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All Journal TRANSIENT: Jurnal Ilmiah Teknik Elektro Majalah Obat Tradisional SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Kesehatan Jurnal Ilmu dan Teknologi Kesehatan Journal of Indonesian Medical Laboratory and Science (JoIMedLabS) Jurnal Farmasi Sains dan Praktis JMLS: Journal of Medical Laboratory and Science Jurnal Kesehatan Farmasi Karimah Tauhid Jurnal Ilmiah Research Student Jurnal Archipelago Jurnal Sains Bangunan Jurnal Wicara Desa
Muhammad Rizki Kurniawan, Muhammad Rizki
Jurusan Teknik Elektro, Fakultas Teknik, Universitas Diponegoro Jl. Prof. Sudharto, Tembalang, Semarang, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Transportation Other

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Journal : Jurnal Farmasi Sains dan Praktis

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POTENTIAL INHIBITION OF AKT1 AND P53 PROTEIN IN COLON CANCER BY GALLIC ACID DERIVATIVES COMPOUND WITH MOLECULAR DOCKING APPROACH Humaedi, Aji; Kurniawan, Muhammad Rizki; Halimatushadyah, Ernie
Jurnal Farmasi Sains dan Praktis Vol 10 No 2 (May-August 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i2.10390

Abstract

Colon cancer is a degenerative disease that attacks the large intestine through a process of initiation, promotion and progression. Related research reports that overexpression of the AKT1 protein was found to be 60-70% and p53 at 50%. This research analyses the affinity, stability and interaction of gallic acid derivative compounds and reference ligands with the target proteins AKT1 and p53 by molecular docking. The study stages carried out include preparation and optimisation of target proteins and ligand compounds, file creation and simulation processes, and analysis and visualisation of docking results. The docking simulation results show that four gallic acid derivative compounds provide potential inhibitory activity against the AKT1 and p53 proteins based on binding energy values. BG and 2HBG compounds have strong inhibitory power against target proteins, thus enabling the formation of strong interactions and complexity towards the active site of amino acids with a bond distance of <3.0 Å. Thus, gallic acid derivative compounds have potential as inhibitors and are expected to activate other proteins, causing cancer cell apoptosis.
Co-Authors Abdul Rohman Aturut Yansen Bambang Agus Herlambang, Bambang Bambang Winardi Budiman, Waras Dewi, Almatin Puspa Edi Pramono Fauziah, Siti Nur Halimatushadyah, Ernie Hermawan Hermawan Heru Sasongko Humaedi, Aji Jayadi, M. Nazir Ihsani Khairani, Nanda Rizki KHOIRUL ANAM Kumalasari, Erina Dwi Mokodongan, Renny Septiani Nirwana, Rima Nisa’, Isna Masruratun Novan Adi Setyawan Novary, Tutur Anugerah Permatasari, Rizky Indah Pitaloka, Nirwana Asri Diah Pratomo, Sunu Arsy Rahmi, Erika Rohmah, Isna Lailatur Royani, Bq. Sifa Saputri, Annisa Juniar Sihotang, Sudiman Siti Munawaroh Syahwidad, Nur Udrayani, Ni Luh Ayu Sri Wardani, Regina Putri Wa’addulloh, Mu’izzaddin Yustisio, Muhammad Desto