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All Journal Jurnal Biotek Majalah Farmasetika Jurnal Ilmiah Farmasi Farmasyifa Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Ilmiah Agribios Jurnal Kebidanan, Keperawatan dan Kesehatan (J-BIKES) Journal of Pharmaceutical and Sciences. Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Ulil Albab
Winata, Hanafis Sastra
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Inflammatory Activity Test of N-Hexant Extract of Kandis Acid (Garcinia Xanthochymus) Against Male White Mice (Rattus norvegicus) Winata, Hanafis Sastra; Hafiz, Ihsanul; Kartika, Yulis; Sihombing, Delima
Budapest International Research and Critics Institute (BIRCI-Journal): Humanities and Social Sciences Vol 4, No 3 (2021): Budapest International Research and Critics Institute August
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v4i3.2290

Abstract

Kandis acid (Garcinia xanthochymus) belongs to the genus Garcinia plants scattered in the tropics of Asia. The fruit is widely used as a flavoring dish by the Malay people. Based on research that has been done on the genus Garcinia, it is known that the largest active compound is the santon group. The research used is experimental. The sample in this study was a male white mouse. Anti-inflammatory activity test was conducted on test animals divided into 5 groups, each amounting to 5 heads with suspension test group N-hexan extract of kandis acid fruit dose 200, 400, 800 mg/kg bb, negative control group is CMC Na 1% susspence and positive control is Na diclofenac 2.25 mg/kg bb. Observations were made for 6 hours then the data was analyzed with a one way annalissys of variance (ANOVA) test. Research showed kandis acid extract (Garcinia xanthochymus) was shown to provide anti-inflammatory effects in male white mice induced caragenan at a dose of 200 mg / kgbb with an average value of udem decrease of 5.25, 400 mg/kgbb with an average udem decrease of 5.17 and 400mg/kgbb with an average udem decrease of 6.08, with the most effective dose in anti-inflammatory reduction being 400 mg/kgbb. The most effective dose of candis acid extract (Garcinia xanthochymus) in anti-inflammatory reduction in male white mice was the dose of kandis acid extract (Garcinia xanthochymus) 400 mg/kgbb. It is recommended to the next researcher to conduct fractionation research on kandis acid fruit plants..  
Formulasi Sediaan Lip Cream Dari Ekstrak Etanol Daun Bayam Merah (Amaranthus tricolor L.) Hafizhatul Abadi; Parhan Parhan; Hanafis Sastra Winata; Nidawah Nidawah
Majalah Farmasetika Vol 7, No 3 (2022): Vol. 7, No. 3, Tahun 2022
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v7i3.38429

Abstract

Lip cream merupakan sediaan pewarna bibir berbentuk semi padat yang dapat memberikan warna menarik pada bibir dan sangat digemari oleh kaum perempuan terutama dikalangan remaja, karena teksturnya yang lembut. Salah satu bahan alami yang dapat dijadikan sebagai sediaan lip cream yaitu daun bayam merah (Amaranthus tricolor L.). Penelitian ini adalah untuk membuat sediaan lip cream dari ekstrak etanol daun bayam merah (Amaranthus tricolor L.) dan mengetahui pengaruh dari konsentrasi yang berbeda. Penelitian ini dilakukan secara eksperimental, yang meliputi ekstraksi daun bayam merah (Amaranthus tricolor L.) menggunakan metode maserasi dan pembuatan sediaan lip cream dengan konsentrasi 14%, 16% dan 18%. Pemeriksaan mutu fisik sediaan yang meliputi uji organoleptis, homogenitas, pH, uji oles, daya lekat, iritasi, stabilitas dan uji kesukaan. Hasil  penelitian diperoleh bahwa pada pemeriksaan uji mutu fisik sediaan lip cream, seluruh sediaan memliki organoleptis yang baik, susunan yang homogen, mempunyai daya oles, daya lekat yang baik, pH yang sesuai dan tidak menimbulkan iritasi. Formulasi yang baik dan disenangi banyak panelis yaitu pada formula 2 dengan konsentrasi 16%. Dari penelitian yang dilakukan bahwa ekstrak etanol daun bayam merah dapat dijadikan sebagai pewarna dalam sediaan lip cream, warna yang dihasilkan yaitu coklat muda, coklat dan coklat tua, semakin tinggi konsentrasi ekstrak etanol daun bayam merah yang digunakan maka semakin pekat warna yang dihasilkan.
Analysis of Kandis Acid as a Study of Science and Socio-Cultural Benefits in Society Hanafis Sastra Winata; Khairani Fitri; Rani Monalisa Hutagaol; Hafizhatul Abadi
Budapest International Research and Critics Institute (BIRCI-Journal): Humanities and Social Sciences Vol 5, No 1 (2022): Budapest International Research and Critics Institute February
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v5i1.3624

Abstract

The main ingredient of kandis acid is the asam padeh part, which is a typical Indonesian food that has a sour and spicy taste and is then processed into instant spices. This study aims to analysis of kandis acid as a study of science and socio-cultural benefits in society. This study used descriptive analysis and the disc diffusion method using several concentrations of ethanol extract of kandis acid leaves, namely 15%, 25%, and 35%, positive control 1% chloramphenicol (w/v), and 1% (v/v) DMSO negative control. The diameter of the inhibition zone produced in the test of ethanol extract from kandis acid leaves against Staphylococcus aureus bacteria, respectively: 10.73 mm; 11.61 mm; 12.98 mm and 25.5 mm for positive control, while for Escherichia coli bacteria, namely: 6.11 mm; 8.16mm; 10.85mm; and positive control 22.75 mm. The results of statistical tests showed that there was a significant difference, meaning that the concentration had an effect on the inhibition zone formed. In conclusion, the ethanolic extract of kandis acid leaves has antibacterial activity against the growth of Staphylococcus aureus and Escherichia coli bacteria. The instant asam padeh seasoning is made from a mixture of various spices and also kandis acid which has a yellowish-orange color.
AKTIVITAS ANTI OKSIDAN DAN EVALUASI SEDIAAN MASKER PEEL-OFF EKSTRAK ETANOL RIMPANG KUNYIT PUTIH (Curcuma zedoaria Roscoe Hendri Faisal; Adek Chan; Hanafis Sastra Winata; Vivi Eulis Diana; Widya Atika
Jurnal Ilmiah Farmasi Farmasyifa Vol 6, No 1 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v6i1.9085

Abstract

Rimpang kunyit putih banyak dipergunakan pada pengobatan tradisional dan industri farmasi karena mempunyai kandungan senyawa flavonoid dan polifenol. Tujuan penelitian ini adalah untuk mengetahui apakah sediaan masker peel-off bersifat sebagai antioksidan dengan konsentrasi ekstrak etanol rimpang kunyit putih 10%, 20% dan 30%. Pembuatan ekstrak dilakukan dengan metode maserasi menggunakan pelarut etanol 96%. Pembuatan formulasi standar sediaan masker peel-off dengan ekstrak rimpang kunyit putih menggunakan bahan dasar polivinil alkohol, Hydroxyl Propyl Methyl Cellulose (HPMC),triehtanolaminea (TEA),gliserin,metil paraben,propil paraben dan akuades. Evaluasi sediaan yang dilakukan  meliputi uji organoleptis, pH, homogenitas, daya sebar, waktu kering, iritasi dan pengujian aktivitas antioksidan menggunakan spektrofotometri UV-Visibel dengan metode DPPH berdasarkan nilai pemerangkapan radikal bebas (nilai IC50).Berdasarkan hasil penelitian diketahui bahwa sediaan masker berbentuk setengah padat berwarna kuning tua hingga coklat, berbau khas rimpang kunyit putih. pH yang dihasilkan 6,0-6,3, sediaan homogen tidak ada butiran kasar, daya sebar 5,1-5,5 cm, waktu kering 14-16 menit dan tidak menyebabkan iritasi. Hasil pengujian antioksidan menunjukkan bahwa masker peel-off dengan ekstrak rimpang kunyit putih memiliki sifat antioksidan sebesar 99,94 (µg/mL), 83,21 µg/mL dan 60,88µg/mL pada konsentrasi ekstrak 10%,20% dan 30%. Kesimpulan penelitian ini adalah ekstrak rimpang kunyit putih (curcuma zedoaria roscoe) dapat diformulasikan menjadi masker peel-off .Ketiga formulasi masker memiliki sifat fisik yang baik dan memiliki sifat antioksidan dalam kategori kuat. Masker peel_off yang memiliki nilai antioksidan terbaik adalah formulasi F3 sebesar 60,88µg/ml.
Penetapan kadar flavonoid total ekstrak etanol buah asam kandis (Garcinia xanthochymus) dengan metode spektrofotometri Uv-Vis dan LCMS Hanafis Sastra Winata; Hendri Faisal; Muhammad Andry; Nurul Aulia; Muhammad Amin Nasution; Ika Julianti Tambunan
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.159

Abstract

Background: Kandis acid fruit (Garcinia xanthocymus Hook. f ex T. Anderson) is a plant of the Clusiase family with many species. Kandis acid fruit has various biological and pharmacological activities such as cytotoxic, anti-inflammatory, antimicrobial, antifungal and antioxidant. Purpose: To determine the content and total flavonoid content of tamarind kandis using quercetin as a reference standard. Method: This study used the TLC (Thin Layer Chromatography) method in qualitative analysis with the parameter Rf, then used the spectrophotometric method in the quantitative analysis with the parameter total flavonoid content (Value of mg QE/g sample) and the LCMS method (Liquid Chromatography Mass Spectrometry) with the parameter retention time (Rt). Result: Shows that tamarind kandis has an Rf value of 0.86 which states that tamarind kandis is positive for flavonoids with a reference standard of quercetin, total flavonoid content of 34.8364 mg QE/g sample with a standard deviation of 0.4355 and a percentage of 0.6967% and has five types of flavonoid compounds namely methyl dihydro quercetin, 1,5-Dihydroxy-3-methoxy xanthone, Afzelechin, Myricetin-3-O-ß-D-galactopiranoside, and Myricetin 7-glucoside. Methyl dihydro quercetin is the largest flavonoid with a composition of 49.57% with a retention time of 0.485 minutes. Conclusion: The identified total flavonoids have different types and levels
Formulasi sediaan pasta gigi ekstrak etanol buah takokak (Solanum torvum Sw.) dan tulang ikan tuna sirip kuning (Thunnus albacares) terhadap bakteri Streptococcus viridans dan bakteri Escherichia coli Hendri Faisal; Hanafis Sastra; Muhammad Andry; Melia Sari; Adek Chan; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.218

Abstract

Takokak (Solanum torvum Sw.) is a traditional plant used as vegetables, fruits, ornamental plants and medicinal purposes. Takokak fruit contains secondary metabolites of alkaloids, flavonoids, saponins, tannins and steroids. Tuna fish bones are one of the biggest wastes from the tuna processing industry. Tuna fish bones contain minerals that are quite high compared to other parts of the body because the main elements of fish bones are calcium, phosphorus and carbonate. This study aims to make toothpaste preparations of ethanol extract of large chili fruit and yellowfin tuna bones and to determine the inhibition zone against Streptococcus viridans and Escherichia coli bacteria. This type of research is done experimentally. This type of research includes the manufacture of toothpaste preparations with concentrations of F1 (10%), F2 (15%), F3 (20%). Preparation evaluation included organoleptic test, homogeneity test, spreadability test, foam formation test, pH test, viscosity test, extrudability test and activity test for Streptococcus viridans and Escherichia coli bacteria. The results of the research were carried out to evaluate the physical preparations of toothpaste with ethanol extract of large chili fruit and yellow fin tuna bones, each toothpaste formulation met the organoleptic requirements, homogeneity, spreadability, foam formation, pH, viscosity and extrudability. Toothpaste preparations of ethanol extract of takokak fruit and yellow tuna bones have antibacterial effectiveness on Streptococcus viridans F1 (9.85 ± 0.32), F2 (11.85 ± 0.45), F3 (13.05 ± 0.34) and Escherichia coli F1 (3.15 ± 0.73), F2 (3.75±0.40), F3 (4.5±0.25). One way Anova data analysis showed a sig value of 0.00 <0.05 meaning that each concentration was significantly different, so that the results of the bacterial inhibition zone affected each concentration of toothpaste preparations.The conclusion of this study is that the ethanol extract of large chili fruit and yellow fin tuna bones can be formulated as a toothpaste preparation and effectively inhibits the growth of Streptococcus viridans and Escherichia coli bacteria in the weak, medium and strong categories.
Antibakteri pada Formulasi Sediaan Sabun Mandi Kombucha Bunga Telang (Clitoria ternatea L) sebagai Produk Bioteknologi Farmasi Firman Rezaldi; Siska Dwi Anggraeni; Aris Ma'ruf; Muhammad Andry; Hendri Faisal; Hanafis Sastra Winata; Indra Ginting; Muhammad Amin Nasution
Jurnal Biotek Vol 11 No 1 (2023): JUNI
Publisher : Department of Biology Education of Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jb.v11i1.36906

Abstract

Copyright©2023 Liquid soap with the active ingredient kombucha butterfly pea can limit the growth of Staphylococcus epidermidis and Pseudomonas aeruginosa bacteria. The purpose of this research was to create a liquid bath soap with the active ingredient fermented liquid from the kombucha flower of the butterfly pea plant that inhibits the development of the two test bacteria and to provide objective data on the maximum inhibitory energy at the concentration of the bath soap preparation that can limit the growth of the two test bacteria. This research was experimental and involved making four different types of bath soap preparations: soap base (negative control), liquid body soap formulated with butterfly pea flower kombucha at concentrations of 20, 30, and 40%, and one of the commercial soaps (positive control). Disc diffusion is the method for measuring the average growth of the two test bacteria. Statistical analysis was a one-way ANOVA statistical test at a 95% confidence level, followed by post hoc analysis. The research showed that the liquid body soap with the active ingredient of telang flower kombucha could positively inhibit the growth of the two test bacteria. The concentration of 40% telang flower kombucha bath soap is the best concentration to limit the development of the two test bacteria, with an inhibition zone of 10 mm on Staphylococcus epidermidis, which is in the strong category, and an inhibition zone of 7 mm on Pseudomonas aeruginosa, which is classified as a moderate category.
Penentuan Kadar Fenolik Total, Profil Metabolit Sekunder dari Ekstrak Daun Manggis dan Pemanfaatan Potensinya dalam Sediaan Teh Herbal sebagai Antikanker Muhammad Andry; Hanafis Sastra Winata
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.265

Abstract

Background; Mangosteen leaves (Garcinia mangostana L.) have secondary metabolites, namely phenolics, flavonoids, tannins, saponins, and triterpenoids. Phenolics are one of the largest groups of compounds found in mangosteen leaves which have several pharmacological and therapeutic functions, one of which is anti-cancer. Objectives; To determine the total phenol content and profile of secondary metabolites and the type of phenolic extract of mangosteen leaves. Method; Using UV-Vis spectrophotometer Folin-Ciocalteu method with the gallic acid standard. Profile of secondary metabolites and phenolic types using LCMS. Results; Based on the research that has been done, the total phenolic content is obtained where the highest concentration is in the ethanol extract 96% (290.90 mg GAE/g extract or 29.08%), then ethyl acetate extract (161.07 mg GAE/g extract or 16, 10%). Identification of LCMS, detected 15 compounds, including 6 phenolic compounds. Phenolic compounds found were gallic acid, amarogentin, oleuropein glucoside, mandelic acid, vanillic acid, and gentisic acid.. Conclusion; Phenolic compounds can act as antioxidants by protecting body cells from damage caused by free radicals such as degenerative diseases, one of which is cancer due to free radical induction.
Inovasi pewarna rambut alami: Formulasi gel berbahan dasar ekstrak umbi bawang dayak (Eleutherine bulbosa (mill.)Urb.) dan uji sifat fisiknya Leny, Leny; Winata, Hanafis Sastra; Sitanggang, Joanna; Hanum, Siti Fatimah; Iskandar, Benni
Majalah Farmasetika Vol 9, No 6 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v9i6.58294

Abstract

Umbi bawang dayak memiliki kandungan antosianin yang tinggi, antosianin merupakansalah satu pigmen yang terdapat pada tanaman yang berpotensi dijadikan pewarnaalami makanan serta dapat menggantikan pewarna sintetis. Tujuan penelitian ini adalahuntuk mengetahui efektivitas ekstrak umbi bawang dayak yang diformulasikan ke dalamsediaan gel pewarna rambut dan mampu mengubah warna rambut. Metode penelitianini dilakukan dengan metode eksperimental yang meliputi pengambilan sampeltumbuhan, determinasi dan pengolahan sampel, pembuatan ekstrak, pembuatansediaan gel pewarna rambut dengan konsentrasi 8%, 10% dan 12%, evaluasi fisiksediaan pewarna rambut, uji stabilitas pewarna rambut, uji pH dan uji iritasi sediaanpewarna rambut. Hasil penelitian menunjukkan sediaan berbentuk gel, berwarnacokelat dan beraroma khas bawang dayak, pH berkisar antara 5,21-5,48. Hasilstabilitas warna terhadap pencucian sebanyak 15 kali dan penjemuran tidakmenunjukkan perubahan warna. Hasil uji hedonik diketahui sediaan F3 merupakansediaan yang paling disukai dengan memperoleh skor tingkat kesukaan sebesar 8.Hasil pewarnaan pada rambut bleaching dengan perendaman rambut selama 4 jamdiperoleh: F1(8%) menghasilkan rambut pirang, F2 (10%) menghasilkan rambut cokelatterang dan pada F3 (12%) berwarna cokelat gelap. Pengujian juga dilakukan padarambut hitam namun hasil pewarnaan pada rambut hitam tidak terjadi perubahan warnayang nyata. Kesimpulan penelitian ini bahwa ekstrak umbi bawang dayak Eleutherinebulbosa (Mill.)Urb. dapat diformulasikan menjadi sediaan gel pewarna rambut yangstabil dan tidak menimbulkan reaksi iritasi atau alergi pada kulit. Sediaan juga mampumenutup warna putih rambut hingga menghasilkan warna cokelat terang sampai cokelatkehitaman.
Formulasi dan Uji Efektivitas Sabun Padat dari Ekstrak Etanol Daun Kopasanda (Chromolaena odorata L.) terhadap Bakteri Staphylococcus epidermidis Hafizhatul Abadi; Hanafis Sastra Winata; Adek Chan; Faadhilah Yusa Simbolon
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 4 (2024): Oktober: Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i4.444

Abstract

Siam Weed leaf plants contain high levels of flavonoids and tannins. These compounds provide antibacterial potential. This study aims to formulate solid soap dosage form of ethanol extract of Siam weed leaves and test the antibacterial activity of it against the growth of Staphylococcus epidermidis bacteria. This is experimental research. Making the extract phytochemical screening test. Evaluation of the dosage form was done by organoleptic tests, homogeneity, pH, foam height, moisture content, irritation, stability, and antibacterial activity tests using the well method. The results showed that solid bath soap dosage form from the ethanol extract of siam weed leaves could be formulated into soap dosage form which had a pH in the range of 9.2 – 9.8, high foam that was stable and did not cause irritation to the skin of volunteers and tested for antibacterial activity on bacteria. Staphylococcus epidermidis with a concentration of 10% 8.84 mm, 15% concentration 10.56 mm and 20% concentration 12.11 mm. The conclusion showed that solid soap dosage form of ethanol extract of Siam weed leaves (Chromolaena odorata L.) could be formulated and fulfilled the requirements after being evaluated and the antibacterial effectiveness of Staphylococcus epidermidis was the best at a concentration of 20% (strong).
Co-Authors Abadi, Hafizhatul Adek Chan Adek Chan Afriadi Afriadi Aris Ma'ruf Bayu Irvia Satria BENNI ISKANDAR Ekawaty Suryani Mastari Faadhilah Yusa Simbolon Fahmi Irsan Nasution Faisal , Hendri Faisal, Hendri Firman Rezaldi Gumilar, Roni Hendri Faisal Hendri Faisal Hendri Faisal Ihsanul Hafiz Ika Julianti Tambunan Indra Ginting izar, Shaflina Kartika, Yulis Khairani Fitri Leny Leny, Leny Luthvia, Luthvia Masturi, Siti Intan Mayang Sari Mayang Sari Melia Sari Muhammad Amin Nasution Muhammad Andry Muhammad Natsir Ilvira MUHAMMAD RIZAL Naziyah, Syifa Ngete, Ani Florida Nidawah Nidawah Nurjanah, Ayu Nurul Aulia Pamungkas, Barolym Tri Panjaitan, Yuli Cahyani Parhan Parhan Rani Monalisa Hutagaol Sahrita Sahrita Sihombing, Delima Siska Dwi Anggraeni Sitanggang, Joanna Siti Fatimah Hanum Siti Intan Masturi Suprianto Suprianto Vivi Eulis Diana Widya Atika Yudianto, Tri