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PERBEDAAN MEMORI JANGKA PENDEK SEBELUM DAN SESUDAH MENDENGARKAN MUSIK SAAT LARI PADA DEWASA MUDA Ardyarini, Hikmatunnisa Tri; Muniroh, Muflihatul; Maharani, Nani
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 7, No 2 (2018): JURNAL KEDOKTERAN DIPONEGORO
Publisher : DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (418.651 KB)

Latar Belakang: Mendengarkan musik saat berolahraga diketahui dapat menimbulkan efek ergogenik dan mempengaruhi sistem kardiovaskuler. Namun, pengaruh kombinasi keduanya terhadap memori, sebagai salah satu fungsi kognitif yang penting pada proses pembelajaran usia dewasa muda, masih belum diteliti lebih lanjut.Tujuan: Mengetahui perbedaan memori jangka pendek sebelum dan sesudah mendengarkan musik saat lari pada kelompok dewasa muda.Metode: Penelitian eksperimental dengan metode pre- dan post-test unequivalent group di Stadion Universitas Diponegoro. Subjek adalah kelompok usia dewasa muda (17-22 tahun) yang pada periode penelitian tercatat sebagai mahasiswa Fakultas Kedokteran Universitas Diponegoro (n=40) dan dipilih secara purposive sampling, kemudian dibagi menjadi 2 kelompok; kelompok lari selama 30 menit dengan mendengarkan musik (n=20) dan kelompok lari selama 30 menit tanpa medengarkan musik sebagai kontrol (n=20). Memori jangka pendek diukur dengan Scenery Picture Memory Test dan analisis data dilakukan dengan uji t-berpasangan, t-tidak berpasangan, Wilcoxon dan Mann-Whitney.Hasil: Terdapat perbedaan memori jangka pendek yang bermakna sebelum dan sesudah mendengarkan musik saat lari (p=0,00). Memori jangka pendek setelah lari dengan mendengarkan musik meningkat secara signifikan (p<0,05) dibandingkan dengan kontrol, dengan rerata peningkatan sebesar 5,0 Â± 2,66 pada kelompok lari dengan mendengarkan musik dan 3,05 Â± 1,76 pada kelompok kontrol.Kesimpulan: Mendengarkan musik saat lari dapat meningkatkan fungsi memori jangka pendek lebih tinggi dibandingkan dengan lari tanpa mendengarkan musik pada usia dewasa muda.

Perbedaan Kadar IgA dan IL6 Pada Penumpang â€œBiosmart and Safety Busâ€ pada Memakai Masker Herbal dan Masker Medis Rahajeng, Herera; Prasetyo, Awal; Susilaningsih, Neni; Sadhana, Udadi; Maharani, Nani; Asri, Hairul
Life Science Vol 10 No 1 (2021): April 2021
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/lifesci.v10i1.47177

Viral infections that attack the respiratory tract are currently a major problem globally. The spread of viral infection can be one of the risks by passengers of the bus. The government's efforts being developed are the application of biosmart and safety buses designed to prevent the virus with stake holders. One of the health protocols is the use of masks. The purpose of this study was to see the differences in IgA and IL6 levels before and after the use of medical masks and herbal masks. Nasal wash samples were taken and analyzed by ELISA. The results obtained were the level of IgA for the control group before wearing medical masks was 23.46834 pg/ml and after wearing 29.74473 pg/ml. While the IL6 levels before were 1.10544 ng / ml and after -2.04119 ng/ml. The results of the IgA in the experimental group before using the herbal mask 24.00840 pg/ml and after using was 29.74473 pg/ml. Meanwhile, the level of IL6 before was 0.91682 ng/ml and after 0.500157 ng/ml. Based on the results, there was an increase in IgA levels after the use of medical masks and herbal masks while IL6 levels decreased after the use of medical and herbal masks. Keywords: Herbal mask; IgA; IL6, Masker herbal;IgA;IL6 Infeksi virus yang menyerang saluran pernapasan saat ini menjadi masalah utama secara global. Penyebaran agen infeksi virus dapat menjadi salah satu risiko yang dihadapi penumpang moda transportasi Bus. Upaya Pemerintah seperti yang saat ini dikembangkan adalah pengaplikasian biosmart and safety bus yang dirancang guna menghambat persebaran virus dengan stake holder yang tepat. Salah satu penerapan protokol kesehatan adalah penggunaan masker. Tujuan dari penelitian ini adalah melihat perbedaan kadar IgA dan IL6 sebelum dan sesudah pemakaian masker medis dan masker herbal pada penumpang biosmart and safety bus. Pengambilan sampel nasal wash dilakukan dan dianalisis dengan ELISA. Penelitian ini merupakan quasi experimental dengan prepost test randomized control design. Hasil yang didapat adalah kadar IgA untuk kelompok kontrol sebelum pemakaian masker medis 23,46834 pg/ml dan setelah memakai masker medis 29,74473 pg/ml. Sementara kadar IL6 sebelum adalah 1,10544 ng/ml dan setelah -2,04119 ng/ml. Hasil IgA kelompok eksperimen sebelum pemakaian masker herbal 24,00840 pg/ml dan setelah memakai masker herbal 29,74473 pg/ml. Sementara kadar IL6 sebelum adalah 0,91682 ng/ml dan setelah 0,500157 ng/ml. Berdasarkan hasil penelitian terdapat peningkatan kadar IgA setelah pemakaian masker medis dan masker herbal sementara kadar IL6 mengalami penurunan setelah pemakaian masker medis dan masker herbal. Keywords: Herbal mask; IgA; IL6, Masker herbal;IgA;IL6

Utilization of banana (Musa paradisiaca L.) peel as pectin source as antidiarrheal on castor oil-induced diarrheal Wistar rats model Martin Adhitya Subagio; Cecilia Noviyanti Salim; Qorina Putri Srisantoso; Yora Nindita; Astika Widy Utomo; Nani Maharani
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 52, No 2 (2020)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Banana (Musa paradisiaca L.) peel, locally name pisang raja, contains a high concentration of pectin which is used as antidiarrheal to absorb irritants and increase stool consistency. However, it’s use to increase the stool consistency has not been studied, yet. The study aimed to investigate the effect banana peel extract (BPE) administration on stool consistency of diarrheal rat model. It was an experimental study with a post-test only control group design. Thirty male Wistar rats were induced diarrhea with castor oil and then randomized into five groups. Group I as positive control group was given attapulgite at dose of 124 mg/kg BW. Group II as negative control was given 0.5 mL of 1% tween 80. Group III, IV and V as treatment group were give BPE at different doses of 100, 200 and 400 mg/kg BW, respectively.T he stool consistency was measured every hour for 4 h by weighing fresh and dry stool weight and then the water content was calculated. Data analysis was conducted using one-way ANOVA and LSD post hoc test. Significantly different in stool consistency between Group III, IV, and V compared to Group II (p<0.05) and between groups Group III and IV compare to Group I (p<0.05) were observed. However, there was no significantly different between group V compared to Group I (p=0.149).In conclusion, BPE can increase the stool consistency of castor oil-induced diarrhea rats. The BPE at the dose of 400 mg/kg BW has similar effect to attapulgite.

Antidiarrheal Effect of Lime Peel Extract on Bisacodyl-Induced Mice Abraham Talent Bawadi Sibarani; Hesti Triwahyu Hutami; Nani Maharani; Yora Nindita
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.32144

Background: Diarrhea is a condition of increased fecal water content of more than 200 grams or 200 ml/24 hours with a liquid or semi-liquid consistency. Complications of diarrhea, dehydration and malnutrition are still world health problems. Lime peel extract contains tannins which have astringent properties. Tannins are indicated as an alternative anti-diarrheal agent by tightening and forming a protective layer on the intestinal mucosa thereby reducing osmolarity.Aim: To examine the consistency, fecal water content, and frequency of defecation of bisacodyl-induced diarrhea in mice that are given lime peel extract.Methods: This research was an experimental with post test only group design. Thirty-six male mice were included and then divided into 5 groups with bisacodyl induction and 1 normal control group (KM) without bisacodyl induction. The negative control group (KN) was given 0.5 ml Tween 80 1%, the positive control group (KP) was given attalpugite 0.4 mg/40gW, treatment group 1 (X1), treatment group 2 (X2), treatment group 3 (X3 ) were given lime peel extract at graded doses of 125, 250, and 500 mg/KgW. Consistency, fecal water content, and frequency of defecation were observed every 30 minutes for 4 hours by observing the consistency of feces, weighing wet and dry feces to measure the water content, and measuring the frequency of defecation in each group. Data were analyzed statitiscally using Kruskal Wallis test with Post Hoc Mann Whitney test.Results: There were significant differences between the comparison of defecation frequency in the X3 group and the KM group, for the fecal water content comparison between the X3 group and the KN group, and no significant differences in the following group comparisons.Conclusion: Lime peel extract cannot reduce the frequency of defecation, fecal water content, and increase the consistency of feces significantly.Keywords: Diarrhea, lime peel extract, tannins, astringent, consistency, fecal water content, frequency of defecation.

THE EFFECT OF CORIANDER LEAF EXTRACT TOWARDS KIDNEY HISTOPATHOLOGICAL FEATURES ON WISTAR RAT INDUCED BY ORALLY ADMINISTERED MERCURY Manda Petrina; Ika Pawitra Miranti; Nani Maharani; Intan Rahmania Eka Dini
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 4 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i4.30095

Background: Mercury’s a toxic heavy metal that damages the kidney through generation of Reactive Oxygen Species (ROS). Previous study has established that coriander leaves contained high level of antioxidants. However, there hasn’t been any experiment that examined renoprotective effect of coriander leaf extract toward the kidney of Wistar rat induced with orally administered mercury.Objective: To examine the nephroprotective activity of coriander leaf extract towards Wistar rat’s proximal tubules induced with orally administered mercuryMethods: : Experimental study with post test only control group design using 20 male Wistar rats divided randomly into 4 groups as samples. Group K0 without treatment, Group K(-) was administered 10 mg/ kgBW mercury chloride orally, Group P1 was administered 10 mg/kgBW mercury chloride and 100 mg/kgBW coriander leaf extract orally, and Group P2 was administered 10 mg/kgBW mercury chloride and 200 mg/kgBW coriander leaf extract orally. The study was carried for 14 days after which the kidneys were examined microscopically.Results: The mean values for damaged proximal tubules were as follows: group K0 2,44±1,19; group K(-) 4,76±3,77; group P1 4,52±2,18; group P2 2,60±1,38. Mann-Whitney test showed significant differences between group K(-)>K0 (p=0,009); group P1>K0 (p=0,001); group P2<K(-) (p=0,015); group P1>P2 (p=0,001). Insignificant differences were found between group P2> K0 (p=0,936) and group P1<K(-) (p=0,579).Conclusion: Coriander leaf extract could reduce the number of damaged proximal tubules from mercury ingestion, with dose of 200 mg/kgBW showing better result than 100 mg/kgBW.Keywords: antioxidants, coriander leaf, kidney, mercury

Hyperuricemia as a Risk Factor for Cardiovascular Diseases Ichiro Hisatome; Peili Li; Fikri Taufiq; Nani Maharani; Masanari Kuwabara; Haruaki Ninomiya; Udin Bahrudin
Journal of Biomedicine and Translational Research Vol 6, No 3 (2020): December2020
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v6i3.9383

Serum uric acid level above 7 mg/dl is defined as hyperuricemia, which gives rise to the monosodium urate (MSU), causing gout and urolithiasis. Hyperuricemia is an independent risk factor as well as a marker for hypertension, heart failure, atherosclerosis, atrial fibrillation, and chronic kidney disease. MSU crystals, soluble uric acid (UA), or oxidative stress derived from xanthine oxidoreductase (XOR) might be plausible explanations for the association of cardio-renovascular diseases with hyperuricemia. In macrophages, MSU activates the Nod-like receptor family, pyrin　domain containing 3(NLRP3) inflammasome, and proteolytic processing mediated by caspase-1 with enhanced interleukin (IL)-1β and IL-18 secretion. Soluble UA accumulates intracellularly through UA transporters (UAT) in vascular and atrial myocytes, causing endothelial dysfunction ad atrial electrical remodeling. XOR generates reactive oxygen species (ROS) that lead to cardiovascular diseases. Since it remains unclear whether asymptomatic hyperuricemia could be a risk factor for cardiovascular and kidney diseases, European and American guidelines do not recommend pharmacological treatment for asymptomatic patients with cardio-renovascular diseases. The Japanese guideline, on the contrary, recommends pharmacological treatment for hyperuricemia with CKD to protect renal function, and it attaches importance of the cardio-renal interaction for the treatment of asymptomatic hyperuricemia patients with hypertension and heart failure.

Adiponutrin and Adiponectin Gene Variants in Indonesian Patients with Non-Alcoholic Fatty Liver Disease: a Preliminary Study Rayvita AN Meagratia; Ferdy Kurniawan Cayami; Udin Bahrudin; Wiwik Lestari; Nani Maharani; Sultana MH Faradz; Hery Djagat Purnomo
Journal of Biomedicine and Translational Research Vol 7, No 2 (2021): August 2021
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v7i2.11777

BackgroundVariants of adiponutrin (PNPLA3) and adiponectin (ADIPOQ) genes were considered to be associated with non-alcoholic fatty liver disease (NAFLD). Although the prevalence of NAFLD is increasing, there are limited numbers of studies about the association in Indonesian population.ObjectiveTo confirm whether specific variants of adiponutrin (PNPLA3) and adiponectin (ADIPOQ) genes are associated with NAFLD in Indonesian patients.MethodsData and DNA of 152 participants were obtained from a previous study in Dr. Kariadi Hospital, Semarang, Indonesia. PCR-RFLP analysis was performed for detection of PNPLA3 rs738409 and ADIPOQ rs2241767 variants. The diagnosis and severity of NAFLD were assessed according to NAFLD activity score (NAS) based on histopathology assessment of liverbiopsy.ResultsAllele G of PNPLA3rs738409 was associated with NAFLD in both bivariate (p=0.009, OR 2.52, CI 95% 1.25–5.07) and multivariate (p=0.008, OR 2.62, CI 95% 1.29%–5.32%) analysis, while ADIPOQ rs2241767 had no significant association. In NAFLD participants, both genotypes showed allele G was higher in the group of possible non-alcoholic steatohepatitis (NASH) – NASH (NAS >2) than in the simple steatosis group (NAS <2) i.e. 40.0% vs. 3.75% for the rs2241767 variant and 23.75% vs. 1.25% for the rs738409 variant, without significant association.ConclusionVariant PNPLA3 rs738409 was associated with NAFLD incidence in studied population. Among NAFLD participants, the frequency of both variants were found higher in the possible NASH – NASH group, yet needs to be confirmed with more participants and a multicenter study.Data and DNA of 152 participants were obtained from a previous study in Dr. Kariadi Hospital, Semarang, Indonesia. PCR-RFLP analysis was performed for detection of PNPLA3 rs738409 and ADIPOQ rs2241767 variants. The diagnosis and severity of NAFLD were assessed according to NAFLD activity score (NAS) based on histopathology assessment of liverbiopsy.

Diagnostic value of SARS-CoV-2 RDT-Ab with RT-PCR: Secondary data at Diponegoro National Hospital Muhammad Thifan Satyagraha; Nani Maharani; Rebriarina Hapsari; Meita Hendrianingtyas
Journal of Biomedicine and Translational Research Vol 8, No 1 (2022): April 2022
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v1i1.13759

Background: The SARS-CoV-2 rapid diagnostic test antibody (RDT-Ab) was most often used as an early detection tool for COVID-19 at the beginning of pandemic. Whereas the antibody response was formed in the second week after the onset of symptoms.Objective: To evaluate the diagnostic value of the SARS-CoV-2 RDT-Ab, including sensitivity (Se), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (PLR), and negative likelihood ratio (NLR), in patients at Diponegoro National Hospital, Semarang, Indonesia.Methods: Data subjects have been selected retrospectively using purposive sampling based on inclusion criteria (patients who had shortness of breath, pneumonia, suspected, possible, or confirmed COVID-19, and data on the results of the SARS-CoV-2 RDT-Ab IgM and/or IgG (Leccurate® SARS-CoV-2 Antibody Rapid Test Kit) with a valid RT-PCR as gold standard) and exclusion criteria (patients who only had one of either SARS-CoV-2 RDT-Ab or RT-PCR). Researchers analyzed the diagnostic value of SARS-CoV-2 RDT-Ab with RT-PCR which gave the possibility of true-positive, false-positive, true-negative, and false-negative results arranged in a 2x2 table. According to WHO, the diagnostic value is said to be good at least having a sensitivity value of 80% and specificity of 97%.Results: The diagnostic value of SARS-CoV-2 RDT-Ab with RT-PCR, which was evaluated from 1142 patients retrospectively, included IgM (Se 65.25%, Sp 89.51%, PPV 46.70%, NPV 94.81%, PLR 6.22, NLR 0.39), IgG (Se 58.16%, Sp 93.01%, PPV 53.95%, NPV 94.04%, PLR 8.32, NLR 0.45), IgM and IgG (Se 53.90%, Sp 94.21%, PPV 56.72%, NPV 93.55%, PLR 9.30, NLR 0.49), IgM and/or IgG (Se 69.50%, Sp 88.31%, PPV 45.58%, NPV 95.36%, PLR 5.95, NLR 0.35).Conclusion: SARS-CoV-2 RDT-Ab (Leccurate® SARS-CoV-2 Antibody Rapid Test Kit) is not ideal to be used as a rapid diagnostic test for COVID-19.Keywords: COVID-19, Rapid diagnostic test, RT-PCR, SARS-CoV-2 antibody

The Efficacy of Genistein-Rich Edamame as a Prevention of Atherosclerotic Lesion in Abdominal Aorta: Study in Rats Model of Atherosclerosis Rizky Aditya Fardhani; Reza Dian Pratama; Nani Maharani; Bahrudin; Yuriz Bakhtiar; M Ali Sobirin; Farmaditya EP Mundhofir
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 10 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i10.414

Background: Atherosclerosis is the main cause of ischemic heart disease which leads to death for people aged more than 40 years old. Genistein is an important isoflavone compound which may protect the blood vessels from endothelial injury. This research is to observe the efficacy of genistein rich edamame as a prevention for atherosclerotic abdominal aortic lesions that seen from abdominal aortic thickness and foam cells count. Method: Thirty rats were divided randomly into five groups and treated for 28 days. The negative control group was given food and drink ad libitum. The positive control group was induced for atherosclerosis using adrenaline 0.006 mg / 200 gr BW injected on the first day and then the next day was given egg yolk 5 gr / 200 gr BW on next day for 28 days. All of the treatment groups were induced for atherosclerosis and treated with genistein-rich edamame extract 5 mg / 200 gr BW, edamame extract 38 mg / 200 gr BW and atorvastatin 1.5 mg / 200 grBW. Data were analyzed using One Way ANOVA - post hoc Bonferroni test, Kruskal Wallis - Mann Whitney test, and Pearson correlation test. Results: There were significant differences (p<0,001) in abdominal aortic thickness and foam cells count between positive control group and treatment genistein-rich edamame extract, edamame extract and atorvastatin. There was a significant correlation between the abdominal aortic wall thickness and foam cells count (correlation coefficient value 0,753; p<0,001). Conclusion: The administration of genistein-rich edamame extract can prevent the thickening of abdominal aorta and foam cell formation. Genistein-rich edamame can prevent foam cells formation better than atorvastatin.

The Efficacy of Genistein-Rich Edamame as a Prevention of Atherosclerotic Lesion in Abdominal Aorta: Study in Rats Model of Atherosclerosis Rizky Aditya Fardhani; Reza Dian Pratama; Nani Maharani; Bahrudin; Yuriz Bakhtiar; M Ali Sobirin; Farmaditya EP Mundhofir
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 10 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i10.414

Background: Atherosclerosis is the main cause of ischemic heart disease which leads to death for people aged more than 40 years old. Genistein is an important isoflavone compound which may protect the blood vessels from endothelial injury. This research is to observe the efficacy of genistein rich edamame as a prevention for atherosclerotic abdominal aortic lesions that seen from abdominal aortic thickness and foam cells count. Method: Thirty rats were divided randomly into five groups and treated for 28 days. The negative control group was given food and drink ad libitum. The positive control group was induced for atherosclerosis using adrenaline 0.006 mg / 200 gr BW injected on the first day and then the next day was given egg yolk 5 gr / 200 gr BW on next day for 28 days. All of the treatment groups were induced for atherosclerosis and treated with genistein-rich edamame extract 5 mg / 200 gr BW, edamame extract 38 mg / 200 gr BW and atorvastatin 1.5 mg / 200 grBW. Data were analyzed using One Way ANOVA - post hoc Bonferroni test, Kruskal Wallis - Mann Whitney test, and Pearson correlation test. Results: There were significant differences (p<0,001) in abdominal aortic thickness and foam cells count between positive control group and treatment genistein-rich edamame extract, edamame extract and atorvastatin. There was a significant correlation between the abdominal aortic wall thickness and foam cells count (correlation coefficient value 0,753; p<0,001). Conclusion: The administration of genistein-rich edamame extract can prevent the thickening of abdominal aorta and foam cell formation. Genistein-rich edamame can prevent foam cells formation better than atorvastatin.

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