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Optimation of meniran (Phyllanthus niruri L.) leaf extract using natural deed eutectic solvent basis choline cloride–glycol on antioxidant Handayani, Marybet Tri Retno; Yulianita, Yulianita; Lohitasari, Bina; P, Rieke Fitria
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1561

Phyllanthus niruri L. has many benefits because it is known that meniran leaves contain secondary metabolites in the form of alkaloids, flavonoids, tannins, saponins and phenolics. The content of phenol compounds which are constituent compounds for antioxidant activity. This research was conducted to determine the combination of Natural Deep Eutectic Solvents (NADES) which can produce extracts with strong antioxidant activity. The preliminary stage determines the best combination of NADES with choline chloride as the Hydrogen Bond Acceptor and the type of sugar as the Hydrogen Bond Donor. The NADES screening obtained the best combination of choline chloride: glycerol, then the optimization stage was carried out using the RSM method with a Central Composite Design. Three variables used were temperature (25°, 40°, 60°C), time (10, 30, 60 minutes) and the ratio of NADES usage (50%, 70% and 90%). Antioxidant activity was determined with the value of in Meniran extract with positive control of vitamin C. The best NADES combination was choline chloride–glycerol (1:1) with an value of 18.039 ppm. Optimization with variations in temperature time and ratio variables obtained optimal conditions at temperature of 60°C with an extraction time of 44 minutes and ratio of 90% NADES obtained values of 8.040 ppm and positive control of vitamin C obtained values of 4.307 ppm. The best results for antioxidant activity are at a temperature of 60°C gives an value of 8.050 ppm was obtained and the average is 8.075 ppm.

The Application Of Fetal Music Instrumental Tools Helps Fetal Growth In The Womb Of Pregnant Women At Posyandu Kemuning 1A Village Sukamakmur Ciomas Handayani, Marybet Tri Retno; Wahyuni, Yuli; Elfrieda, Nyayu Siti Aminah Lily
Society : Jurnal Pengabdian Masyarakat Vol 4, No 2 (2025): Maret
Publisher : Edumedia Solution

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55824/jpm.v4i2.553

Good fetal growth and development from the mother's womb can give birth to a generation that is healthy, intelligent, and of good character. Good fetal growth is influenced by several factors, namely: Good eating habits, hormonal factors and the environment around the fetus. One way to maximize the process of fetal growth in the womb is that the mother must play an active role in making efforts so that the baby grows actively when born later. one of them is to take advantage of fetal stimulation in the womb with a music sound player system for the fetus. Based on the 2023 questionnaire, there is a request from the community for the community service team to hold socialization and training on healthy heart and fetal development using the research results of the Lecturer which can be implemented in the 2024 community service program to implement the Fetal Music Instrumental Tool to Help Fetal Growth in the Womb of Pregnant Women at Posyandu Kemuning 1A Sukamakmur Village, Ciomas. This community service implements IKU 2, namely students gaining experience outside campus and IKU 3 where lecturers carry out activities outside campus and IKU 5, namely the work of lecturers is used by the community. In addition, this activity produces HAKI products, videos of activities, articles in various electronic media, and publications in community service journals.

Effectiveness of Combination Gel of Bilimbi Leaf and Aloe Vera Extract for Healing Burns in Male White Rats Nurmala, Sara; Handayani, Marybet Tri Retno; Hartoyo, Dian Fatimah
Jurnal Kesehatan Vol 16 No 1 (2025): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v16i1.4820

Burns are a global public health problem, with approximately 180,000 deaths each year. The incidence of second-degree burns in Indonesia accounts for 46.7%. Redness, swelling, ulcers, and severe pain characterize these wounds. This study aims to test the effectiveness, percentage of healing, and length of gel application of a combination of star fruit leaf extract and aloe vera leaf pulp on the healing of second-degree burns in male rats. Morton's method was used in this study to measure the diameter of the burn wound. The treatments of this study included a combination gel of star fruit leaf extract and aloe vera leaf with variations in the ratio of F1 (6%: 5%), F2 (6%: 10%), F3 (12%: 5%), and the control group with 5 replicates each group. The results showed that the gel combination of extracts of star fruit leaves and aloe vera leaves effectively treated burn wounds in rats. Duncan's test of the treatment of variations in extract concentration showed a significant difference. The combination of starfruit leaf extract and aloe vera in gel preparation has effectively healed burns in male mice. The duration of administration is 16 days, with the percentage of healing for categories F1, F2, and F3 being 45%, 55%, and 61%, respectively. Burn wound healing activity occurs because the two extracts used contain alkaloids, flavonoids, saponins, and tannins, which act as anti-inflammatories, increase the growth of epithelial cells and collagen, and help the formation of new tissues.

Evaluation of Calcium and Protein Content in Powder and Gummy Candy from Anchovy Extract (Stolephorus commersonnii) Hermawati, Ema; Ismyama, Dian Farida; Handayani, Marybet Tri Retno
Pharmacon: Jurnal Farmasi Indonesia Volume 22, No 1 (2025)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v22i1.10541

Anchovies (Stolephorus commersonnii) are a good source of calcium and protein. Intake of these nutrients is associated with child height. According to the Ministry of Health of the Republic of Indonesia's Nutrition Status Study Report, the prevalence of stunting among Indonesian children in 2022 was 21.6%, which is still higher than the World Health Organization's (WHO) standard of <20%. This study aims to optimize the formulation of anchovy extract gummy candies that meet quality standards and contain high levels of calcium and protein. Anchovy powder contains 328.64 mg/kg of calcium, 28.46% protein, 0.12% ash, and 5.3% moisture. The anchovy extract was prepared using the maceration method with a 70% ethanol solvent. Four gummy candy formulations were made based on variations in anchovy extract concentration: 10%, 7.5%, 3%, and 1.5%. Formulation 4 (F4) with 1.5% anchovy extract produced the best physical quality, with a standard deviation (SD) of <5% for the weight uniformity test. The organoleptic test results for F4 are as follows: the anchovy taste is mild, the color is dark purple, the smell is slightly aromatic, the shape is consistent with the mold, and the texture is chewy. F4 gummy candies contain 1,490.64 mg/kg of calcium, 27.49% protein, 9.17% ash, and 3.96% moisture. A serving size of one gummy (1.5 g) contains 2.24 mg of calcium, 0.41 g of protein, 0.06 g of total fat, 0.07 g of carbohydrates, 0.55 g of sugar, and 4.18 mg of sodium. F4 meets quality standards and is high in calcium and protein.

Introduction to Safe and Appropriate Cosmetics for Teenagers Vocational School Honifa; Wulandari, Asri; Fatmi, Mindiya; Handayani, Marybet Tri Retno; Nurhikmah, Wilda
Jurnal Pengabdian Masyarakat Inovatif Vol. 2 No. 1 (2024): JPMI (Jurnal Pengabdian Masyarakat Inovatif)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jpmi.v2i1.82

Cosmetics are beauty products intended for use on the skin, hair, nails, lips, external genital organs, teeth, and oral mucosa. Knowledge about choosing the right cosmetics is necessary because many people make mistakes in determining the type of cosmetics to use, the types of ingredients used, and cosmetic rules. One step to increase awareness of safe ingredients and the use of cosmetics is to provide education through the university's education, research, and community service activities, namely Community Service. especially among teenagers. This activity aims to provide outreach on how to choose safe and appropriate cosmetics for teenagers and provide education on how to report side effects from using cosmetics to BPOM. In community service activities, the method used is to provide material using a lecture method, followed by discussion and questions and answers. Questions asked for pre and post-test are the same, namely the definition of cosmetics, the purpose of using cosmetics, how to store cosmetics, how to use cosmetics safely, how to choose to buy cosmetics from the marketplace, Knowing Dangerous Cosmetic Ingredients, Seeing Cosmetic ED, How to Store Cosmetics and regarding if you experience irritation/ side effects from cosmetic preparations, then the last order that was carried out after providing the material was that residents' knowledge increased when they filled out the same questionnaire again and was quite different compared to before. Like Knowledge of the meaning of cosmetics education who knew the meaning of cosmetics was 10 people or 45.4% after education increased to 19 people or 86.4% and for other questions there was an increase after providing the material. It can be said that the Community Service Activities that have been carried out can broaden the knowledge of teenagers.

Introduction to Safe and Appropriate Cosmetics for Teenagers Vocational School Honifa; Wulandari, Asri; Fatmi, Mindiya; Handayani, Marybet Tri Retno; Nurhikmah, Wilda
Jurnal Pengabdian Masyarakat Inovatif Vol. 2 No. 1 (2024): JPMI (Jurnal Pengabdian Masyarakat Inovatif)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jpmi.v2i1.82

Cosmetics are beauty products intended for use on the skin, hair, nails, lips, external genital organs, teeth, and oral mucosa. Knowledge about choosing the right cosmetics is necessary because many people make mistakes in determining the type of cosmetics to use, the types of ingredients used, and cosmetic rules. One step to increase awareness of safe ingredients and the use of cosmetics is to provide education through the university's education, research, and community service activities, namely Community Service. especially among teenagers. This activity aims to provide outreach on how to choose safe and appropriate cosmetics for teenagers and provide education on how to report side effects from using cosmetics to BPOM. In community service activities, the method used is to provide material using a lecture method, followed by discussion and questions and answers. Questions asked for pre and post-test are the same, namely the definition of cosmetics, the purpose of using cosmetics, how to store cosmetics, how to use cosmetics safely, how to choose to buy cosmetics from the marketplace, Knowing Dangerous Cosmetic Ingredients, Seeing Cosmetic ED, How to Store Cosmetics and regarding if you experience irritation/ side effects from cosmetic preparations, then the last order that was carried out after providing the material was that residents' knowledge increased when they filled out the same questionnaire again and was quite different compared to before. Like Knowledge of the meaning of cosmetics education who knew the meaning of cosmetics was 10 people or 45.4% after education increased to 19 people or 86.4% and for other questions there was an increase after providing the material. It can be said that the Community Service Activities that have been carried out can broaden the knowledge of teenagers.

The Application Of Fetal Music Instrumental Tools Helps Fetal Growth In The Womb Of Pregnant Women At Posyandu Kemuning 1A Village Sukamakmur Ciomas Handayani, Marybet Tri Retno; Wahyuni, Yuli; Elfrieda, Nyayu Siti Aminah Lily
Society : Jurnal Pengabdian Masyarakat Vol. 4 No. 2 (2025): Maret
Publisher : Edumedia Solution

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55824/jpm.v4i2.553

Good fetal growth and development from the mother's womb can give birth to a generation that is healthy, intelligent, and of good character. Good fetal growth is influenced by several factors, namely: Good eating habits, hormonal factors and the environment around the fetus. One way to maximize the process of fetal growth in the womb is that the mother must play an active role in making efforts so that the baby grows actively when born later. one of them is to take advantage of fetal stimulation in the womb with a music sound player system for the fetus. Based on the 2023 questionnaire, there is a request from the community for the community service team to hold socialization and training on healthy heart and fetal development using the research results of the Lecturer which can be implemented in the 2024 community service program to implement the Fetal Music Instrumental Tool to Help Fetal Growth in the Womb of Pregnant Women at Posyandu Kemuning 1A Sukamakmur Village, Ciomas. This community service implements IKU 2, namely students gaining experience outside campus and IKU 3 where lecturers carry out activities outside campus and IKU 5, namely the work of lecturers is used by the community. In addition, this activity produces HAKI products, videos of activities, articles in various electronic media, and publications in community service journals.

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