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All Journal Pharmaciana: Jurnal Kefarmasian PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Prosiding University Research Colloquium Jurnal Farmasi Klinik dan Sains Medical Sains : Jurnal Ilmiah Kefarmasian Karya Nyata: Jurnal Pengabdian Kepada Masyarakat
Sinta Wahyu Septiani
Universitas Muhammadiyah Gombong
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology

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Penetapan Parameter Standar Simplisia dan Ekstrak Etanol Daun Ganitri (Elaeocarpus serratus L.) Naelaz Zukhruf Wakhidatul Kiromah; Sinta Wahyu Septiani; Wahyu Rahmatulloh; Ari Purnomo Aji
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 01 Juli 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i1.8833

Abstract

Ceylon olive (Elaeocarpus serratus L.) leaves have shown many pharmacological effects. Standardization of crude drug and extract needs to be conducted to assure the quality of the said material and further to support the pharmacological, pharmacokinetics, and toxicity effects. Standardization of Ceylon olive leaf extract is carried out to determine the standard parameters of crude drug and ethanolic extract of Ceylon olive leaves. Determination of the quality standard of crude drug and extract includes specific and non-specific parameters. The extract was obtained from a 70% ethanol maceration method with a yield of 16.02%. Macroscopic observations showed crude drugs of Ceylon olive leaves occurred as green in color, lanceolate leaves, 2-12 mm stems, and jagged leaves not deep, black spots, 10-15 side leaf bones, 6-18 cm long and 2-6 cm wide. Organoleptic of ethanolic extract of Ceylon olive showed thick consistency, blackish-brown colored, with a distinctive odor and a bitter taste. The water-soluble extractive value in crude drugs and extract was 16.48 and 51.54%, while the ethanol-soluble extractive value was 23.17 and 53.67%, respectively. The extract contained tannins, flavonoids, terpenoids, and saponins. Moisture content in the crude drugs and extracts was 22.09 and 25.53%. Total ash content in crude drugs and extracts was 33.53 and 30.62%, while their acid-insoluble ash content was 15.94 and 10.06%, respectively. Loss on drying of the crude drugs and extracts was 20.52 and 23.84% respectively. As the standard parameters of crude drugs and ethanolic extract of Ceylon olive leaves are not yet included in any formal monograph in Indonesia, the values of parameters reported in this study should be used as the reference of the standard quality parameter for those materials.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Ganitri (Elaeocarpus ganitrus Roxb.) dari Kabupaten Kebumen terhadap Bakteri Salmonella typhi Sinta Wahyu Septiani; Naelaz Zukhruf Wakhidatul Kiromah; Titi Pudji Rahayu
Prosiding University Research Colloquium Proceeding of The 12th University Research Colloquium 2020: Mahasiswa Student Paper
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (760.306 KB)

Abstract

Demam tifoid merupakan penyakit infeksi yang diakibatkan oleh bakteri Salmonella typhi. Daun ganitri (Elaeocarpus ganitrus Roxb.) merupakan salah satu bahan alam yang memiliki aktivitas antibakteri, namun belum dimanfaatkan dan belum pernah diteliti di Indonesia. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri dan konsentrasi minimal ekstrak etanol daun ganitri (Elaeocarpus ganitrus Roxb.) untuk menghambat bakteri Salmonella typhi. Uji aktivitas antibakteri dilakukan dengan metode difusi kertas cakram. Seri konsentrasi ekstrak etanol daun ganitri (Elaeocarpus ganitrus Roxb.) yang digunakan adalah 10, 20, 30, 40, 50 dan 100% dengan kontrol positif berupa amoksisilin 5% serta kontrol negatif berupa akuades steril. Data dianalisis secara statistik menggunakan uji One Way ANOVA. Ekstrak etanol daun ganitri (Elaeocarpus ganitrus Roxb.) memiliki aktivitas antibakteri yang tergolong sangat kuat dengan dibuktikan terbentuknya zona hambat setelah masa inkubasi. Hasil uji statistik ANOVA menunjukkan nilai p=0.001 (p<0,05) yang menyatakan bahwa terdapat perbedaan yang signifikan antar seri konsentasi ekstrak. Konsentrasi minimal ekstrak etanol daun ganitri (Elaeocarpus ganitrus Roxb.) untuk menghambat bakteri Salmonella typhi adalah konsentrasi 10% dengan zona hambat sebesar 21.16 mm yang dikategorikan sangat kuat.
FORMULATION AND EVALUATION OF HANDSANITIZER GANITRI LEAVE EXTRACT (Elaeocarpus ganitrus Roxb) Naelaz Zukhruf Wakhidatul Kiromah; Laeli Fitriyati; Sinta Wahyu Septiani
Jurnal Farmasi Klinik dan Sains Vol 2, No 1 (2022): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (679.222 KB) | DOI: 10.26753/jfks.v2i1.815

Abstract

Ganitri (Elaeocarpus ganitrus Roxb.) is one of the traditional medicinal plants that grows in Kebumen Regency, every part of the plant can cure various diseases. The leaves are known to contain carbohydrates, alkaloids, flavonoids, saponins, steroids, glycosides and anthraquinones which show antibacterial activity. Research on the development of pharmaceutical preparations from ganitri leaves has never been done. Seeing the large number of ganitri plants that grow and their great potential, this study aims to develop a pharmaceutical formulation in the form of a Hand Sanitizer.The results showed that formula 1 in the hand sanitizer spray preparation with a concentration of 1% ganitri (Elaeocarpus ganitrus Roxb.) leaf ethanol extract and 5% aloe vera had the best physical evaluation of the preparation. The data from the physical evaluation were analyzed statistically, namely the pH test and the viscosity test. The results of the normality test data and homogeneity test data with P> 0.05, which means that the data is normally distributed and homogeneous. The results of the ANOVA test showed that in the pH test there was no significant difference because the significance value was p> 0.05, while in the viscosity test the significance value was P < 0.05, it could be concluded that the average concentration of each formula in the viscosity test had a significant difference and systemically proven. Formulas 1, 2 and 3 had the diameter of inhibition against all test bacteria with the best inhibition in formula 2 of 18 mm on e.coli bacteria, 17.19 mm on s. aureus bacteria and 17 mm on shigella bacteria.
Antibacterial activities of Elaeocarpus ganitrus Roxb. leaves from Kebumen against Escherichia coli and Shigella flexneri Naelaz Zukhruf Wakhidatul Kiromah; Laeli Fitriyati; Sinta Wahyu Septiani
Pharmaciana Vol 13, No 2 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i2.19219

Abstract

Ganitri (Elaeocarpus ganitrus Roxb) is a plant known for its antibacterial properties, particularly in its leaves. The leaves of Ganitri contain antibacterial compounds such as flavonoids, alkaloids, and tannins. The objective of this study is to investigate the antibacterial activity and determine the minimum concentration of ethanol, methanol, and distilled water extracts from Ganitri leaves in inhibiting the growth of Escherichia coli and Shigella flexneri bacteria. A preliminary study of phytochemical with Thin Layer Chromatogram (TLC) and antibacterial study was conducted. The study was conducted in vitro by disc diffusion method with positive control of ciprofloxacin 50 µg/mL and negative control of sterile aquadest. The extract concentration series used were 10, 20, 30, 40, 50, and 100%. The extracts of ganitri leaves have antibacterial activities against Escherichia coli and Shigella flexneri bacteria. The TLC results were observed under visible light at 254 and 365 nm. Ethanol, methanol, and aquadest extracts of ganitri leaves produce spots that are almost comparable to the compounds of quercetin and tannic acid. The inhibitory zone range of the extracts in Escherichia coli bacteria is 10.33-19.66 mm with a strong category. In comparison, the inhibitory zone range of Shigella flexneri is 8.88-22.62 mm with a moderate-very strong category. ANOVA test results stated a significance value of p = 0.001 (p <0.05). Therefore, it can be concluded that the ethanol, methanol, and aquadest extracts of ganitri leaves had significant differences. The minimum concentration of each extract in inhibiting the bacteria Escherichia coli and Shigella flexneri is 10%.
FORMULATION AND EVALUATION OF HANDSANITIZER GANITRI LEAVE EXTRACT (Elaeocarpus ganitrus Roxb) Naelaz Zukhruf Wakhidatul Kiromah; Laeli Fitriyati; Sinta Wahyu Septiani
Jurnal Farmasi Klinik dan Sains Vol 2, No 1 (2022): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jfks.v2i1.815

Abstract

Ganitri (Elaeocarpus ganitrus Roxb.) is one of the traditional medicinal plants that grows in Kebumen Regency, every part of the plant can cure various diseases. The leaves are known to contain carbohydrates, alkaloids, flavonoids, saponins, steroids, glycosides and anthraquinones which show antibacterial activity. Research on the development of pharmaceutical preparations from ganitri leaves has never been done. Seeing the large number of ganitri plants that grow and their great potential, this study aims to develop a pharmaceutical formulation in the form of a Hand Sanitizer.The results showed that formula 1 in the hand sanitizer spray preparation with a concentration of 1% ganitri (Elaeocarpus ganitrus Roxb.) leaf ethanol extract and 5% aloe vera had the best physical evaluation of the preparation. The data from the physical evaluation were analyzed statistically, namely the pH test and the viscosity test. The results of the normality test data and homogeneity test data with P> 0.05, which means that the data is normally distributed and homogeneous. The results of the ANOVA test showed that in the pH test there was no significant difference because the significance value was p> 0.05, while in the viscosity test the significance value was P < 0.05, it could be concluded that the average concentration of each formula in the viscosity test had a significant difference and systemically proven. Formulas 1, 2 and 3 had the diameter of inhibition against all test bacteria with the best inhibition in formula 2 of 18 mm on e.coli bacteria, 17.19 mm on s. aureus bacteria and 17 mm on shigella bacteria.
UJI AKTIVITAS ANTIOKSIDAN DENGAN MENGGUNAKAN METODE FRAP PADA EKSTRAK BUTANOL DAUN JATI (Tectona grandis) laeli fitriyati; Sinta Wahyu Septiani; Muchromin Muchromin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.759

Abstract

Indonesia memiliki banyak tanaman yang dapat digunakan sebagai obat tradisional. Pengobatan tradisional dengan menggunakan bahan alam telah dilakukan secara turun. Tanaman daun jati (Tectona grandis) bisa digunakan sebagai antibakteri, antioksidan, dan antitoksik karena mengandung senyawa metabolit sekunder seperti tanin, antrakuinon, fenolik, antosianin, alkaloid, flavonoid, dan naftoquinon. Penelitian ini bertujuan untuk mengevaluasi aktivitas antioksidan ekstrak butanol dari daun jati (Tectona grandis). Penelitian ini merupakan penelitian eksperimental yang melibatkan pembuatan dua ekstrak daun jati menggunakan pelarut butanol dengan metode maserasi. Evaluasi dilakukan secara kualitatif (standarisasi dan uji tabung) dan kuantitatif menggunakan metode antioksidan FRAP (Ferric Reducing Antioxidant Power). Hasil penelitian menunjukkan bahwa ekstrak butanol dari daun jati (Tectona grandis) memenuhi persyaratan standarisasi, yaitu memiliki kadar air 9,76% butanol, kadar abu 12,9% butanol, dan kadar abu tidak larut asam 0,7% butanol, serta mengandung saponin, polifenol, dan flavonoid. Nilai Inhibition Concentration 50 (IC50) untuk aktivitas antioksidan adalah 70,848 ppm dan 80,893 ppm, yang termasuk kategori kuat. Oleh karena itu, hasil penelitian ini menunjukkan bahwa ekstrak butanol dari daun jati (Tectona grandis) memiliki aktivitas antioksidan yang kuat. Kata kunci : Daun Jati, Antioksidan, FRAP
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Ganitri (Elaeocarpus ganitrus Roxb.) dari Kabupaten Kebumen terhadap Bakteri Salmonella typhi Septiani, Sinta Wahyu; Kiromah, Naelaz Zukhruf Wakhidatul; Rahayu, Titi Pudji
Prosiding University Research Colloquium Proceeding of The 12th University Research Colloquium 2020: Mahasiswa Student Paper
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Demam tifoid merupakan penyakit infeksi yang diakibatkan oleh bakteri Salmonella typhi. Daun ganitri (Elaeocarpus ganitrus Roxb.) merupakan salah satu bahan alam yang memiliki aktivitas antibakteri, namun belum dimanfaatkan dan belum pernah diteliti di Indonesia. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri dan konsentrasi minimal ekstrak etanol daun ganitri (Elaeocarpus ganitrus Roxb.) untuk menghambat bakteri Salmonella typhi. Uji aktivitas antibakteri dilakukan dengan metode difusi kertas cakram. Seri konsentrasi ekstrak etanol daun ganitri (Elaeocarpus ganitrus Roxb.) yang digunakan adalah 10, 20, 30, 40, 50 dan 100% dengan kontrol positif berupa amoksisilin 5% serta kontrol negatif berupa akuades steril. Data dianalisis secara statistik menggunakan uji One Way ANOVA. Ekstrak etanol daun ganitri (Elaeocarpus ganitrus Roxb.) memiliki aktivitas antibakteri yang tergolong sangat kuat dengan dibuktikan terbentuknya zona hambat setelah masa inkubasi. Hasil uji statistik ANOVA menunjukkan nilai p=0.001 (p<0,05) yang menyatakan bahwa terdapat perbedaan yang signifikan antar seri konsentasi ekstrak. Konsentrasi minimal ekstrak etanol daun ganitri (Elaeocarpus ganitrus Roxb.) untuk menghambat bakteri Salmonella typhi adalah konsentrasi 10% dengan zona hambat sebesar 21.16 mm yang dikategorikan sangat kuat.
Penyuluhan DAGUSIBU Obat sebagai Upaya Peningkatan Pengetahuan Ibu PKK di Desa Kedungpring, Kemranjen-Banyumas Dwiki Fitri; Wahyu Septiani , Sinta; Agamasi, Amalia
Karya Nyata : Jurnal Pengabdian kepada Masyarakat Vol. 2 No. 4 (2025): Desember : Karya Nyata : Jurnal Pengabdian kepada Masyarakat
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/karyanyata.v2i4.2503

Abstract

Mistakes in obtaining, using, storing, and disposing of medication (DAGUSIBU) remain a major issue in Indonesia, including in Kedungpring Village, Kemranjen District, Banyumas Regency. This study aims to improve the knowledge of PKK mothers in Kedungpring Village regarding DAGUSIBU practices through interactive counseling. The method used is a community-based empowerment approach, involving active participation of PKK members in the planning, implementation, and evaluation of activities. The results showed a significant improvement in the participants' knowledge and behavior regarding proper medication management, including proper storage and disposal of expired medication. This activity also encouraged the formation of medication health cadre groups at the RT level to continue educating the community. This DAGUSIBU counseling was proven effective in improving medication literacy at the household level and reducing the risk of medication errors.
Co-Authors Agamasi, Amalia Ari Purnomo Aji Dwiki Fitri Kiromah, Naelaz Zukhruf Wakhidatul Laeli Fitriyati Laeli Fitriyati Muchromin Muchromin Naelaz Zukhruf Wakhidatul Kiromah Naelaz Zukhruf Wakhidatul Kiromah Rahayu, Titi Pudji TITI PUDJI RAHAYU Wahyu Rahmatulloh