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All Journal Biology, Medicine, & Natural Product Chemistry Martabe : Jurnal Pengabdian Kepada Masyarakat Community Medicine and Education Journal Prosiding University Research Colloquium
N Nurhayani
Universitas Muhammadiyah Surakarta
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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In vitro Study of the Antibiofilm Potential of Bay Leaf Extract (Syzygium polyanthum (Wight) Walp) against Streptococcus sanguinis and Streptococcus mutans Listiana Masyita Dewi; Azka Tarisa Atmaja; Muhammad Marcelliano Rifky Aditomo Putra; Devi Usdiana Rosyidah; Nurhayani Nurhayani; Rima Munawaroh
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.1145-1152

Abstract

The ability to form biofilms is one of the characteristics of microbes that has the potential to cause antimicrobial resistance. The oral cavity environment, which is frequently exposed to external environments and has a specific histological structure, can lead to the accumulation of EPS, thereby increasing the risk of biofilm formation. Streptococcus is one of the bacterial groups known to have the ability to produce biofilms. Bay leaves (Syzygium polyanthum (Wight) Walp), a member of the Syzygium genus that has been widely used in treating infectious diseases, both traditionally and medically, due to their eugenol content, are suspected to have antibiofilm activity. This study aimed to prove the antibacterial and antibiofilm effects of ethanol extract of bay leaves against Streptococcus sanguinis and Streptococcus mutans bacteria. This study used a post-test only controlled group design, with a microtiter plate assay technique, and determination of MIC50 and MBIC50 through a probit test. The bacterial test results showed that the MIC50 values for Streptococcus sanguinis and Streptococcus mutans were 37.57% and 9.65%, respectively, while the MBIC50 values were 6.41% and 29.98%, respectively. The coefficient of determination (R2) values for both test bacteria, in both the antibacterial and antibiofilm tests, were close to 1. Thus, it can be concluded that bay leaf extract is effective as an antibacterial and antibiofilm agent against Streptococcus sanguinis and Streptococcus mutans bacteria, with a stronger antibiofilm effect than its antibacterial effect.
Co-Authors Anika Candrasari Azka Tarisa Atmaja Burhanudin Ichsan Candrama Jalu Kumara Devi Usdiana Rosyidah Em Sutrisna Erna Herawati Listiana Masyita Dewi Muhammad Marcelliano Rifky Aditomo Putra Muhammad Shoim Dasuki N. Juni Triastuti Noer Safita Nur Mahmudah Oktamia Nursanty Retno Sintowati Rima Munawaroh Rizky Hari Fernanda Rochmadina Suci Bestari Rusnaindah Ifta Firdausi Slamet Ari Wibowo Sri Wahyu B Tri Agustina Wilda Anggriani Yustika Nurani Wijaya