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All Journal Mandala of Health : A Scientific Journal Medical and Health Journal
Wahyu Dwi Kusdaryanto
Unknown Affiliation
Dentistry Health Professions Medicine & Pharmacology Public Health

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THE EFFECT OF CIPLUKAN EXTRACT (Physalis angulata L.) AS ANTIPSORIATIC AND TO LYMPHOCYTES COUNT OF SKIN TISSUE IN PSORIASIS MICE MODEL Putri Nur'afni Sa'adah; Thianti Sylviningrum; Dody Novrial; Fajar Wahyu Pribadi; Wahyu Dwi Kusdaryanto; Muhamad Salman Fareza
Mandala Of Health Vol 14 No 1 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (538.872 KB) | DOI: 10.20884/1.mandala.2021.14.1.4958

Abstract

ABSTRACT Psoriasis is a chronic skin disease in form of papule-shaped lesion and erythematous plaques with thick white scales. The pathogenesis of psoriasis involves IL-23/Th-17 cytokine pathway that contributes the activation of T-lymphocytes and proinflammatory cytokines. Treatment of psoriasis using methotrexate has inhibitory effect of the synthesis of nucleic acid towards T-lymphocytes and keratinocytes. Ciplukan (Physalis angulata L.) has anti-inflammatory potential effect which contains steroid, flavonoid, alkaloid, and physalin that may inhibit lymphocyte activation and proinflammatory cytokine production. The study is used the method of experimental study with post test only with control group design. Thirty five female mices were divided into 7 groups. The parameters of this study is anti-psoriatic (PASI and Baker’s score) and lymphocytes count in psoriasis mice model. The results of Kruskal-Wallis, PASI and Baker’s score showed that p=0,001 (p<0,05) and the result of lymphocytes count using One Way ANOVA showed that p=0,001 (p<0,05). The 800 mg/kgBW dose of ciplukan extract showed the largest decrease on PASI score and lymphocytes count, and the 1200 mg/kgBW dose one showed the largest decrease on the Baker’s score. The present of the 800 mg/kgBW dose of ciplukan extract gives the most optimal effect in reducing PASI score and skin tissue lymphocytes count in psoriasis mice model that were not significantly different with the treatment control group, while 1200 mg/kgBW dose one gives the most optimal effect in reducing Baker’s score that were significantly different with the treatment control group. Keywords: Ciplukan extract, lymphocytes, methotrexate, Physalis angulata L
Osteomeatal Complex variations and Maxillary Sinusitis: A CT-Based Cross-Sectional Study Siti Attamimi Al Ahdi; Tisna Sendy Pratama; Ary Nahdiyani Amalia; Wahyu Dwi Kusdaryanto; Ismiralda Oke Putranti
Medical and Health Journal Vol 6 No 1 (2026): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.6.1.19035

Abstract

Backgorund The osteomeatal complex (OMC) is the main drainage pathway of the paranasal sinuses, and anatomical variations, such as nasal septal deviation, may disrupt airflow and increase the risk of sinusitis; therefore, a CT Scan is the preferred modality for its evaluation. Objective: To determine the association between OMC anatomical variations and maxillary sinusitis based on head CT Scan results at Ajibarang Regional Hospital in 2024. Methodology: This analytic, observational, cross-sectional study used head CT Scan data, with OMC anatomical variations as independent variables and maxillary sinusitis as the dependent variable. Interobserver agreement was assessed using Fleiss’ Kappa, followed by univariate analysis to determine frequency distribution, and bivariate analysis using the Chi-square (χ²) test with a significance level of p < 0.05. Results: Interobserver agreement was substantial to perfect (κ = 0.76–1.00). Most patients presented with maxillary sinusitis (69.44%), and the most common anatomical variation was nasal septal deviation (52.78%), which was the only anatomical variation to show a significant association with maxillary sinusitis (p = 0.001). Conclusion: Nasal septal deviation is the only OMC anatomical variation significantly associated with maxillary sinusitis, while other variations showed no meaningful association.
Co-Authors Ary Nahdiyani Amalia Dody Novrial Fajar Wahyu Pribadi Fareza, Muhamad Salman Ismiralda Oke Putranti Putri Nur'afni Sa'adah Siti Attamimi Al Ahdi Thianti Sylviningrum Tisna Sendy Pratama