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All Journal Jurnal Farmasi Klinik dan Sains Medical Sains : Jurnal Ilmiah Kefarmasian
Sinta Wahyu Septiani
Universitas Muhammadiyah Gombong
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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FORMULATION AND EVALUATION OF HANDSANITIZER GANITRI LEAVE EXTRACT (Elaeocarpus ganitrus Roxb) Naelaz Zukhruf Wakhidatul Kiromah; Laeli Fitriyati; Sinta Wahyu Septiani
Jurnal Farmasi Klinik dan Sains Vol 2, No 1 (2022): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (679.222 KB) | DOI: 10.26753/jfks.v2i1.815

Abstract

Ganitri (Elaeocarpus ganitrus Roxb.) is one of the traditional medicinal plants that grows in Kebumen Regency, every part of the plant can cure various diseases. The leaves are known to contain carbohydrates, alkaloids, flavonoids, saponins, steroids, glycosides and anthraquinones which show antibacterial activity. Research on the development of pharmaceutical preparations from ganitri leaves has never been done. Seeing the large number of ganitri plants that grow and their great potential, this study aims to develop a pharmaceutical formulation in the form of a Hand Sanitizer.The results showed that formula 1 in the hand sanitizer spray preparation with a concentration of 1% ganitri (Elaeocarpus ganitrus Roxb.) leaf ethanol extract and 5% aloe vera had the best physical evaluation of the preparation. The data from the physical evaluation were analyzed statistically, namely the pH test and the viscosity test. The results of the normality test data and homogeneity test data with P> 0.05, which means that the data is normally distributed and homogeneous. The results of the ANOVA test showed that in the pH test there was no significant difference because the significance value was p> 0.05, while in the viscosity test the significance value was P < 0.05, it could be concluded that the average concentration of each formula in the viscosity test had a significant difference and systemically proven. Formulas 1, 2 and 3 had the diameter of inhibition against all test bacteria with the best inhibition in formula 2 of 18 mm on e.coli bacteria, 17.19 mm on s. aureus bacteria and 17 mm on shigella bacteria.
FORMULATION AND EVALUATION OF HANDSANITIZER GANITRI LEAVE EXTRACT (Elaeocarpus ganitrus Roxb) Naelaz Zukhruf Wakhidatul Kiromah; Laeli Fitriyati; Sinta Wahyu Septiani
Jurnal Farmasi Klinik dan Sains Vol 2, No 1 (2022): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jfks.v2i1.815

Abstract

Ganitri (Elaeocarpus ganitrus Roxb.) is one of the traditional medicinal plants that grows in Kebumen Regency, every part of the plant can cure various diseases. The leaves are known to contain carbohydrates, alkaloids, flavonoids, saponins, steroids, glycosides and anthraquinones which show antibacterial activity. Research on the development of pharmaceutical preparations from ganitri leaves has never been done. Seeing the large number of ganitri plants that grow and their great potential, this study aims to develop a pharmaceutical formulation in the form of a Hand Sanitizer.The results showed that formula 1 in the hand sanitizer spray preparation with a concentration of 1% ganitri (Elaeocarpus ganitrus Roxb.) leaf ethanol extract and 5% aloe vera had the best physical evaluation of the preparation. The data from the physical evaluation were analyzed statistically, namely the pH test and the viscosity test. The results of the normality test data and homogeneity test data with P> 0.05, which means that the data is normally distributed and homogeneous. The results of the ANOVA test showed that in the pH test there was no significant difference because the significance value was p> 0.05, while in the viscosity test the significance value was P < 0.05, it could be concluded that the average concentration of each formula in the viscosity test had a significant difference and systemically proven. Formulas 1, 2 and 3 had the diameter of inhibition against all test bacteria with the best inhibition in formula 2 of 18 mm on e.coli bacteria, 17.19 mm on s. aureus bacteria and 17 mm on shigella bacteria.
UJI AKTIVITAS ANTIOKSIDAN DENGAN MENGGUNAKAN METODE FRAP PADA EKSTRAK BUTANOL DAUN JATI (Tectona grandis) laeli fitriyati; Sinta Wahyu Septiani; Muchromin Muchromin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.759

Abstract

Indonesia memiliki banyak tanaman yang dapat digunakan sebagai obat tradisional. Pengobatan tradisional dengan menggunakan bahan alam telah dilakukan secara turun. Tanaman daun jati (Tectona grandis) bisa digunakan sebagai antibakteri, antioksidan, dan antitoksik karena mengandung senyawa metabolit sekunder seperti tanin, antrakuinon, fenolik, antosianin, alkaloid, flavonoid, dan naftoquinon. Penelitian ini bertujuan untuk mengevaluasi aktivitas antioksidan ekstrak butanol dari daun jati (Tectona grandis). Penelitian ini merupakan penelitian eksperimental yang melibatkan pembuatan dua ekstrak daun jati menggunakan pelarut butanol dengan metode maserasi. Evaluasi dilakukan secara kualitatif (standarisasi dan uji tabung) dan kuantitatif menggunakan metode antioksidan FRAP (Ferric Reducing Antioxidant Power). Hasil penelitian menunjukkan bahwa ekstrak butanol dari daun jati (Tectona grandis) memenuhi persyaratan standarisasi, yaitu memiliki kadar air 9,76% butanol, kadar abu 12,9% butanol, dan kadar abu tidak larut asam 0,7% butanol, serta mengandung saponin, polifenol, dan flavonoid. Nilai Inhibition Concentration 50 (IC50) untuk aktivitas antioksidan adalah 70,848 ppm dan 80,893 ppm, yang termasuk kategori kuat. Oleh karena itu, hasil penelitian ini menunjukkan bahwa ekstrak butanol dari daun jati (Tectona grandis) memiliki aktivitas antioksidan yang kuat. Kata kunci : Daun Jati, Antioksidan, FRAP
Co-Authors Laeli Fitriyati Muchromin Muchromin Naelaz Zukhruf Wakhidatul Kiromah