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All Journal JURNAL KIMIA SAINS DAN APLIKASI Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Indonesia ALKIMIA : Jurnal Ilmu Kimia dan Terapan Jurnal Farmasetis Jurnal Kefarmasian Indonesia
Tunas Alam
Department Of Pharmacy, STIKes Prima Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Engineering Environmental Science Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Journal : JURNAL KIMIA SAINS DAN APLIKASI

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Tyrosinase Inhibitory of Silver Nanoparticles Synthesized using Morus Nigra Leaves Extract Tunas Alam; Ricky Ardiansyah; Sharfina Maulidayanti; Deva Azvara; Frida Octavia Purnomo; Dicky Annas
Jurnal Kimia Sains dan Aplikasi Vol 26, No 3 (2023): Volume 26 Issue 3 Year 2023
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.26.3.85-90

Abstract

A novel preparation of silver nanoparticles using Morus nigra leaves extract, as opposed to the physical and chemical methods had been used in this work. Their active phytochemical compounds will reduce Ag+ and form AgNPs (Ag0). A peak spectrum at 460 nm was formed and confirmed as the Surface Plasmon Resonance (SPR). Vibration at 1643 cm-1 and 3286 cm-1 which characteristic of C=C bonds and (-OH) hydroxyl groups, respectively. An X-ray diffraction (XRD) examination of silver with good crystallinity revealed its distinctive pattern. According to the results of transmission electron microscopy (TEM), the produced AgNPs-Morus nigra leaves extract were between 10 and 20 nm in size. Using L-dihydroxyphenylalanine (L-DOPA) as the substrate, the synthesized AgNPs-Morus nigra were tested for their tyrosinase inhibitory activity, and the results are substantial when compared to kojic acid as a control. The percentages of inhibition from crude extract, AgNPs, and kojic acid at 100 µg/mL are to be found at 12.10 %, 64.80 %, and 59.84 %, respectively. Based on the results of this work, AgNPs can be produced by utilizing a green synthesis method with leaves extract, making them a promising candidate for use in medicine and cosmetics.
Antimicrobial Activities of Synthesized Silver Nanoparticles using Ethanol and Water Extract of Mirabilis Jalapa Tunas Alam; Frida Octavia Purnomo; Asbar Tanjung
Jurnal Kimia Sains dan Aplikasi Vol 24, No 3 (2021): Volume 24 Issue 3 Year 2021
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3116.302 KB) | DOI: 10.14710/jksa.24.3.70-76

Abstract

The focus of this study was to compare the antimicrobial activity of silver nanoparticles (AgNPs) synthesized using ethanol extracts (AgNPE) and water extracts (AgNPA) from four o’clock flowers (Mirabilis jalapa) against Staphylococcus aureus. AgNPs were characterized by UV-Vis diffraction, FTIR, SEM, and X-rays. UV-Vis analysis showed that AgNPA has an SPR band of about 460 nm and 530 nm for AgNPE, which proves the characteristics of the absorbance area of AgNPs. SEM images of AgNPE and AgNPA show a cuboid shape with a mean diameter of 80 and 30 nm, respectively and well dispersed. The response to the presence of polysaccharide biomolecules involved in forming AgNPs was analyzed using a Fourier transform infrared spectrometer. The result was that AgNPA and AgNPE have different reducing agents. The plant extracts, AgNPE and AgNPA, were studied for their antimicrobial activity against Staphylococcus aureus. The result was that both AgNPA and AgNPE showed good activity and showed that AgNPA with less inhibition was more effective than AgNPE.
Co-Authors Andzar Fikranus Shofa Ardy Tanfil. T Asbar Tanjung Dede Irma Hidayat Deva Azvara Dicky Annas Dyah Ayuwati Waluyo Feronika Evma Rahayu Frida Octavia Purnomo Hartono, Olyvia Azzahra Putri Madiabu, Mohammad Jihad Meiliza Ekayanti Nada Permana Nuralih Nuralih Nuralih Nuralih, Nuralih Ricky Ardiansyah Sharfina Maulidayanti Shofa, Andzar Fikranus Zulfikar Hadissabil