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ANALISIS HUBUNGAN KETEPATAN PENGGUNAAN ANTIBIOTIK TERHADAP LAMA RAWAT PADA PASIEN COMMUNITY ACQUIRED PNEUMONIA (CAP) DI INSTALASI RAWAT INAP RUMAH SAKIT ANNA MEDIKA PERIODE 2020 Feri Setiadi; Sharfina Maulidayanti; Nuzul Gyanata Adiwisastra; Devi Naibaho
Jurnal Farmamedika (Pharmamedika Journal) Vol 7 No 2 (2022): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v7i2.141

CAP Community-acquired pneumonia merupakan pneumonia yang menginfeksi pasien di luar rumah sakit atau pada komunitas. Pneumonia adalah adanya inflamasi, pembengkakan atau peradangan pada jaringan parenkim paru yang biasanya dikaitkan dengan pengisian alveoli dengan cairan yang disebabkan oleh mikroorganisme yaitu bakteri, virus, jamur dan parasit Penelitian ini bertujuan untuk mengetahui hubunganketepatan antibiotik terhadap lama rawat pasien Community Acquired Pneumonia (CAP) di instalasi rawat inap Rumah Sakit Anna Medika periode 2020. Penelitian ini merupakan penelitian non-eksperimental secara cross sectional, dan pengambilan data dilakukansecara retrospektif yang berdasarkan catatan data rekam medis. Data yang diperoleh dari rekam medis pasien sebanyak 155 pasien. Hasil penelitian yang dihasilkan bahwa angka kejadian (CAP) terbanyak pada jenis kelamin laki- laki 59,3% dan pada usia 18-60 tahun 74,1%. Golongan antibiotik tunggal yang paling banyak digunakan adalah golongan fluoroquinolon yaitu levofloksasin 33.3 % dan kombinasi levofloksasin dengan seftriaxon 5.6 % Pada penelitian ini didapat penggunaan antibiotik yang tepat sebanyak 46 pasien 85,2%, dan 8 pasien 14,8% penggunaan antibiotik yang tidak tepat, lama rawat pasian 1-7 hari 92.5 % > 7 hari 7.5 %. Berdasarkan dari ketepatan penggunaan antibiotik dari kriteria 4T yaitu, Tepat Pasien 100%, Tepat Obat 100%, Tepat Dosis 85, 2% dan Tepat Indikasi 100%. Hasil dari hubungan antara ketepatan penggunaan antibiotik dengan lama rawat pasien nilai p = 0,008, OR = 0,037, CI = 0,003-0,427. Dengan demikian, terdapat hubungan antara ketepatan penggunaan antibiotik dengan lama rawat pasien.

Tyrosinase Inhibitory of Silver Nanoparticles Synthesized using Morus Nigra Leaves Extract Tunas Alam; Ricky Ardiansyah; Sharfina Maulidayanti; Deva Azvara; Frida Octavia Purnomo; Dicky Annas
Jurnal Kimia Sains dan Aplikasi Vol 26, No 3 (2023): Volume 26 Issue 3 Year 2023
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.26.3.85-90

A novel preparation of silver nanoparticles using Morus nigra leaves extract, as opposed to the physical and chemical methods had been used in this work. Their active phytochemical compounds will reduce Ag+ and form AgNPs (Ag0). A peak spectrum at 460 nm was formed and confirmed as the Surface Plasmon Resonance (SPR). Vibration at 1643 cm-1 and 3286 cm-1 which characteristic of C=C bonds and (-OH) hydroxyl groups, respectively. An X-ray diffraction (XRD) examination of silver with good crystallinity revealed its distinctive pattern. According to the results of transmission electron microscopy (TEM), the produced AgNPs-Morus nigra leaves extract were between 10 and 20 nm in size. Using L-dihydroxyphenylalanine (L-DOPA) as the substrate, the synthesized AgNPs-Morus nigra were tested for their tyrosinase inhibitory activity, and the results are substantial when compared to kojic acid as a control. The percentages of inhibition from crude extract, AgNPs, and kojic acid at 100 µg/mL are to be found at 12.10 %, 64.80 %, and 59.84 %, respectively. Based on the results of this work, AgNPs can be produced by utilizing a green synthesis method with leaves extract, making them a promising candidate for use in medicine and cosmetics.

Aktivitas Antijamur Ekstrak Biji Kopi Hijau Robusta (Coffea canephora) Terhadap Candida albicans. Ing Mayfa Br Situmorang; Putri Salsadila; Sharfina Maulidayanti; Asbar Tanjung
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 6, No 2 (2024)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.39149

Acne is a disease that can be caused by bacteria, one of which is Staphylococcus epidermidis. Acne can be treated with active compounds derived from natural ingredients such as cucumbers and tomatoes. Gel masks peel off. This study aims to determine the average diameter of the inhibition zone, the difference in the average diameter of the inhibition zone, and the antibacterial activity of the peel-off from a mixture of cucumber (Cucumis sativus) and tomato (Solanum lycopersicum) with a concentration of 5%, 10 %, 15%, 20% against Staphylococcus epidermidis. This experimental study uses a Completely Randomized Design (CRD) consisting of one factor and 6 levels. The results showed that the average diameter of the inhibition zone of the anti-acne peel-off gel mask preparation of cucumber and tomato extracts against Staphylococcus epidermidis at a concentration of 5%, 10%, 15% and 20% were 16.38 mm, respectively. ; 24.88 mm; 29.88 mm and 34.88 mm. There was a significant difference in the average diameter of the inhibition zone of the peel off mixture of cucumber and tomato extracts with a concentration of 5%, 10%, 15%, and 20%; against Staphylococcus epidermidis. gel mask preparation peels off from a mixture of cucumber and tomato extracts against Staphylococcus epidermidis at a concentration of 5%, 10% concentration, 15% concentration and 20% concentration, namely strong, very strong, very strong and very strong. Keywords: staphylococcus epidermidis, gel mask peel-off, cucumber, tomato

Analysis of Serum Creatinine Levels, Blood Pressure and Grade of Hypertension of Chronic Disease Management Program Participants Tanjung, Asbar; Nurhidayah, Ika; Maulidayanti, Sharfina; Br Situmorang, Ing Mayfa
Medical Laboratory Technology Journal Vol. 10 No. 2 (2024): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v10i2.619

Indonesia is one of the countries with the highest number of cases of hypertension in the world; the predominant patient is the elderly. In some patients with hypertension, increased blood pressure causes impaired salt and creatinine excretion, resulting in poor kidney function. A chronic disease management program is a health care system with a proactive-integrative approach to prevent further complications. The research objective is to analyze serum creatinine levels, blood pressure, and hypertension grade and determine the relationship between serum creatinine and blood pressure in chronic disease management program participants. The study subjects, 73 participants with hypertension, were obtained by purposive sampling. Patient data and hypertension grade were obtained from medical records; an auto chemistry analyzer analyzed serum creatinine. Data were analyzed using the Pearson correlation test using SPSS. Participants with hypertension fall into the elderly age (60-69 years), totalling 31 (42%); pre-elderly age (45–59 years) includes 28 (38%); and high-risk elderly age (>70 years) includes 14 (19%). Most of the participants (40 participants) fell into hypertension stage II, followed by hypertension stage I (25 participants), and only 8 participants fell into the elevated category. The mean serum creatinine of participants with Elevated blood pressure criteria was 0.89±0.178, Hypertension grade I 0.91±0.322, and hypertension grade II 0.99±0.269, illustrating a trend of increasing serum creatinine levels due to higher blood pressure criteria. Pearson correlation test shows a significant correlation between both systolic blood pressure with serum creatinine levels (p<0.05, r=0.2) and diastolic blood pressure with serum creatinine levels (p=0.007, r=0.342). There was a trend of increasing serum creatinine levels corresponding to the hypertension grade in participants. Blood pressure was significantly correlated with serum creatinine, clearly confirming that an increase in blood pressure may followed by an increase in serum creatinine.

Kajian Durasi Pengobatan dan Dampaknya terhadap Anemia serta Profil Hematologi pada Penderita Kusta Multibasiler: Penelitian Ladyka Viola Aulia Armawan; Noni Farah; Sharfina Maulidayanti; Asbar Tanjung
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 4 No. 1 (2025): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 4 Nomor 1 (Juli 2025 -
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v4i1.2590

Kusta multibasiler (MB) merupakan bentuk kusta yang paling menular dan sering disertai komplikasi sistemik seperti anemia. Penelitian ini bertujuan untuk menganalisis hubungan antara durasi pengobatan Multi Drug Therapy (MDT) dengan kejadian anemia serta mengevaluasi profil hematologi pasien kusta MB di Kabupaten Bekasi. Penelitian ini merupakan studi kuantitatif dengan desain potong lintang yang dilakukan pada April–Juni 2024 di empat puskesmas. Seluruh pasien kusta MB yang memenuhi kriteria inklusi (n=30) dijadikan sampel dengan teknik total sampling. Pemeriksaan hematologi menggunakan alat Hematology Analyzer dan data dianalisis secara univariat dan bivariat. Hasil menunjukkan bahwa 60% responden mengalami anemia, dengan mayoritas dalam kategori ringan (50%). Rata-rata kadar hemoglobin adalah 11,64 g/dL dan nilai minimum mencapai 3,8 g/dL. Namun, uji statistik tidak menunjukkan hubungan bermakna antara lama terapi dan kejadian anemia (p=1,000). Hasil menunjukkan bahwa meskipun anemia sering terjadi pada pasien kusta MB, durasi terapi tidak berpengaruh signifikan. Faktor lain seperti efek samping obat, status gizi, komorbiditas, dan inflamasi kronis diduga turut berkontribusi. Pemantauan hematologi rutin penting untuk deteksi dan penanganan anemia selama terapi MDT.

Evaluation of mangosteen peel extract in the kato-katz technique for enhanced visualization of helminth eggs Tanjung, Asbar; Maulidayanti, Sharfina; Br Situmorang, Ing Mayfa
Journal of Indonesian Medical Laboratory and Science Vol 6 No 2: Oktober 2025
Publisher : Asosiasi Institusi Pendidikan Tinggi Teknologi Laboratorium Medik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53699/joimedlabs.v6i2.299

Background: Mangosteen rind (Garcinia mangostana) contains anthocyanins, which have potential as natural dyes. One promising application is as a substitute for malachite green in the Kato-Katz technique, a fecal examination method used to detect helminth eggs such as Ascaris lumbricoides. Objectives: To evaluate the effectiveness of mangosteen peel extract at various concentrations (25%, 50%, 75%, and 100%) as an alternative staining agent in the Kato-Katz method. Materials and Methods: This laboratory-based experimental study utilized fecal samples positive for A. lumbricoides, which were examined using the Kato-Katz method with selophane tape soaked in mangosteen rind extract. Observed parameters included egg count per gram of feces (epg), clarity of egg morphology, and background contrast under the microscope. Results: The 75% concentration yielded the best performance, with optimal background staining, clear egg morphology, and the highest average egg count (853 eggs per gram). Concentrations of 25%, 50%, and 100% showed lower effectiveness. Conclusions: A 75% concentration of mangosteen rind extract is effective as a natural dye substitute for malachite green in the Kato-Katz method, providing good visual contrast and supporting accurate identification of helminth eggs

"Inhibitory Activity Test of White Turmeric (Curcuma zedoaria) Extract Against Escherichia coli Bacteria" maulidayanti, sharfina; Nafis, Nidhal Mijwan; Situmorang, Ing Mayfa Br; Armawan, Ladyka Viola Aulia
HEALTH SCIENCE & BIOMEDICAL JOURNAL Vol. 1 No. 2 (2025): August 2025 : Health Science & Biomedical Journal (HSBJ)
Publisher : Literasi Indonesia Emas (PT)

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Introduction: Escherichia coli bacteria are microorganisms that are usually found in the digestive tract in both animals and humans. Belonging to the Enterobacteriaceae family, E. coli has a cell size of between 2.0 to 6.0 micrometers by a diameter of 1.1 to 1.5 micrometers. These bacteria are straight rods and They can be found in singular, paired, or in short chains. E. Objective: This study aims to evaluate the inhibition of white turmeric extract (Curcuma zedoaria) against the pathogenic bacteria Escherichia coli, which is one of the causes of gastrointestinal infections or diarrheal diseases. Method: White turmeric extraction was carried out using the maceration method with a 96% ethanol solvent, which was then tested on Escherichia coli bacteria by the Disc diffusion method, using paper discs that had been soaked in various concentrations of onion extract (15%, 25%, 50%). The inhibition zones formed around the disc are observed and measured to determine the effectiveness of inhibition. Result: Based on research on the inhibitory effect of white turmeric extract on the growth of Escherichia coli bacteria, a concentration of 15% resulted in an average diameter of 7.1 mm (resistant), 25% resulted in a diameter of 9.3 mm (resistant), and 50% resulted in a diameter of 11.3 mm (resistant) on Escherichia coli bacteria. Conclusion: The conclusion of this study is that the more effective concentration to inhibit the growth of Escherichia coli bacteria is at 50% concentration.

Aktivitas Antibakteri Ekstrak Umbi Bawang Merah (Allium Cepa L.) terhadap Bakteri Staphylococcus aureus: Antibacterial Activity of Shallot (Allium cepa L.) Tuber Extract against Staphylococcus aureus Nur, Jumriah; Situmorang, Ing Mayfa Br; Maulidayanti, Sharfina; Mahendra, Robert Ariyan
HEALTH SCIENCE & BIOMEDICAL JOURNAL Vol. 1 No. 2 (2025): August 2025 : Health Science & Biomedical Journal (HSBJ)
Publisher : Literasi Indonesia Emas (PT)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Latar Belakang: Staphylococcus aureus merupakan bakteri patogen yang mampu menyebabkan penyakit infeksi pada manusia. Adanya peningkatan resistensi antibiotik pada bakteri tersebut, sehingga perlu dilakukan upaya untuk mencari alternatif pengobatan berbasis bahan alam. Tujuan: untuk mengetahui aktivitas antibakteri ekstrak bawang merah (Allium cepa L.) terhadap bakteri S. aureus. Metode: penelitian ini dilakukan di Laboratorium Mikrobiologi STIKes Prima Indonesia dari bulan April-Juni 2025. Desain penelitian menggunakan rancangan eksperimental laboratorium dengan metode paper-disk (disk diffusion) pada media Mueller Hinton Agar (MHA). Ekstrak bawang merah diperoleh melalui metode maserasi dengan menggunakan etanol 96%, selanjutnya diuji pada berbagai konsentrasi (10%, 15% dan 20%). Zona Hambat diukur setelah inkubasi 24 jam pada suhu 37oC. Hasil: penelitian menunjukan bahwa ekstrak bawang merah memiliki aktivitas antibakteri terhadap bakteri S. aureus dengan zona hambat terbesar pada 20% yaitu sebesar 11,6 mm dengan kriteria lemah, sedangkan konsentrasi terendah 10% menghasilkan zona hambat rerata 8,6 mm dengan kriteria lemah. Kesimpulan: pada penelitian ini adalah ekstrak umbi bawang merah memiliki potensi sebagai agen antibakteri alami terhadap S. aureus dengan efektivitasnya meningkat seiring dengan kenaikan konsentrasi ekstrak.

Aktivitas Antijamur Ekstrak Biji Kopi Hijau Robusta (Coffea canephora) Terhadap Candida albicans. Situmorang, Ing Mayfa Br; Salsadila, Putri; Maulidayanti, Sharfina; Tanjung, Asbar
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 2 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.39149

Acne is a disease that can be caused by bacteria, one of which is Staphylococcus epidermidis. Acne can be treated with active compounds derived from natural ingredients such as cucumbers and tomatoes. Gel masks peel off. This study aims to determine the average diameter of the inhibition zone, the difference in the average diameter of the inhibition zone, and the antibacterial activity of the peel-off from a mixture of cucumber (Cucumis sativus) and tomato (Solanum lycopersicum) with a concentration of 5%, 10 %, 15%, 20% against Staphylococcus epidermidis. This experimental study uses a Completely Randomized Design (CRD) consisting of one factor and 6 levels. The results showed that the average diameter of the inhibition zone of the anti-acne peel-off gel mask preparation of cucumber and tomato extracts against Staphylococcus epidermidis at a concentration of 5%, 10%, 15% and 20% were 16.38 mm, respectively. ; 24.88 mm; 29.88 mm and 34.88 mm. There was a significant difference in the average diameter of the inhibition zone of the peel off mixture of cucumber and tomato extracts with a concentration of 5%, 10%, 15%, and 20%; against Staphylococcus epidermidis. gel mask preparation peels off from a mixture of cucumber and tomato extracts against Staphylococcus epidermidis at a concentration of 5%, 10% concentration, 15% concentration and 20% concentration, namely strong, very strong, very strong and very strong. Keywords: staphylococcus epidermidis, gel mask peel-off, cucumber, tomato

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