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All Journal Dentika Dental Journal ODONTO Dental Journal Dental Journal (Majalah Kedokteran Gigi) E-Prodenta Journal of Dentistry Sinnun Maxillofacial Journal eJournal Kedokteran Indonesia Cakradonya Dental Journal Odonto dental journal
Yuanita Lely Rachmawati
University Of Brawijaya
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Studi In-Vitro Efektifitas Grain Kefir dengan Kombinasi Sorbitol Terhadap Pertumbuhan Streptococcus mutans Viranda Sutanti; Yuanita Lely Rachmawati; Bintang Vallentino Nugraha Putra; Herlambang Pangestu
eJournal Kedokteran Indonesia Vol. 11 No. 2 - Agustus 2023
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.11.259.156

Abstract

Karies gigi adalah penyakit kronis jaringan keras gigi yang disebabkan oleh Streptococcus mutans (S.mutans). Berbagai metode termasuk aplikasi pasta gigi, senyawa antibakteri dan obat kumur yang mengandung fluoride bersama dengan penggunaan pemanis yang tidak dapat difermentasi seperti sorbitol telah disarankan untuk mengurangi aktivitas bakteri ini. Pada studi ekologi mulut telah mengkonfirmasi efektifitas bakteri probiotik dalam mengurangi jumlah S. mutans. Grain kefir merupakan salah satu produk probiotik. Tujuan penelitian ini adalah untuk melihat efektifitas grain kefir murni dan kombinasi dengan sorbitol terhadap pertumbuhan S. mutans secara in vitro. Penelitian dilakukan di laboratorium Biologi Oral Fakultas Kedokteran Gigi Universitas Brawijaya pada bulan Januari-Februari 2023. Dilakukan uji KHM (Konsentrasi Hambat Minimum) menggunakan uji tabung dan KBM (Konsentrasi Bakterisidal Minimum) menggunakan colony counter. Penentuan konstrasi perlakukan diawali dengan uji pendahuluan grain kefir murni konsentrasi 3,125% dan 6,25%, 12,5%, 25%, 50% dan 100%. Nilai KHM grain kefir murni uji pendahuluan terhadap S.mutans pada konsentrasi 12,5%. Pada konsentrasi perlakuan didapatkan nilai KHM grain kefir murni adalah 15% dan kombinasi grain kefir-sorbitol terhadap S.mutans yaitu pada konsentrasi 12,5%. Nilai KBM grain kefir murni didapatkan pada konsentrasi 15% dan kombinasi grain kefir-sorbitol pada konsentrasi 12,5%. Kombinasi grain kefir-sorbitol dapat menurunkan pertumbuhan S. mutans pada konsentrasi 12,5%.
Differences in Caries Severity Based on Sociodemographic Factors in Pediatric Patients at Universitas Brawijaya Hospital Edina Hartami; Yuanita Lely Rachmawati; Ambar Puspitasari; Amirah Nanda Herlambang
Dentika: Dental Journal Vol. 27 No. 1 (2024): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v27i1.15615

Abstract

Early childhood caries (ECC) is influenced by age and gender, with the severity of primary dental cavities being measured using dmf-t index. Therefore, this research aimed to identify differences in caries severity based on age and gender among pediatric patients at Universitas Brawijaya Hospital. The identification process was conducted through an analytical observational method using secondary data, comprising 71 medical records of pediatric patients receiving treatment in the hospital from April 2021 to November 2022. Medical records were observed by examining the number of teeth with decay, missing, and filling, as well as age and gender. According to the chi-square test results, there were no significant differences in caries severity based on age or gender (p > 0.05). In conclusion, this research showed no differences in caries severity based on sociodemographic factors in pediatric patients.
POTENSI OBAT KUMUR BERBAHAN CITRUS SINENSIS MENURUNKAN VIRAL LOAD COVID-19 DI RONGGA MULUT (STUDI PUSTAKA) Amira Rachmatillah; Mahfita Ardyarum; Yuanita Lely Rachmawati
Cakradonya Dental Journal Vol 14, No 2 (2022): Agustus 2022
Publisher : FKG Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/cdj.v14i2.29956

Abstract

Coronavirus 2 (SARS-CoV-2) sebagai penyebab COVID-19 mengakibatkan sindrom pernafasan akut parah dengan sel yang ditargetkan; sel epitel hidung dan bronkus dan pneumosit. SARS-CoV-2 menggunakan tipe 2 transmembran serine protease (TMPRSS2) sebagai media untuk membelahangiotensin 2 converting enzyme receptor (ACE2) dan mengaktifkan protein SAR-CoV-2. ACE2 banyak ditemukan pada sel epitel lidah. Lonjakan protein struktural virus (S) menunjukkan adanya infeksi pada sel yang ditargetkan. Tujuan studi pustaka ini adalah untuk mengetahui potensi obat kumur yang mengandung senyawa bioaktif flavonoid dari citrus sinensis untuk mengurangi viral load SARS-CoV-2. Ekstrak flavonoid seperti hesperidin dari citrus sinensis dapat menghambat respon imun bawaan dan melawan COVID-19. Hesperidin dapat memblokir dengan baik SARS-CoV-2 masuk melalui reseptor ACE2 dengan meningkatkan kekebalan seluler inang terhadap aktivitas antiinflamasi dan infeksi. Hesperidin yang dihasilkan dari proses ekstraksi hidroalkohol diencerkan dengan air suling untuk membuat larutan 4%(v/v) kemudian ditambahkan aspartam dan sodiumbenzoat untuk pembuatan sediaan obat kumur. Disimpulkan hesperidin dari kulit citrus sinensis dalam sediaan obat kumur dapat mengurangi viral load coronavirus 2 (SARS-CoV-2) dalam rongga mulut melalui pengikatan reseptor ACE2.
POTENSI OBAT KUMUR BERBAHAN CITRUS SINENSIS MENURUNKAN VIRAL LOAD COVID-19 DI RONGGA MULUT (STUDI PUSTAKA) Rachmatillah, Amira; Ardyarum, Mahfita; Rachmawati, Yuanita Lely
Cakradonya Dental Journal Vol 14, No 2 (2022): Agustus 2022
Publisher : FKG Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/cdj.v14i2.23680

Abstract

Wabah COVID-19 disebabkan oleh coronavirus 2 (SARS-CoV-2) mengakibatkan sindrom pernafasan akut parah dengan sel yang ditargetkan; sel epitel hidung dan bronkus dan pneumosit. SARS-CoV-2 menggunakan tipe 2 transmembran serine protease (TMPRSS2) sebagai media untuk membelah angiotensin 2 converting enzyme receptor (ACE2) dan mengaktifkan protein SAR-CoV-2. ACE2 banyak ditemukan pada sel epitel lidah. Lonjakan protein struktural virus (S) menunjukkan adanya infeksi pada sel yang ditargetkan. Penularan SARS-CoV-2 terjadi terutama melalui droplet dari kontak tatap muka atau permukaan yang terkontaminasi, dengan rongga mulut sebagai salah satu pintu masuk agen infeksi. Tujuan studi pustaka ini adalah untuk mengetahui potensi obat kumur yang mengandung senyawa bioaktif flavonoid dari citrus sinensis untuk mengurangi viral load SARS-CoV-2. Ekstrak flavonoid seperti hesperidin dari citrus sinensis dapat menghambat respon imun bawaan dan melawan COVID-19. Hesperidin dapat memblokir COVID-19 masuk melalui reseptor ACE2 dengan meningkatkan kekebalan seluler inang terhadap infeksi dan aktivitas anti-inflamasi yang baik. Hesperidin yang dihasilkan dari proses ekstraksi hidroalkohol diencerkan dengan air suling untuk membuat larutan 4%(v/v) kemudian ditambahkan aspartam dan sodium benzoat untuk pembuatan sediaan obat kumur. Hasil studi ini dapat disimpulkan hesperidin dari kulit citrus sinensis dalam sediaan obat kumur dapat mengurangi viral load coronavirus 2 (SARS-CoV-2) dalam rongga mulut melalui pengikatan reseptor ACE2.
Binahong leaf extract (anredera cordifolia) mucoadhesive patch as an alternative therapy for recurrent aphthous stomatitis Saputri, Lisa Oktaviona; Tamimmi, Dania; Nisa, Renita Rahma Chairu; Rossah, Nabila Hardina; Rachman, Afsal Unnisa; Rachmawati, Yuanita Lely
Odonto : Dental Journal Vol 9, No 2 (2022): December 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.279 KB) | DOI: 10.30659/odj.9.2.168-182

Abstract

Background: Recurrent Aphthous Stomatitis (RAS) is one of the most common oral diseases of all ages. There has been no study that defines the leading cause of RAS. The utilization of binahong leaves (Anredera cordifolia) can be beneficial for the treatment of RAS as it acts as an anti-inflammatory and accelerates the proliferation of fibroblasts. The combination between binahong leaves and the mucoadhesive patch will increase the effectiveness of RAS treatment.Method: Literature study through PubMed and Google Scholar databases was conducted using PRISMA flow chart looking for the efficacy of binahong leaves (Anredera cordifolia) for mucosa wound healing and mucoadhesive patches for the treatment of RAS.Result: The search results found 31 articles that met the criteria for analysis. Flavonoids and saponins in binahong leaves extract act as an anti-inflammatory and increase the proliferation of wound healing. Mucoadhesive patch formulation can increase the effectiveness of RAS treatment on the mucosa.Conclusion: Binahong leaves extract in the form of mucoadhesive patches can be used as an alternative treatment for Recurrent Aphthous Stomatitis.
Understanding root caries risk in Indonesian adults: evidence from a nationwide survey Rachmawati, Yuanita Lely; Hanafi Putri, Agustine; Hariyani, Ninuk; Adiatman, Melissa; Yiru Yu, Ollie
Dental Journal (Majalah Kedokteran Gigi) Vol. 59 No. 1 (2026)
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v59.i1.p87-94

Abstract

Background: Root caries (RC) remains a global burden and is often found in older adults. Risk factors for RC can vary in different countries. Purpose: This study aimed to determine the prevalence and risk factors of RC in Indonesian adults. Methods: This study analyzed data from Indonesia’s 2018 National Health Survey, which included 37,057 respondents aged ≥15 years. The survey collected data on sociodemography, oral health practices, general health behaviors, and oral conditions. An oral examination was conducted to measure the number of teeth with RC, decayed, missing, or filled teeth, as well as bleeding on probing (BOP), attachment loss, pocket depth, and number of eroded teeth. Logistic regression was generated to estimate odds ratios and confidence intervals. Results: The prevalence of RC was 59.4%, mainly occurring in participants aged >45 years. Those aged >60 years had 2.52 times (adjusted odds ratio [AOR] = 2.52; 95% confidence interval [95%CI], 2.26–279) the number of RC compared with those who were younger. The likelihood of RC was increased by having a lower education (1.47 times; AOR = 1.47; 95%CI, 1.28–1.70) and never visiting a dentist (1.64 times; AOR = 1.64; 95%CI, 1.22–2.19). Decayed, missing, or filled teeth were shown to increase the risk of RC, where more coronal caries indicated a higher risk. Those with BOP (+) and attachment loss of >3 mm had a greater risk of developing RC. Conclusion: The prevalence of RC was relatively high, occurring mainly in middle-aged and older adults. Root caries in the Indonesian adult population reflects a complex interplay of multiple contributing factors, including sociodemography, oral health practices, general health behaviors, and oral conditions.
Co-Authors Afsal Unnisa Rachman Ambar Puspitasari Amira Rachmatillah Amirah Nanda Herlambang Anestya Wibowo, Marchella Ardyarum, Mahfita Aufa Nikita, Dhea Balbeid, Merlya Bintang Vallentino Nugraha Putra Dania Tamimmi Devi Cahaya Ningtyas Diwya Nugrahini Hapsari Edina Hartami Endah Damaryanti, Endah Hamida Mahardika Ningrum Hanafi Putri, Agustine Herlambang Pangestu Kartika Andari Wulan Kurniawati, Sari Lalita El Milla Lisa Oktaviona Saputri Mahardika Ningrum, Hamida Mahfita Ardyarum Marchella Anestya Wibowo Marchella Anestya Wibowo Melissa Adiatman Melissa Adiatman Merlya Balbeid Nabila Hardina Rossah Nahla Ninuk Hariyani Nisa, Renita Rahma Chairu Palupi, Dyah Nawang Pratamawari, Dyah Nawang Palupi Rachman, Afsal Unnisa Rachmatillah, Amira Rahmadanti, Besti Renita Rahma Chairu Nisa Rossah, Nabila Hardina Saputri, Lisa Oktaviona Tamimmi, Dania Viranda Sutanti Viranda Sutanti Yiru Yu, Ollie