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Serum C-reactive protein and C-reactive gene (-717C>T) polymorphism are not associated with periodontitis in Indonesian male patients Antonius Winoto Suhartono; Benso Sulijaya; Niniarty Zeiroeddin Djamal; Sri Lelyati Chaidar Masulili; Christopher Talbot; Elza Ibrahim Auerkari
Dental Journal (Majalah Kedokteran Gigi) Vol. 48 No. 3 (2015): September 2015
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Periodontitis is an inflammatory disease caused by periodontal pathogens and influenced by multiple risk factors such as genetics, smoking habit, age and systemic diseases. The inflammatory cascade is characterized by the release of C-reactive protein (CRP). Periodontitis has been reported to have plausible links to increased level of CRP, which in turn has been associated to elevated risk of cardiovascular disease (CVD). Purpose: The purpose of this study was t o investigate the relationship amongst the severity of periodontitis, CRP level in blood and CRP (-717 C>T) gene polymorphism in male Indonesian smokers and non-smokers. Method: The severity of periodontitis was assessed for 97 consenting male Indonesian smokers and non-smokers. The CRP level of the subjects was determined by using immuno-turbidimetric assay performed in PARAHITA Diagnostic Center Laboratory ISO 9001: 2000 Cert No. 15225/2. The rate of CRP (-717C>T) gene polymorphism was determined by using PCR-RFLP in Oral Biology Laboratory, Faculty of Dentistry, Universitas Indonesia. Result: The results suggest that the CRP protein level is not significantly associated with the tested CRP gene polymorphism (p>0.05). Also, while the severity of periodontitis increased significantly with subject age, the CRP level in blood serum was not significantly related to the severity of periodontitis. The genotypes of the tested polymorphism did not show significant association with the severity of periodontitis either in smokers or in the combined population including smokers and non-smokers. The results naturally do not exclude such associations, but suggest that to discern the differences the sample size must be considerably increased. Conclusion: The CRP (-717C>T) gene polymorphism and CRP level in blood serum were not found to be associated with the severity of periodontitis in male smokers or in the combined population of smokers and non-smokers.

Radiographic Techniques For Estimating Dental Age: A Comparative Study Khan, Muhammad Salman; Auerkari, Elza Ibrahim; Suhartono, Antonius Winoto
Indonesian Health Journal Vol. 3 No. 3 (2024): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v3i3.574

The determination of dental age using radiographic techniques has become a crucial method in forensic dentistry for estimating the chronological age of individuals, particularly in cases involving children and adolescents. This study aims to compare various radiographic techniques in estimating dental age based on tooth development. A comparative research method was employed, analyzing radiographic data from individuals aged 6 to 18 years. The data were collected using two primary techniques: panoramic and intraoral periapical, and analyzed using well-established methods such as the Demirjian and Nolla methods. The results showed that the Demirjian method had a higher accuracy rate compared to other methods, particularly in age estimation for individuals under 12 years old. The discussion highlights that differences in accuracy between techniques are due to better visualization of dental anatomical structures in some techniques. The conclusion of this study is that radiographic methods, especially the panoramic technique and the Demirjian method, are optimal choices for dental age estimation with high accuracy.

Age estimation of a skeletonized human remains using the mann and lamendin methods: a case report Sandi, Indah Maydila; Safitry, Oktavinda; Suhartono, Antonius Winoto; Pattihahuan, Ira Zefanya; Auerkari, Elza Ibrahim
Padjadjaran Journal of Dentistry Vol 37, No 1 (2025): March 2025
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol37no1.59297

Introduction: An autopsy examines a deceased body to determine the cause of death. Forensic science applies scientific methods to aid law enforcement. After death, the body progresses through five decomposition stages: fresh, bloated, active decay, advanced decay, and skeletal, each providing crucial information for investigations. This case report purpose is to described age estimation of a skeletonized human remains using the mann and lamendin methods. Case Report: The body was in the skeletonization phase with partial soft tissue remaining on various body parts. No signs of trauma or bleeding were found on the bones. A total of 22 teeth were present, and three teeth were missing post-mortem. The biological age of the individual was estimated using Mann's method, which calculates age based on the palatal suture, followed by Lamendin's method, which uses the periodontosis, root height, and the transparency of the teet Conclusion: The estimation of the individual was more than 50 years using Mann’s method, and between 64 to 70 years using Lamendin’s method. This case demonstrates that forensic odontology provides a non-invasive, cost-effective, and accurate approach for determining the age of a skeletonized remains by analyzing the sutura palatina and teeth.

Association of rs235768 A>T polymorphism of the bone morphogenetic protein 2 gene on non-syndromic orofacial cleft in an Indonesian population Kiranahayu, Rarasih; Suhartono, Antonius Winoto; Sulistyani, Lilies Dwi; Latief, Benny Sjariefsjah; Auerkari, Elza Ibrahim
Padjadjaran Journal of Dentistry Vol 32, No 2 (2020): July 2020
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol32no2.23917

Introduction: Orofacial cleft is one of the many congenital malformations that often occur in human, leaving it at the fourth level of the most common orofacial birth defect findings. The incident rate is one in 700-1000 deliveries, where without therapeutic and surgical interventions, children with an orofacial cleft may have problems with speech, nutrition intake, and growth. Bone morphogenetic protein 2 (BMP-2) gene play essential roles in the migration and proliferation of neural crest cell of the early head formation and regulate mineralised tissues such as maxillary, mandible, palate and teeth. This study was aimed to analyse the BMP-2 polymorphism and its potential association with orofacial cleft in an Indonesian population. Methods: Cross-sectional study was conducted towards 128 samples, 32 samples of orofacial cleft patients and 96 samples of control. Extracted genotype and allele was determined with PCR-RFLP method using stored DNA samples from 32 orofacial cleft patients, and 96 healthy control. Results: The TT genotype was showing the p-value = 0.001, OR = 2.43% in orofacial samples (71.4%), which was significantly higher than in control groups (28.6%). The allele distribution was also considered statistically significant (p = 0.036, OR =1.89%. Conclusion: There is a significant association of rs235768 A>T polymorphism of the BMP-2 gene on non-syndromic orofacial cleft patients in Indonesia.

The role of forensic odontology in the identification of a mutilation victim: A case report Yatma, Debby; Auerkari, Elza Ibrahim; Yuniastuti, Mindya; Soedarsono, Nurtami; Suhartono, Antonius Winoto; Kaurow, Farah P.; Pasaribu, Roben Suhadi; Auerkari, Pertti
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p409-414

Background: Forensic odontology is an invaluable resource for human identification. An individual’s bones and teeth may be the only remnants of their identity in certain situations where soft tissue has been lost, carbonized, or destroyed for any other reason. The body’s hardest and best-protected structures are found in teeth, and these have individual characteristics and are resistant to factors such as temperature and chemistry. When antemortem dental records are not available for comparison, dental profiling is performed. Purpose: This case study highlights the importance of teeth in the identification process and their usefulness in estimating biological profile factors such as sex, age, and population affinity. Case: The case of an unidentified woman who was found in a house in a severely decomposed, skeletonized state is presented. The unidentified body was sent to the Forensic Medicine Installation of Bhayangkara Level I Hospital to determine the cause of death and for dental identification. Case management: The body was suspected to be a victim of mutilation. Shovel shapes observed on the lingual surface of the lateral upper incisor and tori palatini are the most outstanding diagnostic features in Mongoloid populations. The specific mesiodistal crown width and mandibular canine index revealed female traits. Using the Lamendin method, the age was estimated to be 52–58 years old. Conclusion: A forensic odontologist can identify individuals by comparing antemortem and postmortem dental data. They can also provide age estimation, sex, and population affinity determination by analyzing teeth.

Radiographic Techniques For Estimating Dental Age: A Comparative Study Khan, Muhammad Salman; Auerkari, Elza Ibrahim; Suhartono, Antonius Winoto
Indonesian Health Journal Vol. 3 No. 3 (2024): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v3i3.574

The determination of dental age using radiographic techniques has become a crucial method in forensic dentistry for estimating the chronological age of individuals, particularly in cases involving children and adolescents. This study aims to compare various radiographic techniques in estimating dental age based on tooth development. A comparative research method was employed, analyzing radiographic data from individuals aged 6 to 18 years. The data were collected using two primary techniques: panoramic and intraoral periapical, and analyzed using well-established methods such as the Demirjian and Nolla methods. The results showed that the Demirjian method had a higher accuracy rate compared to other methods, particularly in age estimation for individuals under 12 years old. The discussion highlights that differences in accuracy between techniques are due to better visualization of dental anatomical structures in some techniques. The conclusion of this study is that radiographic methods, especially the panoramic technique and the Demirjian method, are optimal choices for dental age estimation with high accuracy.

Collaboration between forensic odontology and forensic pathology is crucial in Disaster Victim Identification Salman Khan, Muhammad; Suhartono, Antonius Winoto; Auerkari, Elza Ibrahim
Eduvest - Journal of Universal Studies Vol. 4 No. 7 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i7.1231

While forensic pathologists have always played a pivotal role in victim identification after mass casualties, new developments in forensic methods have given forensic anthropologists more agency in positively identifying individuals who were previously unidentifiable.This review aims to contribute to the refinement of diagnostic tools, ensure optimal utilization of remnants and information available, and emphasize the contributions of forensic pathologists and forensic odontologist to victim identification and the importance of forensic pathologists and forensic odontologist in the criminal justice system. Considering the Interpol DVI Guide's emphasis on fingerprints, dental examinations, and DNA as primary identifiers, the forensic pathologist's role as the leader of a multidisciplinary team of experts in a disaster situation has taken on new significance. This is due to the forensic pathologist's and forensic odontologist training and experience leading similar teams during routine operations at a forensics institute. This thorough examination highlights the utmost significance of the job carried out by forensic pathologists and forensic odontologist. They play an important role in the judicial process by providing expert views in criminal investigations. Their expertise ensures accurate identification of victims and provides critical evidence that is necessary for holding offenders responsible. Their contributions are fundamental to the administration of justice, highlighting the great importance of their function in the overall structure of the criminal judicial system.

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