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Keterkaitan Zat Gizi Makro dan Natrium dalam Terapi Pasien Congestive Heart Failure : Review Alfian Abdul Rajab
Jurnal Gizi Kerja dan Produktivitas Vol 2, No 2 (2021): November
Publisher : Fakultas Kedokteran Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52742/jgkp.v2i2.11377

Tujuan penelitian ini untuk menganalisis keterkaitan antara zat gizi makro dan natrium dalam terapi pasien CHF. Metode yang yang digunakan dalam penyusunan artikel ini yaitu melalui kajian review literature. Sumber informasi didapatkan dari jurnal dan teksbook. Infromasi yang digunakan yaitu tentang gizi makro dan natrium dengan penyakit jantung. Hasil dan pembahasan, pasien CHF mendapatkan terapi nonfarmakologi yang dimana salah satunya pengaturan asupan zat gizi makro (karbohidrat, protein dan lemak) serta pengaturan asupan natrium yang dimana berdasarkan hasil beberapa penelitian menujukkan mempengaruhi keberhasilan terapi pasien CHF. Karbohidrat dapat mempengaruhi kesembuhan pasien dengan cara dapat meningkatka profil lipid seperti trigliserida dan LDL, asupan protein juga berkonstribusi untuk menyababkan/mencegah terjadinya hipertensi dimana beberapa penelitian menujukkan asupan protein memilikin hubungan signifikan dengan kejadian hipertensi. Asupan lemak berlebih dapat memperparah kondisi pasien CHF melalui beberapa mekanisme yang menyebabkan semakin berat kerja jantung. Asupan natrium berperan penting untuk menyebabkan terjadinya hipertensi dan mempengaruhi keseimbangan cairan cairan. Kesimpulannya bahwa zat gizi makro serta natrium memiliki keterkaitan keberhasilan terapi untuk pasien CHF dan diperlukan pengaturan jumlah asupan yang tepat dan sesuai untuk kesembuhan pasien

EFEKTIFITAS EKSTRAK ETANOL DAUN SIRSAK (Annona Muricata L.) TERHADAP KADAR GLUKOSA DARAH TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI ALOKSAN Ainun Najib; Leny Eka Tyas Wahyuni; Adieba Warda Hayya; Alfian Abdul Rajab
Jurnal Penelitian Vol 4, No 2 (2022): JURNAL PENELITIAN
Publisher : Institut Ilmu Kesehatan Nahdlatul Ulama Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47710/jp.v4i2.181

Soursop leaves (Annona muricata L.) contain flavonoid compounds. Flavonoid compounds act as diabetes drugs. This study aimed to determine the effect of soursop leaf ethanol extract on alloxan-induced hypoglycemia in white male rats. In this study, four treatment groups were used, namely. negative control received no treatment, positive control received treatment with metformin 9 mg, the first treatment 7.2 mg and the last group was treated with a second dose of 14.4 mg. Rats were satisfied first before being treated, then measured blood sugar levels were. Rats were induced with alloxan intraperitoneally (IP), then observed the development of their blood sugar levels for three days, and their blood sugar levels were checked once a day. For seven days, then given ethanol extract of Soursop leaves daily for five days. The results showed that soursop leaf ethanol extract could reduce blood glucose on days H4-H8, which decreased by 6.67 mg / mL in the treatment group 1 sample and 5.66 mg / mL in the treatment sample.2. The test results with the Kruskal-Wallis test at the level of 0.05 showed that there was no significant difference between the use of soursop leaf ethanol extract and metformin against blood sugar reduction.

EFEK KOMBINASI BUBUK MENGKUDU DAN KELOR TERHADAP GLUKOSA DARAH PUASA TIKUS DMT2 DISLIPIDEMIA Alfian Abdul Rajab; Adi Magna Patriadi Nuhriawangsa; Setyo Sri Rahardjo
GIZI INDONESIA Vol 46, No 1 (2023): Maret 2023
Publisher : PERSATUAN AHLI GIZI INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36457/gizindo.v46i1.765

The prevalence of people with diabetes mellitus type 2 (DMT2) with dyslipidemia complications continues to increase. Hyperglycemia that occurs in DMT2 patients can cause oxidative stress that disrupts lipid metabolism. Combination of kelor and mengkudu powder has the potential to help lower blood glucose in T2DM with dyslipidemia because it contains flavonoids that can prevent oxidative stress and fiber that can slow the absorption of blood glucose. This study aims to determine the effect of giving a combination of kelor and mengkudu powder on changes in GDP levels in T2DM with dyslipidemia. This type of research is true-experimental with pretest-posttest with control group design. This study used 30 male Wistar rats aged 2-3 months, weighing 150-250 grams. The rats were divided into 6 groups, KN normal conditioned rats, K- T2DM rats without treatment, K+ T2DM rats given the drug atorvastatin and groups P1, P2, P3, T2DM rats given a combination powder of 600 mg/200 gBB /day in the ratio of P1 (0.5: 1.5), P2 (1: 1) and P3 (1.5: 0.5) for 14 days. GDP levels were examined using the GOD-PAP method, data analysis using the Wilcoxon test. After 14 days of intervention, the P2 group experienced the highest decrease in GDP levels of 176.20 ± 20.25 mg/dL (p=0.043) while in the control group there was no significant difference (p=0.416). Giving combination powder has an effect in reducing GDP levels. Combination powder can be considered to reduce glucose levels.Keywords: diabetes, GDP, kelor, mengkudu, powder ABSTRAK Prevelansi penyandang diabetes melitus tipe 2 (DMT2) dengan komplikasi dislipidemia terus mengalami peningkatan. Hiperglikemia yang terjadi pada pasien DMT2 dapat menimbulkan stress oksidatif sehingga mengganggu metabolisme lipid. Bubuk kombinasi kelor dan mengkudu berpotensi membantu menurunkan glukosa darah pada DMT2 dislipidemia karena mengandung flavonoid yang dapat mencegah stres oksidatif dan serat yang dapat memperlambat penyerapan glukosa darah. Penelitian ini bertujuan untuk mempelajari pengaruh pemberian bubuk kombinasi kelor dan mengkudu terhadap perubahan kadar GDP pada DMT2 dislipidemia. Jenis penelitian ini adalah true-experimental dengan pretest-posttest with co ntrol group design. Penelitian ini menggunakan 30 ekor tikus jantan Wistar usia 2-3 bulan dengan berat 150-250 gram. Tikus dibagi menjadi 6 kelompok yaitu KN tikus dikondisikan normal, K- tikus DMT2 tanpa perlakuan, K+ tikus DMT2 yang diberi obat atorvastatin dan kelompok P1, P2, P3 yaitu tikus DMT2 yang diberi bubuk kombinasi sebanyak 600 mg/200 gBB/Hari dengan perbandingan P1 (0,5:1,5), P2 (1:1) dan P3 (1,5:0,5) selama 14 hari. Kadar GDP diperiksa dengan metode GOD-PAP, analisis data menggunakan uji Wilcoxon. Setelah 14 hari intervensi kelompok P2 mengalami penurunan kadar GDP paling tinggi 176,20 ± 20,25 mg/dL (p=0,043) sedangkan pada kelompok kontrol tidak terdapat perbedaan yang bermakna (p=0,416). Pemberian bubuk kombinasi berpengaruh dalam menurunkan kadar GDP. Bubuk kombinasi dapat dipertimbangkan untuk menurunkan kadar glukosa.Kata kunci: bubuk, diabetes, GDP, kelor, mengkudu

EFEKTIFITAS EKSTRAK ETANOL DAUN SIRSAK (Annona Muricata L.) TERHADAP KADAR GLUKOSA DARAH TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI ALOKSAN Ainun Najib; Leny Eka Tyas Wahyuni; Adieba Warda Hayya; Alfian Abdul Rajab
Jurnal Penelitian Sekolah Tinggi Ilmu Kesehatan Nahdlatul Ulama Tuban Vol. 4 No. 2 (2022): JURNAL PENELITIAN
Publisher : Institut Ilmu Kesehatan Nahdlatul Ulama Tuban

Soursop leaves (Annona muricata L.) contain flavonoid compounds. Flavonoid compounds act as diabetes drugs. This study aimed to determine the effect of soursop leaf ethanol extract on alloxan-induced hypoglycemia in white male rats. In this study, four treatment groups were used, namely. negative control received no treatment, positive control received treatment with metformin 9 mg, the first treatment 7.2 mg and the last group was treated with a second dose of 14.4 mg. Rats were satisfied first before being treated, then measured blood sugar levels were. Rats were induced with alloxan intraperitoneally (IP), then observed the development of their blood sugar levels for three days, and their blood sugar levels were checked once a day. For seven days, then given ethanol extract of Soursop leaves daily for five days. The results showed that soursop leaf ethanol extract could reduce blood glucose on days H4-H8, which decreased by 6.67 mg / mL in the treatment group 1 sample and 5.66 mg / mL in the treatment sample.2. The test results with the Kruskal-Wallis test at the level of 0.05 showed that there was no significant difference between the use of soursop leaf ethanol extract and metformin against blood sugar reduction.

Sebuah Tinjauan Sistematis Bunga Telang (Clitoria ternatea L.) untuk Menurunkan Berat Badan dan Memperbaiki Profil Lipid pada Mencit dan Tikus dengan Obesitas : Bunga Telang untuk Memperbaiki Berat Badan dan Profil Lipid Fista Utami; Dono Indarto; Shanti Listyawati; Alfian Abdul Rajab
Amerta Nutrition Vol. 7 No. 4 (2023): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v7i4.2023.638-645

Background: Butterfly pea flowers (Clitoria ternatea L.) are edible plants found in Asian countries that have several phytochemical compounds thathave potential anti-obesity and anti-dyslipidemia. From several in vivo studies, the administration of various extracts of butterfly pea flowers has different effects to reduce body weight (BW) or body mass index (BMI), and lipid profiles. Objectives: To analyze systematically the effects of butterfly pea flowers on BW or BMI and lipid profiles in rodents with or without obesity. Methods: This study used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and bias risk using the Systematic Review Centre for Laboratory Animal Experimentation (SyRCLEs).Original articles were from Google Scholar, PubMed, ResearchGate, and Science-Direct with criteria: randomized control trial (RCT), published from 2019 to 2023, rodents, and research outcomes (BW and lipid profiles). Results: Four original articles met the research criteria. Giving 1,000 mg/kg BW of the aqueous extract of butterfly pea flower for seven days reduced BW. Another study reported that giving 130 mg/kg BW butterfly pea flowers kombucha inhibited weight gain. Doses of 0.25 and 0.50% of the aqueous extracts of butterfly pea flowers for 15 weeks did not affect BW butthe dose of 2% prevented weight gain. Conclusions: Butterfly pea flowers have beneficial effects on reducing BW and improving lipid profiles in rodents with severaldiets although vary in animal models, diet types, extraction methods, and research design. This study becomes important evidence for further study.

the HEALTH EDUCATION RELATED TO “NUTRITION AND MENTAL HEALTH” Mawarni, Elita Endah; ALFIAN, ALFIAN ABDUL RAJAB, S.Tr.Gz., M.Gz.; Mulya, MULYA AGUSTINA, S.Gz., M.Si.; Agus, AGUS PUTRA MURDANI, S.KM, M.Kes
ABDIMASNU: Jurnal Pengabdian kepada Masyarakat Vol. 5 No. 1 (2025): ABDIMASNU
Publisher : Institut Ilmu Kesehatan Nahdlatul Ulama Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47710/abdimasnu.v5i1.545

In our daily lives, nutrition and mental health are two inseparable aspects. Both are the most important parts in maintaining our physical and mental health. This community service activity aims to increase knowledge and understanding and the role of adolescents in maintaining mental health by linking it to balanced nutritional consumption. It is hoped that by knowing the importance of maintaining mental health by fulfilling balanced nutrition, it can reduce the incidence of mental health crises in adolescents. Nutrition is one of the important factors that determines the level of health and in schools. The method used is an interactive lecture and Q&A to students of SMP N 3 Purwoharjo Satu Atap regarding the prevention of mental health crises through the fulfillment of balanced nutrition in adolescents using observation techniques and pre-test data collection with the aim of determining whether or not this educational activity is necessary. Pre-test and post-test analysis are used to determine whether or not there is a change in understanding about prevention and how to prevent mental health crises through the fulfillment of balanced nutrition. The results of educational activities have an effect on increasing the understanding of students of SMP N 3 Purwoharjo Satu Atap about how to prevent mental health crises through the fulfillment of balanced nutrition. Keywords: Mental health, adolescents, balanced nutrition

INTERVENSI TERAPI GIZI PASIEN DIABETES MELLITUS TIPE 2 DENGAN SEPSIS, GANGRENE DAN ANEMIA Rajab, Alfian Abdul
Jurnal Kesehatan Tambusai Vol. 6 No. 2 (2025): JUNI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i2.45152

Diabetes mellitus tipe 2 merupakan permasalahan dimana terjadinya resistensi insulin didalam tubuh yang menyebabkan terjadinya peningkatan kadar glukosa darah. Sepsis dan gangrene merupakan komplikasi yang dijumpai pada pasien DMT2 yang disebabkan karena adanya inflamasi dan infeksi. Terapai gizi diperlukan guna untuk mencegah komplikasi pada pasien dan mempercepat proses kesembuahan pasien. Penelitian ini adalah studi kasus dengan pendekatan observasional deskriptif, dimana melakukan observasi pada pasien dengan diagnosa diabetes mellitus tipe 2 dengan komplikasi. Tn. A, 54 tahun merupakan pasien diabetes mellitus tipe 2 dengan komplikasi sepsis, gangren pedis dextra, ulkus pedis sinistra dan anemia. penelitian ini yaitu diketahui status gizi pasien berdasarkan % LLA adalah 72,8% (Gizi Kurang). Pemeriksaan data biokimia yaitu 2 JPP 134 mg/dL dan gula darah puasa yaitu 117 mg/dL dalam batas normal. Perkembangan fisik pasien yaitu keadaan umum pada hari pertama sampai akhir pasien tetap merasa lemah. Tekanan darah, nadi dan suhu tubuh pasien selama intervensi selalu dalam keadaan normal. RR pasien normal, hari ketiga dan ke empat normal. Evaluasi rata-rata asupan makan pasien selama intervensi gizi sebesar Energi 1340,3 kkal (75%), Protein 78,8 gram (89%), Lemak 43,8 gram (109,5%) Karbohidrat 239,8 gram (90%) dan Fe 12,51 mg (96%) menunjukkan terjadikan peningkatan asupan gizi selama 4 hari. Pemberian terapi gizi yang adekuat dapat membantu perbaikan kondisi pasien diabetes mellitus dengan komplikasi.

EFEKTIFITAS EKSTRAK ETANOL DAUN SIRSAK (Annona Muricata L.) TERHADAP KADAR GLUKOSA DARAH TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI ALOKSAN Najib, Ainun; Tyas Wahyuni, Leny Eka; Hayya, Adieba Warda; Rajab, Alfian Abdul
Jurnal Penelitian Vol 4 No 2 (2022): JURNAL PENELITIAN
Publisher : Institut Ilmu Kesehatan Nahdlatul Ulama Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47710/jp.v4i2.181

Soursop leaves (Annona muricata L.) contain flavonoid compounds. Flavonoid compounds act as diabetes drugs. This study aimed to determine the effect of soursop leaf ethanol extract on alloxan-induced hypoglycemia in white male rats. In this study, four treatment groups were used, namely. negative control received no treatment, positive control received treatment with metformin 9 mg, the first treatment 7.2 mg and the last group was treated with a second dose of 14.4 mg. Rats were satisfied first before being treated, then measured blood sugar levels were. Rats were induced with alloxan intraperitoneally (IP), then observed the development of their blood sugar levels for three days, and their blood sugar levels were checked once a day. For seven days, then given ethanol extract of Soursop leaves daily for five days. The results showed that soursop leaf ethanol extract could reduce blood glucose on days H4-H8, which decreased by 6.67 mg / mL in the treatment group 1 sample and 5.66 mg / mL in the treatment sample.2. The test results with the Kruskal-Wallis test at the level of 0.05 showed that there was no significant difference between the use of soursop leaf ethanol extract and metformin against blood sugar reduction.

the HEALTH EDUCATION RELATED TO “NUTRITION AND MENTAL HEALTH” ALFIAN, ALFIAN ABDUL RAJAB, S.Tr.Gz., M.Gz.; Mulya, MULYA AGUSTINA, S.Gz., M.Si.; Agus, AGUS PUTRA MURDANI, S.KM, M.Kes; Mawarni, Elita Endah
ABDIMASNU: Jurnal Pengabdian kepada Masyarakat Vol 5 No 1 (2025): ABDIMASNU
Publisher : Institut Ilmu Kesehatan Nahdlatul Ulama Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47710/abdimasnu.v5i1.545

In our daily lives, nutrition and mental health are two inseparable aspects. Both are the most important parts in maintaining our physical and mental health. This community service activity aims to increase knowledge and understanding and the role of adolescents in maintaining mental health by linking it to balanced nutritional consumption. It is hoped that by knowing the importance of maintaining mental health by fulfilling balanced nutrition, it can reduce the incidence of mental health crises in adolescents. Nutrition is one of the important factors that determines the level of health and in schools. The method used is an interactive lecture and Q&A to students of SMP N 3 Purwoharjo Satu Atap regarding the prevention of mental health crises through the fulfillment of balanced nutrition in adolescents using observation techniques and pre-test data collection with the aim of determining whether or not this educational activity is necessary. Pre-test and post-test analysis are used to determine whether or not there is a change in understanding about prevention and how to prevent mental health crises through the fulfillment of balanced nutrition. The results of educational activities have an effect on increasing the understanding of students of SMP N 3 Purwoharjo Satu Atap about how to prevent mental health crises through the fulfillment of balanced nutrition. Keywords: Mental health, adolescents, balanced nutrition

EFEKTIVITAS EMO-DEMO PEMBUATAN GUMMY BUAH NAGA DAN IKAN LEMURU TERHADAP PENGETAHUAN GIZI DI IBU PKK DESA WRINGINPITU Caressa, Dea Amanda; Rajab, Alfian Abdul; Amanda, Efina; Murdani, Agus Putra
Jurnal Kesehatan Tambusai Vol. 6 No. 3 (2025): SEPTEMBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i3.49212

Gizi kurang adalah masalah kesehatan global, termasuk di Indonesia, yang berdampak pada pertumbuhan dan perkembangan anak. Menurut SSGI 2023, prevalensi stunting pada balita mencapai 21,5%, sehingga memerlukan penanganan serius. Salah satu penyebab utama gizi kurang adalah kekurangan asupan gizi selama periode 1000 hari pertama kehidupan. Pengetahuan gizi menjadi faktor kunci dalam pemenuhan kebutuhan gizi pada masa tersebut, sehingga diperlukan intervensi edukatif, salah satunya melalui metode emo-demo. Penelitian ini bertujuan untuk mengetahui perbedaan tingkat pengetahuan ibu mengenai cara membuat gummy berbahan dasar buah naga dan ikan lemuru sebagai alternatif edukasi gizi, dengan menggunakan pendekatan Emo-Demo yang dievaluasi melalui pretest dan posttest. Penelitian ini memakai pendekatan kuantitatif dengan desain One Group Pre-Test Post-Test. Kegiatan dilakukan pada hari Rabu, 14 Mei 2025, di Aula Balai Desa Wringinpitu. Seluruh populasi yang terdiri dari 43 orang ibu dijadikan sampel dengan teknik total sampling. Untuk menganalisis perubahan tingkat pengetahuan sebelum dan sesudah edukasi, digunakan uji Wilcoxon. Selain itu, analisis N-Gain dilakukan untuk menilai seberapa efektif metode emo-demo dalam meningkatkan pengetahuan peserta. Pengetahuan ibu-ibu anggota PKK di Desa Wringinpitu meningkat setelah diberikan edukasi melalui metode emo-demo. Hasil uji Wilcoxon menunjukkan adanya perbedaan yang signifikan antara nilai pretest dan posttest dengan nilai signifikansi 0,018. Sementara itu, perhitungan N-Gain menunjukkan bahwa peningkatan pengetahuan termasuk dalam kategori sedang. Metode emo-demo terbukti cukup efektif dalam meningkatkan pemahaman ibu mengenai pembuatan gummy dari ikan lemuru dan buah naga sebagai bagian dari edukasi gizi.

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