF antibodies was performed to make histological slides. Observations were made with a light microscope with 1000x magnification in the CA1 area of the hippocampus.Results: There is a significant difference in BDNF expression in the CA1 area of the hippocampus in all groups (p=0.000). The highest BDNF expression was in the P3 group and the lowest in group K.Conclusion: There is an effect of propolis on BDNF expression in the hippocampus of the stress-induced rat. Propolis dose of 100 mg/kgBW/day has increased BDNF expression.
Nicotine in Vapor Exposure Decreases Hippocampal Neurons in Rats Indrayani, Tsaniya Ahda; Hamidah Ikhwan, Salma Nur; Handayani, Ety Sari; Kuswati, Kuswati
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 13, No 2 (2024): September 2024
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v13i2.3948

Abstract

Background: Recently, many people have considered electronic cigarettes to be a safer alternative to conventional tobacco cigarettes, even though they still contain harmful substances such as nicotine, which is associated with a decrease in hippocampal neurons. Objective: This study aimed to examine the effect of exposure to e-cigarettes on hippocampal neurons in rats. Methods: An experimental study was performed using 26 tissue samples obtained from Wistar rats. The rats were randomly assigned to four groups and treated over an eight-week period as follows: the control group (K) (n=7) had no vapor exposure; the V0 group (n=6) received vapor without nicotine (0 mg/ml); the V6 group (n=7) was exposed to vapor and 6 mg/ml nicotine; and the V12 group (n=6) was exposed to vapor and 12 mg/ml nicotine. Hippocampal neurons were examined using hematoxylin-eosin staining at 400x magnification across 7 fields of view. Data were analyzed using the Kruskal-Wallis test with the Mann-Whitney post-hoc.  Results: The number of hippocampal neurons was significantly reduced in both the V12 and V0 groups compared to that in the control group (p<0.05). The lowest number of hippocampal neurons was observed in the V0 group (0 mg/ml nicotine), followed by the V12 group (12 mg/ml), and then the V6 group (6 mg/ml).Conclusion: The present study showed that the variation of nicotine in vapor exposure decreases hippocampal neurons in rats.
Heterologous Booster Profiles for Recipeints of CoronaVac Inactivated Primary Vaccine: A Scoping Review Handayani, Ety Sari; Hidayah, Nurul
Indonesian Journal of Clinical Pharmacy Vol 12, No 1 (2023)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2023.12.1.68

Abstract

The administration of booster vaccines has been implemented in a number of countries. Unfortunately, there are limited studies of the immune response after booster to recipient with CoronaVac inactivated primary vaccine. This scoping review aims to determine heterologous booster profiles for recipients of the CoronaVac inactivated primary vaccine. This study obtained data from PubMed, Cochrane Library, Medrxiv, Google Scholar and Grey literature. The inclusion criteria were Sars-Cov-2 article, heterologous boosters and CoronaVac vaccine published from 2020 to 2022, written in English, and in a form of an original research articles, project reports, articles with RCT research designs, cohorts and articles with human research subjects. The keywords were Sars-cov-2, COVID-19, heterologous boosters and CoronaVac. Profiles assessed were heterologous vaccine types, immune responses, intervals between the booster administration and the primary vaccine, and heterologous booster doses. The number of articles that met the inclusion criteria was 19 articles. Types of vaccines that could be used as heterologous boosters for recipients of CoronaVac inactivated primary vaccine were BNT162b2, AZD1222, mRNA-1273, Ad26.COV2-S. The administration of heterologous booster vaccines for recipients of the CoronaVac inactivated primary vaccine was able to increase antibody levels against of the Sars-Cov-2 variants of Mild, Beta, Gamma, Delta and Omicron. The doses of booster vaccines (Ad26.COV2-S, BNT162b2, AZD1222, mRNA-1273 (Moderna) and CoronaVac) for the CoronaVac recipients respectively were 0.5 mL, 0.3 mL, 0.5mL, 100 µg and 0.5 mL. In conclusion, the heterologous boosters for the CoronaVac recipients could enhance immune responses against the Sars Cov 2.
Effect of Leaves and Stems Extract of Ciplukan (Physalis Angulata L.) on The Severity of Steatosis in Wistar Rat Liver Induced by Egg Yolk and Propylthiouracil Nugraha, Adi; Handayani, Ety Sari; Adyaksa, Dewa Nyoman Murti; Pramaningtyas, Miranti Dewi
Biomedika Vol 17, No 1 (2025): Biomedika Februari 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v17i1.2339

Abstract

The increasing habit of consuming high-fat foods and a sedentary lifestyle increases the incidence of hepatic steatosis. There are currently no approved medical drugs to prevent and treat steatosis. The leaves and stems of the ciplukan plant (Physalis Angulata (L.)) are rich in flavonoid compounds and phenolic acids which have preventive and curative effects on steatosis. This research aimed to determine the impact of ciplukan leaves and stems extract on the severity of steatosis in the liver of Wistar rats induced by egg yolk and propylthiouracil. This research consisted of four groups: first group induced by egg yolk and propylthiouracil for six weeks (n=7), second group induced egg yolk and propylthiouracil plus simvastatin 0.18 mg/200 gBW for six weeks (n=7), third group induced by egg yolk and propylthiouracil plus ciplukan extract 400 mg/kgBW for six weeks (n=7), fourth group induced by egg yolk and propylthiouracil plus ciplukan extract 800 mg/kgBW for six weeks (n=7). The severity of steatosis was determined based on histopathological observations by an anatomical pathology specialist. The first group had four preparations with moderate degree of steatosis. The second group had three preparations with moderate degree of steatosis. The third group had two preparations with moderate degree of steatosis. The fourth group had two preparations with moderate degree of steatosis. The statistical test results showed no significant difference in severity between the treatment groups (p=0.692). The administration of ciplukan leaves and stems extract can prevent a decrease in high-density lipoprotein levels in Wistar rats induced by egg yolk and propylthiouracil. However, no significant influence was found on the severity of hepatic steatosis.
Co-Authors Adi Nugraha Adyaksa, Dewa Nyoman Murti Afiqoh, Ainun Nur Ajeng G. Nanda, Ajeng G. Ayu Kurnia Priyantiningrum Chandra Muhammad Rauf Dwi N. Ahsani, Dwi N. Farah Jasmine Dianita Gea Sonia Amanda Hamidah Ikhwan, Salma Nur Ika Fidianingsih Indrayani, Tsaniya Ahda Kuswati Kuswati Kuswati Nugroho, Kuswati Kuswati, Kuswati MARIA BINTANG Miranti Dewi Pramaningtyas Muhammad Yusuf Hisyam Nesti Herennadia Nurmasitoh, Titis Nurul Hidayah NURUL HIDAYAH Nurul Hidayah Rahmanti, Fishella Aprista Rika Yulita Rahmawati Sahdella Sahdella Salsabila Ajeng Untung Widodo Utami Mulyaningrum Wicaksana, Zulfikar Loka Wimpy Wimpy Yuantari, Rahma Yusa Muhammad Thoriq Zainuri Sabta Nugaha Zainuri Sabta Nugraha Zainuri Sabta Nugraha, Zainuri Sabta Zhafirrahman, Muhammad