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Journal : Sinteza

Efektivitas Infusa Daun Jarak Kepyar (Ricinus communis L.) terhadap Kadar Kolesterol Total dan HDL Serum Darah Tikus Galur Wistar Hikmah, Rani Anggraini; Hariadi, Puspawan; Sovia, Fitriwati
Sinteza Vol. 2 No. 1 (2022): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (175.569 KB) | DOI: 10.29408/sinteza.v2i1.4367

Abstract

Jarak  kepyar (Ricinus communis L.) adalah salah satu tanaman herbal yang mengandung flavonoid khususnya kuersetin, tanin, dan saponin dimana senyawa-senyawa ini dipercaya dapat memberikan efek antihiperlipidemia. Tujuan dari penelitian ini untuk mengetahui efektivitas infusa dan untuk mendapatkan konsentrasi infusa daun jarak kepyar yang paling efektif sebagai antihiperlipidemia pada tikus galur wistar. Penelitian ini merupakan jenis penelitian true exsperimental dengan rancangan pretest-postest kelompok. Hewan uji terbagi menjadi 5 kelompok yaitu kontrol positif (simvastatin), kontrol negatif dan perlakuan (infusa daun jarak kepyar) dengan konsentrasi 10%, 20% dan 30%  dengan masing-masing kelompok sebanyak 5 ekor. Sebelum perlakuan hewan uji diberikan induksi kuning telur selama 25 hari kemudian diukur kadar kolesterol total, trigliserida, dan HDL. Pengukuran dilakukan sebelum dan sesudah induksi kuning telur kemudian dilakukan kembali setelah infusa daun jarak kepyar diberikan. Parameter yang diukur adalah kadar kolesterol total, trigliserida dan HDL. Berdasarkan hasil pengukuran kadar setelah pemberian infusa daun jarak kepyar diperoleh hasil persentasi penurunan kolesterol total yaitu kontrol negatif (8.43%), kontrol positif (15.28%), konsentrasi 10% (10.23%), konsentrasi 20% (20.03%), dan kelompok konsentrasi 30% (27.13%) dan peningkatan  HDL yaitu kelompok kontrol negatif (1.23%), kontrol positif (9.23%), konsentrasi 10% (2.96%), konsentrasi 20% (7.85%), dan kelompok konsentrasi 30% (5.14%).  Konsentrasi 20% dan 30% memberikan penururunan kadar kolesterol total secara signifikan (p<0.05)  dan peningkatan kadar HDL secara signifikan (p<0.05) oleh kontrol 20% jika dibandingkan dengan kontrol negatif. Infusa daun jarak kepyar (Ricinus communis L.) konsentrasi 30% paling efektif menurunkan kadar kolesterol total dan trigliserida, sedangkan yang paling efektif untuk meningkatkan kadar HDL  adalah konsentrasi 20%.
Gambaran Tingkat Kepuasan Pasien terhadap Pelayanan Informasi Obat di Apotek Wilayah Lombok Timur Hartono, M. Herry; Oktresia, Erma Ewisa; Sovia, Fitriwati
Sinteza Vol. 3 No. 2 (2023): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v3i2.18969

Abstract

Pharmaceutical services are a direct and responsible service to patients. One of the pharmaceutical service activities that align with the concept of pharmaceutical care is found in the quality of Drug Information Services (PIO) in pharmacies. The aim of this research is to determine the implementation of DIS based on the Indonesian Minister of Health Regulation No.73 of 2016 in pharmacies in the East Lombok region. This study is observational descriptive using quantitative analysis in the form of calculating the percentage of Respondent Achievement Level (TCR). Data was collected using a questionnaire covering eight activities that pharmacists should undertake when providing drug information, which were subsequently used as indicators. Sample selection was done through purposive sampling with a minimum of 96 samples. Based on the research results, the TCR percentage values for the indicators were as follows: information on drug efficacy at 78% with a good category; dosage form at 78% with a good category; usage instructions at 75% with a good category; drug dosage at 74% with a good category; side effects at 74% with a good category; drug storage at 74% with a good category; safety for pregnant and nursing mothers at 46% with a fair category; information on drug prices obtained a score of 90% with a very good category. The average TCR score for the 8 indicators was 73.3% with a good category in providing drug information services in accordance with the Indonesian Minister of Health Regulation No.73 of 2016 in pharmacies in the East Lombok region.
Analisis Efektivitas Biaya Penggunaan Insulin Lantus dan Apidra di RSUD Dr. R. Soedjono Selong Oktresia, Erma Ewisa; Sovia, Fitriwati; Ramadhan, Leny; Ramadani, Lalu Khilal
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.26475

Abstract

Indonesia is one of the countries with the highest number of type II diabetes mellitus patients in the world, reaching 10.7 million people. Diabetes mellitus requires long-term treatment to control patients' blood glucose levels. The types of therapy used vary, leading to differences in costs and treatment outcomes. The use of insulin is a significant issue in diabetes mellitus therapy, especially at RSUD Dr. R. Soedjono, concerning its cost-effectiveness and therapeutic efficacy. This study aims to analyze the cost-effectiveness of using Lantus and Apidra insulin therapies.This research is an observational analytic study with a cross-sectional design, and data collection was conducted retrospectively at RSUD Dr. R. Soedjono Selong. The sample selection was based on predetermined inclusion and exclusion criteria. Observations were made on the Length of Stay (LOS) and Direct Medical Cost (DMC) for each sample. Based on LOS and DMC data, the Average Cost-Effectiveness Ratio (ACER) was calculated. The results showed that the average LOS for Lantus insulin use was 4 days, while for Apidra insulin use, it was 5 days. The average DMC for Lantus insulin was Rp.2,395,734, while for Apidra insulin, it reached Rp. 2,590,218. Based on LOS and DMC data, the ACER value for Lantus insulin was Rp 598,934/day, while for Apidra insulin, it was Rp 518,043/day. The use of Apidra insulin is more cost-effective because it has a lower ACER value.