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All Journal AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Narra J Cermin Dunia Kedokteran Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Journal of Medical Science; Jurnal Ilmu Medis Rumah Sakit Umum Daerah dr. Zainoel Abidin, Banda Aceh The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Narra X
Hendra Zufry, Hendra
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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Knowledge Enhancement: Peran Edukasi Perawat Tentang Terapi Insulin Terhadap Kepatuhan Menggunakan Insulin pada Pasien Diabetes Melitus Rawat Inap Firdausa, Sarah; Zufry, Hendra; Sukri Ekadamayanti, Agustia; Suhanda, Rachmad; Wardhana Sucipto, Krishna
Journal of Medical Science Vol 4 No 2 (2023): Journal of Medical Science
Publisher : LITBANG RSUDZA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55572/jms.v4i2.76

Abstract

Penanganan diabetes di ruang rawat inap lebih kompleks dan intensif dibanding rawat jalan. Kebanyakan pasien rawat inap menggunakan terapi insulin. Perawat ruangan adalah tenaga kesehatan garda depan yang intensif berhadapan dengan pasien sehingga sangat potensial menjadi edukator dalam maintenance terapi insulin. Penelitian ini bertujuan meningkatkan kapasitas pengetahuan dan keterampilan perawat serta mengevaluasi kepatuhan pasien diabetes menggunakan insulin setelah keluar dari rawat inap. Pengetahuan perawat dievaluasi melalui kuesioner sebelum intervensi knowledge enhancement berupa workshop insulin. Pengumpulan sampel penelitian cross sectional ini secara total sampling yaitu seluruh perawat ruang rawat inap non akut di RSUDZA selama Agustus−September 2022. Objek penelitian adalah pasien diabetes yang menggunakan insulin selama perawatan di rumah sakit.  Data karakteristik responden, pengetahuan, asuhan keperawatan dan kepatuhan pasien ditampilkan secara deskriptif, untuk menilai kepatuhan pasien sebelum dan sesudah intervensi digunakan analisis independent t-test. Jumlah responden yang berpartisipasi 354 orang, 50,8% memiliki tingkat pengetahuan baik, namun hanya 29,7% berketerampilan baik dalam hal injeksi insulin. Berdasaran hasil asesmen tersebut, dilakukan workshop insulin untuk menjawab gap pengetahuan dan keterampilan. Kepatuhan pasien diukur sebelum dan sesudah workshop. Pasien dengan kepatuhan tinggi sebanyak 44,4% sebelum intervesi dan 40% sesudah intervensi, sedangkan pasien dengan tingkat kepatuhan rendah berkisar di atas 20% baik sebelum maupun sesudah intervensi. Studi ini menyimpulkan bahwa knowledge enhancement terhadap perawat ruang inap tidak berpengaruh terhadap kepatuhan pasien menggunakan insulin. Hal ini mungkin disebabkan peningkatan kapasitas perawat tentang injeksi insulin tidak menjamin terjadinya peningkatan edukasi perawat terhadap pasien, dan belum membudayanya edukasi terapi insulin yang komprehensif terhadap pasien yang dirawat inap.
Targeting phosphoglycerate dehydrogenase enzyme using ginger compounds to suppress thyroid cancer progression Rahman, Faris I.; Zulfa, Putri O.; Beočanin, Anđelija; Faisal, Ibraheem M.; Louca, Nicolas; Carstoiu, Maria I.; Zufry, Hendra
Narra X Vol. 2 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v2i1.112

Abstract

Recent studies have recognized the potential of inhibiting phosphoglycerate dehydrogenase (PHGDH) enzyme as a therapeutic strategy for treating papillary thyroid cancer. However, research on the efficacy of herbal compounds in inhibiting the PHGDH enzyme that have been reported to possess anticancer activities, including those found in ginger (Zingiber officinale), remains limited. The aim of this study was to examine the potential of ginger compounds in inhibiting PHGDH enzyme and to identify its potential use in the treatment of papillary thyroid cancer. The study employed computational methods to identify ginger-derived compounds that inhibit the PHGDH and impede papillary thyroid cancer progression. Crystallized protein structures were obtained from the Protein Data Bank, and Discovery Studio software was utilized to remove water molecules, double chains, and ligands. The receptor was modified by adding polar hydrogen, and AutodockTools4 software was employed to establish an accurate binding site based on the position of the previous ligand. Molecular docking experiments were conducted with 125 ginger-derived phytochemicals retrieved from the PubChem database. The results revealed nine active compounds found in ginger (galanolactone, myricetin, quercetin, cyanin, kaempferol, chlorogenic acid, delphinidin, alpha-cadinol, and curcumin) with strong binding affinities to PHGDH (minimum score threshold <-7 kcal/mol), indicating their potential for drug development. Galanolactone, myricetin, and quercetin were the top three compounds with the strongest binding affinity (-8.2, -7.9, and -7.9 kcal/mol, respectively), involving multiple bonds in the ligand-protein complex interaction. Notably, myricetin and quercetin formed three hydrogen bonds each, contributing to strong and stable bonds with the pocket region of PHGDH. In conclusion, ginger-derived compounds show promise in inhibiting PHGDH for the treatment of papillary thyroid cancer. However, further research is needed to validate the efficacy of these compounds and their interactions with the PHGDH in the context of thyroid cancer therapy.
A Rare Case Of Acute Pancreatitis Cause by Newly Diagnosed Graves’ Disease: A Successful Therapeutic Option Abubakar, Azzaki; Yusuf, Fauzi; Maghfirah, Desi; Gunawan, Andrie; Zufry, Hendra; Edward, Meutia Nailan; Ho, Khek Yu
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, August, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025195-200

Abstract

Acute pancreatitis is a frequent disorder whose severity level varies from mild to life-threatening. This condition is characterized by abrupt inflammation of the pancreas. A 53-year-old male was having upper right abdominal pain and epigastric pain which began four hours after hospitalization. This case highlights the complexities of managing acute pancreatitis in a patient with Graves' disease, where hyperthyroidism may worsen pancreatitis and vice versa. Graves' disease is an autoimmune disorder causing hyperthyroidism, which can complicate pancreatitis management, particularly when treated with methimazole, which has been associated with acute pancreatitis. This case suggests a potential link between untreated Graves' disease and idiopathic acute pancreatitis. In patients presenting with unexplained pancreatitis, evaluation for hyperthyroidism may be warranted. The novelty of this case lies in the exclusion of all conventional etiologies and the possible role of autoimmune thyroid disease in pancreatic inflammation.
Efikasi Penambahan Insulin Basal Kerja Panjang Pada Insulin Kerja Cepat Intravena Dalam Tatalaksana Krisis Hiperglikemia Zufry, Hendra; Krishna W. Sucipto; Agustia Sukri Ekadamayanti1
Journal of Medical Science Vol 7 No 1 (2026): Journal of Medical Science
Publisher : LITBANG RSUDZA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55572/jms.v7i1.263

Abstract

Abstrak   Krisis hiperglikemia merupakan komplikasi akut diabetes melitus yang dapat mengancam jiwa dan memerlukan terapi insulin intensif. Terapi standar dengan insulin kerja cepat intravena efektif menurunkan kadar glukosa darah, tetapi sering diikuti oleh rebound hiperglikemia dan fluktuasi kadar glukosa setelah penghentian infus. Penambahan insulin basal kerja panjang terbukti membantu mempertahankan kestabilan glukosa selama masa transisi terapi. Penelitian ini bertujuan untuk menilai efikasi penambahan insulin basal kerja panjang terhadap insulin kerja cepat intravena dalam memperbaiki resolusi glikemik dan menurunkan komplikasi metabolik pada pasien dengan krisis hiperglikemia. Penelitian eksperimental dengan rancangan quasi-experimental ini melibatkan 80 pasien krisis hiperglikemia yang dirawat di RSUD dr. Zainoel Abidin, Aceh, Indonesia. Subjek dibagi menjadi dua kelompok: kelompok kombinasi yang menerima insulin basal kerja panjang bersama insulin kerja cepat intravena, dan kelompok kontrol yang hanya menerima insulin kerja cepat intravena. Parameter yang dievaluasi meliputi durasi hiperglikemia, kebutuhan total insulin, kejadian rebound hiperglikemia, episode hipoglikemia, lama rawatan, dan mortalitas. Kelompok kombinasi menunjukkan waktu resolusi hiperglikemia yang lebih singkat dibanding kelompok kontrol (47,0 ± 26,0 jam vs 79,35 ± 30,64 jam; p < 0,001) serta insiden rebound hiperglikemia yang lebih rendah (7,5% vs 22,5%; p = 0,04). Tidak terdapat perbedaan bermakna pada kebutuhan total insulin (p = 0,19), episode hipoglikemia (p = 0,40), lama rawatan (p = 0,28), maupun mortalitas (p = 0,65). Penambahan insulin basal kerja panjang pada terapi insulin kerja cepat intravena secara signifikan mempercepat pencapaian kontrol glikemik dan menurunkan kejadian rebound hiperglikemia tanpa meningkatkan risiko hipoglikemia atau mortalitas. Hasil penelitian ini menunjukkan bahwa tujuan penelitian, yaitu meningkatkan kestabilan glikemik pada krisis hiperglikemia, telah tercapai dengan baik.                 Kata Kunci: Krisis hiperglikemia, insulin basal kerja panjang, insulin kerja cepat intravena, kontrol glikemik, rebound hiperglikemia.   Abstract   A hyperglycemic crisis is an acute, life-threatening complication of diabetes mellitus requiring intensive insulin therapy. Standard treatment with intravenous rapid-acting insulin effectively lowers glucose levels, but is often followed by rebound hyperglycemia and glucose fluctuations after infusion cessation. The addition of long-acting basal insulin may help maintain glycemic stability during the transition period. This study aims to evaluate the efficacy of adding long-acting basal insulin to intravenous rapid-acting insulin in improving glycemic resolution and reducing metabolic complications in patients with hyperglycemic crisis. This quasi-experimental study enrolled 80 patients with hyperglycemic crisis at Dr. Zainoel Abidin General Hospital, Aceh, Indonesia. Subjects were allocated into two groups: one group received a combined regimen of long-acting basal insulin and intravenous rapid-acting insulin. In contrast, the other group received intravenous rapid-acting insulin alone. Measured outcomes included duration of hyperglycemia, total insulin requirement, incidence of rebound hyperglycemia, hypoglycemic episodes, length of hospital stay, and mortality. The combination group achieved a significantly shorter duration of hyperglycemia compared to the control group (47.0 ± 26.0 h vs. 79.35 ± 30.64 h; p < 0.001) and a lower incidence of rebound hyperglycemia (7.5% vs. 22.5%; p = 0.04). There were no significant differences in total insulin requirement (p = 0.19), hypoglycemic episodes (p = 0.40), length of stay (p = 0.28), or mortality (p = 0.65). Adding long-acting basal insulin to intravenous rapid-acting insulin significantly accelerates glycemic resolution and reduces rebound hyperglycemia without elevating the risk of hypoglycemia or mortality. The study demonstrates that achieving the research objective improving glycemic stability in hyperglycemic crisis was successful.   Keywords: Hyperglycemic crisis, basal insulin, intravenous rapid-acting insulin, glycemic control, rebound hyperglycemia.  
Co-Authors -, Jamhur Agustia Sukri Ekadamayanti1 Azzaki Abubakar, Azzaki Benalcazar, Andrés MMB. Beočanin, Anđelija Burhan, Henry W. Carstoiu, Maria I. Edward, Meutia Nailan Ekadamayanti, Agustia S. Ekadamayanti, Agustia Sukri Faisal, Ibraheem M. Fajar, Jonny Karunia Fauzi Yusuf, Fauzi FIRDAUSA, SARAH Gunawan, Andrie Hidayah, Cut Intan Ho, Khek Yu Iqhrammullah, Muhammad Kamarlis, Reno K. Krishna W. Sucipto Lia Meuthia Zaini, Lia Meuthia Louca, Nicolas Maghfirah, Desi Maulina Debbyousha N. Nazaruddin Pratama, Sergio Rachmad Suhanda Rahman, Faris I. Sari , Julia Sucipto, Krishna W. Sucipto, Krishna Wardhana Sukri Ekadamayanti, Agustia Wardhana Sucipto, Krishna Zulfa, Putri O.