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All Journal Biotropika Current Biochemistry Jurnal Sumberdaya Hayati Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Bioma : Jurnal Biologi Indonesia JMM (Jurnal Masyarakat Mandiri) Jurnal Jejaring Matematika dan Sains Bubungan Tinggi: Jurnal Pengabdian Masyarakat IJOEP : International Journal of Ecophysiology Konservasi Hayati International Journal Of Science, Technology & Management (IJSTM) Bioactivities
Frans Grovy Naibaho
Program Studi Biologi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Palangka Raya
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Mathematics Mechanical Engineering Medicine & Pharmacology Physics Social Sciences Transportation Other

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ISOLASI BAKTERI ENDOFIT BAWANG DAYAK (Eleutherine bulbosa) DAN UJI ANTAGONISME TERHADAP BAKTERI Escherichia coli DAN Staphylococcus aureus Frans Naibaho; Ebrry Dwi Putra; Liswara Neneng; Desimaria Panjaitan
Bioma Vol. 19 No. 1 (2023): Bioma
Publisher : LPPM Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/Bioma19(1).5

Abstract

Antibiotic resistance is one of the main challenges faced by the health world today. Therefore, various efforts are being made to find new alternative antibiotics from various sources. Endophytic bacteria from medicinal plants are thought to have an antibacterial activity that can potentially inhibit pathogenic bacteria growth. This study aimed to isolate and characterize endophytic bacteria from the Dayak onion plant and determine their potential to inhibit the growth of two pathogenic bacteria Escherichia coli and Staphylococcus aureus. Bacterial isolation was carried out using the surface sterilization method and grown on nutrient agar media. The endophytic bacteria isolates obtained were then characterized macroscopically and microscopically. The agar plug diffusion method carried out the antagonism test against pathogenic bacteria. The result showed that 40 isolates of endophytic bacteria were successfully isolated from the Dayak onion plant's leaves, bulbs, and roots. Based on the antagonism test, 3 isolates were able to inhibit E.coli while 8 isolates were able to inhibit S. aureus. Three isolates (CED3, CED4, and CEU6) were able to inhibit both pathogenic bacteria, and the highest activity was shown by CED3 isolates.
Antimicrobial and Antioxidant Activities of Some Xylariaceous Fungi Panjaitan, Desimaria; Noraini; Norwahyunie; Fastanti, Fandri Sofiana; Naibaho, Frans Grovy
Biotropika: Journal of Tropical Biology Vol. 13 No. 3 (2025)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2025.013.03.01

Abstract

The Xylariaceae family comprises cosmopolitan ascomycetous fungi that predominantly live as saprobes, contributing ecologically and forming interactions with various organisms. Due to their cultivability under laboratory conditions and potential to produce bioactive metabolites, members of Xylariaceae are increasingly explored for bioprospecting. This study aimed to evaluate the antimicrobial and antioxidant activities of mycelial extracts from Xylariaceae isolates collected from Central Kalimantan, Indonesia, as an initial step in exploring their bioprospective traits. Fungal specimens obtained from forest exploration were cultured in vitro to obtain axenic cultures. Liquid-state fermentation was performed to induce metabolite secretion, and the biomass was extracted (macerated) using ethyl acetate (EtOAc) and methanol (MeOH). The antimicrobial activity was tested against Bacillus cereus, Staphylococcus aureus, and Candida albicans using the disk diffusion method. Antioxidant capacity was assessed via the DPPH radical scavenging assay and expressed as IC50 values. Morphological examination of six isolates (DP61–DP66) revealed characteristic features of Xylariaceae, such as upright stromata, clavate dark structures, and smooth to punctate surfaces, while their mycelia appeared white and unpigmented. Ethyl acetate extracts generally exhibited broader antibacterial effects than methanolic extracts. The EtOAc-DP62 extract exhibited strong antibacterial activity, with inhibition zones of 13.3 mm and 13.2 mm against B. cereus and S. aureus, respectively. MeOH-DP66 demonstrated the strongest antifungal activity, with an inhibition zone of 21.7 mm. DP62 also exhibited potent antioxidant activity (IC50 = 3.44 µg/mL), surpassing ascorbic acid (IC50 = 28.32 µg/mL). Molecular identification based on ITS-rDNA sequences revealed DP62 as Nectriopsis epimycota (Bionectriaceae) and DP66 as Xylaria plebeja (Xylariaceae). Interestingly, DP62 may represent an endohyphal fungus initially associated with a xylariaceous fruiting body. These findings highlight the bioprospective value of these fungal isolates as promising antimicrobial and antioxidant-producing agents.
Co-Authors Adrian Hartanto Aryanti Pada Soa, Christina Ayuchecaria, Noverda Damanik, Nina Septania Desiana Sinta Desimaria Panjaitan Desimaria Panjaitan Dian Mutiasari, Dian Ebrry Dwi Putra Erman Munir Fachriyan Hasmi Pasaribu Faridah Tsuraya Fastanti, Fandri Sofiana Hibatullah, Alnadia Yusriya Ivan Permana Putra Jendri Mamangkey Krestina, Widya Liswara Neneng MARIA BINTANG Mirnawati Dewi Nina Septania Damanik Noraini Noraini Noraini Norwahyunie Norwahyunie Norwahyunie NUNUK PRIYANI Nunuk Priyani Rahmawati, Maynissa Retno Agnestisia Rizko Hadi Rosenta Purba, Ika Vinsen Willi Wardhana Zulviana Zulviana Zulviana