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All Journal Jurnal Respirasi (JR) Jurnal Locus Penelitian dan Pengabdian eJournal Kedokteran Indonesia
Ni Luh Gede Yoni Komalasari, Ni Luh Gede Yoni
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Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Electrical & Electronics Engineering Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Public Health

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Weaving Activity and High Plasma Levels of Brain-Derived Neurothrophic Factor (BDNF) As A Protective Factors Against Cognitive Dysfunction in Middle-Aged Women Yuniarni, Ruth Sharon; Widyadharma, I Putu Eka; Juhanna, Indira Vidiari; Rumai, I Made Winarsa; Dewi, Ni Nyoman Ayu; Komalasari, Ni Luh Gede Yoni
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 8 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i8.4671

Abstract

Cognitive dysfunction is a common problem associated with ageing and affects quality of life. As a repetitive activity, weaving and brain-derived neurotrophic factor (BDNF) levels are believed to be essential in maintaining cognitive function. This study aims to prove the relationship between weaving activity, BDNF levels, and cognitive dysfunction. This study is an observational study with a case-control design. The study subjects were middle-aged women (45–59 years) divided into two groups: CD (cases) and non-CD (controls). CD status was determined using the Mini-Mental State Examination (MMSE) score. Weaving activity was assessed through a questionnaire, with the criterion for active weaving being at least 3–5 times per week (minimum 60 minutes per session), categorised as weaving (+) and non-weaving (–). Plasma BDNF levels were measured using an ELISA kit and categorised as high BDNF (+) and low BDNF (–) based on the mean value. The researchers performed statistical analysis using the Chi-Square test and logistic regression. The Chi-Square test showed a significant association between weaving activity as a protective factor against CD occurrence (p < 0.001; OR: 0.038) and high BDNF levels as a protective factor against CD occurrence (p < 0.001; OR: 0.013). Multivariate analysis using logistic regression indicated that weaving activity (p = 0.001; AOR: 0.028; CI: 0.003–0.247) and high BDNF levels (p < 0.001; AOR: 0.011; CI: 0.001–0.100) were independent protective factors against CD occurrence. This study indicates that weaving activity and high plasma BDNF levels are independent protective factors against CD.
The Expression of LFA-1, MMP-9, and Dicer1 in The Histological Grading of Colorectal Cancer Wahyuniari, Ida Ayu Ika; Sumadi, I Wayan Juli; Darwinata, Agus Eka; Linawati, Ni Made; Ratnayanti, I Gusti Ayu Dewi; Sugiritama, I Wayan; Wiryawan, I Gusti Nyoman Sri; Komalasari, Ni Luh Gede Yoni; Arijana, I Gusti Kamasan Nyoman; Ganesha, I Gde Haryo
eJournal Kedokteran Indonesia Vol. 13 No. 2 (2025): Vol 13, No. 2 - Agustus 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.1076.1

Abstract

Colorectal cancer (CRC) remains one of the most common cancers in many Asian countries, alongside lung and breast cancer. Tumor dissemination to the organs, particularly the liver, contributed to the mortality of this disease. The β2 subunit of lymphocyte function-associated antigen-1 (LFA-1) was revealed to cause impairments in liver endothelial activation, cytokines release, and tumor cell retention in the liver of CRC in the in vivo study. Epigenetic and matrix metalloproteinase (MMP)-9 are essential for CRC progression and poor prognosis. Tumor differentiation grade correlates with TNM staging, prognostic factors, patient survival, and lymph node metastasis. This study aimed to investigate the expression of the β2 subunit of LFA-1, MMP-9, and Dicer1 in the histological grading of CRC. A total of 38 formalin-fixed paraffin-embedded (FFPE) CRC samples were classified into low-grade, high-grade, and histology variants. Tissue samples were processed for qRT-PCR to examine the β2 subunit of LFA-1 expression and immunohistological staining to evaluate Dicer1 and MMP-9 expression. The results show that the expression of LFA-1 was significantly higher in high-grade compared to low-grade (p<0.05), except for mucinous type adenocarcinoma. In contrast, no significant difference was found in Dicer1 and MMP-9 expressions of all grades of CRC (p>0.05). In addition, no significant correlation (p>0.05) was found between Dicer1 expression and LFA-1 and MMP-9. In conclusion, the expression of LFA-1 is upregulated in high-grade tumors; however, Dicer1 and MMP-9 expressions are not correlated with the histological grade.
Needle Aspiration in Tuberculosis-Associated Secondary Spontaneous Pneumothorax Candrawati, Ni Wayan; Indraswari, Putu Gita; Komalasari, Ni Luh Gede Yoni
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.50-54

Abstract

Introduction: The management of tuberculosis-associated secondary spontaneous pneumothorax mostly requires chest tube insertion for complete drainage and resolution. We reported a case of tuberculosis-associated secondary spontaneous pneumothorax that improved with needle aspiration. Case: A 29-year-old female with pulmonary tuberculosis presented with sudden onset shortness of breath. Chest examination revealed asymmetry, decreased vocal fremitus, hypersonor, and decreased vesicular sound in the right lung field. Chest radiograph showed right pneumothorax with a 2 cm intrapleural distance. Needle aspiration was performed because the patient refused chest tube insertion. The first needle aspiration evacuated approximately 615 cc of air. The second needle aspiration was repeated 24 hours later due to clinical deterioration, and 610 cc of air was evacuated. Chest radiograph evaluation on the 6th day of treatment showed no pneumothorax. During hospitalization, the patient received oxygen therapy, anti-tuberculosis drugs, chest physiotherapy, and other symptomatic therapies such as mucolytics. The patient's condition improved, and she was discharged on the 9th day of hospitalization. Tuberculosis-associated secondary pneumothorax occurs in 1-3% of cases. Conclusion: Needle aspiration is a therapeutic modality for tuberculosis-associated secondary spontaneous pneumothorax. This modality has several advantages, including shorter length of stay, less cost and pain, and fewer complications. Needle aspiration combined with oxygen therapy, anti-tuberculosis drugs, and chest physiotherapy should be the modality of treatment for tuberculosis-associated secondary pneumothorax.
Giant Cell Lung Carcinoma: A Case Report of a Rare Histology Type of Non-Small Cell Lung Cancer Putri, Kadek Sri Adi; Kusumawardani, Ida Ayu Jasminarti Dwi; Sriwidyani, Ni Putu; Komalasari, Ni Luh Gede Yoni
Jurnal Respirasi Vol. 10 No. 2 (2024): May 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.2.2024.143-148

Abstract

Introduction: Giant cell carcinoma (GCC) of the lung is a subtype of lung cancer, undifferentiated non-small cell carcinoma, in which there are no features of small cell carcinoma, adenocarcinoma, or squamous cell carcinoma. Due to its aggressive clinical manifestations and peculiar pathological features, GCC of the lung is a highly anaplastic variant of bronchogenic carcinoma. Case: A 45-year-old woman was clinically suspected of having a lung malignancy, and a biopsy of the right lower lobe pleura and parietal pleura was performed. The histopathology showed hypercellular tumor cell clusters, forming a syncytia-like sheet pattern. Tumor cells were pleomorphic and contained many giant cells that confirmed the diagnosis of GCC. The patient was diagnosed with GCC of the lung, stage IVB, Karnofsky scores 50-60% with malignant pleural effusion, peritoneal metastases, bone metastases, and grade 3 malignant ascites with bacterial peritonitis. The patient passed away due to septic shock caused by bacterial peritonitis. GCC of the lung is one of the aggressive types of lung cancer. GCC has an unusual tendency to metastasize to the gastrointestinal tract. In this case, the patient had an enlarged abdomen since it was known that she had a malignancy that had continued to grow. From the ascitic fluid analysis, a carcinoma was found to be seeding. Conclusion: The prognosis of GCC of the lung is generally poor. Our case was diagnosed with GCC of the lung that had already spread to the bone, peritoneal, and had grade ascites. The patient's survival rate was generally poor, and she passed away due to bacterial peritonitis without having received any therapy for her cancer.
Co-Authors Agus Eka Darwinata Candrawati, Ni Wayan I Gde Haryo Ganesha I Gusti Ayu Dewi Ratnayanti I Gusti Kamasan Nyoman Arijana I Gusti Nyoman Sri Wiryawan I Putu Eka Widyadharma I Wayan Juli Sumadi I Wayan Sugiritama Ida Ayu Ika Wahyuniari Ida Ayu Jasminarti Dwi Kusumawardani Juhanna, Indira Vidiari Ni Made Linawati Ni Nyoman Ayu Dewi Ni Putu Sriwidyani Putri, Kadek Sri Adi Putu Gita Indraswari, Putu Gita Rumai, I Made Winarsa Yuniarni, Ruth Sharon