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All Journal Majalah Kesehatan FKUB PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Neshya Ruriana Putri, Neshya Ruriana
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Agriculture, Biological Sciences & Forestry Economics, Econometrics & Finance Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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Efek Ekstrak Alga Coklat (Sargassum sp.) sebagai Supresor Protein Bcl-2 in vitro pada Sel HeLa Putri, Neshya Ruriana; Lyrawati, Diana; Indra, M. Rasjad
Majalah Kesehatan FKUB Vol 1, No 4 (2014)
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (487.995 KB)

Abstract

Prevalensi kanker rahim di Indonesia masih tinggi. Protein Bcl-2 salah satu protein yang menghambat apoptosis melalui jalur mitokondria. Pada kanker serviks terjadi mutasi p53 sehingga Bcl-2 mengalami ekspresi berlebihan.Terapi kanker serviks menggunakan bahan kimia dapat menimbulkan banyak efek samping. Senyawa anti kanker dari bahan alam yang  sedikit menimbulkan efek samping diharapkan mampu mempengaruhi ekspresi protein Bcl-2. Pada semua jenis Sargassum sp. mengandung fukosantin dengan kadar tinggi. Fukosantin dapat menurunkan ekspresi protein Bcl-2 pada sel kanker. Tujuan penelitian ini adalah membuktikan bahwa pemberian ekstrak alga coklat (Sargassum sp.) dapat menghambat ekspresi Bcl-2 pada kanker serviks (sel HeLa). Penelitian ini merupakan penelitian eksperimental laboratorik dengan rancangan true experimental. Sampel yang digunakan adalah sel HeLa yang terbagi atas 1 kontrol dan 3 perlakuan. Kelompok I adalah kontrol sel HeLa. Kelompok II-IV diberi perlakuan ekstrak alga coklat dengan kadar yang berbeda-beda (31,25 µg/ml, 62,5 µg/ml, dan 125 µg/ml). Semua kelompok diinkubasi selama 24 jam. Parameter yang diukur adalah ekspresi Bcl-2 pada sel HeLa yang dideteksi secara imunohistokimia. Hasil analisis statistika menunjukkan bahwa ekstrak alga coklat menurunkan eskspresi Bcl-2 sel HeLa secara signifikan (ANOVA, p = 0,000; R² = 0,947). Penurunan ekspresi Bcl-2 mulai terlihat sejak pemberian ekstrak Sargassum dengan kadar 31,25 µg/ml. Pemberian ekstrak alga coklat kadar 31,25 µg/ml, 62,5 µg/ml, dan 125 µg/ml menurunkan ekspresi Bcl-2 sebesar 21 %, 44 %, dan 68 %. Kesimpulan penelitian ini adalah ekstrak alga coklat (Sargassum sp.) mampu menurunkan ekspresi Bcl-2 sel HeLa dengan kadar efektif terendah 31,25 µg/ml. Kata kunci: Bcl-2, Ekstrak alga coklat (Sargassum sp), Sel HeLa.
Skrining Tekanan Darah Sebagai Langkah Preventif Komplikasi Hipertensi Pada Masyarakat Desa Kasemen, Provinsi Banten: Blood Pressure Screening as a Preventive Effort to Reduce Hypertension Complications in Kasemen Village Community, Banten Province Adhayati, Baety; Prameswari, Yuda Nabella; Hermawati, Luluk; Wulansari, Ekawati Rini; Zulfa, Hilizza Awalina; Putri, Neshya Ruriana
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 12 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i12.10337

Abstract

Hypertension is a non-communicable disease that is a leading cause of global morbidity and mortality. In Indonesia, the prevalence of hypertension continues to rise, particularly among the productive and elderly populations. This community service activity aims to conduct early detection and provide education on hypertension through blood pressure screening in Kasemen Village, Serang City, Banten Province. The method employed is a participatory approach involving faculty members and medical students from the Faculty of Medicine and Health Sciences at UNTIRTA. A total of 247 village residents participated in this activity, and from 230 valid data, it was found that 51.30% of respondents had hypertension. The highest proportion of hypertension was observed among the elderly group (71.6%) and men (80%). In addition to blood pressure measurement, education on the importance of regular blood pressure monitoring and healthy lifestyle changes was also provided to raise community awareness. The results of this activity demonstrate that community-based screening, combined with health education, is an effective strategy for preventing and controlling hypertension, while also serving as a field-based learning opportunity for medical students.
Co-Authors Adhayati, Baety Diana Lyrawati Ekawati Rini Wulansari Luluk Hermawati M. Rasjad Indra Yuda Nabella Prameswari Zulfa, Hilizza Awalina