Article Per Year (5 Year)
p-Index From 2020 - 2025
2.17
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences E-Jurnal Medika Udayana Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kesehatan Andalas Majalah Kesehatan FKUB Oryza : Jurnal Pendidikan Biologi Hang Tuah Medical Journal Jurnal Kefarmasian Indonesia
Ida Ayu Ika Wahyuniari
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Education Health Professions Medicine & Pharmacology Nursing Public Health Other

Published : 13 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 13 Documents
Search

 1   2 
Efek Blueberry (Vaccinium sp.) Terhadap Kelembapan Kulit yang Terpapar Sinar Ultraviolet Akut ADNYANA PUTRA, I GEDE AGUS DIVA; IDA AYU IKA WAHYUNIARI; NI MADE LINAWATI; I GUSTI KAMASAN NYOMAN ARIJANA
Hang Tuah Medical Journal Vol 21 No 1 (2023): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i1.337

Abstract

Introduction: Maintained skin moisture is an indication of healthy skin. Acute UV exposure can cause sunburn, which is characterized by a loss of moisture in the skin. Polyphenol compounds are one practical approach to protecting the skin from sunburn so that skin moisture is maintained. Blueberries are one of the natural ingredients consists of anthocyanin compounds, which are polyphenols from the flavonoid group. Aims: To determine the effect of blueberries on skin moisture exposed to acute ultraviolet rays. Methods: Literature study using references in the form of research articles and literature reviews from national and international journals and related books published in the last 10 years. In writing this literature review, 42 references were used which were accessed through Google Scholar, NCBI, Crossref, and Pubmed. Results: Blueberries anthocyanins can maintain skin moisture from increased transepidermal water loss (TEWL) due to acute UV ray exposure by reducing the formation of UV stimulated reactive oxygen species (ROS) and lipid peroxidation in keratinocyte cells to maintain the elastic modulus and mechanical properties of keratinocytes as well as can prevent sunburn by reducing the skin's modulation of UV exposure. However, the absorption of anthocyanin compounds in the intestine is so low that taking blueberries orally alone is not enough to achieve good biodistribution. Conclusion: Blueberries affect retaining moisture in skin exposed to acute UV rays, so they have the potential to be used as skincare ingredients. However, further research needs to be done, especially to determine the side effects that can be caused and the required extract concentration.
PENGARUH INFUSA TEH HIJAU (CAMELLIA SINENSIS) TERHADAP DIAMETER NODULUS LIMFATIKUS LIMPA MENCIT (MUS MUSCULUS) YANG DIPAPAR ROKOK ELEKTRIK Sidauruk, Dona Uli; Wahyuniari, Ida Ayu Ika; Linawati, Ni Made; Arijana, I Gusti Kamasan Nyoman
E-Jurnal Medika Udayana Vol 13 No 5 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i05.P05

Abstract

E-cigarettes are the most widely used nicotine replacement therapy (NRT), particularly among young people. Exposure to e-cigarette vapor increases free radicals and suppresses the body's immune system. The accumulation of reactive oxygen species (ROS) in the spleen causes inflammation and tissue injury that decreases immune reactivity. It causes changes in the histoarchitecture of the spleen, including the lymphatic nodules. It might be repaired by the antioxidant and immunomodulatory activity of green tea that stimulates and enhances the immune system. Green tea polyphenols affect the production of cytokines along with the activation, proliferation, and differentiation of lymphocytes in the body. Increasing the diameter of the lymphatic nodules is an indicator of the immunomodulatory activity of green tea in mice exposed to e-cigarette vapor. The study design was a randomized post-test only controlled group with 27 sampled mice divided randomly into 3 groups, namely; P0 (e-cigarette vapor), P1 (e-cigarette vapor + green tea 0.020 g/bb/day), and P2 (e-cigarette vapor + green tea 0.040 g/bb/day). There were significant differences between the control and treatment groups, while between green tea doses of 0.020 g/bb/day and 0.040 g/bb/day was no significant difference. The study showed green tea infusion with an optimal dose of 0.020g/bb/day affected increasing the diameter of the spleen lymphatic nodules of mice exposed to e-cigarette vapor. Further research based on the difference in duration of infusion exposure and overall observation of the white pulp component are needed. Keywords : Green tea infusion, Lymphatic nodules, E-cigarette vapor.
POTENTIAL OF GREEN TEA INFUSION IN REDUCING LUNG MDA LEVELS OF BALB/C MICE DUE TO EXPOSURE TO ELECTRIC CIGARETTE VAPOR Adnyana, I Made Diatmika; Wahyuniari, Ida Ayu Ika; Linawati, Ni Made; Arijana, I Gusti Kamasan Nyoman
E-Jurnal Medika Udayana Vol 13 No 8 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i08.P01

Abstract

This research aims to evaluate the potential of green tea infusion in reducing Malondialdehyde (MDA) levels in the lungs of mice exposed to electronic cigarette vapor. The research employed an experimental method with a Randomized Post-Test Only Control Group design. The research sample consisted of 20 male mice aged 3-4 months with an average weight of 30 grams, divided into four groups: normal group (CN), negative control (NC), treatment 1 with a dosage of green tea 0.03 g (T1), and treatment 2 with a dosage of green tea 0.06 g (T2). After the treatment, an analysis of MDA levels in the mice's lungs was conducted by TBARS test. The average levels of MDA in mice were obtained as follows: CN=12.669 µM, NC=23.940 µM, T1=10.997 µM, T2=14.395 µM. Statistical analysis using the One-Way ANOVA test revealed significant differences (p<0.05) between CN and NC, NC and T1, and NC and T2. These findings indicate that green tea infusion has the potential to reduce MDA levels in the lungs of mice exposed to electric cigarette vapor. Thus, this research provides a foundation for further studies regarding optimal dosage and the mechanism of action of green tea infusion in combating the negative effects of exposure to electronic cigarette vapor on respiratory organs.
Efek Pemberian Kulit Buah Naga merah (Hylocereus polyrhizus) terhadap Tebal Endometrium dan Miometrium Tikus Model Menopause Wong, Ferdinand; Sugiritama, I Wayan; Ratnayanti, I Gusti Ayu Dewi; Wahyuniari, Ida Ayu Ika; Wiryawan, I Gusti Nyoman Sri
E-Jurnal Medika Udayana Vol 12 No 6 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i06.P15

Abstract

ABSTRACT Effects of Giving Red Dragon Fruit Skin (Hylocereus polyrhizus) as Phytoestrogens on Endometriak Thickness and Myometrium of Menopausal Model Rats Background: Menopause is a condition in which the body experiences a lack of estrogen due to decreased ovarian function. Decreased estrogen levels result in particular changes in the thickness and shape of the uterus. Phytoestrogens are herbal compounds that have several similarities to the functions and structures of estrogen. Phytoestrogens also can be an alternative as a therapeutic option when they need a substitute for estrogen. Among several types of phytoestrogens, anthocyanin is one of the potential. Anthocyanins are mostly found in the red dragon fruit, Hylocereus polyrhizus. Red dragon fruit skin contains anthocyanins. Anthocyanins compounds have the potential to overcome the symptoms caused by menopause through their phytoestrogens and antioxidant activity.Objective: The main purpose of this study is to determine the effect of red dragon fruit skin extract (Hylocereus polyrhizus) on the thickness of the endometrium ad myometrium in menopausal model rats. Methods: This study applied a randomized post-test only control group design using a sample of 30 female wistar rats that met the inclusion and exclusion criteria. The sample was divided into 3 (three) treatment groups where a group was consisted of 10 female wistar rats. The treatment group 1 was the control group, while the treatment group 2 was the group given the ethanol extract of red dragon fruit skin at a dose of 60 mg/200 grBW/day for 30 days, and the treatment group 3 was the group given the ethanol extract of red dragon fruit skin at a dose of 90 mg/200 grBW/day for 30 days. Results: The study signified an increase in the endometrial thickness after being given red dragon fruit extract (Hylocereus polyrhizus) at a dose of 60 mg/200 grBW and 90 mg/200 grBW in menopausal model rats. In the single-lane ANOVA test, the thickness of the endometrium found a significance value of 0.038 (p<0.05), while the thickness of the myometrium found a significance value of 0.000 (p<0.05).
PENGARUH PEMBERIAN EKSTRAK BUAH BIT (Beta vulgaris L) DAN UBI JALAR UNGU (Ipomoea batatas) TERHADAP KADAR TRIGLISERIDA PADA TIKUS DENGAN DIET TINGGI LEMAK Radjibu, Gabriela Anastasya Viorezky; Wahyuniari, Ida Ayu Ika; Linawati, Ni Made; Arijana, I.G Kamasan Nyoman
E-Jurnal Medika Udayana Vol 12 No 10 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i10.P18

Abstract

Antioksidan betalain dan betasianin yang terkandung dalam Beta vulgaris L menurunkan kadar kolesterol dan trigliserida dalam darah. Demikian juga dengan kandungan antosianin dalam Ipomoea batatas untuk menurunkan kadar glukosa dan trigliserida dalam darah. Penelitian ini dilakukan untuk menguji pengaruh kombinasi antioksidan dari ekstrak Beta vulgaris dan Ipomoea batatas terhadap kadar trigliserida pada tikus wistar ( Rattus norvegicus ). Penelitian ini merupakan penelitian ekperimental melalui uji laboratorium. Rancangan penelitian yang digunakan adalahTrue Experimental Post Test Only Control Group Design . Subjek penelitian menemukan 24 ekor tikus wistar ( Rattus norvegicus ), yang terbagi ke dalam 4 kelompok penelitian. Data dianalisis dengan SPSS versi 16.0. Penelitian ini merupakan penelitian awal yang mengkombinasikan 2 (dua) ekstrak umbi yaitu Beta vulgaris L dan Ipomoea batatas, yang hasilnya berbeda dengan hasil penelitian yang telah dilakukan oleh peneliti-peneliti sebelumnya yang hanya mengamati pengaruh satu ekstrak umbi terhadap kadar trigliserida wistar. Hasil uji One-Way ANOVA menunjukkan bahwa tidak terdapat perbedaan signifikan di dalam kelompok maupun di antara kelompok kontrol, perlakuan 1, perlakuan 2, dan perlakuan 3, dengan demikian hipotesis yang diterima dalam penelitian ini adalah H0 yaitu kombinasi ekstrak Beta vulgaris L dan Ipomoea batatas dosis 10,8 mg/200grBB tidak berpengaruh terhadap kadar trigliserida pada tikus wistar. Kata kunci : ekstrak Beta vulgaris L, ekstrak Ipomoea batatas , trigliserida
PENGARUH PEMBERIAN EKSTRAK ETANOL KULIT BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) TERHADAP EKSPRESI KOLAGEN DINDING VAGINA PADA TIKUS MODEL MENOPAUSE Rahcmanita, Dhila Cahya; Sugiritama, I Wayan; Ratnayanti, I Gusti Ayu Dewi; Wahyuniari, Ida Ayu Ika
E-Jurnal Medika Udayana Vol 12 No 6 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i06.P16

Abstract

The skin of red dragon fruit (Hylocereus polyrhizus) contains polyphenols, in particular anthocyanins, which may act as phytoestrogens and antioxidants. Phytoestrogens can help synthesize collagen through their bonds with estrogen receptors and antioxidants prevent the accumulation of free radicals that can damage collagen, so the skin of red dragon fruit has the potential to prevent vaginal organ disorders due to the reduced amount of collagen in the vaginal wall during menopause. This study aims to prove the effectiveness of the ethanol extract of Hylocereus polyrhizus rind in preventing decreased collagen in the vaginal wall of menopausal rats. This study was structured using a randomized post-test only control group design on 30 female Wistar rats, which were divided into three groups, namely the control group (P0) was given normal saline, the treatment group (P1) was given ethanol extract 60mg/200grBW and (P2) was given ethanol extract 90mg/200grBB. Dosing rats orally for 30 days, then vaginal wall samples were taken to examine vaginal collagen levels with Sirius red staining. The amount of collagen is calculated by the percentage area of ??the collagen pixels compared to the pixels of the entire vaginal tissue. The results show that the mean amount of collagen at P0, P1 and P2 is 55.53 ± 8.12 respectively; 67.50±3.89; 78.14±5.87. The One-way ANOVA test shows statistically significant differences among the groups (p = 0.000). The post hoc analysis using the LSD test finds that the mean amount of vaginal collagen in P2 is the highest than P0 (p=0.000) and P1 (p=0.001) and P1 is higher than P0 (p=0.000). It is concluded that giving of ethanol extract of Hylocereus polyrhizus rind is able to prevent the decrease in vaginal wall collagen in menopausal rats.
PENGARUH PEMBERIAN EKSTRAK UBI JALAR UNGU DAN EKSTRAK BUAH BIT TERHADAP KADAR KOLESTEROL PADA TIKUS WISTAR YANG DIBERI DIET TINGGI LEMAK Tohjiwa, G. Raditya; Wahyuniari, Ida Ayu Ika; Linawati, Ni Made; Arijana, I G Kamasan Nyoman
E-Jurnal Medika Udayana Vol 11 No 6 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i06.P02

Abstract

Cardiovascular disease is a disease that often occurs in Indonesia. Cholesterol and free radicals can stimulate an increase in oxidative stress on the walls of the coronary arteries which can trigger coronary heart disease. Ipomea Batatas and Beta Vulgaris L contain flavonoids and betalains which is useful to lower cholesterol levels in the body to prevent cardiovascular disease. This study aimed to determine the effect of the combination of purple sweet potato and beetroot extract on cholesterol levels in rats fed a high-fat diet. The study design was an experimental study using the Post Test Only Control Group Design method with a sample of 24 male wistar rats fed a high-fat diet and divided into 4 groups. Aquadest was given to the control group (K-) while Ipomea Batatas extract (P1), Beta Vulgaris L extract (P2) and a combination of Ipomea Batatas and Beta Vulgaris L extract (P3) were given to the treatment group. Cholesterol levels will be tested using photometrics with Diasys Cholesterol reagent using blood serum. Data is analyzed with One Way ANOVA. This research showed that there were significant differences in cholesterol levels between the control group and the treatment group given purple sweet potato extract and combination extract with a P value <0.05. The cholesterol level of Group K- 116.8 mg/dL, P1 88.8 mg/dL, P2 99.0 mg/dL, and P3 92.5 mg/dL In conclusion, purple sweet potato extract and the combination extract could reduce cholesterol levels in male wistar rats fed a high-fat diet. Keywords: Ipomoea batatas, Beta vulgaris L, Cholesterol Levels
Tinjauan Literatur: PATOGENESIS DAN TERAPI ATROFI VAGINA Sugiritama, I Wayan; Linawati, Ni Made; Wiryawan, I Gusti Nyoman Sri; Wahyuniari, Ida Ayu Ika; Ratnayanti, Gusti Ayu Dewi; Arijana, I Gusti Kamasan Nyoman
Majalah Kesehatan Vol. 11 No. 2 (2024): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2024.011.02.8

Abstract

Atrofi vagina adalah masalah kesehatan yang paling banyak dialami oleh wanita menopause. Patogenesisnya berkorelasi dengan penurunan kadar hormon estrogen, yang mengakibatkan  epitel vagina lebih tipis dengan proporsi sel-sel superfisial yang menurun. Pada dinding vagina terjadi penurunan jumlah serabut kolagen, penurunan massa otot polos dan penurunan vaskularisasi. Konsekuensi dari perubahan tersebut adalah dinding vagina mengalami penurunan dalam ukuran, elastis, lubrikasi, dan integritas lapisan mukosa. Gejala  yang paling sering dialami adalah rasa nyeri pada vagina, yang akhirnya menyebabkan ketakutan untuk melakukan aktivitas seksual.Penanganan gejala atrofi vagina menjadi penting karena populasi wanita menopause yang besar dan akan terus meningkat. Tujuan penulisan tinjauan literatur adalah mengulas patogenesis atrofi vagina dan berbagai macam pilihan terapinya. Literatur didapatkan melalui pencarian pada Google Scholar dan PubMed database selama tahun 2022 dan dipilih terbitan 10 tahun terakhir, baik dalam Bahasa Indonesia maupun Bahasa Inggris. Kata kunci yang digunakan adalah menopause, atrofi vagina, patogenesis atrofi vagina, terapi atrofi vagina, fitoestrogen, Selective Estrogen Estrogen Receptors (SERM), dan terapi sulih hormon. Hasil menemukan bahwa sebagian besar kasus tidak terdiagnosis dan hanya sedikit yang mendapat terapi yang tepat. Sebagian besar wanita menopause mengobati sendiri gejala atrofi vagina yang dialami dengan obat-obat yang dijual bebas dan ada banyak kasus yang tidak diobati. Terapi utama atrofi vagina adalah hormon yang diberikan secara sistemik atau topikal. Salah satu terapi sistemik adalah SERM. Terapi topikal pilihannya sangat banyak yaitu fitoestrogen, asam hialuronat, pelembab, pelumas, kolostrum, vitamin, herbal, terapi laser dan radio frekuensi. Berbagai jenis metode terapi memiliki mekanisme kerja yang berbeda, sebagian besar terbukti efektif mampu memperbaiki struktur dan fisiologi vagina serta mampu mengurangi gejala atrofi vagina dan juga memperbaiki fungsi seksual.
Ekstrak Etanol Ubi Jalar Ungu untuk Mencegah Peningkatan pH Vagina setelah Ovariektomi Bilateral pada Tikus Wistar Sugiritama, I Wayan; Sri Wiryawan, I Gusti Nyoman; Linawati, Ni Made; Wahyuniari, Ida Ayu Ika; Ratnayanthi, I Gusti Ayu Dewi; Arijana, I Gusti Nyoman Kamasan
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.5641

Abstract

AVaginal atrophy is one of the most common health problems in postmenopausal women. The disease is characterized by decreasing layers and maturation index of the vaginal epithelium and an increase in vaginal pH. A decrease in vaginal acidity will increase the susceptibility to infections since acidic pH protects the vagina from pathogens infection. The previous study has proven that phytoestrogens were effective to improve the microstructures of the vaginal, reduce urogenital complaints, and improve vaginal pH. The purple sweet potato (Ipomea batatas L.) which is cultivated in Bali was recognized for its high anthocyanin content and was reported to have phytoestrogen activity. The aim of the present study is to evaluate the effect of purple sweet potato on vaginal pH in an animal model of menopause. The randomized pre-test post-test control group design study was conducted using 36 bilateral ovariectomized female Wistar rats as an animal model of menopause. The animals were divided randomly into a control group (T0) which was given saline and a treatment group (T1) given an ethanolic extract of purple sweet potato 400 mg/day for 30 days. Vaginal pH was measured before treatment, every week during treatment, and after treatment. The result of the study showed that there was an increase in vaginal pH of the T0 on the 2nd and 3rd week, and after treatment (P
Pengaruh Pemberian Ekstrak Terong Ungu (Solanum melongena L.) Terhadap Kadar Kolesterol dan Profil Lipid Pada Tikus Yang Diberi Diet Tinggi Lemak Susilo, Yunike; Wahyuniari, Ida Ayu Ika; Sugiritama, I Wayan
ORYZA ( JURNAL PENDIDIKAN BIOLOGI ) Vol 13 No 2 (2024): ORYZA: Jurnal Pendidikan Biologi
Publisher : Program Studi Pendidikan Biologi STKIP Bima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33627/oz.v13i2.2727

Abstract

Kandungan antioksidan dalam terong ungu juga berpotensi mengurangi peradangan dan oksidasi lipid, yang merupakan faktor penting dalam perkembangan aterosklerosis. Tujuan dalam penelitian ini adalah untuk mengetahui pemberian ekstrak terong ungu (Solanum melongena L.) dapat menurunkan kadar kolesterol total pada tikus yang diberi diet tinggi lemak, pengaruh pemberian ekstrak terong ungu (Solanum melongena L.) terhadap kadar LDL dan HDL pada tikus yang diberi diet tinggi lemak dan untuk mengetahui ekstrak terong ungu (Solanum melongena L.) memiliki efek signifikan dalam menurunkan kadar trigliserida pada tikus yang diberi diet tinggi lemak. Metode penelitian yang digunakan dalam penelitian ini adalah Systematic Literature Review (SLR). Hasil dalam penelitian ini adalah ekstrak ini memiliki potensi signifikan dalam menurunkan kadar trigliserida. Senyawa aktif seperti antosianin dan flavonoid dalam ekstrak terong ungu berperan dalam mengurangi peradangan, meningkatkan sensitivitas insulin, dan menghambat sintesis trigliserida di hati, yang semuanya berkontribusi pada penurunan kadar trigliserida.
Co-Authors ADNYANA PUTRA, I GEDE AGUS DIVA Adnyana, I Made Diatmika Agus Eka Darwinata Arijana, I G Kamasan Nyoman Arijana, I Gusti Nyoman Kamasan Arijana, I.G Kamasan Nyoman Badri, Amelia A. Febrina, Jessica I Gde Haryo Ganesha I Gusti Ayu Artini I Gusti Ayu Dewi Ratnayanti I Gusti Kamasan Arijana I Gusti Kamasan Nyoman Arijana I Gusti Nyoman Sri Wiryawan I Gusti Nyoman Sri Wiryawan I MADE MULIARTA . I Wayan Juli Sumadi I Wayan Sugiritama Muhammad Ashhabul Kahfi Mathar Ni Luh Gede Yoni Komalasari, Ni Luh Gede Yoni Ni Made Linawati Ni Nyoman Ayu Dewi Radjibu, Gabriela Anastasya Viorezky Rahcmanita, Dhila Cahya Ratnayanthi, I Gusti Ayu Dewi Ratnayanti, Gusti Ayu Dewi Sidauruk, Dona Uli Susilo, Yunike Tohjiwa, G. Raditya Widianti, I Gusti Ayu Wong, Ferdinand