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All Journal Jurnal Penelitian Kesehatan Suara Forikes Jurnal Inovasi Teknik Kimia Jurnal Penelitian Sekolah Tinggi Ilmu Kesehatan Nahdlatul Ulama Tuban PROFESSIONAL HEALTH JOURNAL Jurnal Penelitian Jurnal Kefarmasian Indonesia
Ainun Najib
Department Of Medical Laboratory Technology, STIKES Banyuwangi, Banyuwangi, East Java
Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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EFEKTIFITAS EKSTRAK ETANOL DAUN SIRSAK (Annona Muricata L.) TERHADAP KADAR GLUKOSA DARAH TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI ALOKSAN Ainun Najib; Leny Eka Tyas Wahyuni; Adieba Warda Hayya; Alfian Abdul Rajab
Jurnal Penelitian Vol 4, No 2 (2022): JURNAL PENELITIAN
Publisher : Institut Ilmu Kesehatan Nahdlatul Ulama Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47710/jp.v4i2.181

Abstract

Soursop leaves (Annona muricata L.) contain flavonoid compounds. Flavonoid compounds act as diabetes drugs. This study aimed to determine the effect of soursop leaf ethanol extract on alloxan-induced hypoglycemia in white male rats. In this study, four treatment groups were used, namely. negative control received no treatment, positive control received treatment with metformin 9 mg, the first treatment 7.2 mg and the last group was treated with a second dose of 14.4 mg. Rats were satisfied first before being treated, then measured blood sugar levels were. Rats were induced with alloxan intraperitoneally (IP), then observed the development of their blood sugar levels for three days, and their blood sugar levels were checked once a day. For seven days, then given ethanol extract of Soursop leaves daily for five days. The results showed that soursop leaf ethanol extract could reduce blood glucose on days H4-H8, which decreased by 6.67 mg / mL in the treatment group 1 sample and 5.66 mg / mL in the treatment sample.2. The test results with the Kruskal-Wallis test at the level of 0.05 showed that there was no significant difference between the use of soursop leaf ethanol extract and metformin against blood sugar reduction.
EFEKTIFITAS EKSTRAK ETANOL DAUN SIRSAK (Annona Muricata L.) TERHADAP KADAR GLUKOSA DARAH TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI ALOKSAN Ainun Najib; Leny Eka Tyas Wahyuni; Adieba Warda Hayya; Alfian Abdul Rajab
Jurnal Penelitian Sekolah Tinggi Ilmu Kesehatan Nahdlatul Ulama Tuban Vol. 4 No. 2 (2022): JURNAL PENELITIAN
Publisher : Institut Ilmu Kesehatan Nahdlatul Ulama Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (40.246 KB) | DOI: 10.47710/jp.v4i2.181

Abstract

Soursop leaves (Annona muricata L.) contain flavonoid compounds. Flavonoid compounds act as diabetes drugs. This study aimed to determine the effect of soursop leaf ethanol extract on alloxan-induced hypoglycemia in white male rats. In this study, four treatment groups were used, namely. negative control received no treatment, positive control received treatment with metformin 9 mg, the first treatment 7.2 mg and the last group was treated with a second dose of 14.4 mg. Rats were satisfied first before being treated, then measured blood sugar levels were. Rats were induced with alloxan intraperitoneally (IP), then observed the development of their blood sugar levels for three days, and their blood sugar levels were checked once a day. For seven days, then given ethanol extract of Soursop leaves daily for five days. The results showed that soursop leaf ethanol extract could reduce blood glucose on days H4-H8, which decreased by 6.67 mg / mL in the treatment group 1 sample and 5.66 mg / mL in the treatment sample.2. The test results with the Kruskal-Wallis test at the level of 0.05 showed that there was no significant difference between the use of soursop leaf ethanol extract and metformin against blood sugar reduction.
Efektivitas Ekstrak Daun Annona Muricata Terhadap Penurunan Kolesterol Total Pada Lansia Dengan Hiperkolesterolemia Di Panti Werdha Mojopahit Mojokerto Muhammad Al Amin; ainun najib; ali syahbana
PROFESSIONAL HEALTH JOURNAL Vol 5 No 1 (2023): Desember
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (PPPM) STIKES Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/phj.v5i1.405

Abstract

The elderly experience a decrease in function, especially in the function of blood circulation. Blood circulation diseases and hormonal metabolism disorders experienced by the elderly include hypercholesterolemia. Hypercholesterolemia is a disorder of fat metabolism that triggers an increase in total blood cholesterol levels, namely> 200 mg/dl. The study aimed to determine the effectiveness of A. muricata leaf extract in decreasing total cholesterol levels in the elderly with hypercholesterolemia. Quantitative research method, using a quasi-experimental type with a group pretest-posttest design, with a sample size of 20 elderly. The sampling technique used purposive sampling, was carried out for a week consuming three times a day. The paired t-test showed a value of 8.73 and a p-value of 0.001. This study's results indicated a significant difference between the average cholesterol levels in the pre-test and post-test administration of Annona Muricata leaf extract. Compounds contained in soursop leaves, namely flavonoids, by reducing the activity of HMG-koa reductase (enzyme β-Hydroxy β-methylglutaryl-CoA) can reduce the activity of ACAT (enzyme acyl-Coa cholesterol acyltransferase), and reduce the absorption activity of cholesterol in the liver. Digestive tract. Saponin compounds in soursop leave lower cholesterol by binding to cholesterol in the intestinal lumen, thereby preventing the reabsorption of cholesterol. Saponins can bind with bile acids, which in turn will reduce the enterohepatic circulation of bile acids and cause an increase in the process of excretion of cholesterol.
Reducing blood uric acid levels after drinking Annona muricata linn (soursop leaf) extract: study in elderly with hyperuricemia Muhammad Al Amin; ainun najib; ali syahbana; efina amanda
PROFESSIONAL HEALTH JOURNAL Vol 6 No 1 (2024): In Progress issue
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (PPPM) STIKES Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/phj.v6i1.788

Abstract

Introduction: Gout is a degenerative disease that often attacks joints, especially in older adults. This disease is caused by the buildup of uric acid crystals in the joints, which causes inflammation and severe pain. One of the main indications that someone suffers from gout is if the results of measuring the uric acid level in the blood are more than 7.0 (mg/dL), whereas in women, it is more than 5.7 mg/dL. Objectives: Research to determine the effectiveness of A. Muricata leaf extract in reducing uric acid levels in older adults with hyperuricemia. Methods: Quantitative research, using a quasi-experimental type with Pre-test, Post-test design with control group design, with a sample size of 30 older adults, sampling technique using random sampling carried out for one week consuming one day three times. Results: The paired t-test showed a p-value of 0.0001, indicating a significant difference between the average uric acid levels before and after Annona muricata leaf extract administration. Soursop leaves contain flavonoid and tannin compounds, where flavonoids can inhibit the production of the enzyme xanthine oxidase. By inhibiting this enzyme, the process of forming hypoxanthine into xanthine is also hampered, thereby reducing excess uric acid production. Apart from reducing uric acid levels in the blood, soursop leaves can also reduce pain in people with gouty arthritis thanks to the tannin, resin and Agostini content, which can relieve pain and reduce swelling and pain. Conclusions: Administration of A. Muricata leaf extract has proven effective in reducing uric acid levels in older adults with hyperuricemia
Efektivitas Ekstrak Daun Azadirachta indica Terhadap Kadar Interleukin-10 pada Mencit Swiss yang Diinokulasi Plasmodium Berghei ANKA Najib, Ainun; Kisdjamiatun RMD, RA; Firmanti, Tria Anisa
Jurnal Penelitian Kesehatan SUARA FORIKES 2022
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf13nk327

Abstract

Malaria is a health problem for the world's population in tropical and subtropical regions. Malaria infection is caused by the protozoa Plasmodium spp. This study aims to determine the effectiveness of Azadirachta indica leaf extract on interleukin-10 levels in Swiss mice inoculated with Plasmodium berghei ANKA (PbA). This study used a post-test only design with control group which used 24 Swiss mice weighing 30-35 grams as subjects and divided into 4 groups (K, T1, T2, T3); all groups were inoculated with PbA. Group T1 (inoculated with PbA and treated with Azadirachta indica at a dose of 0.25 mg/gBW), Group T2 (inoculated with PbA and treated with Azadirachta indica at a dose of 0.5 mg/grBW), Group T3 (inoculated with PbA and treated with Azadirachta indica with a dose of 1 mg/gBB). Data analysis used Anova + posthoc test. The results showed that there were differences in IL-10 levels, both in the control group and in the treatment group after being given treatment with a p value <0.05. A greater increase in IL-10 levels occurred in the T3 group (mean +158.6 pg/ml) compared to the K group (mean +73.4 pg/ml), the T1 group (mean +143.2 pg/ml), and the T2 group (mean +136.7 pg/ml).Keywords: Azadirachta indica extract; interleukin-10; Plasmodium berghei ANKA ABSTRAK Malaria merupakan salah satu masalah kesehatan bagi penduduk dunia yang berada di kawasan tropis maupun subtropis. Infeksi malaria disebabkan oleh protozoa Plasmodium spp. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak daun Azadirachta indica terhadap kadar interleukin-10 pada mencit Swiss yang diinokulasi Plasmodium berghei ANKA (PbA). Penelitian ini menggunakan rancangan post-test only with control group yang menggunakan subjek mencit Swiss dengan berat 30-35 gram sebanyak 24 ekor dan dibagi menjadi 4 kelompok (K, T1, T2, T3); semua kelompok diinokulasi PbA. Kelompok T1 (diinokulasi PbA dan terapi Azadirachta indica dengan dosis 0,25 mg/gBB), Kelompok T2 (diinokulasi PbA dan terapi Azadirachta indica dengan dosis 0,5 mg/grBB), Kelompok T3 (diinokulasi PbA dan terapi Azadirachta indica dengan dosis 1 mg/gBB). Analisis data menggunakan uji Anova + posthoc. Hasil penelitian menunjukkan bahwa ada perbedaan kadar IL-10, baik pada kelompok kontrol maupun pada kelompok perlakuan setelah diberikan treatment dengan nilai p <0,05. Peningkatan kadar IL-10 yang lebih besar terjadi pada kelompok T3 (rerata +158,6 pg/ml) dibandingkan kelompok K (rerata +73,4 pg/ml), kelompok T1 (rerata +143,2 pg/ml), dan kelompok T2 (rerata +136,7 pg/ml). Kata kunci: ekstrak Azadirachta indica; interleukin-10; Plasmodium berghei ANKA
UJI ANTIOKSIDAN PADA EKSTRAK GENJER (Limnocharis flava) DAN SABUN CUCI TANGAN DARI DAUN GENJER Viera Salsabiela Rachman; Ani Qomariyah; Ainun Najib
Jurnal Inovasi Teknik Kimia Vol 9, No 4 (2024)
Publisher : Fakultas Teknik Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/inteka.v9i4.11199

Abstract

Penelitian ini mengkaji efektivitas antioksidan dari tanaman Genjer (Limnocharis flava), dengan fokus pada bagian batang, daun, dan bunga. Dalam menghadapi kerusakan yang ditimbulkan oleh radikal bebas, yang berasal dari faktor internal seperti reaksi kimia dalam tubuh, serta eksternal seperti polusi dan konsumsi makanan tidak sehat, antioksidan alami dapat menawarkan perlindungan dengan cara mengisi kembali elektron yang hilang pada radikal bebas tersebut. Tanaman Genjer, yang dikenal kaya akan vitamin C, E, fenol, dan flavonoid, diuji untuk mengidentifikasi kandungan antioksidannya menggunakan metode maserasi dengan pelarut etanol 96% untuk menghindari kerusakan termal pada senyawa antioksidan. Hasil uji fitokimia menunjukkan bahwa daun Genjer memiliki kandungan flavonoid dan fenol yang lebih tinggi dibandingkan dengan bagian lainnya, yang menandakan potensi antioksidan yang kuat. Pengujian antioksidan dengan metode DPPH menghasilkan nilai IC50 sebesar 122 ppm untuk ekstrak daun, menunjukkan efektivitas sedang dalam menangkap radikal bebas. Selanjutnya, aplikasi ekstrak ini dalam pembuatan sabun cuci tangan juga diuji, namun menunjukkan aktivitas antioksidan yang sangat lemah dengan nilai IC50 sebesar 805 ppm, yang menunjukkan penurunan aktivitas antioksidan akibat interaksi dengan bahan kimia lain dalam formulasi sabun. Penelitian ini menggarisbawahi pentingnya pemilihan metode ekstraksi dan formulasi produk dalam mempertahankan efektivitas antioksidan dari bahan alami. Meskipun ekstrak daun Genjer memiliki potensi sebagai sumber antioksidan yang baik, aplikasinya dalam produk seperti sabun cuci tangan memerlukan strategi formulasi yang lebih cermat untuk mengoptimalkan dan mempertahankan efektivitas antioksidannya. Penelitian lebih lanjut diperlukan untuk mengembangkan formulasi yang dapat meminimalkan pengurangan aktivitas antioksidan ketika diintegrasikan dengan bahan kimia lain.
Green Synthesis of Silver Nanoparticles using Curcuma xanthorrhiza as an Antibacterial Agent Against Staphylococcus aureus Adieba Warda Hayya; Ainun Nadjib
Jurnal Kefarmasian Indonesia VOLUME 16, NUMBER 1, JUNE 2026
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study synthesized silver nanoparticles (Cur-AgNPs) using Curcuma xanthorrhiza rhizome extract via a green synthesis method to address the growing concern of nosocomial infections. Nosocomial infections, particularly those caused by Staphylococcus aureus, remain a significant healthcare challenge due to increasing antimicrobial resistance. The aim of this study was to evaluate the antibacterial activity of Cur-AgNPs against Staphylococcus aureus. Silver nanoparticles were synthesized using 1 mM AgNO₃ at 60°C for 24 h, followed by characterization using UV-Vis spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), and Scanning Electron Microscopy (SEM). Antibacterial activity was assessed using the disk diffusion method at concentrations of 10, 20, 40, 80, and 160 μg/mL, with Clindamycin as a positive control. The results showed that Cur-AgNPs exhibited concentration-dependent antibacterial activity, with inhibition zones ranging from 5 ± 0.25 mm to 15 ± 0.89 mm, while the positive control (Clindamycin) produced an inhibition zone of 14 ± 0.2 mm. These findings suggest that Cur-AgNPs possess promising in vitro antibacterial activity against Staphylococcus aureus. However, this study is limited to a single bacterial species and in vitro evaluation. Further studies are required, including minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assays, cytotoxicity testing, nanoparticle stability analysis, and evaluation in in vivo models to confirm their potential biomedical applications.
Co-Authors Adieba Warda Hayya Alfian Abdul Rajab ali syahbana Ali Syahbanaa Ani Qomariyah Dea Amanda Caressa efina amanda Firmanti, Tria Anisa Hapzi Ali Hayya, Adieba Warda Kisdjamiatun RMD, RA Leny Eka Tyas Wahyuni Muhammad Al Amin Mulya Agustina Nyoman Suci Widyastiti Viera Salsabiela Rachman