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All Journal Jurnal Kesehatan Masyarakat Jurnal Riset Kesehatan The Indonesian Biomedical Journal Smart Medical Journal Smart Society Empowerment Journal
Dyonisa Nasirochmi Pakha
Departemen Farmakologi, Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health Other

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The Affecting Factors of Compliance Diabetes Mellitus Type 2 Treatment in Pandemic Era Febrinasari, Ratih Puspita; Solikah, Tri Agusti; Nasirochmi, Dyonisa; Dilma’aarij, Dilma’aarij
KEMAS: Jurnal Kesehatan Masyarakat Vol 17, No 4 (2022)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v17i4.29885

Abstract

Diabetes mellitus (DM) is one of the non-communicable diseases that cause serious health problems. This chronic disease requires lifelong treatment to prevent complications and death. In the pandemic era, DM became comorbid that contributed to the death rate in Covid-19 cases, so that patients with type 2 DM become important to comply with the treatment underway. Aim: This study aimed to evaluate the treatment compliance in patients with DM type 2 at the Purwodiningratan primary health care, Surakarta. Method: This study was conducted in 2020 used an analytical method with crosssectional design. Populations were all of the patients who experience DM type 2, sampling techniques used total sampling with 108 respondents. Univariate, bivariate analysis, and logistic regression were used in this study. Compliance levels measured used the MMAS-8 questionnaire. Result:  The results of this study were obtained from several independent variables that related to compliance with DM type 2 treatment. The descriptive analysis result of patient compliance showed that 70.4% of patients were obedient. The significant variable was the side effects on DM drugs with (OR = -0.44; 95% CI = -0.74 - 0.15; p = 0.003). Conclusion: Most of the patients were adherent to the treatment and the most influencing factor was the side effect of the drug.
THE EFFECTIVENESS OF ETHANOL EXTRACT OF JAMBLANG LEAVES (Syzygium cumini L.) IN INCREASING HDL LEVELS IN WISTAR RATS MODELS OF METABOLIC SYNDROME Muthmainah Muthmainah; Ida Nurwati; Selfi Handayani; Dyonisa Nasirochmi Pakha
Jurnal Riset Kesehatan Vol 12, No 1 (2023): MAY 2023
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jrk.v12i1.9305

Abstract

One of the characteristics of metabolic syndrome (MetS) is the low high-density lipoprotein (HDL) levels. Jamblang leaves (Syzygium cumini L.) contain various phytochemicals, which have antihyperglycemic, antihyperlipidemic, and antioxidant properties. This study aims to demonstrate the effectiveness of ethanol extract of jamblang leaves in increasing HDL levels in the Wistar rats model of MetS. A pretest-posttest with a control group design was conducted using 30 male Wistar rats, divided into five groups randomly, with six rats for each group.  Here, KN means normal control group, K- negative control group, and P1, P2, and P3: treatment groups that were administered the 100 mg/kg/day, 150 mg/kg/day, and 200 mg/kg/day of ethanol extract of jamblang leaves for 28 days, respectively. The rat MetS model was developed by administering the high-fat fructose diet and streptozotocin-nicotinamide. The data were analyzed using paired t-test and one-way ANOVA (α=0.05). This study found that extract administration in P2 and P3 increased HDL levels significantly, but not with the P1 group. However, HDL levels in P1 were significantly higher compared to the K- group. Moreover, increasing the dose was significantly followed by higher HDL levels, although the highest dose did not reach the HDL level as in the KN group.
Red Rice Bran Ethanol Extract Reduces IL-1β as the Risk of Pancreas Fibrogenesis in Type 2 Diabetic Rat Model Brian Wasita; Ratih Dewi Yudhani; Dyonisa Nasirochmi Pakha; Diana Nurrohima; Muthmainah Muthmainah; Nanang Wiyono; Shariza Fakurazi
The Indonesian Biomedical Journal Vol 17, No 1 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i1.3410

Abstract

BACKGROUND: Oxidative stress and inflammation contribute to pancreatic cell dysfunction that promote insulin resistance in type 2 diabetes (T2D). Red rice bran contains bioactive substances with anti-inflammatory and antioxidant properties which improved insulin resistance in obese mice. However, no studies have explored the potential of ethanol extract of red rice bran (EERRB) to prevent T2D progression, particularly pancreatic fibrosis complications. This study was conducted to investigate the effect of EERRB on inflammation measured with interleukin (IL)-1β and fibrosis of pancreatic tissue in a rat model of T2D. METHODS: Rats were induced with streptozotocin and nicotinamide to induce diabetes, and then separated into five groups. One group received no treatment, while the other four received 9 mg/kg/day acarbose, 165, 330, or 660 mg/kg/day EERRB orally for 21 days. Immunohistochemistry was conducted on pancreas tissues to measure the expression of IL-1β, while pancreatic fibrosis was assessed with Masson’s Trichrome staining.RESULTS: EERRB reduced the expression of pro-inflammatory cytokine, IL-1β, in pancreas tissue in a dose dependent manner. Significantly lower IL-1β expression were found in group receiving 660 mg/kg/day EERRB (10%) compared to diabetic with no treatment group (50%) (p<0.0001). Additionally, the IL-1β expression in the highest dose of EERRB group was comparable to the group receiving acarbose (10%). CONCLUSION: This finding suggests the beneficial effect of EERRB in the hyperglycemic condition that causes oxidative stress through blocking the IL-1β expression, hence alleviating the inflammation in pancreas tissue, and have a tendency in preventing pancreatic fibrosis progression, a process implicated in T2D pathogenesis. KEYWORDS: diabetes, inflammation, pancreatic fibrosis, red rice bran
The Increase of HDL-C Levels using Ethanol Extract of Vernonia amygdalina Leaves in Wistar Rats Models of Metabolic Syndrome Pakha, Dyonisa Nasirochmi; Nurwati, Ida; Sunggoro, Agus Jati; Muthmainah, Muthmainah; Handayani, Selfi
Smart Medical Journal Vol 6, No 3 (2023): December
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v6i3.80480

Abstract

Introduction: Metabolic syndrome (MetS) is a cluster of metabolic factors, including low high-density lipoprotein cholesterol (HDL-C) levels. Vernonia amygdalina (VA) leaves have been documented for their anti-cholesterol properties. The purpose of this study to evaluate ethanol extract of VA leaves in rising HDL-C levels in the MetS model.Methods: An experimental study using pre-and post-test design was conducted using 30 male Wistar rats divided into five groups randomly. KN group served as the control group. KP group was the MetS model without ethanol extract administration. Meanwhile, P1, P2, and P3 were MetS models and were administered ethanol extract of VA leaves administration (50mg/kg, 100mg/kg, and 150 mg/kg) for 28 days. The data were analysed using paired t-test and one-way ANOVA (α=0,05).Results: This study discovered that administering the extract in P1, P2, and P3 significantly improved HDL levels. Furthermore, increasing the dose resulted in significantly greater HDL levels. VA leaves contain phytochemicals that have impacts on cholesterol levels in the blood. Flavonoids and tannin inhibit ester cholesterol formation. Terpenoid and flavonoid hinder HMG-CoA. Saponin contributes to free cholesterol transporter, reducing oxidative stress and increasing LDL receptors. Lastly, vitamin C raises catabolism levels and clearance LDL.Conclusion: There are increases in HDL levels in the MetS model group receiving ethanol extract VA leaves. 
Edukasi dan Aplikasi Loci pada Guru SD di Wilayah Kecamatan Kerjo Karanganyar Muthmainah, Muthmainah; Nurwati, Ida; Subandono, Jarot; Hermawan, Danus; Budiani, Dyah Ratna; Hakim, Fikar Arsyad; Handayani, Selfi; Pakha, Dyonisa Nasirochmi; Sunggoro, Agus Jati
Smart Society Empowerment Journal Vol 3, No 3 (2023): November
Publisher : Faculty of Medicine, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/ssej.v3i3.79482

Abstract

Pendahuluan: Fakta di lapangan menunjukkan sebagian besar guru SD di Kecamatan Kerjo, Karanganyar belum pernah mendengar atau mengetahui metode Loci. Metode Loci merupakan salah satu cara untuk meningkatkan daya ingat dengan mengoptimalkan keseimbangan fungsi otak kiri dan kanan. Tujuan pengabdian masyarakat ini adalah melakukan edukasi dan aplikasi metode Loci melalui penyuluhan kepada para guru SD tersebut untuk meningkatkan daya ingat.Metode: Penyuluhan dilakukan pada Selasa, 23 Mei 2023 jam 08.00-12.30, di aula kantor Korwilcam Bidang Pendidikan Kecamatan Kerjo, Karanganyar. Peserta penyuluhan adalah para guru SD dalam wilayah Kecamatan Kerjo, Karanganyar sebanyak 50 orang. Di Kecamatan Kerjo terdapat 29 SD, dari tiap-tiap SD mewakilkan 1-2 orang guru. Tahap-tahap kegiatan pengabdian masyarakat meliputi persiapan, pelaksanaan, dan pelaporan kegiatan. Penyuluhan diberikan melalui ceramah interaktif dan mempraktekkan cara menghafal dengan metode Loci. Peserta menjalani pretes sebelum dan postes sesudah penyuluhan. Nilai pretes dan postes dibandingkan menggunakan uji statistik Wilcoxon (α=0,05). Hasil dan pembahasan: Kegiatan pengabdian masyarakat yang berupa penyuluhan metode Loci telah dilaksanakan sesuai rencana dan diikuti oleh 50 orang guru SD dari 29 SD yang ada di wilayah Kecamatan Kerjo, Karanganyar. Rerata nilai pretes peserta 42,56±21,04 dan nilai postes 62,56±28,11 dengan nilai signifikansi p<0,001. Hal ini berarti bahwa penyuluhan yang berupa ceramah interaktif dan praktek aplikasi metode Loci, selain dapat memberikan pemahaman mengenai pengetahuan metode Loci, juga berpengaruh dalam meningkatkan daya ingat peserta.Kesimpulan: Edukasi dan aplikasi metode Loci yang diberikan melalui penyuluhan dapat memberikan pemahaman mengenai metode Loci dan dapat meningkatkan daya ingat pada para guru SD di Kecamatan Kerjo, Karanganyar.
Co-Authors Brian Wasita Diana Nurrohima Dilma’aarij, Dilma’aarij Djoko Suwito Dyah Ratna Budiani Hakim, Fikar Arsyad Hermawan, Danus Ida Nurwati Ida Nurwati Jarot Subandono Muhammad Afif Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Nanang Wiyono Ratih Dewi Yudhani Ratih Puspita Febrinasari Selfi Handayani Selfi Handayani Shariza Fakurazi Solikah, Tri Agusti Sunggoro, Agus Jati Tri Agusti Sholikah