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All Journal Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ Jurnal Mandala Pharmacon Indonesia Jurnal Kefarmasian AKFARINDO Jurnal Penelitian Farmasi dan Herbal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Riset Farmasi
Muhammad Alfian
Departement Of Pharmaceutical Technology, Faculty Of Halal Industry, Universitas Of Nahdlatul Ulama Yogyakarta, Yogyakarta, Special District Of Yogyakarta, 55162, Indonesia
Chemistry Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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Keywords: Antioxidant, DPPH, Turmeric Instant Powder, UV-Vis Spectrophotometer and IC50 value. muhammad alfian
Jurnal Penelitian Farmasi & Herbal Vol 5 No 2 (2023): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v5i2.1056

Abstract

Abstract Turmeric and tamarind herbal medicine is one of the drinks with turmeric and tamarind as raw materials which is quite widely consumed by the community, either in liquid form or in powder form. Jamu turmeric acid can be used to prevent the negative effects of free radicals on the body because there are active antioxidant compounds, besides that it can be used as a natural antioxidant. There are many natural antioxidants in nature, one of which is in traditional medicine. The content of Jamu turmeric acid is curcuminoids where this compound is useful as an anti-inflammatory and antioxidant. This study aims to determine the antioxidant activity of instant turmeric powder drink produced by of UMKM Healthy Partners, Kiringan Bantul herbal tourism village, using the DPPH method (2,2-diphenyl-1-picrylhydrazyl). The absorbance measurement to determine the antioxidant activity of each sample of turmeric tamarind powder was tested using a UV-Vis spectrophotometer at a maximum wavelength of 516 nm. Determination of antioxidant activity by the DPPH method is expressed by the IC50 (Inhibiton Concentration 50) value. The results showed that the antioxidant activity of the instant turmeric powder drink (Curcuma domestica val.-tamarindus indica l.) produced by Mitra Sehat SME in the Jamu Kiringan Tourism Village, Bantul, was included in the very weak category with an IC50 value of each sample successively. The participants were sample A of (276.005 ppm), sample B of (265.434 ppm), and sample C of (256.183 ppm). Keywords: Antioxidant, DPPH, Turmeric Instant Powder, UV-Vis Spectrophotometer and IC50 value.
Formulation and Physical Stability of Temulawak (Curcuma xanthorhiza Roxb.) Antiaging Lotion with Natural Colorant from Strawberry Extract (Fragaria vesca L) Muhammad Alfian; Mochamad Luqni Maulana; Muhammad Mustainin
Jurnal Mandala Pharmacon Indonesia Vol. 9 No. 1 (2023): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v9i1.289

Abstract

Skin protection is needed to reduce the unwanted effects of free radicals, such as antiaging lotions. Temulawak (Curcuma xanthorhiza Roxb.) contains curcumin which has antioxidant activity with the potential to antiaging. Strawberries (Fragaria vesca L) contain anthocyanins known used as natural dyes. This study aims to determine the antioxidant activity of temulawak extract then formulated as a lotion with the addition of natural colorant from strawberries and tested for physical stability. Curcuma extraction was carried out by maceration using 70% ethanol solvent to obtain a thick extract, infundation method was used to extract a strawberry. Determination of the antioxidant activity of temulawak extract using the DPPH method is expressed by the IC50 value. The antioxidant activity of temulawak extract is included in the moderate category with an IC50 value   of  144.126   ppm.  Evaluation  of  physical  quality characteristics of temulawak lotion with natural colorant strawberry included organoleptic observations, spreadability, adhesion, pH test, viscosity, emulsion stability as well as stability to temperature and humidity. The results of the study after temperature and humidity treatment showed that the temulawak lotion was in the form of semi-solid, pink in color, the spreadability values were, respectively in centimeter 7.95 ; 7.35 ; 6.8 ; 7.05 ; 5.45 ; 5.85 ; 5.25 ; and 5.5 , the adhesive values are respectively in second 0.52 ; 0.56 ; 0.46 ; 0.51 ; 0.52 ; 0.50 ; 0.82 ; and 0.48, the pH value are 7; 6; 7; 7; 7; 7; 7; and 7, the viscosity values are in Pa.S  0.017; 0.031; 0.113; 0.055; 0.352; 0.263; 0.18; and 0.324. The conclusion of this study shows best formulation stability was formulas E, F, and H.
UJI AKTIVITAS TABIR SURYA EKSTRAK DAN LOTION KUNYIT (Curcuma domestica Val.) SECARA INVITRO MENGGUNAKAN SPEKTROFOTOMETER UV-VIS Alfian, Muhammad; Hasanudin, Muhammad Nurul; Maulana, Mochamad Luqni; Mustainin, Muhammad
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1623

Abstract

Excessive UV B radiation can lead to premature skin aging, but research suggests that turmeric (Curcuma domestica Val.) may have antioxidant compounds that could serve as a sunscreen. To investigate, the researchers tested turmeric extracts and lotions in vitro using a UV-Vis spectrophotometer. They extracted turmeric by maceration with 70% ethanol to obtain a thick extract, then evaluated the physical characteristics of turmeric lotion preparations including organoleptics, spreadability, adhesion, pH, SPF values (using the Mansur method), and Erythema Transmission Percentage (%T) in vitro using a UV-Vis spectrophotometer with absorbance wavelengths of 290-320 nm. The results showed that F1 to F5 turmeric lotion preparations were semi-solid, brownish yellow, fragrant, with spreadability above 7 cm, adhesion less than 1 second, and pH below 8. The highest SPF value of turmeric extract was at a concentration of 500 mg with SPF 46, while the highest SPF of turmeric lotion was F5 with SPF 15. All turmeric extracts are categorized as sunblock, while F5 lotion is also sunblock and F1 to F4 lotions are fast-tanning. Although the SPF value decreases when turmeric extract is made into a lotion, it still has sunscreen potential.
UJI AKTIVITAS ANTIOKSIDAN MINUMAN SERBUK INSTAN TEMULAWAK (Curcuma xanthorriza Roxb) PRODUKSI MITRA SEHAT KIRINGAN BANTUL Naila Imroatus Sholikhah; Muhammad Alfian; Fitri Andriani Fatimah
Jurnal Kefarmasian Akfarindo Vol 8 No 1 (2023)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.v8i1.179

Abstract

Temulawak (Curcuma xanthorhiza Roxb) merupakan tanaman yang sering dimanfaatkan sebagai obat tradisional dan diketahui tanaman ini mengandung senyawa kurkumin yang dapat berperan sebagai antioksidan. Pada penelitian Meiliyana (2021) menunjukkan hasil kadar rata-rata kurkumin dalam minuman serbuk instan temulawak UMKM Mitra Sehat di Desa Wisata Jamu Kiringan dari 3 kemasan yang berbeda berturut-turut adalah sampel A sebesar 42,28%, sampel B sebesar 40,4% dan sampel C sebesar 46,54% yang membuktikan bahwa sampel mengandung kurkumin. Namun belum ada pembuktian uji antioksidan pada serbuk instan temulawak tersebut. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan pada serbuk instan temulawak yang di produksi UMKM Mitra Sehat di Desa Wisata Jamu kiringan. Pada penelitian ini dilakukan uji antioksidan pada tiga sampel yang berbeda menggunakan metode DPPH (2,2-Diphenyl-1-picrylhydrazyl). Masing-masing sampel diuji menggunakan spektrofotometri UV-Vis pada panjang gelombang 516 nm. Penetapan aktivitas antioksidan dengan metode DPPH dinyatakan dengan nilai IC50 (Inhibiton Concentration 50). Hasil penelitian menunjukkan bahwa aktivitas antioksidan pada minuman serbuk instan temulawak (Curcuma xanthorriza Roxb) yang di produksi UMKM Mitra Sehat di Desa Wisata Jamu Kiringan Bantul termasuk dalam kategori sedang dengan nilai IC50 masing-masing sampel secara berturut-turut adalah sampel A sebesar (144,126 ppm), sampel B sebesar (141,839 ppm), dan sampel C sebesar (141,765 ppm).
ANALISIS KANDUNGAN BORAKS PADA MAKANAN CILOK MENGGUNAKAN SPEKTROFOTOMETRI UV-VIS SEBAGAI VERIFIKASI PRODUK HALAL DI DAERAH ISTIMEWA YOGYAKARTA Akbar, Muhammad; Hidayati, Listiana; Alfian, Muhammad
Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ Vol 11 No 01 (2024): Januari
Publisher : Lembaga Penelitian, Penerbitan dan Pengabdian Masyarakat (LP3M) UNSIQ

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32699/ppkm.v11i01.6313

Abstract

Cilok adalah makanan yang terbuat dari tepung kanji yang berbentuk bulat. Boraks adalah suatu senyawa yang berbentuk kristal berwarna putih, senyawa kimia dengan nama natrium tetraborate. Uji halal karena sesuai dengan Fatwa MUI No. 43 Tahun 2012. Tujuan penelitian ini untuk mengetahui apakah cilok yang dijual di wilayah Daerah Istimewa Yogyakarta mengandung boraks. Metode yang digunakan adalah metode kuantitatif jenis eksperimental menggunakan uji Spektrofotometri UV-Vis, untuk uji kualitatif menggunakan uji nyala api, dan uji kertas tumerik dengan pengambilan sampel secara purposive sampling yang di mana pengambilan sampel dilakukan di Daerah Istimewa Yogyakarta. Hasil dari penelitian ini yaitu untuk uji kualitatif boraks pada 12 sampel menunjukkan hasil negatif mengandung boraks. Pada uji kuantitatif menggunakan spektrofotometri UV-Vis didapat regresi linier y = 0,0233x + 0,4146, sehingga dapat dilakukan untuk penentuan kadar boraks pada sampel. Uji kuantitatif diperoleh hasil negatif. Uji kehalalan untuk cilok di Daerah Istimewa Yogyakarta adalah terverifikasi halal.
Formulasi Sabun Cair Antibakteri dengan Bahan Aktif Ekstrak Biji Kakao (Theobroma cacao L.) Muhammad Alfian; Lita Siswanti; Fitri Andriani Fatimah
Jurnal Riset Farmasi Volume 4, No. 2, Desember 2024, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrf.v4i2.4866

Abstract

Abstrak. Mikroorganisme patogen, seperti Staphylococcus aureus, dapat menyebabkan penyakit kulit. Biji kakao mengandung metabolit sekunder, seperti flavonoid, tanin, dan alkaloid, dengan aktivitas antibakteri. Penelitian ini bertujuan mengidentifikasi kandungan metabolit sekunder pada ekstrak biji kakao, serta menguji sifat fisik dan aktivitas antibakteri sabun cair ekstrak biji kakao terhadap S. aureus. Ekstraksi dilakukan dengan metode maserasi, diikuti skrining fitokimia, dan formulasi sabun cair F0 (ekstrak 0%), F1 (20%), F2 (40%), dan F3 (60%). Uji aktivitas antibakteri menggunakan metode difusi sumuran dengan diameter zona hambat diukur pada semua formula dan kontrol positif (sabun cair Dettol). Hasil fitokimia menunjukkan ekstrak mengandung flavonoid, alkaloid, dan tanin. Uji organoleptik, tinggi busa, dan homogenitas semua formula memenuhi syarat, namun viskositas hanya F0 dan F1 yang memenuhi. Uji pH semua formula tidak memenuhi standar. Uji antibakteri menunjukkan daya hambat kuat pada F0 (12,698 mm), F1 (13,251 mm), F2 (10,12 mm), dan F3 (14,383 mm), sedangkan kontrol positif memiliki daya hambat kategori sedang (6,195 mm). Abstract. Skin diseases are conditions affecting the body's surface, often caused by microorganisms like Staphylococcus aureus. Cocoa beans (Theobroma cacao) contain secondary metabolites such as alkaloids, flavonoids, and tannins, which exhibit antibacterial properties. This study aimed to identify the phytochemical compounds in cocoa bean extract, develop a liquid soap formulation, assess its physical properties, and evaluate its antibacterial activity against S. aureus. The cocoa bean extract was obtained through the maceration method and underwent phytochemical screening. Four liquid soap formulations were created: F0 (0% extract), F1 (20% extract), F2 (40% extract), and F3 (60% extract). Antibacterial activity was tested using the well diffusion method by measuring the inhibition zone diameters of the formulations and the positive control (liquid Dettol soap). Phytochemical analysis confirmed the presence of flavonoids, alkaloids, and tannins. Organoleptic tests, including foam height and homogeneity, met the standards for all formulations, while viscosity standards were met only by F0 and F1. However, none of the formulations met pH standards. Antibacterial tests showed strong inhibition in all formulations: F0 (12.698 mm), F1 (13.251 mm), F2 (10.12 mm), and F3 (14.383 mm). The positive control showed medium inhibition (6.195 mm).
Ekstraksi Protein Bungkil Sawit serta Karakterisasinya dengan FTIR dan Uji Kjeldahl Yogananda, Amrina Amalia; Alfian, Muhammad; Hidayati, Listiana; Yulianti, Selvia; Cahyani Irawan, Hisba; Restu Dwi Saputro, Rafly; Cita Cahyani, Anggun
Jurnal Riset Farmasi Volume 5, No. 2, Desember 2025, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrf.v5i2.8207

Abstract

Abstract. Palm kernel cake is a byproduct of the palm oil industry that remains underutilized despite its high content of non-starch polysaccharides and carbohydrate-bound proteins with potential as plant-based biomaterials. This study aimed to extract protein from palm kernel cake and identify its functional groups and protein content using Fourier Transform Infrared (FTIR) spectroscopy and the Kjeldahl method. Protein extraction was carried out using an alkali–acid process involving solubilization with NaOH followed by isoelectric precipitation with HCl. The dried protein extract was analyzed using FTIR to detect characteristic protein absorption bands, while protein content was quantified using the Kjeldahl method. The extraction produced a yield of 9.6%. FTIR spectra showed the presence of Amide I (1650 cm⁻¹), Amide II (1540 cm⁻¹), and Amide III (1230 cm⁻¹) bands, confirming the protein structure within the extract. The Kjeldahl analysis revealed a protein content of 49.27%, which is higher than previously reported values and exceeds the minimum protein requirement of 13% set by the Indonesian National Standard (SNI). These findings demonstrate that palm kernel cake is a promising raw material for the development of plant-derived protein suitable for pharmaceutical and biomaterial applications. Abstrak. Bungkil sawit merupakan produk samping industri minyak sawit yang masih belum dimanfaatkan secara optimal, meskipun mengandung polisakarida bukan pati dan protein terikat yang berpotensi sebagai sumber biomaterial nabati. Penelitian ini bertujuan untuk mengekstraksi protein dari bungkil sawit serta mengidentifikasi struktur fungsional dan kadarnya menggunakan spektroskopi Fourier Transform Infrared (FTIR) dan metode Kjeldahl. Proses ekstraksi dilakukan menggunakan metode alkali–asid dengan pelarutan NaOH dan presipitasi isoelektrik menggunakan HCl. Sampel protein kering dianalisis menggunakan FTIR untuk mendeteksi pita-pita karakteristik protein, sedangkan kadar protein ditentukan secara kuantitatif dengan metode Kjeldahl. Hasil penelitian menunjukkan rendemen protein sebesar 9,6%. Spektrum FTIR memperlihatkan pita Amida I pada 1650 cm⁻¹, Amida II pada 1540 cm⁻¹, dan Amida III pada 1230 cm⁻¹ yang mengonfirmasi keberadaan struktur protein. Uji Kjeldahl menunjukkan kadar protein sebesar 49,27%, lebih tinggi daripada nilai yang dilaporkan pada penelitian sebelumnya dan telah memenuhi standar SNI minimal 13%. Temuan ini menunjukkan bahwa bungkil sawit berpotensi sebagai sumber protein nabati untuk pengembangan aplikasi farmasi dan biomaterial.
Co-Authors Cahyani Irawan, Hisba Cita Cahyani, Anggun Fitri Andriani Fatimah Hasanudin, Muhammad Nurul Listiana Hidayati Lita Siswanti Maulana, Mochamad Luqni Mochamad Luqni Maulana Muhammad Akbar Muhammad Alfian Muhammad Mustainin Restu Dwi Saputro, Rafly Yogananda, Amrina Amalia Yulianti, Selvia