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All Journal Journal of Agromedicine and Medical Sciences Jurnal Biologi Tropis Jurnal Biotek Jurnal Abdimas Bina Bangsa Jurnal Ilmiah Farmasi Attamru (JIFA) Medimuh : Jurnal Kesehatan Muhammadiyah International Journal Mathla'ul Anwar of Halal Issues PCJN Pharmaceutical and Clinical Journal of Nusantara Medimuh : Jurnal Kesehatan Muhammadiyah Medimuh : Jurnal Kesehatan Muhammadiyah
Firman Rezaldi
4Program Studi Farmasi, Sekolah Tinggi Ilmu Kesehatan Bhakti Husada Mulia, Madiun
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ANALISIS KEBUTUHAN BIOKIMIA GIZI BALITA DAN PENGENALAN KOMBUCHA BUNGA TELANG (Clitoria ternatea L) TERHADAP ORANG TUA BALITA DALAM MENINGKATKAN IMUNITAS: ANALYSIS OF NUTRITIONAL BIOCHEMICAL REQUIREMENTS OF TOddlers and the Introduction of KOMBUCHA FLOWER (Clitoria ternatea L) ON PARENTS OF TOTAL CHILDHOOD IN INCREASING IMMUNITY Nurullah Asep Abdilah; Mu’jijah; Firman Rezaldi; Aris Ma’ruf; Endang Safitri; M. Fariz Fadillah
Medimuh : Jurnal Kesehatan Muhammadiyah Vol 3 No 2 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/mh.v3i2.446

Abstract

Zat gizi menjadi salah satu faktor dalam meningkatkan sistem imunitas (imunonutrisi). Penelitian yang telah dilakukan adalah penelitian secara deskriptif kuantitatif dengan menggunakan metode single case riset. Penelitian ini di lakukan di Posyandu Wilayah Kota Cilegon dalam waktu 2 bulan, terhadap  39 responden anak usia 6 sampai 24 bulan. Variabel yang diamati adalah asupan karbohidrat, lemak, protein, buah, sayur, Mpasi, ASI, dan Kombucha Bunga Telang bagi Orang Tua Balita. Hasil penelitian membuktikan bahwa 98.5% balita telah diberikan asupan zat gizi berupa karbohidrat berupa nasi, 3.8% diberikan karbohidrat jenis lainnya. 82.7% balita memperoleh lemak yang berasal dari minyak goreng 18.09% berasal dari mentega serta 12.09% belum memperoleh lemak tambahan 98.5% balita telah mengkonsumsi protein hewani dan nabati. Sedangkan 1.5% belum mengkonsumsi buah dan sayur. 86.8% balita telah mengkonsumsi ASI secara ekslusif dan 24.2% telah mengkonsumsi ASI yang dikombinasikan dengan susu formula. Sebanyak 29.1% telah mengkonsumsi bubur instan dan 70,9% balita telah mengkonsumsi zat gizi berupa asi buatan. 97% orang tua balita belum mengetahui kombucha bunga telang dan sebanyak 3% telah mengetahui kombucha bunga telang.
Antimikroba Pada Produk Bioteknologi Farmasi Berupa Sediaan Obat Kumur Kombucha Bunga Telang (Clitoria ternatea L) Firman Rezaldi; Rina Nurmaulawati; Arikha Ayu Susilowati; Kuncara Nata Waskita; Sylvia Puspita; Vivi Rosalina
Jurnal Ilmiah Farmasi Attamru (JIFA) Vol 3 No 2 (2022): JURNAL ILMIAH FARMASI ATTAMRU (AGUSTUS)
Publisher : Universitas Islam Madura

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Abstract

Sakit pada gigi merupakan tanda-tanda yang disebabkan adanya aktivitas mikroba patogen yang dapat menyebabkan penyakit maupun infeksi. Streptococcus mutan dan Candida albicans merupakan mikroba-mikroba patogen yang dapat menyebabkan penyakit maupun infeksi pada gigi. Upaya atau solusi dalam mencegah terjadinya kedua pertumbuhan mikroba adalah dengan cara menggunakan obat kumur kumur herbal dengan bahan aktif larutan fermentasi kombucha bunga telang. Hasil penelitian sebelumnya telah terungkap bahwa sediaan larutan fermentasi kombucha bunga telang telah berpotensi dalam mencegah pertumbuhan Streptococcus mutan dan Candida albicans. Tujuan penelitian ini adalah untuk membuat formulasi dan sediaan obat kumur herbal yang berbahan aktif larutan fermentasi kombucha bunga telang dengan konsentrasi gula 20%, 30%, dan 40%. Pada hasil penelitian sebelumnya konsentrasi gula yang berbeda-beda secara farmakologi berpotensi dalam menghambat pertumbuhan mikroba baik pada spesies bakteri maupun jamur. Penelitian ini bersifat eksperimental laboratorium dengan menyediakan obat kumur yang tersedia dipasaran berupa betadine sebagai kontrol positif dan membuat sebanyak 4 sediaan obat kumur yang meliputi basis obat kumur yaitu tanpa zat aktif sebagai kontrol negatif, basis obat kumur yang ditambahkan larutan fermentasi kombucha bunga telang pada konsentrasi 20%, 30%, dan 40%. Difusi cakram merupakan salah satu metode yang digunakan untuk menghambat kedua pertumbuhan mikroba uji dari masing-masing sediaan obat kumur. Analisis data yang digunakan dalam penelitian ini adalah ANOVA satu jalur pada taraf kepercayaan 95% dilanjut melalui analisis pos hoc. Hasil penelitian ini telah terbukti dan dapat disimpulkan bahwa berdasarkan uji ANOVA satu jalur dengan nilai p masing-masing kurang dari 0,05 dapat dilanjutkan melalui analisis pos hoc dimana konsentrasi 40% pada sediaan obat kumur merupakan konsentrasi yang terbaik dalam menghambat kedua pertumbuhan mikroba uji dan berbeda nyata dengan konsentrasi 20% dan 30%.
Antibacterial of Clostridium botulinum From Eagle Flower (Clitoria ternatea L.) Kombucha Body Wash as a Pharmaceutical Biotechnology Product Hari Hariadi; Titin Sulastri; Firman Rezaldi; Susanti Erikania; Rina Nurmaulawati
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): January - March
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i1.4470

Abstract

Liquid bath soap made from telang flower kombucha fermented solution has potential as a pharmaceutical biotechnology product in inhibiting the growth of Clostridium botulinum bacteria. The aim of this study was to formulate and prepare a liquid bath soap with an active ingredient based on fermented eggplant kombucha solution in inhibiting the growth of Clostridium botulinum bacteria. The research design was carried out experimentally by making four liquid body wash preparations consisting of body wash base ingredients without active substances as negative controls. The basic ingredients for bath soap with the active ingredient are fermented butterfly pea flower kombucha solution with a concentration of 20%; 30%; and 40%. Disc diffusion is a test method used to inhibit the growth of test bacteria from each soap preparation. One way ANOVA and post hoc analysis are methods used to statistically analyze all liquid body wash preparations to see their effect on the growth of the test bacteria. The results of the study were proven and it can be concluded that based on one way ANOVA with a p value <0.05, 40% concentration of telaga kombucha bath soap is the best treatment for inhibiting the growth of test bacteria with an average diameter of the resulting inhibition zone of 18.50 mm and entering the strong category. The concentration of 40% was significantly different in inhibiting the growth of the test bacteria compared to the concentrations of 20% and 30% but not significantly different from the bath soap on the market as a positive control.
Anti-Inflammatory Activity of Stem Barks Ethanol Extracts of Asam Kandis On Male White Rats Hanafis Sastra Winata; Muhammad Andry; Muhammad Amin Nasution; Firman Rezaldi; Ade Shindy F Br Sembiring
Journal of Agromedicine and Medical Sciences Vol 9 No 1 (2023)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v9i1.37478

Abstract

Inflammation is a complex series of changes in tissue due to tissue injury caused by bacteria, trauma, chemicals, heat, and pain. Gamboge (Garcinia xanthochymus) is a fruit-bearing tree native to Southeast Asia. Plants of the genus garcinia are rich in secondary metabolites such as flavonoids, steroids, and triterpenes which have potential pharmacological activity. This study aimed to determine the anti-inflammatory activity based on the reduction in edema volume of Gamboge (Garcinia xanthochymus) stem bark. The inquiry was experimental. Through maceration, an ethanol extract of the gamboge stem was created. The animals were divided into five groups, each containing five white male rats. The test given was a suspension of gamboge ethanol extract at doses of 200, 400, and 600 mg/kgBW, a negative control of 1% Na CMC suspension, and a positive control of 2.25 mg/kgBW sodium diclofenac. Observations were made for 6 hours, and then data were analyzed using a two-way analysis of variance (ANOVA) test. The results showed that gamboge ethanolic extract was proven to have an anti-inflammatory effect in white male rats induced by carrageenan starting at doses of 200, 400, and 600 mg/kgBW, marked by a significant difference to the negative control (p<0.05). The 600mg/kgBW dose group showed no significantly different results from the positive control group (p>.05). These results concluded that the dose group 600mg/kgBW was the best dose of gamboge stem ethanol extract had an anti-inflammatory activity based on reducing the volume of leg edema of white male rats. Keywords: Asam Kandis Stem Bark; Anti-Inflammation; Male White Rats
HALAL BIOTECHNOLOGY ON FERMENTATION AND LIQUID FERTILIZER PREPARATION FROM KOMBUCHA WASTE OF TECABLOWE WASTE IN INCREASING EGGPLANT (Solanum molengena) GROWTH Muhammad Faizal Fathurrohim; Fajar Hidayanto; Firman Rezaldi; Yuliana Kolo; Kusumiyati
International Journal Mathla’ul Anwar of Halal Issues Vol. 2 No. 2 (2022)
Publisher : Universitas Mathla’ul Anwar Banten

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Abstract

The fermented waste of butterfly pea flower kombucha can be used in the formulation and preparation of organic liquid fertilizer to support the growth of this eggplant plant. The purpose of this study was to determine the effectiveness of liquid fertilizer made from the waste of butterfly pea flower kombucha fermentation in supporting the growth of eggplant plants. The design of this study was a completely randomized design (CRD) with a single factor, namely the difference in the concentration of organic liquid fertilizer that had been treated five times. The data from this study were analyzed through ANOVA and DMRT. The results of this study have shown that the T5 treatment in the form of formulations and preparations of organic liquid fertilizer from a 5 mL/L concentration of Tela kombucha fermentation waste is the best treatment for the growth parameters of eggplant plant height, eggplant leaf number, and eggplant wet and dry weight, so that it can It was concluded that the butterfly pea flower kombucha can be used as a halal probiotic drink, and its waste can also be used as a halal organic liquid fertilizer to support the growth of eggplant plants.
PEMANFAATAN KOMBUCHA BUNGA TELANG (Clitoria ternatea L) SEBAGAI UPAYA DALAM MENCEGAH STUNTING DAN MENINGKATKAN IMUNITAS DI DESA NGAGLIK MAGETAN PARANG Firman Rezaldi; Irmawati Mathar; Rina Nurmaulawati; Achmad Vindo Galaresa; Priyoto Priyoto
Jurnal Abdimas Bina Bangsa Vol. 4 No. 1 (2023): Jurnal Abdimas Bina Bangsa
Publisher : LPPM Universitas Bina Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46306/jabb.v4i1.383

Abstract

One of the trending topics that is currently happening in Indonesia is stunting. This disease is caused by the failure rate of growth and development in children where children who are stunted ideally are chronically malnourished. This requires special attention from the local government and the state so that cases of stunting that occur in children do not tend to experience an increase. One of the efforts to prevent stunting is the need for education from the surrounding environment, so this has led to the desire of the team of lecturers from Stikes Bhakti Husada Mulia Madiun to provide education about the benefits of butterfly pea flower kombucha and the process of making butterfly pea flower kombucha to improve immune system and also increase insight into the people who live in Ngaglik Village. Pararang District. Magetan Regency. East Java. The first step in carrying out community service includes obtaining permits for the local community, conducting initial identification regarding stunting problems, determining activity targets and objectives, conducting outreach and education consisting of a pre test. Evaluate and achieve program achievements through check list evaluations. The results of the evaluation have proven that the people in Ngaglik Village have increasing insight regarding the systematic utilization and production of telang flower kombucha which can be applied as a probiotic drink to enhance the immune system, therapeutic, nutritious drink, nutritious animal feed nutrition, and application of liquid fertilizer eco-friendly organic
In Vitro Pharmacological Activity Test on Pharmaceutical Biotechnology Products in The Form of Kombucha Bath Soap Pineapple Honey Subang As Antibacterial Gram Positive and Negative Saraswati Prabawardani; M. Fariz Fadillah; Desi Trisnawati; Firman Rezaldi; K Kusumiyati; Irmawati Mathar
Jurnal Biologi Tropis Vol. 23 No. 2 (2023): April-June
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i2.4838

Abstract

One of the probiotic drinks produced by Scoby fermentation, namely Kombucha Honey Pineapple Subang, has been found as a source of gram-positive and gram-negative antibacterials in previous studies. In addition to its significance in the pharmaceutical (cosmetic) industry, Subang pineapple honey-based kombucha has the potential to be utilized as a functional food. Especially useful when making liquid body wash because it stops the growth of the skin-harming bacteria S. aureus, S. epidermidis, P. aeruginosa, and E. coli. The research was conducted with the intention of developing pharmaceutical biotechnology products in the form of liquid bath soap that contained the active ingredients of fermented kombucha solution and pineapple honey in concentrations of 15%, 25%, and 35%, respectively.This research method was a laboratory experiment using four soap-based preparations, including soap made from white sand with a sugar concentration of 15%, 25%, and 35%, a solution of fermented Kombucha Pineapple honey in Subang, and biore for market bath soap. The method used is disc diffusion. One-way ANOVA and post hoc analysis follow-up tests were used for data analysis. The study found that the most effective treatment for gram-positive and gram-negative bacteria was bath soap with a concentration of 35% of the active ingredient, kombucha fermented pineapple honey earring solution. The most recent advancement in preventing gram-positive and gram-negative bacteria from growing is the subject of this study.
Study of Computational Biotechnology (Bioinformatics) on Telang Flower Kombucha (Clitoria Terantea L) as an Immunomodulator to Suppress Immunoglobulin E (IgE) for Allergy Sufferers Nurrizka Kurniawati; Ika Sutra Permirahayu Aji Saputri; Firman Rezaldi
Jurnal Biologi Tropis Vol. 23 No. 2 (2023): April-June
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i2.4895

Abstract

Telang flower kombucha has been known to have pharmacological movement in vitro in repressing the development of microbes and organisms. Besides that, it also has the potential in vivo to inhibit cholesterol in livestock, so that it can be used or utilized as an active ingredient in drugs and cosmetics. In addition, allergy can cause immunity to tend to decrease due to the synthesis of immunoglobulin E protein, so this study aims to provide an initial picture for allergy sufferers through computational biotechnology or bioinformatics studies on the vitexin compound in tela flower kombucha to inhibit the formation of IgE as a cause of allergy based on its binding affinity value. The research method used was molecular docking and validation of the vitexin compound in butterfly pea flower kombucha in inhibiting IgE formation. The results of single point calculations and geometric optimization of the vitexin compound in butterfly pea flower kombucha were 2.99585 kcal/mol and 5.20442 kcal/mol respectively. The research results show that based on the binding affinity value of -7.1, vitexin contained in telang flower kombucha is able to inhibit the formation of Immunoglobulin E (IgE) as one of the causes of allergies.
Pharmaceutical Biotechnology Products in the Form of Hand Washing Soap Kombucha Bunga Telang (Clitoria ternatea L) as Antibacterial for Salmonella thypi and Listeria monocytogenes Devita Anugrah Anggraini; Firman Rezaldi; Anggita Sofianti; Irmawati Mathar; Yuliana Kolo
Jurnal Biologi Tropis Vol. 23 No. 2 (2023): April-June
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i2.4892

Abstract

The growth of Salmonella thypi and Listeria monocytogenes bacteria can be inhibited by butterfly pea flower kombucha. This is because telang flower kombucha has pharmacological activity so it can be developed in the pharmaceutical field. This research needs to be carried out to make hand washing soap made from an active solution of telang kombucha diffusing solution so that it can stop the growth of Salmonella thypi and Listeria monocytogenes bacteria. The research method uses laboratory experiments. The data obtained were then analyzed using One Way Analysis of Variance and post hoc. The results of the study showed that the formulation and preparation of hand washing soap with a concentration of 40% active ingredient in a solution of butterfly pea flower was able to stop the growth of both bacteria with a P value <0.05. In conclusion, these two bacteria can be inhibited with hand washing soap containing 40% of a decoction of butterfly pea flower kombucha.
Antibacterial Activity of Staphylococcus capitis, Bacillus cereus, Pantoea dispersa From Telang Flower (Clitoria ternatea L) Kombucha Bath Soap as a Pharmaceutical Biotechnology Product Yuliana Kolo; Firman Rezaldi; M. Fariz Fadillah; Aris Ma'ruf; Fernanda Desmak Pertiwi; Fajar Hidayanto
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 01 (2022): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (437.276 KB) | DOI: 10.58549/pcjn.v1i01.1

Abstract

Telang lower kombucha is a probiotic drink that has the potential to enhance the immune system, active cosmetic ingredients, and its waste has been proven to be used as an organic liquid fertilizer preparation. The purpose of this study was to make a formulation and preparation of liquid bath soap with an active ingredient in a solution of seagrass kombucha fermentation at a sugar concentration of 20%, 30%, and 40% in inhibiting the growth of S. capitis, B. cereus, and P. dispersa bacteria. via the disc diffusion method. The results of the study have proven that based on the post hoc test analysis, kombucha bath soap at a concentration of 40% is significantly different from the concentration of 20% and 30% but not significantly different from the positive control and the concentration of 40% is the best concentration in inhibiting the growth of the three test bacteria. compared with the treatment and the two comparisons.
Co-Authors Abdilah, Nurullah Asep Ade Shindy F Br Sembiring Ade Sumiardi Anggita Sofianti Arikha Ayu Susilowati Aris Ma'ruf Aris Ma'ruf Aris Ma’ruf Desi Trisnawati Devita Anugrah Anggraini Endang Safitri Fernanda Desmak Pertiwi Galaresa, Achmad Vindo Hari Hariadi Hari Hariadi Hendri Faisal Ika Sutra Permirahayu Aji Saputri Indra Ginting Kuncara Nata Waskita Kusumiyati M. Fariz Fadillah M. Fariz Fadillah M. Fariz Fadillah Mathar, Irmawati Mochammad Imron Awalludin Mu’jijah Muhammad Amin Nasution Muhammad Andry Muhammad Faizal Fathurrohim Muhammad Faizal Fathurrohim Nurrizka Kurniawati Priyoto Priyoto Rina Nurmaulawati Rina Nurmaulawati Rina Nurmaulawati Saraswati Prabawardani Siska Dwi Anggraeni Susanti Erikania Suseno Amien Syariful Mubarok Sylvia Puspita Titin Sulastri Vivi Rosalina Winata, Hanafis Sastra Yuliana Kolo Yuliana Kolo Yusep Ikrawan