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All Journal CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Kimia (Journal of Chemistry) Jambura Journal of Chemistry JURNAL FARMASIMED (JFM) Health Sciences and Pharmacy Journal Jurnal Pengabdian Al-Ikhlas Jurnal Farmamedika (Pharmamedica Journal) Jurnal Inovasi Teknik Kimia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Yoga Dan Kesehatan Jurnal Farmasetis Jurna Beta Kimia Acta Holistica Pharmaciana Borneo Journal of Pharmacy Jurnal Sains dan Kesehatan Dharma: Jurnal Pengabdian Masyarakat Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Esati, Ni Ketut
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Total Flavonoid Levels in n-hexane and Ethyl Acetate Fractions of Rosmarinus officinalis L. Leaves and Their Antibacterial and Antioxidant Activities Esati, Ni Ketut; La, Elisabeth Oriana Jawa; Sudiasih, Ni Putu; Saniasih, Ni Nyoman Dina
Borneo Journal of Pharmacy Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i1.4034

Abstract

The rosemary (Rosmarinus officinalis L.) is a plant of the Lamiaceae tribe that has not been widely studied regarding its pharmacological activity, known from previous studies to contain secondary metabolites of flavonoids. Flavonoids are phenol compounds with many pharmacological activities, including antibacterials and antioxidants. This study aims to determine the total flavonoid levels in R. officinalis leaves and their effect on antibacterial and antioxidant activities. This research began with the preparation of ethanol extract from R. officinalis leaves, then the fractionation of the extract produced n-hexane and ethyl acetate fractions. Total flavonoid levels were determined against both fractions by UV-Vis spectrophotometry. A test of the fraction’s antibacterial activity against Staphylococcus aureus was performed using the disc diffusion method. The antioxidant test is carried out by the DPPH method. The total flavonoid content of the ethyl acetate fraction is 47.437 ± 1.947%, higher than the n-hexane fraction. Test antibacterial and antioxidant activity showed more significant results in the ethyl acetate fraction than in the n-hexane fraction. In conclusion, the total flavonoid levels of ethyl acetate fraction are directly proportional to the antibacterial and antioxidant activities of R. officinalis leaves.
Penyuluhan Tanaman Kunyit dan Pacar Air Sebagai Alat Deteksi Zat Polutan (Boraks) di Desa Bongkasa-Bali Esati, Ni Ketut
Dharma: Jurnal Pengabdian Masyarakat Vol. 3 No. 2 (2023): Juni
Publisher : LPPPM STAI Darul Hikmah Bangkalan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35309/dharma.v3i2.60

Abstract

The activity of community service in Bongkasa Village, Bali was themed the counseling on turmeric (Curcuma domestica Val.) and water henna plants (Impatiens balsamina L.) as indicator to detecting pollutant substances (borax). The activity targeted young people who were members of Seka Teruna Teruni (STT) Banjar Tanggayuda. This activity was carried out in Bongkasa Village, seeing that the abundance of the plant was very much planted by the villagers. The content of chemical compounds in turmeric rhizome and henna flowers could react with borax to form a colored complex, so that these properties could be used to detect the presence of borax in food. It was known that economic problems caused producers to be irresponsible by adding borax as a food preservative, which is actually prohibited. Borax was a chemical compound derived from the heavy metal boron which generally was used as an antiseptic and bacteria killer, if used as a food additive it could endanger the health of consumers. The activity began with giving the questions to measure the knowledge of the counseling participants, then providing material, demonstrating the manufacture of a borax detector, as well as testing the detector on foods containing borax. Finally, an evaluation of the activity was carried out. The results obtained from this activity that the extension participants were very enthusiastic, this education was expected to add information to the public that there is a simple way to find out if a food contains the dangerous compound borax.
IDENTIFIKASI KONTAMINAN TIMBAL DENGAN ELEKTRODA KERJA PASTA KARBON TERMODIFIKASI Ni Ketut Esati; Kadek Duwi Cahyadi
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.409

Abstract

This research identified lead (Pb) contaminants in vegetables. The measurement method used was anodic stripping voltammetry (ASV) with a working electrode of carbon paste modified acid-activated natural zeolite. The stages of the research were formulation of the working electrode, validation of the measurement method and measurement of lead levels in vegetables. The result showed that the optimum formulation of working electrode gave the highest measurement peak current. The optimum formulation with composition of graphite: liquid paraffin: acid activates zeolite is 100:35:10. This electrode was used for determination linear range concentration, limit of detection, percent recovery, and repeatability. The measurement of Pb using electrode by ASV method which gave valid results. It can be seen from a wide concentration range from 50-3000 ppb, a low detection limit of 55.28 ppb, good accuracy and precision. The application of this method is to measure Pb levels in vegetables, and the result is 1.43 mg/Kg.
EFEK EKSTRAK ETANOL AKAR CAKAR SETAN (Martynia annua L) TERHADAP AKTIVITAS SGPT DAN SGOT PADA TIKUS YANG DIINDUKSI CCl4 Elisabeth Oriana Jawa La; Repining Tiyas Sawiji; Ni Ketut Esati
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.414

Abstract

SGPT and SGOT activity from ethanol extract of cakar setan root (Martynia annua L) was investigated. Phytochemical screening was carried out on ethanol extract of cakar setan root (Martynia annua L). The animals were grouped into five groups which consist of 5 rats for each group. The normal/healthy group was only given food and drink the negative control group was given an aqueous suspension of 1 % CMC , the positif control group was given tablets Curcuma at a dose of 200 mg/Kg BB, the group ethanol extract Martynia annua L were each given extract at a dose of 200 mg/Kg BB and 400 mg/Kg BB. All groups were treated for 21 days orally. On day 22 were given injection of CCl4 1.0 mL/kg intraperitoneally except healthy group. The rats blood was taken and analyzed through eye orbitalis sinus AST and ALT activities. The result were statistically analyzed using One Way ANOVA test followed by LSD test. Phytochemical screening ethanolic extract of Martynia annua L root positively contains flavonoids, alkaloids, tannin, phenolic, and terpenoids. The result study that ethanol extract of cakar setan root (Martynia annua L) has hepatoprotective effect of being able to reduce activities of SGPT and SGOT in CCl4 induce white rats.
Antipyretic Activity Test of 70% Ethanol Extract of Red Andong Leaves (Cordyline fruticosa (L) A. Chev) in Male Wistar Rats (Rattus norvegicus) Jawa La, Elisabeth Oriana; Salma, Cut Asyifa Baezura Mangkurat; Ni Ketut Esati; Repining Tiyas Sawiji
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/cjzzj881

Abstract

Introduction: Fever is a common health problem that can cause discomfort and may lead to serious complications. One alternative treatment for fever is the use of herbal plants that have been proven to possess antipyretic effects, such as red to plant leaves (Cordyline fruticosa (L.) A. Chev). Objective: To evaluate the secondary metabolite content and assess the antipyretic activity of 70% ethanol extract of red ti plant leaves in male Wistar rats induced with fever using 5% peptone. Methodology: This research used a completely randomized design (CRD) with five treatment groups: a negative control group (1% Na-CMC), a positive control group (paracetamol at a dose of 500 mg/kgBW), and three test groups receiving 70% ethanol extract of red ti plant leaves at doses of 1,200 mg/kgBW, 1,800 mg/kgBW, and 2,400 mg/kgBW. Antipyretic activity was assessed by measuring the reduction in body temperature of the test animals, expressed as a percentage of antipyretic power, and statistically analyzed to evaluate the antipyretic effect of the extract. Results: The study showed that the 70% ethanol extract of red to plant leaves tested positive for flavonoids, tannins, and saponins, which are potential antipyretic compounds. Additionally, the extract demonstrated significant antipyretic activity, as indicated by a notable reduction in the body temperature of the test animals. All three doses of the extract resulted in a temperature decrease, with the 2,400 mg/kgBW dose showing the most optimal antipyretic effect, approaching the effectiveness of paracetamol as the positive control. Conclusion: The 70% ethanol extract of red ti plant leaves has been proven to exhibit antipyretic activity, with the 2,400 mg/kgBW dose demonstrating an effect comparable to paracetamol. The extract also contains secondary metabolites such as flavonoids, tannins, phenol, terpenoids and saponins.
Analysis of the Antioxidant Activity of Strawberry Kombucha using the UV–Vis Spectrophotometric Method Esati, Ni Ketut; Lestari, Gusti Ayu Dewi; Griadnyana, Ida Bagus Nanda
Jurnal Beta Kimia Vol 5 No 2 (2025): Volume 5 Issue 2, November 2025
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jbk.v5i2.24419

Abstract

The development of modern lifestyles, which tend to favor instant foods and beverages, has increased the risk of degenerative diseases associated with oxidative stress. This condition has driven the demand for foods and beverages rich in antioxidants. Kombucha is a fermented beverage recognized for its probiotic and antioxidant properties, while strawberries are rich in natural antioxidant compounds. The combination of these two components has the potential to produce a functional beverage beneficial to health, particularly as a source of antioxidants. Therefore, this study aimed to determine the effect of fermentation duration on the antioxidant activity of strawberry kombucha and to identify the optimal fermentation duration for achieving the highest antioxidant activity. This study employed a quantitative research design using a laboratory experimental method. Strawberry kombucha was prepared from a mixture of fresh strawberries, water, granulated sugar, SCOBY starter solution, and SCOBY, followed by fermentation for 7, 10, and 13 days. Antioxidant activity was evaluated using the UV-Vis spectrophotometric method with DPPH reagent. The results demonstrated that fermentation duration significantly affected the antioxidant activity of strawberry kombucha. The highest antioxidant activity was achieved on day 10, with an IC50​ value of 24.69 ppm, which was categorized as very strong antioxidant activity. Fermentation on day 13 resulted in an IC50​ value of 30.69 ppm, which also fell within the very strong category, whereas fermentation on day 7 produced an IC50​ value of 74.38 ppm, categorized as strong antioxidant activity. Therefore, a fermentation duration of 10 days was identified as the optimal condition for producing the highest antioxidant activity. The findings of this study are expected to contribute to the development of beverage formulations rich in antioxidant compounds.
Co-Authors Anak Agung Putra Riana Prasetya B. Ankamwar Darmawan, Gede Agus Duwi Cahyadi, Kadek Griadnyana, Ida Bagus Nanda Gusti Ayu Dewi Lestari Gusti Ayu Putu Prima Purnamasari Hery Suyanto I Putu Eka Budiarta Irdhawati Irdhawati Iryanti Eka Suprihatin Jawa La, Elisabeth Oriana K. D. Cahyadi Kadek Duwi Cahyadi Kadek Duwi Cahyadi Ni Ketut Sinarsih Ni Ketut Sinarsih Ni Made Umi Kartika Dewi Ni Made Widayanti Ni Made Widayanti Ni Nyoman Dina Saniasih Ni Putu Sudiasih, Ni Putu Ni Wayan Natih Lestari Ni Wayan Nieskajanti Kedeh Van Kempen Pandi, Rensiana Kartini Pramana, I Gede Komang Aditya Purnamasari, I Gusti Ayu Putu Prima Putra, Kadek Ria Dwitya Putu Dian Marani Kurnianta Rensiana Kartini Pandi Salma, Cut Asyifa Baezura Mangkurat Saniasih, Ni Nyoman Dina Sawiji, Repining Tiyas Sujayanti, Luh Gede Tina Yani, Ketut Tia Pran Anggar