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All Journal Jurnal Ilmiah Farmasi JURNAL PHARMASCIENCE Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JOPS (Journal Of Pharmacy and Science) Majalah Farmasetika Borneo Journal Of Pharmascientech Journal of Global Pharma Technology Eduvest - Journal of Universal Studies Pharmacon: Jurnal Farmasi Indonesia ASEAN Journal for Science and Engineering in Materials
Suci Hanifah
Department Of Pharmacy, Universitas Islam Indonesia
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Journal : Jurnal Ilmiah Farmasi

 1 
POTENSI KEJADIAN INTERAKSI OBAT PADA PENGGUNAAN OBAT UNTUK PASIEN ANAK YANG DIRAWAT INAP DENGAN DIAGNOSA INFEKSI SALURAN PERNAFASAN DI SALAH SATU RUMAH SAKIT SWASTA DI SURAKARTA Saepudin Saepudin; Suci Hanifah; Wachidah Rahmawati
Jurnal Ilmiah Farmasi Vol. 3 No. 1 (2006)
Publisher : Universitas Islam Indonesia

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ABSTRACTThis research was aimed at knowing potential drug interactions on drug prescribing fortreatment of hospitalized pediatric patients with respiratory tract infection. Research was carriedout at a private hospital in Surakarta and data were collected from medical records of patients werehospitalized during January – December 2005. Potential drug interactions were determinedtheoretically using some literatures on drug interaction. From total 186 patients included in thisresearch, 67.2% were 0-4 years old with common cold was the most diagnosed. There were 52.7%patients receiving 4-6 item of drugs and 76.9% patients were hospitalized during 1-3 days.Potential drug interactions were identified in 30.7% patients with 1.8% and 15.8% of them at level 1and 2 clinical significance, respectively. Statistically, there was a relationship between potentialdrug interactions and length of hospitalization (p = 0.001). Some further investigations(prospectively) are needed to ensure results from this research.Key words : drug interaction, respiratory tract infection, pediatric
HEPATOTOKSISITAS PADA PENGOBATAN TUBERKULOSIS DI RSUD TANGERANG – INDONESIA Vitarani Dwi Ananda Ningrum; Arnia Megasari,; Suci Hanifah
Jurnal Ilmiah Farmasi Vol. 7 No. 1 (2010)
Publisher : Universitas Islam Indonesia

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Reaksi obat yang tidak dikehendaki atau yang dikenal dengan ADR (Adverse Drug Reaction) merupakan respon pasien terhadap obat yang berbahaya dan tidak diharapkan yang terjadi pada penggunaan obat dengan dosis normal untuk tujuan profilaksis, diagnosis, terapi suatu penyakit, maupun modifikasi fungsi fisiologis. Obat yang telah diketahui dapat menimbulkan hepatotoksisitas atau kerusakan fungsi hepar adalah golongan antimikobakteri yang digunakan dalam pengobatan tuberkulosis (TB) paru. Pasien tuberkulosis harus menggunakan obat secara teratur sampai periode pengobatan selesai. Penggunaan OAT (Obat Antituberkulosis) secara terus menerus dalam jangka waktu yang cukup lama dapat menimbulkan ADR. Penelitian ini bertujuan untuk mengetahui kejadian hepatotoksisitas pada pasien tuberkulosis paru serta faktor-faktor yang mempengaruhi terjadinya hepatotoksisitas. Metode penelitian dilakukan dengan menggunakan rancangan studi cross sectional. Pasien yang dilibatkan dalam penelitian ini adalah pasien yang mendapatkan regimen terapi antituberkulosis di RSUD Tangerang pada periode 2006 - Februari 2009. Penilaian kejadian hepatotoksisitas berdasarkan adanya peningkatan kadar AST/ALT serum. Hasil penelitian dari 55 pasien menunjukkan bahwa kejadian hepatotoksik sebesar 38,2%. Hasil uji statistik menggunakan analisis Regresi Binary Logistik dengan taraf kepercayaan 95% menunjukkan jenis kelamin laki-laki dan penggunaan obat hepatotoksis lain memiliki pengaruh terhadap kejadian hepatotoksik. Selain itu terdapat faktor yang dapat mengurangi kejadian hepatotoksik diantaranya penghentian obat, penggantian obat, dan pemberian curcumin. 
Variabilitas konsentrasi pada pemberian obat-obat infus: studi kasus di Pediatric Intensive Care Unit (PICU) Suci Hanifah
Jurnal Ilmiah Farmasi Vol. 13 No. 2 (2017): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol13.iss2.art2

Abstract

Latar belakang: Studi penggunaan obat di PICU menunjukkan tingkat kesalahan paling banyak pada tahap penyiapan dan pemberian obat, yang berakibat pada terjadinya variasi kadar obat. Salah satu faktornya adalah teknik pencampuran dan pemberian multi-infus.Tujuan: Penelitian ini bertujuan untuk mengetahui variabilitas kadar obat pada teknik pencampuran manual dan pemberian multi-infus seperti yang biasa dikerjakan di PICU rumah sakit.Metode: Uji homogenitas dilakukan dengan mengukur kadar obat midazolam, dobutamin, dan norepinefrin setelah direkonstitusi dengan glukosa 5% dalam spuit 50 mL secara manual sebanyak lima kali penggojokan. Variasi kadar obat pada multi-infus dievaluasi dengan membandingkan sistem infus menggunakan satu pompa dan sistem multi-infus (tiga pompa) yang diparalel.Hasil: Pencampuran secara manual memberikan variasi konsentrasi yang besar (%RSD >10%, p-value<0,05). Sementara itu, variasi konsentrasi pada pencampuran dengan sonikasi rendah (%RSD <10%, p-value >0,05).Kesimpulan: Hasil penelitian ini menyimpulkan bahwa pencampuran secara manual dengan lima kali penggojokan tidak cukup memberikan homogenitas yang baik. Sementara itu, pemberian obat dalam tiga pompa infus paralel memberikan variasi yang masih diterima secara statistik (%RSD <0,10, p-value >0,05).Kata kunci: variabilitas, konsentrasi obat, homogenisasi, infus bercabang
IDENTIFIKASI pH OBAT-OBAT YANG DIGUNAKAN DI PEDIATRIC INTENSIVE CARE UNIT (PICU) UNTUK PENCEGAHAN INKOMPATIBILITAS INTRAVENA Suci Hanifah
Jurnal Ilmiah Farmasi Vol. 11 No. 2 (2015): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

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Intisari Pasien anak-anak di unit perawatan intensif sering mendapatkan banyak obat dalam satu jalur infus. Presipitasi akibat perbedaan pH obat-obat yang bertemu i jalur intravena cenderung terjadi secara cepat sehingga menimbulkan masalah di jalur infus. Oleh karena itu, data pH sangat penting bagi praktisi untuk membuat panduan dalam menentukan jenis jalur yang tepat sehingga inkompatibilitas tidak terjadi. Penelitian ini bertujuan  untuk mengidentifikasi obat-obat yang sering digunakan di PICU dan mengukur pH dari obat-obat yang umum digunakan di ICU. Data obat dikumpulkan dari dokumen logistic farmasi selama tahun 2013. Keempat puluh obat injeksi yang siap diberikan, diuji nilai pHnya dengan pH meter. Berdasarkan nilai pH yang diperoleh, potensi inkompatibilitas banyak terjadi pada obat-obat pH asam seperti kardiotonik dan antikolinergik dan obat-obat yang memiliki pH tinggi (basa) misalnya misalnya Asiklovir, Ampisilin, Ampi-Sulbaktam, Fenobarbital, Fenitoin, Furosemid, dan Omeprazo. Berdasarkan hasil identifikasi pH masing-masing obat, untuk mencegah inkompatibilitas, sedikitnya diperlukan tiga jalur; jalur obat asam, jalur obat basa, dan jalur khusus. Jalur yang spesifik digunakan untuk cairan yang cenderung tidak bisa melalui jalur asam maupun basa, karena hiperosmolar atau sulit larut misalnya mannitol dan diazepam.  Kata Kunci : pH, intravena, pediatric intensive care unit, inkompatibilitas
Stability and beyond-use date of anesthetic agents used in surgical procedures: a review: Stability and Beyond-Use Data of Anesthesia Wijayanti, Shofia; Hanifah, Suci; Fudholi, Dhomas Hatta
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art4

Abstract

Background: Anaesthesia drugs are often divided into other syringes to be soluted or mixed with other medications to share with other patients for the sake of efficiency. Objectives: This study aims to know the stability of anesthetic agents and the compatibility with co-simultaneous drugs used. Methods: This review was conducted by searching literature through the following databases: PubMed, Science Direct, and Google Scholar. The keywords used in the search for articles were "stability," "beyond use date," "anesthetic drug," and "intravenous."Results: The data showed that mixing fentanyl with levo-bupivakain or epinefrin is relatively stable up to one month, but it decreases only for 72 hours in dextrose 5% or normal saline (NS). Pethidin can be mixed with acetaminophen and metoclopramide using dextrose, NS, or water and stored up to 24 hours. Midazolam diluted in dextrose 5% (D5) or mixed with other medications maintains stability for up to 14 days or more. Stability of ketamine is 24 hours longer whether it is mixed in solvent or acetaminophen. Mixing with propofol induces instability because of the emulsion form of propofol. Conclusion: In general, the anesthetic drugs of fentanyl, pethidine, midazolam, and ketamine are stable and safe for preparation and administration in more than 24 hours. These four medications are compatible with NS and D5 and all tested medications during 24 hours.
Update on pharmacist role in sterile compounding in hospital Albesht, Hanan; Hanifah, Suci; Abukres, Salem
Jurnal Ilmiah Farmasi Vol. 21 No. 1 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss1.art8

Abstract

Background: Sterile compounding, a critical aspect of pharmaceutical practice, involves the preparation of customized medications in a sterile environment. Pharmacists play a pivotal role in ensuring the safety and efficacy of compounded sterile products (CSPs), making their involvement integral to the healthcare system. Objective: This article aims to describe the role of pharmacists in sterile compounding based on literature. Method: Articles from Medline/PubMed, guidelines, reports, and databases related to sterile compounding have been searched and compiled. This review collected the qualitative data and identified the critical point for continuous quality improvement initiatives in sterile compounding.Results: This comprehensive narrative review explores the multifaceted responsibilities of pharmacists in sterile compounding, drawing insights from various studies and databases. However, the study related to the pharmacist's role in sterile compounding practices is very limited. Recent articles that mention the pharmacist's role in sterile compounding commonly come from the guidelines or government documents. In general, CSP needs a commitment to comply with regulatory standards for achieving patient safety using the integration of technology and healthcare collaboration. Continuous professional development is a crucial contributor to keeping the quality of compounded sterile products. Conclusion: The findings from various journals underscore the complexity of their responsibilities and emphasize the need for a holistic approach to ensure the integrity and safety of compounded sterile products in diverse healthcare settings.
POLA PENGGUNAAN OBAT UNTUK PENDERITAGAGAL GINJAL AKUT DI INSTALASI RAWAT INAP RUMAH SAKIT UMUM PUSAT (RSUP) DR. SARDJITO YOGYAKARTA TAHUN 1997-2001 Hanifah, Suci
Jurnal Ilmiah Farmasi Vol. 1 No. 1 (2004)
Publisher : Universitas Islam Indonesia

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ABSTRACTDrug Utility Review for ARF’ patients of Internal Unit, Sardjito’s hospital was examed. Itinvolved 109 ARF’s patients. Medical Record Unit reported that this number was 0,12% of alldisese i.e. 93.445 case in 2001. The level was 93rdfrom 945 kind of disease. It was studied bynonanalitical descriptive design. using notes of Medical Record system. Collecting of data byretrospektive methode. This research was aimed to study the Drug Utility Review for ARF’spatients, especially to study ; drug variation included kind and class of drugs, route ofadministration, variation drug number, length of stay, and regimen dosage of drugs. To complete it,mortality persentaged was reported. The result of the study showed that ARF’s patients got somany variation of drugs. Using of antibiotic, diuretic, and electrolit was the most case. It conformedto Health Care Standard in Sardjito’s hospital. The others was aimed to simptomatical drugs i.e.antihypertensi, cardioasculer drugs, analgetic, antiemetic, multivitamin, laxan etc. It depended onsymptoms and complication of patients. Variation of number between 1-24. The average numberwas 7,7 drugs. It tended to use new generation of antibiotic and combinatins antibiotic, as indicatorof extravagant prescibing. Route of administratin by orally in most case and 38 % by injection.Injection route so indicate extravagant prescibing except on emergency care. The others used bysublingual and suppositoria. Length of stay averaged 12,52 days. Mortality persentaged was 22%.Key words : Drug Utility Review, ARF, Medical Record,Extravagant Prescribing
Co-Authors Abukres, Salem Albesht, Hanan Anggani, Herninggar Aulia Anisa, Yuni Arnia Megasari, Azza, Lintang Prava Ball, Patrick A. Chynthia Pradiftha Sari, Chynthia Pradiftha Febrian, M. Pandoman Fudholi, Dhomas Hatta Hermawatiningsih, Oktaviarika Dewi Kennedy, Ross A. Khoiriyah, Umatul Kurniasih, Fatimah Intan Laksmy Anggun Larasati Lily Annisa, Lily Mafruhah, Okti Ratna Medisa, Dian Mutiara Herawati, Mutiara Mutmainah, Isti Nur Aini Mardea Pratiwi, Martania Rachman, Chintia Khairunnisa Robi Kurniawan Rosdiana Rosdiana Rosdiana Rosdiana Saepudin Saepudin Susi Ari Kristina Vitarani Dwi Ananda Ningrum Wachidah Rahmawati Wijayanti, Shofia Yosi Febrianti, Yosi Yuni Anisa