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All Journal Medali Jurnal : Media Dental Intelektual The Indonesian Journal of Dental Research Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Majalah Obat Tradisional Dental Journal (Majalah Kedokteran Gigi) JIKG (Jurnal Ilmu Kedokteran Gigi) B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Odonto dental journal
Ahmad Syaify, Ahmad
Department Of Periodontology, Faculty Of Dentistry, Universitas Gadjah Mada
Dentistry Health Professions Medicine & Pharmacology Public Health

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Journal : B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah

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HERBAL THERAPY SUPPRESS INTERLEUKIN-1β IN PERIODONTITIS AND TYPE 2 DIABETES MELLITUS Padang, Lastry Ruth; Syaify, Ahmad; Karina, Vincensia Maria
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Vol 12, No 1 (2025): Vol 12 No 1 (Juni 2025)
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/jbd.v12i1.1764

Abstract

Background: Interrelated pathological conditions such as periodontitis and Type 2 Diabetes Mellitus (T2DM) still be the mistery to solve. The production of secondary metabolites due to hyperglycemia conditions, namely AGEs, contributes to inflammation that arises in periodontal tissue. Periodontal inflammation is exacerbated by systemic dysregulation resulting in periodontitis being one of the potential complications aggravating the condition of T2DM. Excessive production of pro-inflammatory cytokines damages periodontal tissue and pancreas B cells and thus leads to insulin resistance. Many approach have been conducted to break the relationship between these two diseases, especially from the inflammatory pathway. Herbal therapy is one of the potential treatment to manage the bidirectional relationship.  Objective: The aim of this study is to elaborate the effects of herbal therapy on decreasing IL-1β cytokines as potential targeted therapeutic targets for both periodontitis and type 2 diabetes condition.Methods: Literature research done from 2013 to 2023 to find relevant articles. Result: Several herbal therapies effective in decreased Interleukin-1β and correlated to systemic and periodontal condition. Conclusion:Herbal therapy is effectively decreasing Interleukin-1β as a potential therapeutic target in periodontitis and Diabetes Mellitus Type 2 management.
Co-Authors Aulida Arum Mubarokah Beta Widya Oktiani Dahlia Herawati Dewi Nurdiana Edi Karyadi Indi Kusumawati Ivan Arie Wahyudi Kwartarini Murdiastuti Marsetyawan HNES Marsetyawan HNES Muhammad Yusuf Nungky Devitaningtyas Nur Rahman Ahmad Seno Aji Osa Amila Hafiyyah Padang, Lastry Ruth Pritama, Muhammad Fauzi Adityawan Rahman, Friska Ani Shinta Ferronika Siti Sunarintyas Sri Budi Barunawati Sri Pramestri Lastianny, Sri Pramestri Sudibyo Sudibyo Suryono Suryono Suryono Suryono Vincensia Maria Karina Wildan, Muhammad Nabeel