Article Per Year (5 Year)
p-Index From 2021 - 2026
0.61
P-Index
This Author published in this journals
All Journal Jurnal Ilmiah Farmasi e-Journal Pustaka Kesehatan STOMATOGNATIC- Jurnal Kedokteran Gigi UNEJ e-Proceeding Journal of Islamic Pharmacy Jurnal Ilmu Kefarmasian Indonesia Farmasis: Jurnal Sains Farmasi Pharmaceutical Sciences and Research (PSR)
Fransiska Maria Christianty
Fakultas Farmasi, Universitas Jember
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Public Health

Published : 14 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : UNEJ e-Proceeding

 1 
IN VITRO ALFA-GLUCOSIDASE INHIBITORY ACTIVITY OF VARIOUS TEA (Camellia sinensis L.) EXTRACTS Fransiska Maria Christianty; Diana Holidah; Yasmin Yasmin
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes mellitus is a group of metabolicdiseases characterized by hyperglycemia [1]. DM isclassified based on the pathogenic process that leadsto hyperglycemia as opposed to earlier criteria suchas age of onset or type of therapy. There are twobroad categories of DM, designated type 1 and type2 [2]. There were 10 million cases of diabetes inIndonesia in 2015. The number of these cases ispredicted to continue rising [3].Therapeutic approaches for the treatment oftype 2 diabetes, such as diet, sulphonylurea,metformin and insulin therapy, are all successful indecreasing fasting glucose levels. The importance ofpostprandial hyperglycaemia has led to thedevelopment of new agents to control this importantaspect of diabetes.Thus, α-glucosidase enzyme hasbecome one of important target in the treatment oftype-2 diabetes [4,5].α-glucosidase inhibition will slow thedigestion of carbohydrate and absorbtion ofmonosaccahrides in the proximal jejenum [6].Acarbose is an oligosaccharide which reversiblyinhibits intestinal α-glucosidase enzymes responsiblefor digestion of complex carbohydrates anddisaccharides to absorbable monosaccharides [7].The most common adverse effect of acarbose isabdominal discomfort associated with flatulence anddiarrhoea [8]. The undesirable side effects that existunderlie the emergence of research for alternativetherapy of type 2 diabetes, particularly through themechanism of inhibition enzyme α-glucosidase.Tea (Camellia sinensis L.) is annual plant thatwidely spread in Southest Asia, India, South China,Northwest Laos, Thailand and Burma. Tea is one ofthe most popular beverages consumed worldwide[9]. Various studies have reported beneficial effectof tea extract, including for diabetes mellitustherapy. Previous studies showed that tea extracthave antidiabetic activity in mice induced bystreptozotocin [10]. Antidiabetic activity of teaextract have been reported by Yang and Koh. Theresults showed that black tea extract had higheractivity to inhibit α-glucosidase than green teaextract. The present study was designed to comparein vitro α-glucosidase inhibitory activity of varioustea extracts, such as black tea, green tea, oolong tea,and white tea.
GREEN TEA EXTRACT EFFECT ON BLOOD GLUCOSE LEVEL AND LIVER HISTOPATHOLOGY IN DIABETIC MICE Diana Holidah; Fransiska Maria Christianty; Wilda Zidni Ilma
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes mellitus is a disorder of hyperglycemia andglucose intolerance due to insulin deficiency,impaired of insulin receptor or both (Unwin et al.,2009). There are generally two types of diabetes aretype 1 diabetes (pancreatic beta cell damage causedabsolute insulin deficiency) and type 2 (acombination of a lack of insulin production andsecretion and sensitivity to insulin receptor) (Dipiroet al, 2008).Diabetes mellitus disease is increasing rapidly inworlwide. The incidences in 2010 were about 285million people and It has been estimated that by theyear 2025, the global incidence of diabetes wouldincrease to 350 million (International diabetesfederation, 2006).In diabetes, activation of hepatic gluconeogenesisenzymes can increase glucose production and thuscontribute to increase blood glucose which coulddeteriorate diabetes (Sundaram et al., 2013). Thestate of diabetes characterized by decreased insulinsensitivity is the major cause of NAFLD (Non -Alcoholic Fatty Liver Disease), because in diabetesstate occurs disorders of glucose metabolism and fatso that could result in fibrosis, infiltration,necroinflamation, to acute liver disease (Marchesiniet al., 2001).Treatment of diabetes mellitus is chronic and longlife, causing undesirable side effects (Unwin et al.,2009). Metformin is an oral hypoglycemic agent,which belongs to the class known as the biguanides.Metformin is now widely used as one of themainstays in the management of type 2 diabetes.Metformin reduces fasting plasma glucoseconcentration by reducing rate of hepatic glucoseproduction via gluconeogenesis and glycogenolysis.Metformin improves glycemic control asmonotherapy and in combination with other oralantidiabetic agents, such as sulfonylureas andthiazolidinediones (Frendell et al. 2003).Several plant extracts are known to have antidiabeticproperties and a large number of compounds fromplant extracts have been reported to have beneficialeffects for treatment of diabetes mellitus (Anhauser,2003). Tea (Camellia sinensis L.) is one of plant thatcan decrease blood glucose. Green tea is producedby enzymatic inactivation of the leaves of Camelliasinensis followed by rolling or comminution anddrying. In the manufacturer of green tea, theenzymatic inactivation achieved by steam or panfiring treatment to preserve natural polyphenolswith respect to the health promoting properties.Green tea derived products are mainly extracts ofgreen tea in liquid or powder form varying in theproportion of polyphenols (45-90%) and caffeinecontent (0.4-10%). The polyphenolic fraction ofgreen tea, has been reported to have multiplepharmacological actions (Sano et al., 1995).Green tea is an excellent source of polyphenolantioxidants, known as green tea catechins. Theimportant catechins of green tea are epicatechin(EC), epicatechin-3-gallate (ECG), epigallocatechin(EGC) and epigallocatechin-3-gallate (EGCG). Thepolyphenolic fractions of green tea have beenreported to have multiple pharmacological actions.They exhibit potent antioxidant activity in vitro andin vivo. Epidemiologic observation and laboratorystudies have indicated that polyphenolic compoundspresent in the tea may reduce the risk of a variety ofillnesses, including cancer and coronary heartdisease (McKay and Blumberg 2002).Some studies suggest that green tea extract loweredcholesterol levels and blood glucose on mice and rat(Yang et al., 2001). Green tea extract at dose of300mg /kg /day can lower blood glucose in diabeticrats and was also able to reduce the lipids in heartdefects (Babu et al., 2006). Blood glucose loweringactivity of green tea was greater and totalpolyphenol content was higher when compared withblack tea and oolong tea (Holidah et al., 2015).
Co-Authors Andrean Roni Antonius Nugraha Widhi Pratama Antonius Nugraha Widhi Pratama Aryani, Dhita Evi Dhea Nanda Aliefia Dhita Evi Aryani Diana Holidah Ema Rachmawati Ema Rachmawati Fifteen Aprila Fajrin Fifteen Aprilia Fajrin Gati Dwi Sulistyaningrum Gustia Alinda Lintarsari Hakimah, Farda Husnun, Khoiriyah Haifa Ika Norcahyanti Imam Susilo Irvina Anggita Baharini Junaidi Khotib Lina Winarti Machlaurin, Afifah Monica Cinuradha Aura Salsabina Nanda Puspasari Sinta Rachmawati Suharjono, Suharjono, Suharjono Wilda Zidni Ilma Yasmin Yasmin Yasmin Yasmin