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All Journal Medicina Indonesian Journal of Cancer
Ni Wayan Armerinayanti, Ni Wayan
Bagian/SMF Patologi Anatomi, Fakultas Kedokteran Universitas Udayana/ Rumah Sakit Umum Pusat Sanglah Denpasar Bali
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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KEMATIAN JANTUNG MENDADAK PADA WANITA UMUR 37 TAHUN DENGAN MIOKARDIOPATI HIPERTROFIK VAKUOLAR Armerinayanti, Ni Wayan; Sumadi, I Wayan Juli; Mulyadi, Ketut
Medicina Vol 46 No 2 (2015): Mei 2015
Publisher : Medicina

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (209.533 KB)

Abstract

Kematian mendadak pada orang dewasa merupakan dasar masalah melakukan bedah mayat untukmencari penyebab kematian. Kasus seorang wanita umur 37 tahun ditemukan mati di dalamkamarnya, mayat dalam keadaan kaku, terdapat lebam mayat dan resapan darah subkutis kepala.Bedah mayat dilakukan di Rumah Sakit Kupang menemukan paru, otak, hati tidak menunjukkankelainan, sedangkan jantung dengan miokardium ventrikel kiri tebalnya 2 cm. Pada pemeriksaanhistopatologi jantung, sel-sel miokardium membengkak, mengandung vakuola jernih, inti sel terdesakke pinggir, tidak terdapat nekrosis, perdarahan, penebalan dari pembuluh darah, dan infiltrat neutrofil,pada pewarnaan periodic acid schiff menunjukkan hasil yang negatif. Pada pemeriksaan otak tidakdapat dibuktikan adanya penimbunan glikogen pada sel-sel glia. Berdasarkan temuan patologidisimpulkan kelainan tersebut adalah miokardiopati hipertrofik vakuolar tipe kardiak stadium IIIyang mengakibatkan kegagalan jantung atau aritmia sebagai penyebab kematian. [MEDICINA2015;46:135-8].Sudden death of adult people is a basic reason to do the autopsy to define exactly the causa of mortis.A case of a 37 year old woman found dead in her room and her deadly body has already in rigor and livormortis, also with blood spot on subcutaneous part of the head. The autopsy was held in general hospitalof Kupang, and there was no disorders found in the lung, brain, hepar, and the thickness of left myocardiacventrikel of heart is 2 cm. On histologic examination of heart specimen, myocardiac cells were swollen,with clear vacuolar, the nuclei displaced to periphery, there was no necrosis, haemorrhagic, thickeningof vascular, and neutrophil infiltrate. Periodic acid schiff staining has showed negative result. Therewas no evidence of glycogen storage on glial cells in brain examination. Based on pathologic finding weconcluded that the disorder was vacuolar hypertropic cardiomyopathy, cardiac type, stage III causingheart failure or arrhythmias as the causa of mortis. [MEDICINA 2015;46:135-8].
The Correlation of PD-L1 Overexpression With Tumor Budding In Cervical Carcinoma Lestari, Desak Putu Oki; Analysa, Analysa; Armerinayanti, Ni Wayan; Riasa, I Nyoman Putu; Artha, I Gusti Alit
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1103

Abstract

Background: Several studies have proven the relationship between PD-L1, which is known as an immunotherapy target, and poor prognosis. The presence of a tumor budding (TB) group tumor outside the main tumor is also associated with a poor prognosis. The purpose of this study was to determine the relationship between PD-L1 and the grade of TB in cervical carcinoma. Methods: The design of this research is a case-control study with a retrospective approach. The sample is from a paraffin block of the primary cervical cancer tumor from the results of surgery in Balimed Denpasar Hospital between 2020 and 2023. From the statistical formula for the case-control study, a minimum sample of 15 is obtained for the case group with the criteria of high-grade TB, while 15 people were in the control group with low-grade TB. Immunohistochemistry (IHC) PD-L1 is positive if the membrane or cytoplasm is brown, and is negative if there is no brown color on the membrane or cytoplasm. Inferential statistics were used to evaluate the relationship between PD-L1 overexpression and low- and high-grade TB in cervical carcinoma using a chi-square test. Results: The results of this research revealed (p = 0.273) that there was no correlation between PD-L1 expression and high- and low-grade TB. Overexpression of PD-L1 was associated with a 2.250-fold increased risk of high-grade TB (OR = 2.250 with a 95% confidence interval of 0.103–1.915). Conclusions: The severity of TB does not correlate with PD-L1 expression. The functions of PD-L1 and other variables in the carcinogenesis of TB development are the cause of this weak association.
Correlation of Age, Tumor Size, and Histopathological Type with Indicator Tumor Progression of Penile Squamous Cell Carcinoma in Bali Astuti, Ni Luh Putu Vina Juni; Lestari, Desak Putu Oki; Sari, Ni Luh Putu Eka Kartika; Armerinayanti, Ni Wayan; Evayanti, Luh Gde; Perdana, I Gede Sukma Okta
Indonesian Journal of Cancer Vol 19, No 3 (2025): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i3.1340

Abstract

Background: Penile cancer is a rare malignancy globally, but Bali accounts for approximately 40% of Indonesia’s cases. Age, tumor size, and histopathological type are recognized factors influencing penile cancer progression, with grade, depth of invasion, lymph node metastasis, and distant metastasis serving as key indicators. However, the prognostic value of these factors, particularly depth of invasion, remains debated. This study aimed to evaluate the correlation between age, tumor size, and histopathological type with indicators of tumor progression in penile squamous cell carcinoma (SCC) in Bali.Method: A cross-sectional analytical study was conducted on 160 cases of penile SCC. Dependent variables included tumor grade, depth of invasion, and lymph node metastasis, while independent variables were age, tumor size, and HPV status (inferred from histopathology). Age was categorized as 60 or ≥60 years, tumor size as 4 cm or ≥4 cm, and depth of invasion as T1–T4. Multivariate analysis using the chi-square test was performed to assess associations.Results:  Most patients were aged ≥ 60 years, had HPV-independent SCC, tumor size ≥ 4 cm, grade 2 tumors, and T1 depth of invasion, with lymph node metastasis observed in a minority. Multivariate analysis revealed significant correlations between age, tumor size, and histopathological type with grade (p = 0.026, R² = 0.056), depth of invasion (p 0.001, R² = 0.445), and lymph node metastasis (p = 0.004, R² = 0.075). Tumor size demonstrated the strongest association with depth of invasion (OR = 9.618, p 0.001) and lymph node metastasis (OR = 6.846, p 0.001).Conclusion: Tumor size is a significant predictor of both depth of invasion and lymph node metastasis in penile SCC. Clinical assessment of tumor size should be emphasized as a key prognostic factor to guide early intervention strategies in patients with penile SCC in Bali.
Correlations of Protein 53 (p53) Expression with the Degree of Tumor Budding in Cervical Carcinoma Wardana, Ni Komang Sara Kusuma; Armerinayanti, Ni Wayan; Cahyawati, Putu Nita
Indonesian Journal of Cancer Vol 19, No 3 (2025): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i3.1270

Abstract

Background: Cervical carcinoma is a malignant tumor that is most often found in the female reproductive system. Persistent Human Papillomavirus (HPV) infection is the most important factor in the development of cervical carcinoma. The E6 and E7 oncoproteins in HPV inhibit the action of p53. As a result, p53 transcription and the apoptosis process are inhibited. Tumor budding has been extensively studied and established as a significant prognostic factor. This study aims to determine the relationship between p53 expression and the degree of tumor budding of cervical carcinoma.Method: This cross-sectional study used 50 paraffin blocks and secondary data from patients diagnosed with cervical carcinoma stored at BaliMed Denpasar Hospital. Paraffin blocks were then subjected to immunohistochemical examination to evaluate p53 expression and HE examination to evaluate the degree of tumor budding. Data analysis was performed using the Spearman test and linear regression test with the SPSS 25 software program. Results: The results showed that thirty-two subjects had low expression of p53, and 62,5% of them had high-grade tumor budding. The p53 expression is lower in cervical cancer with highgrade tumor budding compared with low-grade tumor budding (rs = -0.33). There are significant correlations between p53 expression and the degree of tumor budding in patients with cervical carcinoma (p = 0.018). A total of 50 samples that met the inclusion and exclusion criteria were analyzed. The majority of patients were aged ≤ 50 years (58%) and had squamous cell carcinoma (90%) in the early stage (92%). Low p53 expression was found in 64% of samples. A significant negative correlation was found between p53 expression and tumor budding grade (p = 0.018; r = -0.333), which remained significant in multivariate analysis (p = 0.024; r² = -0.328), indicating that low p53 expression is associated with high-grade tumor budding. Conclusion: The p53 expression was significantly downregulated in cervical carcinoma with highgrade tumor budding. These findings indicate that tumor budding can be considered as a prognostic marker, but further research that sorts HPV dependent and HPV independent cervical carcinomas is needed.
Co-Authors Analysa, Analysa Artha, I Gusti Alit Astuti, Ni Luh Putu Vina Juni Cahyawati, Putu Nita Desak Putu Oki Lestari I Wayan Juli Sumadi Ketut Mulyadi Luh Gde Evayanti Perdana, I Gede Sukma Okta Riasa, I Nyoman Putu Sari, Ni Luh Putu Eka Kartika Wardana, Ni Komang Sara Kusuma