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All Journal Sari Pediatri Paediatrica Indonesiana Medica Hospitalia
Gatot Irawan Sarosa, Gatot Irawan
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Comparison of oral caffeine and oral theophylline for apnea of prematurity: A randomized clinical trial Anggrainy, Nensy; Sarosa, Gatot Irawan; Suswihardhyono, Adhie Nur Radityo
Paediatrica Indonesiana Vol. 64 No. 4 (2024): July 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.4.2024.350-5

Abstract

Background Caffeine and theophylline are methylxanthine compounds that have been widely used in the treatment of apnea of prematurity (AOP). Previous studies comparing the two agents have shown inconsistent results and have mostly used intravenous preparations. Objective To assess the effectiveness of oral administration of caffeine compared to oral theophylline as therapy for apnea of prematurity. Methods Fifty consecutively recruited premature neonates (gestational age 28-34 weeks, birth weight <2,500 g) with AOP who were able to tolerate at least 10 mL/kg of enteral feeding were randomized to receive either oral caffeine or oral theophylline for seven days. The main outcome was the daily frequency of apnea after treatment. Secondary outcomes were duration of oxygen or CPAP administration, duration of oxygen fraction (FiO2) taper to reach 21%, time to achievement of full feeding tolerance, length of hospital stay, and side effects. Results We randomized 25 subjects into each group. The distribution of baseline characteristics (gender, gestational age, mode of delivery, birth weight and length, age at onset of AOP, and initial frequency of AOP) was similar between both groups. The mean daily number of apnea episodes after treatment was significantly higher in the caffeine group compared to the theophylline group [3.16 (SD 1.31) vs. 2.28 (SD 1.40); P=0.031]. The caffeine group, compared to the theophylline group, also had a longer mean duration of oxygen or CPAP use [12.56 (SD 7.67) days vs. 8.40 (SD 6.41) days; P=0.030] and duration of FiO2 taper [5.76 (SD 2.68) vs. 4.08 (SD 2.54); P=0.035]. There were no significant differences in mean time to full feeding and mean length of hospital stay. There was no significant difference in the occurrence of side effects between the two groups. Conclusion In premature neonates with AOP, oral theophylline is slightly more effective than oral caffeine in reducing the frequency of apnea and is associated with a shorter duration of oxygen or CPAP use and duration to reach 21% FiO2.
Coronavirus Disease 2019 (COVID-19) Pada Anak (Studi Literatur) Anantyo, Dimas Tri; Kusumaningrum, Ayu Anggraini; Rini, Arsita Eka; Radityo, Adhie Nur; Rahardjani, Kamilah Budhi; Sarosa, Gatot Irawan
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 1A (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (395.552 KB) | DOI: 10.36408/mhjcm.v7i1A.479

Abstract

Latar Belakang: Pandemi Novel Coronavirus Disease 2019 (COVID-19) yang disebabkan oleh virus SARS CoV-2 ini berawal dari Wuhan, China, menyebar ke lebih dari 200 negara dan mengakibatkan puluhan ribu kematian termasuk anak. Studi literatur yang membahas COVID-19 pada orang dewasa mulai bermunculan, namun pada anak masih terbatas. Dalam studi literatur ini kami mengulas beberapa artikel ilmiah dan literatur terbaru tentang COVID-19 pada anak yang dipublikasikan sejak Januari 2020 hingga akhir Juli 2020, khususnya manifestasi klinis dan pemeriksaan penunjang. Metode: Mengulas publikasi 35 literatur ilmiah mengenai COVID-19 anak pada jurnal seperti Pubmed, Google Scholar, Science Direct, The Lancet sejak Januari hingga Juli 2020. Hasil: Kejadian COVID-19 pada anak lebih rendah dan memiliki gejala yang lebih ringan dibandingkan orang dewasa. Gejala yang sering muncul adalah batuk, faring hiperemis, dan demam. Belum ada bukti jelas mengenai kejadian transmisi intrauterine yang dilaporkan. Prognosis menunjukkan respon terapi yang baik dan pemulihan yang lebih cepat dibandingkan dengan orang dewasa. Kesimpulan: Kejadian COVID-19 lebih rendah, manifestasi klinis lebih ringan dan prognosis lebih baik pada anak dibandingkan dengan orang dewasa. Kata kunci: COVID-19, anak, studi literatur Background: The Novel Coronavirus Disease 2019 (COVID-19) pandemic caused by the SARS CoV-2 virus originated in Wuhan, China, spread to more than 200 countries and resulted in tens of thousands of deaths including children. Literature studies discussing COVID-19 in adults are starting to emerge, but in children it is still limited. In this literature study, we review some of the latest scientific articles and literature on COVID-19 in children published from January 2020 to the end of July 2020, in particular clinical manifestations and supporting examinations. Methods: Reviewing 35 scientific literatures about children with COVID-19 in journals such as Pubmed, Google Scholar, Science Direct, The Lancet from January to July 2020. Results: The incidence of COVID-19 in children was lower and had milder symptoms than adults. Symptoms that often appear are cough, hyperemic pharynx, and fever. There was unclear proof of intrauterine transmission. The prognosis of children with COVID-19 showed a good response to therapy and faster recovery compared to adults. Conclusion: The incidence of COVID-19 is lower, the clinical manifestations are milder, and the prognosis is better in children compared to adults. Keywords: COVID-19, children, literature study
Karakteristik Bayi Baru Lahir dari Ibu Terkait COVID-19 di RSUP Dr. Kariadi Semarang Radityo, Adhie Nur; Rini, Arsita Eka; Anam, Moh Syarofil; Sarosa, Gatot Irawan
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 1A (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (268.32 KB) | DOI: 10.36408/mhjcm.v7i1A.481

Abstract

Latar belakang Kejadian kasus COVID-19 pada bayi belum banyak dilaporkan dan mekanisme penularan terhadap bayi baru lahir masih belum jelas. Tujuan Melaporkan perbedaan karakteristik bayi baru lahir dari ibu terkait COVID-19 di RSUP Dr. Kariadi Semarang Metode Penelitian retrospektif dengan data sekunder catatan medik bayi baru lahir dari ibu terkait COVID-19 di RSUP dr Kariadi Semarang pada periode April-Mei 2020 dengan kelompok pembanding bayi baru lahir dari ibu tidak terkait COVID-19. Kriteria inklusi semua bayi lahir dari ibu terkait COVID-19 dirawat di rumah sakit dan dilakukan pemeriksaan PCR dengan spesimen swab nasofaring. Data yang dikumpulkan adalah usia kehamilan, jenis kelamin, berat lahir, cara persalinan, usia ibu dan jenis minum yang diberikan pada bayi. Dilakukan uji beda menggunakan uji chi square dan shapiro wilk. Analisis data menggunakan program komputer SPSS. Hasil Dari 46 sampel penelitian terdiri dari 23 bayi lahir dari ibu terkait COVID-19 dan 23 bayi lahir dari ibu tidak terkait COVID-19 dilakukan analisis dengan hasil tidak terdapat perbedaan bermakna dari usia kehamilan, berat lahir, cara persalinan dan usia ibu. Pada kelompok bayi lahir terkait COVID-19 mayoritas lahir dengan jenis kelamin perempuan (74%) dan jenis minum yang diberikan sekitar 86% dengan susu formula. Tidak ada bayi yang mendapat ASI eksklusif pada bayi yang lahir dari ibu terkait COVID-19. Semua bayi yang lahir dari ibu terkait COVID-19 didapatkan hasil swab nasofaring negatif dan tidak menunjukkan gejala apapun sampai dengan pulang. Simpulan Tidak didapatkan perbedaan karakteristik usia kehamilan, berat lahir, cara persalinan dan usia ibu. Terdapat perbedaan karakteristik jenis kelamin dan jenis minum yang diberikan pada kedua kelompok penelitian. Keyword: bayi baru lahir, COVID-19 Background The incidence of COVID-19 cases in newborn has not been widely reported and the mechanism of transmission to the newborn is unclear. Objective To report the characteristics of newborns from mothers related to COVID-19 at Kariadi Hospital Semarang. Method Retrospective study with secondary data on medical records of newborns from mothers related to COVID-19 at Kariadi Hospital in the April-May 2020 period with a comparison group of newborns from mothers not related to COVID-19. Criteria for inclusion of all infants born to mothers associated with COVID-19 were hospitalized and PCR examination carried out with nasopharyngeal swab specimens. Data collected were gestational age, sex, birth weight, mode of delivery, maternal age and type of dietary given to the baby. Analysis tests were performed using chi square test and Shapiro Wilk. Data analysis using SPSS computer programs Result Of the 46 study samples consisting of 23 babies born to mothers related to COVID-19 and 23 babies born to mothers not related to COVID-19 were analyzed with the results that there were no significant differences in gestational age, birth weight, mode of delivery and maternal age. In the group of babies born with COVID-19 the majority were born with a female sex (74%) and the type of dietary given was around 86% with formula milk. No baby gets exclusive breastfeeding for babies born to mothers related to COVID-19. All babies born to mothers related to COVID-19 obtained negative nasopharyngeal swab results and did not show any symptoms until discharge. Conclusion There were no differences in the characteristics of gestational age, birth weight, mode of delivery and maternal age. There were differences in the characteristics of the sexes and types of dietary given in the two study groups. Keyword: newborn, COVID-19
Edwards Syndrome and Trisomy 8: a case report of a newborn with multiple congenital anomalies with double aneuploidy Utari, Agustini; Maharani, Nani; Indriyati, Rita; Sihombing, Nydia Rena Benita; Sarosa, Gatot Irawan; Winarni, Tri Indah
Paediatrica Indonesiana Vol. 65 No. 4 (2025): July 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.4.2025.350-6

Abstract

Chromosomal aneuploidy is the most common genetic cause of multiple congenital anomalies (MCA), contributing to high neonatal mortality and morbidity rates in intensive care units. Prevalence of live birth double trisomy is rarely reported, with previous studies reporting the involvement of autosomal aneuploidy combined with sex chromosomal aneuploidy that is a more tolerable or benign phenotype. Mostly, a live-born baby with a double trisomy is associated with mosaicism.  This report aims to present a rare case of a viable baby with non-mosaic double autosomal trisomy involving chromosomes 8 and 18. A term baby from advanced maternal and paternal age with low birth weight and height was born from spontaneous vaginal delivery from unremarkable pregnancy. The phenotype was suitable with Edward syndrome with congenital heart anomalies confirmed by cytogenetic analysis with additional extra chromosome 8 (48, XX,+8,+18). The baby was on and off the mechanical ventilator due to respiratory failures, and her health condition gradually deteriorated, leading to her death at the age of 2.5 months due to neonatal pneumonia.
Jadwal Imunisasi Anak Usia 0-18 Tahun Rekomendasi Ikatan Dokter Anak Indonesia Tahun 2024 Kaswandani, Nastiti; Gunardi, Hartono; Prayitno, Ari; Kartasasmita, Cissy B.; Prasetyo, Dwi; Husada, Dominicus; Sarosa, Gatot Irawan; Oswari, Hanifah; Ismoedijanto, Ismoedijanto; Rusmil, Kusnandi; Maddepunggeng, Martira; Sitaresmi, Mei Neni; Raihan, Raihan; Handryastuti, Setyo; Soedjatmiko, Soedjatmiko; Hadinegoro, Sri Rezeki S.; Munasir, Zakiudin
Sari Pediatri Vol 26, No 5 (2025)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp26.5.2025.328-36

Abstract

Satuan Tugas Imunisasi Ikatan Dokter Anak Indonesia secara periodik melakukan kaji ulang jadwal imunisasi dengan menyelaraskan dengan buku pedoman imunisasi di Indonesia edisi ke 7 tahun 2024, dan sumber-sumber lainnya. Jadwal imunisasi selalu dievaluasi ulang karena beredarnya vaksin baru yang telah disetujui oleh BPOM dan vaksin yang tidak tersedia lagi di Indonesia. Terdapat beberapa perubahan dalam jadwal imunisasi rekomendasi IDAI tahun 2024 yaitu ketersediaan jenis vaksin, seperti pada pneumococcal conjugate vaccine (PCV), vaksin rotavirus, vaksin varisela, vaksin dengue, dan vaksin human papillomavirus (HPV). Agar dalam pelaksanaan lebih mudah, disertakan juga tabel jadwal imunisasi tahun 2024 di akhir.
Co-Authors Adhie Nur Radityo Adhie Nur Radityo Suswihardhyono Agustini Utari Anam, Moh Syarofil Anantyo, Dimas Tri Anggrainy, Nensy Ari Prayitno, Ari Arsita Eka Rini Cissy B. Kartasasmita Dominicus Husada Dwi Prasetyo Hanifah Oswari Hartono Gunardi Indriyati, Rita Ismoedijanto Kamilah Budhi Rahardjani, Kamilah Budhi Kusnandi Rusmil Kusumaningrum, Ayu Anggraini Maddepunggeng, Martira Mei Neni Sitaresmi Nani Maharani Nastiti Kaswandani Raihan Raihan, Raihan Setyo Handryastuti, Setyo Sihombing, Nydia Rena Benita Soedjatmiko Soedjatmiko Sri Rezeki S. Hadinegoro, Sri Rezeki S. Tri Indah Winarni Zakiudin Munasir