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All Journal Jurnal Ilmu Kefarmasian Indonesia Interdisciplinary Social Studies Indonesian Journal of Multidisciplinary Science Journal of Social Research
Swandiny, Greesty Finotory
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Public Health Social Sciences

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Penelitian Terbaru terhadap 3 (Tiga) Jenis Ekstrak Teripang di Pulau Tegal Mas, Lampung Hutapea, Manuel; Swandiny, Greesty Finotory; Syafawi, M. Irfan; Putra, Fahreza Pratama; Kokadir, Sucipto; Basilianus, Edward; Putri, Vinessa Gracia; Abdillah, Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1447

Abstract

Sea cucumbers are deep-sea-dwelling invertebrate animals that are rich in nutrients and have been empirically used to prevent various degenerative diseases, especially due to their ability to dampen free radicals. The purpose of this study was to identify, and determine antioxidant activity, total phenolic content, and toxic properties in extracts of several sea cucumber species originating from Tegal Mas Island, Lampung. The identification results of the three sea cucumber species were Stichopus vastus Sluiter (SV), Stichopus monotuberculatus Quay & Gaimard (SM), and Stichopus quadrifasciatus Massin. (SQ). The extraction was performed by kinetic maceration against all parts of the sea cucumber using a 70% ethanol solvent. Antioxidant activity test using the DPPH (2,2-diphenylpicrilhydrazyl) free radical suppression method and determination of the total phenolic content using the Folin-Ciocalteu method. The results showed that SV had the highest total phenolics and antioxidants with the lowest toxicity. However, optimisation of extraction between wet and dry sea cucumbers is still required. Extraction optimisation with various solvents can also be done to gain secondary metabolites more effectively.
50% ethanol extract cytotoxic test of temulawak on MCF-7 breast cancer cells Anindita, Kintan; Syamsudin, Syamsudin; Nuralih, Nuralih; Djamil, Ratna; Swandiny, Greesty Finotory
Indonesian Journal of Multidisciplinary Science Vol. 3 No. 3 (2023): Indonesian Journal of Multidisciplinary Science
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/ijoms.v3i3.798

Abstract

According to WHO, the number of breast cancer sufferers always increases from year to year. One of the medicinal plants used is temulawak. The levels of active compounds in plants can differ depending on several factors, one of which is the planting location, therefore research was conducted on the cytotoxicity of 50% ethanol extract of temulawak rhizomes from 5 regions on MCF-7 breast cancer cells in vitro using the MTT-Assay method. Temulawak used in this research comes from 5 regions in Indonesia, namely Tembalang, Wonogiri, Jambi, Sumba and Sukabumi. Cytotoxic testing of 50% ethanol extract of temulawak rhizomes used 6 concentrations, namely 500; 250; 125; 62.5; 31.25; and 15,625 ppm. The IC50 value obtained from 50% ethanol extract of temulawak rhizomes from Tembalang, Wonogiri, Jambi, Sumba and Sukabumi at MCF-7 was 109; 550.9; 622.3; 341.6; and 116.5 ppm. The results of the cytotoxic test showed that the 50% ethanol extract of temulawak rhizomes from Tembalang obtained the best IC50 value compared to temulawak rhizome extracts from other areas.
Identification and Antibacterial Activity of Propionibacterium Acnes of Ethyl P-Methoxy Cinnamate Isolated from Kaempferia Galanga Linn Utami, Usi Hikmah; Djami, Ratna; Rahmat, Deni; Fajriah, Sofa; Swandiny, Greesty Finotory
Journal of Social Research Vol. 3 No. 1 (2023): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v3i1.1718

Abstract

Kaempferia galanga Linn is a typical Indonesian plant that contains the compound Ethyl P-Methoxy Sinnamate which has antibacterial activity. Acne is a common skin condition characterized by inflammation of the hair follicles and oil glands in the skin. The most effective acne treatment is the use of antibiotics. This research is an experimental study and aims to identify galangal rhizome isolates (Kaemperia galangan L) obtained from N-Hexane extract. using Thin Layer Chromatography (TLC) and Densitometry TLC as well as testing the antibacterial activity of the acne-causing Propionibacterium acnes ATCC 6919 using Complete Tool Design (RAL) with SPSS analysis, confidence level (p<0.05) and continued with the ANOVA test using the disc diffusion and liquid dilution methods for MIC. On In Vitro test Kaempferia galanga Linn contains antibacterial compounds that cause acne, namely Ethyl P-Methoxy Sinnamate with medium-strong strength at a concentration of 0.6%; 1.2%, and 2.4% with an inhibition zone of 8.70 mm; 10,10 mm and 11.70 mm. The clear zone for Clindamycin is 27.30 mm. Ethyl P-Methoxy Cinnamate (EPMS) isolated from Kaempferia galanga Linn N-Hexane extract Kaempferia galanga Linn has a concentration of 1.572 g/mL and has activity against Propionibacterium acnes bacteria at a concentration of 0.6%; 1.2% and 2.4%
The nanoparticle formula optimization from Temulawak extract (Curcuma xanthorrhiza) as adjuvant therapy Swandiny, Greesty Finotory; Nafisa, Safira; Qodriah, Rahmatul; Nugroho, Gumilar Adhi; Bakhtiar, Muhammad Taher
Interdisciplinary Social Studies Vol. 3 No. 2 (2024): January-March 2024 (Regular Issue)
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/iss.v3i2.629

Abstract

Temulawak extract was synthesized using temulawak sodium alginate. The nanoparticle formula was obtained by combining the characteristics of temuwak extract and temusawak. The microbeads were characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The size of Alg-Curcuma was measured at SEM. The particle size distribution of the sample was analyzed using FTIR spectra. The results showed that the size of the resulting beads is microparticle in size. It was found that the temurawak extract is a good candidate as an anticancer agent. Therefore, there are several recommendations that can be done to optimize the synthesis of the material. The study reported that the recommended parameter is 12.5 kV with a flow rate of 0.1 mL/h (first batch synthesis).
Co-Authors . Syamsudin Anindita, Kintan Bakhtiar, Muhammad Taher Basilianus, Edward Djami, Ratna Djamil, Ratna Gumilar Adhi Nugroho Kokadir, Sucipto MANUEL HUTAPEA, MANUEL Nuralih Nuralih, Nuralih Putra, Fahreza Pratama Putri, Vinessa Gracia Qodriah, Rahmatul RAHMAT, DENI Safira Nafisa Sofa Fajriah Syafawi, M. Irfan Syamsudin Syamsudin Utami, Usi Hikmah