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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Syntax Literate: Jurnal Ilmiah Indonesia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Ilmiah Kesehatan Masyarakat : Media Komunikasi Komunitas Kesehatan Masyarakat COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat
Muzaijadah Retno Arimbi
Bagian Ilmu Penyakit Dalam, FK.Universitas Wijaya Kusuma Surabaya
Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Health Professions Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Study of Anti-tuberculosis Polyclonal Antibody and Its Potential As A Rapid Test Kit for Tuberculosis Detection Arimbi, Muzaijadah Retno
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 5, No 2 (2016): Edisi September 2016
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tuberculosis (TB) is one of the long-known diseases and is still the leading cause of death in the world. A variety of detection methods have been and are being implemented in order to suppress TB prevalence. The aim of this study was to isolate protein from serum pulmonary tuberculosis patients with sputum BTA (+), isolate protein from serum pulmonary tuberculosis patients with sputum BTA (-), and to know the level of antibody specificity in serum pulmonary tuberculosis patients with sputum BTA (+) and serum pulmonary tuberculosis patients with sputum BTA (-). The type of research used was laboratory experimental in Wistar rat experimental animals with Control Group Post Test Design research design. The research design was used with 3 different treatment groups, ie Control Group (without treatment), Group I (treated with isolate protein from serum of Pulmonary TB patients with sputum BTA (+)), and Group II (treated with protein isolate from serum of Pulmonary TB patient with sputum BTA (-) From collected data After dot blot is complete, tabulation of diagnostic test result (dot blot.) To obtain a standard in assessing the results of dot in each of these studies used CorelPhotopaint X4 program to obtain accurate data about the thickness of thin black spots (nilaimean) on the nitrocellulose membrane quantitatively.The data collected is processed using software (software) statistics SPSS version 11.5 From the electrophoresis test results of an exciting protein sample m of Pulmonary TB patients with BTA (+) and protein from serum of Pulmonary TB patients with AFB (-), obtained specific protein with molecular weight of 39 kDa. From the serum 1 serum easternbloting test result from pulmonary TB patients with BTA (+) and serum 2 protein derived from serum of Pulmonary TB patients with BTA (-), positive reaction occurred between antibodipoliklonal (anti 39 kDa) and serum protein of Pulmonary TB with BTA (+), or proteins from serum patients with pulmonary TB with AFB (-). The anti-tuberculosis polyclonal antibody in the study appears to be quite sensitive as Rapid tuberculosis detection test, but no specificity as evidenced by statistical calculation has significance> 0.05, so the anti-tuberculosis polyclonal antibody in this study is quite sensitive, but not specifically used as an MTb detection device Keywords: tuberculosis, specific protein, polyclonal antibody, specificity test Tuberculosis (TB) is one of the long-known diseases and is still the leading cause of death in the world. A variety of detection methods have been and are being implemented in order to suppress TB prevalence. The aim of this study was to isolate protein from serum pulmonary tuberculosis patients with sputum BTA (+), isolate protein from serum pulmonary tuberculosis patients with sputum BTA (-), and to know the level of antibody specificity in serum pulmonary tuberculosis patients with sputum BTA (+) and serum pulmonary tuberculosis patients with sputum BTA (-). The type of research used was laboratory experimental in Wistar rat experimental animals with Control Group Post Test Design research design. The research design was used with 3 different treatment groups, ie Control Group (without treatment), Group I (treated with isolate protein from serum of Pulmonary TB patients with sputum BTA (+)), and Group II (treated with protein isolate from serum of Pulmonary TB patient with sputum BTA (-) From collected data After dot blot is complete, tabulation of diagnostic test result (dot blot.) To obtain a standard in assessing the results of dot in each of these studies used CorelPhotopaint X4 program to obtain accurate data about the thickness of thin black spots (nilaimean) on the nitrocellulose membrane quantitatively.The data collected is processed using software (software) statistics SPSS version 11.5 From the electrophoresis test results of an exciting protein sample m of Pulmonary TB patients with BTA (+) and protein from serum of Pulmonary TB patients with AFB (-), obtained specific protein with molecular weight of 39 kDa. From the serum 1 serum easternbloting test result from pulmonary TB patients with BTA (+) and serum 2 protein derived from serum of Pulmonary TB patients with BTA (-), positive reaction occurred between antibodipoliklonal (anti 39 kDa) and serum protein of Pulmonary TB with BTA (+), or proteins from serum patients with pulmonary TB with AFB (-). The anti-tuberculosis polyclonal antibody in the study appears to be quite sensitive as Rapid tuberculosis detection test, but no specificity as evidenced by statistical calculation has significance> 0.05, so the anti-tuberculosis polyclonal antibody in this study is quite sensitive, but not specifically used as an MTb detection device  
Sputum Smear Conversion as Prognostic Determinant of Timely Complete Therapy on Pulmonary Tuberculosis Bastiana Bastiana; Muzaijadah Retno Arimbi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 28, No 3 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i3.1974

Abstract

Tuberculosis (TB) remains a major health problem worldwide. The bacteriological diagnosis of TB is confirmed by a sputum smear, which shows a positive result. Sputum culture conversion at two months of TB therapy has a higher possibility of completing therapy; however, this method is time-consuming and expensive. This study aimed to analyze the initial smear and smear conversion of sputum in the intensive phase therapy as a prognostic determinant of appropriate time-targeted therapy. This was a retrospective study on pulmonary TB patients collected from January 2016 to December 2017. The research subjects at the beginning of the intensive phase were divided into Acid-Fast Bacilli (AFB)-negative and AFB-positive (1+, 2+, 3+) sputum smears. The sputum smear examination was evaluated at the end of the intensive phase and the end of the six-month treatment. The pulmonary TB patients in this study were 430 patients, dominated by males with the main distribution age of 45-54 years. At the beginning of the intensive phase, the negative results of the AFB examination were 85.4% and the total positive results with 1+, 2+, or 3+ were 14.6%. At the end of the intensive phase, the sputum smear examination of all patients showed 100% conversion, and the sputum smear examination at the end of six months of treatment showed negative results. This study has revealed that sputum conversion at the end of the 2-month intensive phase can be used as a prognostic determinant of timely complete therapy on pulmonary tuberculosis.
Sputum Smear Conversion as Prognostic Determinant of Timely Complete Therapy on Pulmonary Tuberculosis Bastiana Bastiana; Muzaijadah Retno Arimbi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 3 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i3.1974

Abstract

Tuberculosis (TB) remains a major health problem worldwide. The bacteriological diagnosis of TB is confirmed by a sputum smear, which shows a positive result. Sputum culture conversion at two months of TB therapy has a higher possibility of completing therapy; however, this method is time-consuming and expensive. This study aimed to analyze the initial smear and smear conversion of sputum in the intensive phase therapy as a prognostic determinant of appropriate time-targeted therapy. This was a retrospective study on pulmonary TB patients collected from January 2016 to December 2017. The research subjects at the beginning of the intensive phase were divided into Acid-Fast Bacilli (AFB)-negative and AFB-positive (1+, 2+, 3+) sputum smears. The sputum smear examination was evaluated at the end of the intensive phase and the end of the six-month treatment. The pulmonary TB patients in this study were 430 patients, dominated by males with the main distribution age of 45-54 years. At the beginning of the intensive phase, the negative results of the AFB examination were 85.4% and the total positive results with 1+, 2+, or 3+ were 14.6%. At the end of the intensive phase, the sputum smear examination of all patients showed 100% conversion, and the sputum smear examination at the end of six months of treatment showed negative results. This study has revealed that sputum conversion at the end of the 2-month intensive phase can be used as a prognostic determinant of timely complete therapy on pulmonary tuberculosis.
Waktu Konversi Negatif Swab PCR Pasien Covid-19 Dengan dan tanpa Penyakit Komorbid pada Rumah Sakit Rujukan di Jawa Timur Budhi Setiawan; Muzaijadah Retno Arimbi; Akhmad Sudibya; Indah Widyaningsih
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (173.998 KB) | DOI: 10.36418/syntax-literate.v7i7.9001

Abstract

Pandemi COVID-19 memberikan efek pada semua negara di dunia. Indonesia merupakan salah satu negara yang terdampak dengan pandemi ini. Menurut data per 27 juli 2020 jumlah penderita terkonfirmasi di Indonesia adalah 100.303 kasus. Jawa Timur merupakan penyumbang nomor dua terbanyak kasus di Indonesis setelah DKI Jakarta (Data Tim COVID-19, 2020).Pusat Pengendalian dan Pencegahan Penyakit Amerika Serikat juga mencatat bahwa rawat inap enam kali lebih tinggi di antara pasien dengan komorbid daripada mereka yang tidak. Di antara 287.320 (22 persen) kasus dengan data yang cukup tentang kondisi pasien dengan komorbid, yang paling umum adalah penyakit kardiovaskular (32 persen). Tujuan Penelitian Penelitian kami adalah mengkaji apakan ada hubungan cepatnya konversi negatif PCR pada penderita Covid-19 tanpa komorbid dan dengan penderita Covid-19 dengan komorbid. Metode penelitian, Penelitian dilakukan di RSI JemuR Sari Surabaya dan RS Muhamadiyah Gresik bulan April sampai bulan Juli 2020 didapatkan sejumlah 71 orang. Diagnosis digunalan swab nasofaring dengan metode PCR. 42 orang penderita covid-19 tanpa komorbid dan 29 orang dengan komorbid. Hasil penelitian: penderita Covid-19 dengan komorbid mendapatkan hasil konversi PCR negative lebih lama dengan dibandingkan dengan penderita Covid-19 tanpa komorbid.
Tuberkulosis Laten pada Tenaga Kesehatan di RSI Jemur Sari Surabaya Ayu Cahyani Noviana; Febtarini Rahmawati; Indah Widyaningsih; Muzaijadah Retno Arimbi; Theodora Theodora
Jurnal Ilmiah Kesehatan Masyarakat : Media Komunikasi Komunitas Kesehatan Masyarakat Vol 14 No 1 (2022): JIKM Vol. 14, Edisi 1, Februari 2022
Publisher : Public Health Undergraduate Program, Faculty of Health Science, Universitas Pembangunan Nasional Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52022/jikm.v14i1.305

Abstract

Abstrak Latar belakang: Prevalensi TB paru dengan konfirmasi bakteriologis sebesar 759 (95% CI589-961) per 100.000 penduduk yang berumur 15 tahun ke atas. Petugas kesehatan yang bekerja di bagian paru rumah sakit, sangat rentan terpapar kuman Mycobacterium tuberculosis, dikarenakan setiap hari ada hubungan/ kontak dialog (anamnesis) dengan penderita tuberkulosis aktif yang sedang berobat. Tujuan penelitian ini adalah untuk mengetahui prevalensi TB Laten pada tenaga Kesehatan dengan metode IGRA Metode: Metode penelitian deskriptif dengan sample adalah seluruh tenaga kesehatan di bagian paru RSI Jemur Sari terdiri dari 2 dokter, 2 analis dan 6 perawat, terutama yang telah bekerja lebih dari 5 tahun diambil darahnya untuk diperiksa antibodi interferon gamma dengan metode IGRA. Hasil: Hasil penelitian didapatkan dari 10 sampel yang berhasil dilakukan pemeriksaan didapatkan 70% tenaga kesehatan yang kontak dengan penderita positif antibodi interferon gammanya. Kesimpulan: Kontak dengan penderita Tuberkulosis yang terus menerus memungkinkan tertular, dimana imunitas yang baik dapat menyebabkan tenaga kesehatan tersebut tanpa gejala dan keluhan.Diperlukan penatalaksanaan administratif yang baik agar dapat menurunkan angka kejadian tuberculosis laten Kata Kunci : IGRA, Tenaga kesehatan, Tuberkulosis laten Abstract Background The prevalence of pulmonary TB with bacteriological confirmation was 759 (95% CI589-961) per 100,000 population aged 15 years and over. Health workers who work in the pulmonary section of the hospital are very susceptible to exposure to Mycobacterium tuberculosis, because every day there is a relationship/contact dialogue (anamnesis) with active tuberculosis sufferers who are being treated. The purpose of this study was to determine the prevalence of latent TB in health workers using the IGRA method Method Descriptive research method with samples were all health workers in the pulmonary section of RSI Jemur Sari consisting of 2 doctors, 2 analysts and 6 nurses, especially those who had worked for more than 5 years had their blood taken for examination of interferon gamma antibodies using the IGRA method. Results From 10 successfully examined sample, 70% of the health workers that has contact with the patients has positive interferon gamma antibody. Conclusion Prolonged contact with Tuberculosis patient raises the probability of contagion, whereas decent immunity allows the health workers to proceed without any symptoms. An excellent administrative governance is required to reduce the occurrence of latent tuberculosis. Keywords : Health workers, IGRA, Latent tuberculosis
Pembentukan “Pondok Paru Sehat” Sebagai Pusat Edukasi dan Deteksi Dini Penyakit Paru Obstruktif Kronis, Asma, dan Tuberkulosis di Kelurahan Dukuh Kupang Kota Surabaya Farida Anggraini Soetedjo; Muzaijadah Retno Arimbi; Nur Khamidah; Johanes Aprilius Falerio Kristijanto
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 4 No. 3 (2024): COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/comserva.v4i3.1391

Abstract

The Forum of International Respiratory Societies melaporkan penyakit paru obstruktif kronis (PPOK), asma, dan tuberkulosis (TB) masih menjadi penyebab utama kematian dan disabilitas di dunia. Di Indonesia, Riset Kesehatan Dasar (Riskesdas) 2018 menunjukkan preval_ensi ketiga penyakit tersebut masih tinggi, sedangkan penelitian terbaru melaporkan bahwa masih banyak kasus PPOK, asma, dan TB yang tidak terdeteksi (underdiagnosed). Riskesdas 2018 juga melaporkan bahwa rata-rata penderita penyakit tersebut berada pada kelompok usia produktif dan lansia. Upaya promotif, preventif, dan deteksi dini dini masih menjadi kunci utama dalam menurunkan angka mortalitas dan morbiditas serta meningkatkan kualitas hidup. Oleh karena itu, pengabdian kepada masyarakat melalui pembentukan “Pondok Paru Sehat” bertujuan sebagai sarana edukasi dan deteksi dini PPOK, asma, dan TB di Kelurahan Dukuh Kupang Kota Surabaya. Mitra ini dipilih karena memiliki jumlah penduduk usia produktif dan lansia mencapai 11.775 individu yang berisiko menderita ketiga penyakit tersebut. Selain itu, Kelurahan Dukuh Kupang dipilih sebagai wujud pelaksanaan tri dharma Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya (FK UWKS) terhadap masyarakat sekitar. Kegiatan ini melibatkan Departemen Ilmu Penyakit Dalam dan Ilmu Kesehatan Masyarakat FK UWKS serta sebagai implementasi Mata Kuliah / Blok Respiratory System (RS) oleh mahasiswa semester 4 FK UWKS. Edukasi dilakukan dengan pemaparan materi oleh dosen FK UWKS dan dilanjutkan skrining PPOK melalui kuesioner skor PUMA yang disediakan oleh Perhimpunan Dokter Paru Indonesia (PDPI), kuesioner CAPTURE, dan pemeriksaan Peak Expiratory Flow Rate (PEFR) / Arus Puncak Ekspirasi (APE) untuk mengestimasi fungsi paru, sedangkan skrining asma dan TB dilakukan melalui kuesioner.
Co-Authors Akhmad Sudibya Ayu Cahyani Noviana Bastiana Bastiana Budhi Setiawan Farida Anggraini Soetedjo Febtarini Rahmawati Indah Widyaningsih Johanes Aprilius Falerio Kristijanto Nur Khamidah THEODORA