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All Journal e-Journal Pustaka Kesehatan Jurnal Kajian Ilmiah Kesehatan Dan Teknologi (JKIKT) Jurnal Farmamedika (Pharmamedica Journal) Journal of Pharmacy Science and Technology Indonesian Journal of Science and Pharmacy Jurnal Dedikasi Masyarakat
Hilmia Lukman, Hilmia
Fakultas Farmasi Universitas Jember
Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Penentuan Kadar Flavonoid pada Ekstrak Daun Tanaman Menggunakan Metode NIR dan Kemometrik (Determination of Flavonoid in Leave Extracts Using NIR and Chemometric) Hilmia Lukman; Lestyo Wulandari; Yuni Retnaningtyas
Pustaka Kesehatan Vol 4 No 1 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Flavonoids are a group of natural compounds with variety phenolic structures and are found in plants. The aim of this research was to study whether NIR and chemometric methods could be used to determine the flavonoid content. These methods were compared to UV-Vis spectrofotometry. Flavonoid was extracted from plant leaves by ultrasonic and maceration. NIR spectral data of selected leave extracts were correlated with flavonoid content using chemometric. In this study, the chemometric method that used for quantitative and qualitative analysis were Partial Least Square (PLS) and Linear Discriminant Analysis (LDA), respectively. The PLS R2 calibration was 0.9916499 and RMSEC was 2.1521897. In addition, the R2 of LOOCV and 2-Fold-Cross-Validation were 0.9986664 and 0.9823225, respectively. Furthermore, LDA gave accuracy of 100%. The significance of flavonoid content that have been measured by NIR and UV-Vis spectrofotometry was evaluated with paired samples t-test. In conclusion, flavonoid content that have been measured with both methods gave no significant difference. Keywords: flavonoid, chemometric, LDA, NIR, PLS
Antioxidant Activity Evaluation of Carrot (Daucus carota L.) Extract-Enriched Lip Balm: A Natural Approach for Lip Protection Hilmia Lukman; Vivi Shofia; Salsabila, Shinta Nova; Maysaroh, Titis
Indonesian Journal of Science and Pharmacy Vol. 2 No. 2 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i2.79

Abstract

Lips are a part of the body that is vulnerable to free radicals and UV radiation, thus requiring special protection. One effort to protect the lips is through the use of lip balm containing antioxidants. However, synthetic antioxidants in cosmetics can pose health risks, necessitating natural alternatives. This study aims to develop and evaluate lip balm based on carrot extract (Daucus carota L.) as a source of natural antioxidants. The methods used include carrot extraction using the reflux method with 96% ethanol, lip balm formulation with varying concentrations of extract (10%, 15%, and 20%), and antioxidant activity testing using the DPPH method with UV-Vis spectrophotometry. The results showed that lip balm containing carrot extract exhibited good physical characteristics, including homogeneity, color variation depending on the extract concentration, and pH within the suitable range for lip cosmetics (4.5–6.5). Antioxidant testing revealed that the higher the concentration of carrot extract, the greater the antioxidant activity, as indicated by IC50 values of 5.9214 ppm (F1), 3.5381 ppm (F2), and 1.9427 ppm (F3), which are classified as very strong antioxidants. The conclusion of this study is that carrot extract has potential as a source of natural antioxidants in lip balm, with effectiveness increasing with higher extract concentrations. This product can serve as a safe and beneficial natural cosmetic alternative for protecting lips from free radical damage.
Edukasi DAGUSIBU dan pemusnahan obat di SMA Unggulan BPPT Zainul Hasan Probolinggo Azis, Fahmi Dimas Abdul; Lukman, Hilmia; Anggara, Suwandre Dwi; Khalishah, Nur
Jurnal Dedikasi Masyarakat Vol. 8 No. 1 (2024): Jurnal Dedikasi Masyarakat
Publisher : P3HKI - Universitas Muhammadiyah Parepare

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31850/jdm.v8i1.3555

Abstract

Education regarding DAGUSIBU and how to destroy drugs at SMA Unggulan BPPT Zainul Hasan Genggong. Indonesian people are now getting used to the use of various types of medicines. Among teenagers, most of them consume drugs without knowing how to use and handle drugs properly and correctly, such as how to get drugs, use drugs, store drugs and dispose of drugs. The aim of DAGUSIBU drug education is one of the efforts that can be made as a pharmaceutical worker to prevent irrational use of drugs and ensure that there is no protection of drugs by the public. The method used, namely collaborating with SMA Unggulan BPPT Zainul Hasan Genggong to provide education in the form of interactive seminars with a visual approach, so that students are explained about obtaining, using, storing and disposing of medicines. The indicator of success of this activity is increasing the knowledge of BPPT Zainul Hasan Genggong High School students about obtaining, using, storing and disposing of medicines. Apart from that, students are expected to become agents of change in their families and surrounding communities by spreading the knowledge they have acquired.
Perbandingan Kandungan Kurkumin Kunyit Kuning (Curcuma Longa) dan Kunyit Putih (Curcuma Zedoaria) Hasil Ekstraksi Soxhlet dengan Metode Spektrofotometri Visible Shofia, Vivi; Lukman, Hilmia
Jurnal Kajian Ilmiah Kesehatan dan Teknologi Vol 7 No 1 (2025)
Publisher : Politeknik Unggulan Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52674/jkikt.v7i1.220

Abstract

Turmeric (Curcuma longa) is a perennial herbaceous plant belonging to the ginger family (Zingiberaceae), characterized by its distinctive rhizomes. Recent studies have elucidated the mechanisms of action of turmeric and its bioactive components. The primary polyphenolic compound naturally present in Curcuma longa rhizomes is curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), also known as diferuloylmethane. In Asian countries, Curcuma longa has been traditionally employed as an herbal remedy due to its well-documented antioxidant, anti-inflammatory, antimutagenic, antimicrobial, and anticancer properties. While yellow turmeric (Curcuma longa) is widely recognized as a primary source of curcumin, another variety white turmeric (Curcuma zedoaria) remains understudied and underutilized despite its potential therapeutic value. This study aimed to compare the curcumin content between yellow turmeric (Curcuma longa) and white turmeric (Curcuma zedoaria) through Soxhlet extraction followed by visible spectrophotometric analysis. Samples of both species were collected from Probolinggo, Indonesia, and evaluated for their potential as alternative curcumin sources. Quantitative analysis revealed curcumin concentrations of 74104,4±4745,97 mg/mL in yellow turmeric and 265,37±21,25 mg/mL in white turmeric, demonstrating Curcuma longa's superior curcumin yield. These findings provide critical data for selecting optimal raw materials in herbal drug development and highlight the need for further investigation into the bioactive compounds of Curcuma zedoaria.
FORMULASI DAN KARAKTERISASI TABLET EKSTRAK DAUN SIRIH DENGAN VARIASI KONSENTRASI AMILUM ZEA MAYS L. SEBAGAI BAHAN PENGHANCUR Latifah, Luluk; Lukman, Hilmia
Jurnal Farmamedika (Pharmamedika Journal) Vol 10 No 1 (2025): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v10i1.464

Abstract

Daun sirih (Piper betle L.) mengandung senyawa aktif yang berkhasiat sebagai antiseptik dan antiinflamasi, serta telah dikembangkan dalam berbagai sediaan farmasi seperti kapsul dan sediaan cairan. Amilum Zea mays L. atau pati jagung merupakan salah satu bahan penghancur alami yang umum digunakan dalam formulasi tablet. Amilum ini menyerap air dan mengembang, sehingga mempercepat disintegrasi tablet. Selain itu, amilum Zea mays L. memiliki daya hancur yang baik karena memiliki struktur granulosa yang mudah menyerap cairan tubuh, sehingga mempercepat pecahnya tablet menjadi partikel kecil. Penelitian ini bertujuan untuk mengembangkan formulasi tablet ekstrak daun sirih menggunakan variasi konsentrasi amilum Zea mays L. (5%, 10%, 15%) sebagai bahan penghancur dengan metode granulasi basah. Evaluasi meliputi karakterisasi fisikgranul (kecepatan waktu alir dan sudut diam) serta tablet (organoleptis, keseragaman bobot, kekerasan, dan kerapuhan). Hasil pengujian menunjukkan peningkatan konsentrasi amilum Zea mays L. meningkatkan kecepatan waktu alir (7,23±0,44 gram/detik, 8,35±0,47 gram/detik, dan 9,07±1,47 gram/detik masing-masing untuk konsentrasi 5%, 10%, dan 15%), dan menurunkan sudut diam (27,92±0,07°, 27,47±0,06°, dan 27,02±0,12° masing-masing untuk konsentrasi 5%, 10%, dan 15%). Tablet dari ketiga formula memiliki bau khas sirih, berbentuk bulat, dan warna agak kehijauan. Semua formula memenuhi syarat keseragaman bobot tablet. Sementara itu, peningkatan konsentrasi amilum menyebabkan penurunan kekerasan tablet dan peningkatankerapuhan. Kesimpulannya, ekstrak daun sirih dapat diformulasikan menjadi tablet menggunakan amilum Zea mays L. sebagai bahan penghancur alami. Formula dengan konsentrasi 10% (F2) memberikan hasil paling optimum dengan keseimbangan terbaik antara kekerasan dan kerapuhan tablet.
REVIEW ARTIKEL : ANALISIS KANDUNGAN ASAM ASKORBAT PADA BEBERAPA TANAMAN Lukman, Hilmia; Shofia, Vivi
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 4 No. 1: Desember 2023
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v4i2.88

Abstract

Ascorbic acid or vitamin C is an essential organic compound for the body and has many health benefits. Vitamin C cannot be produced by the body, so it must be obtained from outside the body through food consumption. The vitamin C in plants varies considerably depending on the type, the part of the plant, and the growing environment. Vitamin C analysis can be carried out using qualitative and quantitative methods. This article review aims to review qualitative and the quantitative analysis of vitamin C using plant samples. The plants used in the study are plants that are widely consumed in Indonesia, namely matoa fruit (Pometia pinnata), water spinach (Ipomoea reptana Poir), spinach (Amaranthus spinosus), cucumber (Cucumis sativus L.), enau fruit (Arenga pinnata Merr.) and katuk leaves (Sauropus Androgynus). The qualitative analysis of vitamin C used FeCl3, KMnO4, Methylene blue and AgNO3 reagents, while the qualitative analysis uses the UV-Vis spectrophotometry method and several titration methods.
Co-Authors Anggara, Suwandre Dwi Azis, Fahmi Dimas Abdul Khalishah, Nur Latifah, Luluk Lestyo Wulandari Maysaroh, Titis Salsabila, Shinta Nova Vivi Shofia Vivi Shofia Yuni Retnaningtyas