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All Journal Jurnal Ilmu Kefarmasian Indonesia Indonesian Journal of Multidisciplinary Science
Swandiny, Greesty Finotory
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Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Public Health Social Sciences

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Penelitian Terbaru terhadap 3 (Tiga) Jenis Ekstrak Teripang di Pulau Tegal Mas, Lampung Hutapea, Manuel; Swandiny, Greesty Finotory; Syafawi, M. Irfan; Putra, Fahreza Pratama; Kokadir, Sucipto; Basilianus, Edward; Putri, Vinessa Gracia; Abdillah, Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1447

Abstract

Sea cucumbers are deep-sea-dwelling invertebrate animals that are rich in nutrients and have been empirically used to prevent various degenerative diseases, especially due to their ability to dampen free radicals. The purpose of this study was to identify, and determine antioxidant activity, total phenolic content, and toxic properties in extracts of several sea cucumber species originating from Tegal Mas Island, Lampung. The identification results of the three sea cucumber species were Stichopus vastus Sluiter (SV), Stichopus monotuberculatus Quay & Gaimard (SM), and Stichopus quadrifasciatus Massin. (SQ). The extraction was performed by kinetic maceration against all parts of the sea cucumber using a 70% ethanol solvent. Antioxidant activity test using the DPPH (2,2-diphenylpicrilhydrazyl) free radical suppression method and determination of the total phenolic content using the Folin-Ciocalteu method. The results showed that SV had the highest total phenolics and antioxidants with the lowest toxicity. However, optimisation of extraction between wet and dry sea cucumbers is still required. Extraction optimisation with various solvents can also be done to gain secondary metabolites more effectively.
50% ethanol extract cytotoxic test of temulawak on MCF-7 breast cancer cells Anindita, Kintan; Syamsudin, Syamsudin; Nuralih, Nuralih; Djamil, Ratna; Swandiny, Greesty Finotory
Indonesian Journal of Multidisciplinary Science Vol. 3 No. 3 (2023): Indonesian Journal of Multidisciplinary Science
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/ijoms.v3i3.798

Abstract

According to WHO, the number of breast cancer sufferers always increases from year to year. One of the medicinal plants used is temulawak. The levels of active compounds in plants can differ depending on several factors, one of which is the planting location, therefore research was conducted on the cytotoxicity of 50% ethanol extract of temulawak rhizomes from 5 regions on MCF-7 breast cancer cells in vitro using the MTT-Assay method. Temulawak used in this research comes from 5 regions in Indonesia, namely Tembalang, Wonogiri, Jambi, Sumba and Sukabumi. Cytotoxic testing of 50% ethanol extract of temulawak rhizomes used 6 concentrations, namely 500; 250; 125; 62.5; 31.25; and 15,625 ppm. The IC50 value obtained from 50% ethanol extract of temulawak rhizomes from Tembalang, Wonogiri, Jambi, Sumba and Sukabumi at MCF-7 was 109; 550.9; 622.3; 341.6; and 116.5 ppm. The results of the cytotoxic test showed that the 50% ethanol extract of temulawak rhizomes from Tembalang obtained the best IC50 value compared to temulawak rhizome extracts from other areas.
Safety and efficacy test of a cream combination containing jujube (Ziziphus mauritiana L.) and perilla (Perilla frutescens L. Britton) leaf extracts Shaliha, Khansa Fitrah; Taurhesia, Shelly; Swandiny, Greesty Finotory
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1688

Abstract

Excessive free radicals accelerate skin degradation by causing oxidative damage to keratinocytes and fibroblasts, leading to structural protein breakdown (collagen, elastin, keratin), lipid peroxidation, and DNA damage. This process compromises skin barrier integrity, reduces elasticity, and promotes premature aging. Antioxidants play a crucial role in protecting the skin by neutralizing reactive oxygen species (ROS) and preventing lipid peroxidation. This study aimed to develop a topical cream containing jujube (Ziziphus mauritiana L.) and perilla (Perilla frutescens L. Britton) leaf extracts and evaluate its antioxidant activity and dermal safety. Extracts were obtained through kinetic maceration using 70% ethanol and formulated into oil-in-water creams at two concentration levels. The creams were assessed for physical characteristics (organoleptic properties, cream type, pH, homogeneity, spreadability, rheology, viscosity), stability under room and accelerated conditions (40°C for 4 weeks), antioxidant activity via DPPH assay, and irritation potential using albino rabbits. All formulations exhibited good physical properties, stability, and homogeneity. Irritation testing showed no erythema or edema, confirming the cream’s safety for topical application. Antioxidant testing revealed strong free radical scavenging activity, with IC50 values of 119.705 ppm (F1) and 66.938 ppm (F2). Accelerated storage slightly reduced antioxidant activity, while higher extract concentrations enhanced antioxidant effects compared to the base formulation. These findings indicate that jujube (Ziziphus mauritiana L.) and perilla (Perilla frutescens L. Britton) leaf extracts synergistically enhance antioxidant activity in a safe topical cream formulation, demonstrating potential as a natural preparation for skin protection against oxidative damage.
Co-Authors . Syamsudin Anindita, Kintan Basilianus, Edward Djamil, Ratna Kokadir, Sucipto MANUEL HUTAPEA, MANUEL Nuralih Nuralih, Nuralih Putra, Fahreza Pratama Putri, Vinessa Gracia Shaliha, Khansa Fitrah Syafawi, M. Irfan Syamsudin Syamsudin Taurhesia, Shelly