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All Journal Dentika Dental Journal MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Majalah Kedokteran Gigi Indonesia Dental Journal (Majalah Kedokteran Gigi) Journal of Dentomaxillofacial Science Journal of Indonesian Dental Association B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Interdental Jurnal Kedokteran Gigi (IJKG) Cakradonya Dental Journal PEDAMAS (Pengabdian Kepada Masyarakat)
Sri Lelyati C Masulili
Departemen Periodonsia Fakultas Kedokteran Gigi Universitas Indonesia Jakarta, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Energy Engineering Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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Human Beta-defensin-1 and Periodontal Disease: The Past, Present, and Future Benso Sulijaya; Sri Lelyati C Masulili; Elza Ibrahim Auerkari
Journal of Indonesian Dental Association Vol. 4 No. 1 (2021): April
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jida.v4i1.624

Abstract

Human beta-defensin-1 (HBD-1), a peptide released by the immune system, has been investigated for its association with periodontal disease. Several studies have found positive findings of its expression related to disease progression, whereas others have reported some tendencies. This review highlights studies associated with HBD-1 and periodontal disease in both primary and clinical investigations, as well as the underlying mechanism and discusses further research possibilities for HBD-1. HBD-1 acts as an innate immune apparatus and mediating the adaptive immune system; therefore, its role in the pathogenesis of a periodontal disease is indisputable. HBD-1 is mainly expressed in the oral stratified epithelium and sulcular epithelium, where the barrier junction properties (e.g., E-cadherin and β-catenin in the adherent junction) of the gingival epithelial cells serve as the first line of defense against periodontal infection. The HBD-1-reinforced epithelium therefore provides both a mechanical and a chemical barrier action. Critical issues that arise in the gingival epithelium can therefore be alleviated by modulation of HBD-1 production to enhance its protective function. The antimicrobial, anti-inflammatory, and wound healing properties of HBD-1 support its use as a promising clinical treatment strategy.
Co-Authors Antonius Winoto Suhartono, Antonius Winoto Benso Sulijaya, Benso Chaidar Masulili Chaidar Masulili Christopher Talbot Cindy Ariyani Hokardi Cindy Cahaya Dewi Saputri Dimas Ilham Hutomo Elza Ibrahim Auerkari Esti Cahyani Adiati Fatimah Tadjoedin INDAH PUSPITASARI Irene Sukardi Irene Sukardi Levina Mulya Moh Firman Irwanto Niniarty Zeiroeddin Djamal Nur Rahma Prihantini Pitu Wulandari Puji Astuti Putra, Mardikacandra Manggala Putri Lenggogeny Ranny Rachmawati Rendy Sumali Robert Lessang Sandra Olivia Kuswandani Saputri, Dewi Sara Ekaputri Soeroso , Yuniarti Sugiharto Wijaya Widaryono, Adityo Yulianti Kemal Yuniarti Soeroso