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All Journal JBIO: jurnal biosains (the journal of biosciences) Indonesian Journal of Global Health research Indonesian Journal of Global Health Research
Ririe Fachrina Malisie
Universitas Sumatera Utara
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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EFFECT OF ETHANOLIC EXTRACT OF MELINJO PEEL (Gnetum gnemon) ON SERUM MALONDIALDEHYDE (MDA) LEVELS IN HYPERURISEMIA WISTAR STRAIN RATS Indra Priawan; Yetty Machrina; Ririe Fachrina Malisie
JBIO: jurnal biosains (the journal of biosciences) Vol 8, No 3 (2022): JBIO: jurnal biosains (the journal of biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v8i3.43187

Abstract

Hyperuricemia is a state of uric acid in the body that is higher than the body's tolerance limit. The formation of uric acid will be accompanied by the formation of Reactive Oxygen Species (ROS) by the changes of Xanthine Dehydrogenase to Xanthine Oxide with the help of NAD+ and Oxygen, which can trigger oxidative stress, causing cell damage and apoptotic cell, one of which is through lipid peroxidation followed by the release of Malondialdehyde (MDA) into the extracellular space. This study aims to analyze the effect of giving melinjo peel ethanol extract (Gnetum gnemon) on serum MDA levels in hyperuricemic Wistar strain rats. Rats were grouped into 4 treatment groups, namely K0 (without treatment), Kneg (hyperuricemia and CMC), Kpos (hyperuricemia and allopurinol), and P (hyperuricemia and ethanol extract of melinjo peel). Manufacture a hyperuricemic rat model by giving a high-fructose diet and then measuring uric acid levels to ensure that the rat is already in hyperuricemia. The high-fructose diet was continued until the rats were executed. Serum MDA was measured using the Thiobarbituric acid (TBA) method. The results showed differences in MDA levels between groups of hyperuricemic rats. Based on the examination of lower MDA levels after administration of melinjo peel ethanol extract compared to the CMC group and the allopurinol group, statistically significant differences were obtained (p = 0.001). Based on the analysis results, it was concluded that the ethanolic extract of melinjo peel (Gnetum gnemon) could reduce serum MDA levels in hyperuricemic Wistar rats.
Relationship between Age and the Occurrence of Depression Symptoms in Children with Acute Lymphoblastic Leukemia Dwika Intania Riano; Ika Citra Dewi Tanjung; Ririe Fachrina Malisie; Arlinda Sari Wahyuni; Olga Rasiyanti Siregar; Rini Savitri Daulay
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6230

Abstract

In children and adolescents, depressive symptoms often presenting as irritability, anhedonia, or behavioral changes. Despite significant advancements in survival rates due to improved therapeutic protocols, the psychological burden experienced by children with ALL.Objective: To evaluate the relationship between age and the presence of depressive symptoms in children diagnosed with ALL.Methods: A cross-sectional study was done using consecutive sampling with 40 children aged from 7 to 18 years old acquired, conducted from August to October 2024 at the outpatient unit of Adam Malik Hospital, Medan. Forty children aged 7–18 years with a confirmed diagnosis of ALL were included. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9). Categorical variables were analyzed using the chi-square test, followed by bivariate to identify significant predictors of depression.Results: Among the 40 participants, the most age group were children ≤ 10 years old (65%). A statistically significant association was found between age group and the presence of depressive symptoms (p = 0.001, OR= 33,3). Conclusions: Age is significantly associated with the severity and presence of depressive symptoms in pediatric patients with ALL. Older children were more likely to report higher levels of depression. Psychological evaluation and targeted mental health support may be especially important in older age groups.
Association of Level Serum Ferritin and Lung Function in Pediatric with Transfusion – Dependent Thalassemia Putri Nahrisa Nasution; Bidasari Lubis; Ririe Fachrina Malisie; Juliandi Harahap; Wisman Dalimunthe; Hendri Wijaya
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.342

Abstract

Pulmonary dysfunction in children with thalassemia can be restrictive, obstructive, or diffusion impairment. Elevated serum ferritin levels are a cause of pulmonary dysfunction in transfusion-dependent thalassemia patients. The aim of this study was to assess  relationship between serum ferritin levels and pulmonary dysfunction in transfusion-dependent thalassemia patients.  This cross-sectional study was conducted on 44 transfusion-dependent thalassemia children between May and June 2025 at the Thalassemia Clinic of Adam Malik Hospital, Medan. Demographic characteristics were obtained from interviews and medical records. Lung function was assessed using a spirometer. Associations were analyzed using Shapiro Wilk, Kruskal-Wallis test, and multinomial logistic regression test. A total of 17 children (38.6%) had normal lung function, while 27 children (61.3%) had impaired lung function. Restrictive impairment was present in 24 children (54.5%), and obstructive impairment in 3 children (6.8%). Analysis showed significant differences in serum ferritin levels and splenomegaly in relation to impaired lung function, with p-values of <0.001 and 0.013, respectively. Each 1 ng/mL increase in ferritin levels increased the likelihood of developing restrictive and obstructive pulmonary dysfunction by 0.2% (OR = 1.002; 95% CI: 1.001–1.003). However, gender, hepatomegaly, and duration of transfusion did not show significant differences.
Co-Authors Arlinda Sari Wahyuni Bidasari Lubis Dwika Intania Riano Hendri Wijaya Ika Citra Dewi Tanjung Juliandi Harahap Olga Rasiyanti Siregar Priawan, Indra Putri Nahrisa Nasution Rini Savitri Daulay Wisman Dalimunthe Yetty Machrina